'tIs C.KC

AF 2091 653P.

KCC is dcretese orfm I lescl udneoum,d( )neujujm yb aftty caid, oamin iad.c

imna nficstonu of CKC .re 1a inc rncaicapet ston2ee.icr nic lrballdaged r3cotncotnai . cin risctga .giepy4tn m npsceihtr of didO eaaliorxtn

Acts on nlruea mcsciurina awhsytpa to ausec rep.tni eceniasotrcca n(to nrecoidne tounl)aimtis t&g-; o/R (C)

alamsP aernsbmem era a ipdli ,lbyreai ailclypyt twhi popastehh dsaeh no chae arfseuc nad olng cbnoar sliat no teh .iesnid hTees bsoncra era naleurt, dan udgneor ryboopcihhd isnnaitcteor ofr na tgnleeceaylir aaoeflbrv etas.t

grtelIan abmrneem eotrnpis apss uohtghr shti dpiil ,eblyiar and os smtu be acpbela fo cigtrneitna thob ithw teh olpar ostnlesv of calilteanrrul nad xtulellarerca speca, as llew as the dibryhoophc croe fo eht rlaey. heT mmeasabnrernt toonrpi tnfeo hsa hlcel-aiaahlp yaderscon nictfmoarn,oo hitw ybhorphoicd dussieer lkei nlgieyc no eht soeiudt rowstda het boacrn altsi tihw ploar manoi cadi isruedse ekdctu .ni

ehT nietpta sha a irrpo rsythoi of ytmceoehtyrs thiw braatliel riy,eompnhosalt-pogooc and ceeridve eertlanx bmea aiorantid ot hte pievsl. The tapeitn wno ssaiypld dsrisooepyrhhn dna rdtoyhree,ru ithw dtails aertrlue rwnnagiro ltailaylrbe. eTh stiiellke potnio is ttah ew rea ensgie dsiasnhoe rfmo eiuovrsp uegrrys nstocicrt het etsu,rer nicgasu s.tih

)E lathriUleo accmraino o(asl eclald tnltioaainrs ecll imnaccro)a is aols a o.sypitbsili Wtha ksmea sthi kyllieun si the :tnlioaoc lieata.brl eTh ioprr rmohteyytsce nad aletilrba otylphopsgooioarcnem- dwoul veeal srac uteiss on obth esisd fo hte ,ydob utb eth osdd of oirlaluhte cnomrciaa srginia yearliblalt aer yvre m.isl

)A Teh tiaetnp adh a ,ottyceserymh so teh sodd of rrurceetn cecviarl aroacmnci ear oasl iblidncrey wol. C) dan )D aUrlrhte oyomdnlca nda uhatrrle iaosrnlaittn clle mllaapipo ear ni eth ornwg cioalotn to cutanoc rfo rlialbtea uhelratr igwnarnro itwh o.erruerdhty

HCM I nfnoucit is lretaing ot cracen r.sseiosnppu CHM I yasdpils ooulengdsney sdeniysthez onptseir dan tsernesp temh ot 8DC+ T lcle.s The fliuear to aiyldsp HCM ,I or HMC I lydspai of nse-lonf nd(a yb ineteonxs ccesnar)uo rentpsoi trrgeigs a relllcua unimme on,erpses lngiade to duttcirenos of the ellc.

heT srpaoeotme si ueds rof eth aniaetdordg fo orwn tu,o t,seeencns ro ormamflde iropn.est sA enaccr ovd,lpese rome ntoaiustm dale ot ercadinse gnorw ntpsre.io Only by osesnxiepr fo het oet,omraspe ro sti vpeor-orneesxis, acn shtee utmtna poerisnt be drdadeeg tsaf ohugne ot ton be epdsdyial yb HCM I and dale to eht clel ginbe l.dkile rzioombtBe bcoksl teh eomtoeasp,r os the nuttma npretsio ear ddiyeapls no teh rs,fueca loglwani the eunimm mstsye ot rngczieeo nad likl olahcilaoptg lelcs.

hCiria-dBud nyrdsoem sorcuc hwen eetrh is osicocunl fo the ecptaih eivn ro hte hiecatp niev lsifa to inard iont eht IVC. Thsi nac be udsace by smobithrso fo het ethcapi ienv, or by rhtgi sided atreh ualierf asiu(ncg oolbd to a'kcb 'pu eeewvrhe,ry btu tis taaennmtiosif tguhhor teh ihpteac niev aer lal hte sgnis fo Crdu-iiaBdh soenm)ry.d gihytAnn hatt nca ncersiae eth rksi fo osmisohrtb acn etnh eacerisn het srik fo BdCauiird-h m.yeordns Tihs declunis ocliympayteh r,ave a bleeocrghlaapyu tat.es ruO tnipate adn VP btu isdesm his npipeotantm wot eewsk .oag eH nwo seretnsp twih sclaler irsetuc, an lgneared lev,ri nad oesm sgnsi fo lpator tnispe.nyoerh hTmsbsoroi fo eht yonl aamolicant notipo srpdenete ahtt rceovs lla fo itsh si hte ahcitpe vein ie oru attpine sha Bhrd.iu-Cdai memrbeRe taht draiiuBCdh- lwil eahv a unt"gem "irlev eepacanrap no ssgro pg.yaohlot

B) cptHeai osisrci-rh ti's tyreleni pboliess uro nttpiae oesd ehav pihetac rhcrisios for arteeulnd ran,soes oerhewv the atuce esnto maske tsih slse l.ikely C) Picnaartce -airmaoncc acaticnerp arnaocimc bniotustrco fo teh cmnoom ebli dtcu clduo uscae a 'bakc pu' of l,bei tleyaliutm iucnsga smeo leirv damgae nad rcselal sceutri. erwevoH ocen gnaia hte ginimt mseak htsi yelinlku. )D artolP nvei bh-oriosmst plraot eniv ibrsohostm odulc eacsu omes cniplse mlrtaneegne dan tlrpao t.oyrenpishne eo,vwHre tsi ttiusobrcno lwodu not csaue a teerdn, aenedlgr ilevr euceasb it si terampsu. E) mPraryi eomhta-ircsomohs due ot a dcefte ni cidehinp op,cuniodtr shti oirn aelroodv eetpsrns whti dedeaknr ikns, ilsinnu ,euisditonrlga ptehica edgaam wth(i the tanoeltip for alclotpurealhe a)rnocicam dna tarhe seaside treiet(sircv ro eldaitd rdyc,taoipaomyh degienndp on oruy o.scu)re Teh yonl noe of eehts ssnig htta ruo apettin hsa si na eerlagnd lv.rie

So aaclblisy thaw hsit si iysgan taht NDA ilwl be rtntasmtedi to eht enrogpy tno AR .NSo ADN will ieeralcpt ni eth 2G hpaes nad asertrnf fo DNA arleatmi ot ygenrop liwl crouc ni teh M a.heps heT ARN aym be tdmuaet and ngikam ifedceetv sp,cdotru utb sthi lliw not ttiramsn toni hte yr,genop tuhs otn cgftianef ieepscs lvsauriv edbas on RNA asttmniuo.

ruumrM htat si lruoed ihtw edrcued sunevo truenr ;&tg= hriHortpeypc pooryimhacydat

HMOC si eud ot oauimtnst gindncoe eosrramcse ucsh sa nsomyi ngniibd npiroet C and abet nysoim hayev hnci.a

Muumrr tath si odeurl wtih udcrdee voesnu rruetn ;&t=g thyocirprepH toiypmdayaroch

OHCM is ued ot omattnusi goidcnen rmoreacess chus sa syomin nniigdb tnporie C dan teba mnosiy yaveh inhac.

preeEnhniip si the lyno G copldue optererc oairtcatv teh is.tl Teh rest era thiree re-ictnleulrla or a itreynos kiensa (n.liui)sn

Why si isht otn ?HUS woH idd uyo gusy pahropac eth ?ntoiqesu

os I asw stkuc no isth seuebca shi NBU nt/anicerie oaitr del em ot hnkti eh hda na cnriiints laner ncofnuditsy. And a P2IG hiiiibontn uoldw elda ot a ea-nelrrp zatiaoem, eerwh teh /NBU iinaretenc riota uwdol eb omer thna 0.2 I onwk tath ADSNIs thiinib PS.IG tuB who rae you spdsupeo to scosr otu ncdotiinu fo tlsaid burtalu iiossc?ad

oS fro adinCda we nac ues

zeoslA nufceol(z)loa inthibi( 0YCP45 tieatyhodnme)l

Amhnrpeocit B po(re ftaimnroo in agflun clel )earmenmb

aiCfnposgnu tevn(rpe nsiosnkrcgil of taeb cslunag ni lcel l)lwa

ro stinayN ofr aolr ro paaghesleo asecs (poer mftaon)oir

siTh qtiesnou is ngaysi hatt seh is ngakti na LOAR rdug ot rteta iacadnd niatisvg.i

mhcAeontpri si IV

infognsCaup si sola VI

so ee'wr letf tiwh lzeoas

ozseAl ihbiitn hsseysitn of gresltoero by nihitbinig CPY 450 hatt nocvsetr aetonllrso to .eroegotrsl

tnis' ddaiacn ayste rmfo duner body ree?pmautret ywh eth pcuriet wossh a odlm ofmr?

nI an lyelrde ittapne thwi adsloite vdleetea laealink hhpassoatep aor(mln suerm icucalm dan pae)tshhop gsPte'a daeesis fo beon slhodu eb ta the pot of hte deiffnt.erail hsTi esiasde si edu to oenlsduagityr fo ocalitesocts dan ibcstlosatoe vc;aittyi rftsi an laitini otloatssce pcrhiiayvyett ea,psh hent cneirdsea atbosestlo tyviacti rof a i,mxrteu thne seotsslacot ob"tr"uun gndilae to rina-ezonlmovatreii dna lcreoctis ebon sualqp.e nI iaidondt, hist can rcaeet oiuevrnraotse suhstn ni het onesb hiwhc ssdaceeer ,eicersntsa dlaengi to hhgi ottupu iaacrcd ilraeuf a( arsmili elmopbr can iesra ni satevourenroi ftssaliu fmro ldoob dy)ilsa.si nO oyolgitsh ti lliw eavh a cai""smo enr.ptta

)-A lmyAeruans bneo cs-ty elgrlya a urotdpc of yvrytiiaepcth of os,lscasotet shit suorcc oemr tnoef ni het bms,li dna hwsso a tscyci ecpsa hiwt nbaoll-keiol dlti.nioa B) mor-aoasicgAn acmaoosigrna fo eth bnoe is n atolsm eplruy ycitl niel.so yheT crouc moer leyutnreqf ni renoyug epo.epl C) aincNi ec-niefyicd I cna dfni tnoghin utboa tnbiivma 3B ifideecync vngoiinlv bens.o B3 dceitencfi tleurss ni lge,lpraa iwht eht scsalic eherT s-D' idiattrsem rahs( ckanelec on 4C3C/ ,meemrt)aod entidma,e nda .rhireada )E oeaam-scsOrto odFnu masotl ysulvxeclei ni ronueyg peplo,e isth onbe wortgh scourc ta het tohrwg e,tpla aprualilyrct ta teh ixmaolrp ned of the iibta, saitld ned fo teh eufmr, ro pxairoml den fo teh shuruem i(n eht lgon sbone anurod ryou neeks or ta rouy ueos)lhsd.r It hsosw a lrgae, osdil onwiggr mssa htat aym risae teh ituemoserp in a unursstb da/ratsnno'pmetC rl.etigna F) tPsiartco iacn-rmcoa rrea rfo nbige noe fo, if not teh ynol secmaittat nebo rnaecc htat is pruyel ooic.easttsbl

nI na lreldey atetpni twhi asetodil vdetleae aelnikal stpehhaspao onrl(ma rmues amculic dna oppehah)st Ptgs'ae sieaeds fo bone dolush be ta teh pto of hte eein.laftfrid Tshi daesise si eud to edyogunrlsait fo ctotasloseic nad soiscebatlot iayc;itvt rtsif na iiiantl stcostaoel ciayptviheytr s,apeh nthe sedneiarc esoostbalt vticatyi fro a imr,texu ethn tlsctsoaoes to"ubn"ru ginalde ot -oariiaznvelretonim dna orctleics enob s.qalupe In toa,idind htis nac eatecr resoourianetv hsusnt ni eht ebson whihc erdsaeesc iace,senrts naegidl ot ighh otuput idrcaac leaurif a( lmriias lrmobep anc eiars ni ievonaorruest tlsfasiu rmof obold yssla.idi) On tlhogsiyo ti wlli ahve a amco"si" r.ettpna

A-) ymlAenusra enbo y-stc leyglar a uptdorc of riihcypvattye of alo,tsssetoc hits cuorsc meor nteof in eth lsim,b dna sowhs a sycitc pecas hwti nae-oolkllbi oitadli.n B) raaocAogs-min ornaicgoamas fo the eonb si n laomts yupelr tlciy .inolse ehTy curco remo lefunrqeyt ni ngeoyru pl.eepo )C iNnica iinfyde-cce I can ndfi nhtgnio buoat nmiibvat 3B cniyediefc inoinlvgv .ebsno B3 ifcnideetc ueslrst ni earllgpa, whti teh icslsac rThee D'-s tdasmtiier sa(rh lncaekce no C43C/ are)em,mdto inma,tdee adn arheard.i E) tamOcas-oreos dnuoF osltma eceixlvulsy in orunyeg eoeplp, tsih oenb hrogtw scuorc at teh wrghto tpela, itpucylrlara ta het ioapmrxl nde of eht biai,t tdilsa end of hte uer,mf ro raipxoml end of het heusrum (ni eht nlog nbeos duoanr uyro ksnee ro ta ouyr sr)o.hsedul tI ohwss a alge,r odils oiggrnw assm htat yma esari eth usmetroipe ni a suusrntb snmaa'tdConert/p a.elginrt F) satciotPr -ncacmirao arer rof ebing neo ,fo fi tno teh yonl mttstieaac ebno renacc thta is pyuelr ecsb.tooislta

pyhnnaeoinpmaleplro si na ahpla atgsnio ttah sumtsteial aethlurr mohost lumsce naocrc.ontti - rfmo dp,eottua ewrhvo,e ti loas ssya ti is not emdneecdomr tttenemra nareomy

U,gh I aws oLw PB dan toughth enllsatog natapsciteir /w rhgehoarme so I piekcd eysllnsue'o/Ccmhsec gin.s

i gto igrn mwor form a refnis'd act adn os my luwaf emldid scoloh eenerceixp pedlhe me srnwea tish qneotisu

i tog irng owrm morf a frid'nse cat adn os ym luafw lemddi hlcoso eereixnpce dheepl em erwans tish euonqsit

Lylkie an iihnntioib of rayheyo.dsxl21- iTsh si eht omst mocmon fo hte toaiglnecn enaldra ypsihsrpeal.a enePrsst ni nayfcin or codiohl.dh

tnrohAe tymspmo yhte yma heva ttha e'Iv ense durnoa si !!viotmgin Toko me a whlei to idnf ti, btu ehty rea last snawigt by hgavni no otnsodelr,ae os eht slos of eesolyrttcle is cisngau aneecdrsi ICP.

dBoars dan neBody hsa a ogdo wlof hrtac rof subuioamg Ie.taagfi nli eth tpniate is XX - do tehy vaeh naelrlmui ?stusuetcrr If eys, sti' HAC ansrcdeei( ranfIgo)s end. ythe aeptint si YX - do teyh veha lmaineurl utcsetru?rs If e,ys gnldoaa sseisndgey n(o ).IMH If ,no hten ti ocldu be deu to oblaarmn onreagdn oeteps,rrc ,AHC or wlo .DHT

nrDiug nrolam pranii,tnosi eliolav tstrsa mfor HF(mO20mCR) ot 1- mh;mO2 thsi TIANEVEG suerrspe skscu rai .in nI PP,V eht cameinh si ughisnp air agmkni nesrop od aon"iiri"npst tub nwo laarvloe errseups si OEISTV.IP pm&a; tehn ptiieranox ouccsr ipssvelay by( lisctae iol.)rce PEEP si an ndotadiali RVONESI of PPV. Heer, ew do VPP ,tub ni aent,prixio ftear osme easispv icreol NED( ROIXYTEPRA RSEPEU,S)R eth niemach sepush eosm .iar oS the nlgu dose nto ulfly ftleade and errutn kcab to RC.F hts'aT woh we ezbisltai the lmsla lioleva rmof egntigt losdaplce fater yevre PVP. ,MMBREEER ni PPEE, lugn VENRE EGSO ACKB TO .CRF S,o vlealorA resseurp ilwl YSLWAA eb S.OVPEIIT lolNryam PPI is -5 ftear OPXINETAIR DED()NL-TAI nad -8 reatf ATSININIPO.R Hree ew rae vgigin +10 htiw .ttenoaiVlni hTat lwli ocrevmeo lanorm DIDNL-ETA ()5- kmnagi LAIEN-DDT IPP ot +.5 Adn of osu,rce thsi 5+ has on achcen ot beecom enev 4+ auscbee eth enhmiac iwll uhsp the ria inudrg iatiinrpsno icwhh lliw akem IPP nvee emro Ee+PEPv. si udse to Rx omHaexpiy fo RDA.S ehT inodsdwe is, iths e+v PIP esaercde VR ot tR hrtae dan oals tL th&ergt;a ncdieugr aidCcra .uuOtpt

Hree si na eAsowme oediv that lwil ep:hl sha_48gwt:=?ymtw.b2o.tst//uwgepau/wHocckLvh

oamoolCb si an eey amotbynilar atth rcsocu ofeebr bhri.t eyTer'h missnig seipce fo isutes in rtctusrsue thta fmro eth yee.

• oComoabls inefagctf hte ,srii whchi usrtel in a e"koel"hy aeppncarae of hte ,plpui elyleargn od nto alde ot ivsnoi .ossl

• olboomsaC voniingvl hte etainr slurte ni iovsin osls in fpceisic tsrap fo het siluav fedl.i

• Laerg tnraiel olcoobmas ro tohse cffiagent teh pcoti reenv acn acesu wol vsni,oi ihchw aemsn ovinis sslo taht oanntc be lemecoltpy eoterdccr ihtw laessgs or otnccta enes.sl

wy"h ondt' uoy opst tawh yrou'e oigdn acbeues ts'i u"i.iuoclrsd tal-acu- snawre

the seoiqutn emlsipi atht it si a seca of livxaaet suabe ( stuh lietcaomb lska)osila ubt eht wernsa nrtsu tou to eb hte rtllyeeceto arsudbnetic fo mlsyip irrahdea alnro(m onian pga emlbtaci dasoiis)c . stuno eiq gnlyrow daesrhp nda nunsifogc

Wneh satetinp are nveig Ntciiinoc N(diinacc)ai heyt are ldot to pxctee mcoomn dsie ftfeces to uoccr uhcs sa mtwrha nda rdsnsee. nOe cna oaivd shete sied sfecfet by iatnkg isanipr

I tge tshi is a uflfyf eoqnutsi nad aegkdlnncowgi the 'tsnpeita ssonear for nmiissg lnnusii nnijeoisct si het sdculi,dte tbu I flee like htis nerswa owts the ilen a .tbi uoY ton'd wnat to ysa atht imsnsig dsoes is ,ko but oyu sloa no'td twna to be nema ot aettnpi i.trhee I hhtgout tshi wresan )A( was ndgioncon ehr mgissin eht esnt,jicino so I edicpk .)C( nI ,sortteepcr I esgus nolcwdageke mesna lkat suoucofta/b eht eovsontcrina no.daur

mooa,inAerd a slacs III aaciinytmhtrrh g,udr ash llepuimt cfsfete no ridaalycmo ozinaeodiaptlr dan oonaialtiprzer ttha eamk it an eexemtlry ieefcfetv nihmtayathcirr ugrd. ,worHvee namoodreai si stsaiadcoe hitw a bumner fo esdi fe,tecfs ugndiinlc otyhidr udnfnsoyict bo(th oyp-h nad tmri)shroyhey,pdi hwhic is deu to na'rademoois ihhg iidone tnnceto adn sit rdetic oixtc eefftc on teh irt.yhdo (tp.ecoouadmt)

cnliarTysecet vhae a hihg anityffi ot orfm scltaeeh ihwt lentylvapo almiectl scnaoit scuh as Fe++,+ ,e++F +Al,++ ++Mg dan C++.a Myna fo tseeh neymaaelrtcti-ltec mpsceloex rae theeir illseounb or wseirothe ypoolr laobesrabb fmor hte niaos-ntgltistaer t.arct lMik dna oetrh dayir ,cptuosdr caisdtna nnnctioaig yalvnptole s,tncioa as wlel as srauoiv iron tsals gsneedti uylsmanuielsot htiw nitectcreayl ver,ietsdiva tmihg reetinfer hiwt hteir npbsiotaro yb 05 ot 90% or vene m.reo u :csero nel4unv9t6.5dwhs.g8.:t9bp/pw.i/n//ihmwocmb

ootaShscsmi nismaon nda meitauhboam acn eb 'IDd yb rheit iueunq peissn. .S nnmsioa ahs a etlraal iespn as esne on het thap lwehi .S mbahiutomae has a etairmln senip (.S uncpjmoia sah no p)ni.se

eeS gfnwoloil rfo thap scsonioapmr im(annso L, immtaeuoabh M, juapcnoim )R

p0wute/esfre/g/ogas:oi%s/m.t/solhpsiSphwormjoito/ecnghs/tsg.seeslgiwtouedtm2g.efya/