NBME 20 Cilostazol (NBME Answers)

need help with your account or subscription? click here to email us (or see the contact page)

search for anything ⋅ score predictor (“predict me!”)

Retired NBME 20 Answers

nbme20/Block 3/Question#43 (reveal difficulty score)
A 71-year-old man comes to the physician ...
Cilostazol 🔍 / 📺 / 🌳 / 📖
tags:

+5 upvote downvote
submitted by ∗neonem(630)

get full access to all content ⋅ pick a username

Cilostazol is a phosphodiesterase inhibitor; leads to increased cAMP which inhibits platelet degranulation/activation while also causing vasodilation. All of the other options work on either vasculature or platelets but not both.

get full access to all content ⋅ pick a username

kernicterusthefrog Just to add: cAMP activates protein kinase A (PKA), which is the more direct mediator of platelet aggregation inhibition, and of myosin light-chain kinase inhibition (which causes inhibition of smooth muscle contraction and thus vasodilation). Just in case there's a question that gets more specific than this one! +14

brbwhat wasn’t dypirdamole an option? +

fataldose I believe they also cause vasodilation by decreasing the cellular reuptake of adenosine by endothelial cells and the adenosine causes vasodilation. +

+2 upvote downvote
submitted by ∗isaacmed2020(2)

get full access to all content ⋅ pick a username

-Page 429- First Aid 2019 Edition. Antiplatelet phosphodiesterase inhibitors

get full access to all content ⋅ pick a username

+0 upvote downvote
submitted by ∗fatboyslim(118)

get full access to all content ⋅ pick a username

I chose Aspirin. So aspirin is a non-reversible inhibitor of COX-1 and 2 which should decrease TXA2 levels, and according to FA 2020 page 485, TXA2 causes platelet aggregation and increases vascular tone...I'm guessing the overall combined effect of COX 1 & 2 inhibition will cause a net effect of either vasoconstriction or no change to vascular tone?

get full access to all content ⋅ pick a username

spaceboy98 Me too. i thought aspirin blocking off the TXA2 production would allow for vasodialation. +1

kevin This was a UWorld question. I originally thought the same, it's just cilostazol does the vasodilation and inhibition of platelet activation most directly +1

Must-See Comments from nbme20

amorah on Cytomegalovirus infection
masonkingcobra on Contact with parakeets
hayayah on Capillary hydrostatic: increased; ...
hayayah on X chromosome-linked isoenzymes
medbitch94 on Mannose 6-phosphate
hello on Capillary hydrostatic: increased; ...
hayayah on Osteoblasts
imgdoc on Hypophosphatemia
hayayah on Missense
celeste on 50%
justgettinby on Omeprazole
andrewk1 on Cold, dry air
yotsubato on Jugular venous pressure of 12 mm Hg
strugglebus on Drug effect