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NBME 20 Answers

nbme20/Block 3/Question#26 (32.5 difficulty score)
A 3-month-old boy is brought to the physician ...
Mannose 6-phosphate🔍,📺

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submitted by medbitch94(38),
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A12F09 gape 7:4 lIlce- eidesas slcinu(oin lelc splsemoie/osscduiaidi pety —nthdr)IeIiei olsmyalos setrgoa rreidosd; tcdefe in hnoylscnrestca-rsoshlymue1pfgto-aaiapeNl- ;rr&ra arlfuei fo hte goliG to teoosayhhpprl eoannms sresediu irmgfo(n tnhhossoae6)maep-p-n no ltoyrnigsopce &ar;rr rtsoinpe are scdreete rxallrcueyletal hrtaer tnha eddelveri ot yslmo.oses sRuetsl ni acrsoe afclia us,ertaef iglngiva lhaapierp,sy edlucdo nsco,are ercdtrtsie ntoji et,enmmvso aclw hdna ,tiifmoseerd coi,phossloikys dan hgih plmaas levsel of lmsooyasl yeesnmz. Oetfn atfal ni odhlhio.dc

submitted by andremosq(6),

I-cell trafficking disease: Failure Golgi to phosphorylate mannose residues so, decrease mannose 6 phosphate: coarse facial features, restricted joint movements, high plasma levels of lysosomal enzymes.