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Retired NBME 23 Answers

nbme23/Block 4/Question#26 (reveal difficulty score)
A 28-year-old man has hypertriglyceridemia ...
Aspirin ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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 +4  upvote downvote
submitted by โˆ—lfsuarez(160)
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When pntiaste rae vineg iintNicco (cnicia)diaN tyeh aer tdlo to epetcx nmoocm dies fsetcfe ot uocrc husc sa mhwatr dan rdnsse.e enO nac aivdo hseet ides fseftec yb nktagi pnirias

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mcl  To dpnexa on t,ihs het engharhswunsmtdlfei/s/r si edu to reealse of P2DG and G2EP hiwhc is ywh gtkain na NDIAS .selph +20
snripper  Dnt'seo eoetacanhmnpi nistbhii COX -1,2 ?oot Why t'cna uoy use ttah staneid of r?sanpii sJut gnodie.nrw +4
raspberryslushy  I dah hist esam osneuqti too, nad dha ti rdnwoaer dnow to ohets wto .occseih nddeE up niogg irniaspw/ utb ti wsa tsor of a noic stso. iltlS not rsue wyh 'sti nto eho.nmcatiaenp +
eagleeeee  I khint eht nserao si thta eonnhctiepaam si neiihbdti elphiareyrpl and is milyan dseu to itbnihi XCO in het SCN +8
whatup  Teh swtro edsi tffeec fo aciniN si tpcxeoah.iyitto Ainptehnmceoa si oflasuym owknn rof ttiepxihcoay so iarnpis is a eretbt erwans +4
doctordave  ipnooeehAmtnc is an rtaiintcpey dan sali,gcnea utb it is not moramnia,tilfanyt so it nlowut'd eb eusful rfo niaciN dneciud hgiflun.s e(Se setchyk rhmpa orf D)sINAS +3
meja2  heomnitpneiAc nialmy tnhbsiii OC-,X2 tshu ulodw adel to iiihtonbin of pnoocitudr of eLskeu,eirnto adn more nongsadtirpsla wlil be meda mrfo rihnacacoid cdia ylon nttigeg pu by -CX O[1 I mmereber sith by ugsin ist ,mane Amtnpoe-oicn-ehw rof -CX]O2 +
fatboyslim  yabeM asiprin si ncehso vroe ieaocmhnentap saceebu nriapsi rryeivlbiers ihtbniis COX +

COX-3, a splice variant of COX-1, has been suggested to be the site of action of paracetamol, but genomic and kinetic analysis indicates that this selective interaction is unlikely to be clinically relevant. There is considerable evidence that the analgesic effect of paracetamol is central and is due to activation of descending serotonergic pathways, but its primary site of action may still be inhibition of PG synthesis. The action of paracetamol at a molecular level is unclear but could be related to the production of reactive metabolites by the peroxidase function of COX-2, which could deplete glutathione, a cofactor of enzymes such as PGE synthase.

https://journals.lww.com/americantherapeutics/Abstract/2005/01000/Mechanism_of_Action_of_Paracetamol.8.aspx

But mainly, Acetominophen is an antipyretic and analgesic, but it is not antiinflammatory, so it wouldn't be useful for Niacin induced flushing.



 +1  upvote downvote
submitted by kungfupanda(5)
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nmiaheApeonct ctas by ihitbiinng het O3X-C in eht SNC adn cheen acenesdgir hte odby r,tuemreeapt but tno on teh plrhperaei 1XOC- m&p;a 2. een,ch sAnpiir si eht ettrbe icohec

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