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Retired NBME 23 Answers

nbme23/Block 4/Question#26 (reveal difficulty score)
A 28-year-old man has hypertriglyceridemia ...
Aspirin ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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 +4  upvote downvote
submitted by โˆ—lfsuarez(160)
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eWnh sinettpa are egivn coiNnitic d(ai)icacniN heyt era odlt ot etxpec onommc sedi sefecft to cucor uhsc sa trhmwa nad nedrse.s eOn acn viado eshet iesd csfetfe by tniagk nisarpi

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mcl  oT xpneda on this, eth gf/wmhseldint/aunherrss si ude ot saelree fo D2GP and PGE2 chwih is why iatkng an IDASN lphs.e +20
snripper  nDso'et opacteahnemni hiitinbs OXC 2,-1 to?o Why a'ctn oyu esu ttah eatnisd of ?nrsiapi Jsut nirdwen.go +4
raspberryslushy  I hda hits amse istquone oot, nad adh it adernorw wdno ot osthe wot hec.scio ddenE pu gogin rpsawn/ii tub it aws sort fo a oinc .stos Slilt ont ersu wyh ts'i ont mnaipeet.nocha +
eagleeeee  I thnki hte asoner si atth nomcepaineath si dibiethni parierelhply dna is iamnyl uesd ot ntbiiih XOC ni eht SNC +8
whatup  hTe rowts sdie etcfef of icinaN si .pooiyctxhatite nhmtcnepaeoiA si ylouafsm nnowk orf tyiexhtoiacp os asipnir si a retteb nrsewa +4
doctordave  heeinmtoocpAn is an yatniptreci dan gesc,laina tbu it is tno ftaortyninima,alm os it uwlot'nd eb lsuuef ofr nNiaci ecdndiu .uglnshif eSe( ckhsyet hpmar rfo SI)AsND +3
meja2  eiioephntcnAm inalym istibnhi OX-,2C thsu ldowu deal to ohtinibini of ciroouptnd of euneLitser,ok and orem npnrtdosaigasl iwll be emda mrfo aoacrdichni acid nyol tgngtei pu by C-1 XO[ I erermmeb sith by sguin sti ,mnea Aen--owoecnmphti rfo 2X]O-C +
fatboyslim  baMey iipnars is cshneo roev tnamhpoeceain ebceasu iapnisr ebrylvirirse ihinsbit XCO +

COX-3, a splice variant of COX-1, has been suggested to be the site of action of paracetamol, but genomic and kinetic analysis indicates that this selective interaction is unlikely to be clinically relevant. There is considerable evidence that the analgesic effect of paracetamol is central and is due to activation of descending serotonergic pathways, but its primary site of action may still be inhibition of PG synthesis. The action of paracetamol at a molecular level is unclear but could be related to the production of reactive metabolites by the peroxidase function of COX-2, which could deplete glutathione, a cofactor of enzymes such as PGE synthase.

https://journals.lww.com/americantherapeutics/Abstract/2005/01000/Mechanism_of_Action_of_Paracetamol.8.aspx

But mainly, Acetominophen is an antipyretic and analgesic, but it is not antiinflammatory, so it wouldn't be useful for Niacin induced flushing.


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 +1  upvote downvote
submitted by kungfupanda(5)
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antpohecmieAn stac yb iinnitihgb teh -C3XO in hte CSN dna ncehe sarngdecei teh oydb rtpa,ueermte utb otn no teh lhrreieapp XOC-1 ;am&p 2. ,nehec npiriAs si het rteteb echoci

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