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Welcome to qfever’s page.
Contributor score: 42

Comments ...

 +4  (nbme22#35)

Hypothalamus controlling temperature set point is briefly mentioned in Pathoma 2018 edition page 13, Chapter 2 III Cardinal signs of inflammation D. Fever

Pyogenes -> macrophage release IL-1 and TNF -> increased cyclooxygenase activity in hypothalamus perivascular cells -> increased hypothalamus PGE2 -> raised temperature set point

 +0  (nbme20#28)

Pathoma 2018 edition page 4 chapter 1 - Cellular Injury - III. Reversible & irreversible cellular injury - B.1.

I had difficulty trying to figure out what hydropic change means though...

bharatpillai  i swear i've done the same question before on uworld/ one of the previous NBMEs and the answer to that was intracellular Ca accumulation. +1
mangotango  @bharatpillai that's also true! Dec ATP >> dec activity of Ca2+ and Na+/K+ pumps >> cellular swelling (earliest morphologic manifestation of reversible cell injury), mitochondrial swelling --- FA, pg 207 Na+/K+ ATPase inhibited >> inc intracellular Na+ >> dec activity of Ca2+/3Na+ exchange pump >> inc intracellular Ca2+ --- this is the same way digoxin works in the heart! +

 +1  (nbme20#19)

Does anyone know what are A, C, D? For C not sure if it's pointing to the ribosomes on RER.

(I'm assuming E is glycogen granules based on a comment below!)

Subcomments ...

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I get wyh its rlalaet utb notd all lncaiar renve pecetx 4 arise ?laVrynlte FTW yeth add hits sDroo feebro ta?lrale

qfever  I think it's the nucleus affected in lateral medullary syndrome (instead of the nerve axons) +  
nerdstewiegriffin  Because in the medulla section the nucleus is dorsal motor nucleus of X +  

submitted by lsmarshall(393),
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Spaiyntbvnroe si teh geratt fo nnetomsaiatsp tnusea(t x;io)tn cmleus sssmap aer hsracr.accetiit lOny oreth sneawr oyu mtihg ieorsncd si ceseAoereiyhtnatlcls iecns eh si a merraf dan zbuozrdws ofetn racyr us ot hte sdmioerp aln..d. but omspmsyt of a egrclicinoh rosmt are sabnet.

vshummy  Synaptobrevin is a SNARE protein. Why they couldn’t just give us SNARE I’ll never know. +41  
yotsubato  Cause they're dicks, and they watched sketchy to make sure our buzzwords were removed from the exam +42  
yotsubato  Oh and they read FA and did UW to make sure its not in there either +34  
soph  This toxin binds to the presynaptic membrane of the neuromuscular junction and is internalized and transported retroaxonally to the spinal cord. Enzymatically, tetanus toxin is a zinc metalloprotease that cleaves the protein synaptobrevin, an integral neurovesicle protein involved in membrane fusion. Without membrane fusion, the release of inhibitory neurotransmitters glycine and GABA is blocked. -rx questions! +6  
qfever  So out of curiosity I checked out B) N-Acetylneuraminic acid It's sialic acid typical NBME +2  
alexxxx30  shocked they haven't started calling a "farmworker" a "drudge" <-- word I pulled from thesaurus. +2  
snripper  "You shouldn't memorize buzzwords. You gotta learn how to think." Lemme pick another random ass word that doesn't have anything to do with critical thinking skills and use it instead. +5  
mw126  Just as an FYI, there are multiple "SNARE" Proteins. Syntaxin, SNAP 25, Synaptobrevin (VAMP). From google it looks like Tetanospasmin cleaves Synaptobrevin (VAMP). Botulism toxin has multiple serotypes that target any of the SNARE proteins. +2  
wrongcareer69  Here's one fact I won't forget: Step 1 testwriters are incels +2  
baja_blast  FML +  
j44n  its not an ACH-E inhib because he doesnt have dumbell signs +  

submitted by hayayah(1056),
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Cbolmaoo is na yee nmyaibatlor atht uccsor efboer ihbrt. yTr'ehe smgisni ecpise fo ssteiu ni rtussecurt ttha romf eth .yee

  • mlbCsoooa egcfitnfa teh sii,r ihhcw slruet in a ehyo""kel ecrapaenap of teh ,piulp geelrnaly od tno eald ot iiovsn l.oss

  • Claobsoom nigiolnvv teh aernit uesrtl in oivnis olss in scicfipe tarps of hte usaivl .dilef

  • eragL eianlrt oolosmbca ro setoh eaftgifnc eht ticop nerev anc cuase wol ni,vsio hwhci smnae ivsnoi sslo thta canont eb oplltyceem reccetdor ithw asslegs or cottcna es.senl

mousie  thanks for this explanation! +  
macrohphage95  can any one explain to me why not lens ? +  
krewfoo99  @macrophage95 Lens are an interal part of the refractive power of the eye. Without the lens the image would not be formed on the retina, thus leading to visual loss +4  
qfever  Do anyone know why not choroid? +1  
adong  @qfever, no choroid would also be more detrimental to vision since it supplies blood to the retina +2  
irgunner  That random zanki card with colobomas associated with a failure of the choroid fissure to close messed me up +11  
mnemonicsfordayz  Seems like the key to this question is in what is omitted from the question stem: there is no mention of vision loss. If we assume there is no vision loss, then we can eliminate things associated with visual acuity (weird to think of in 2 week old but whatever): C, D, E, F. Also, by @hayayah 's reasoning, we eliminate E & F. If you reconsider the "asymmetric left pupil" then the only likely answer between A & B is B, Iris because the iris' central opening forms the pupil. I mistakenly put A because I was thinking of the choroid fissure and I read the question incorrectly - but it's a poorly worded question IMO. +  
mamed  Key here is that it doesn't affect vision- the only thing would be the iris. All others are used in vision. Don't have to know what a coloboma actually is. +2  
azibird  The extra section of that Zanki card specifically says that a coloboma "can be seen in the iris, retina, choroid, or optic disc." Don't you dare talk trash about Zanki! +1  

submitted by sajaqua1(519),
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satavnPairt is hte only tnaist udrg tno beemzodatil yb eth 5P40 ymsets ni the .ivrel eBceasu of i,tsh ttsavrniaap is losa iunuqe in htta rmeo of ti si exceetrd by het yikends tnha nya horte atisnt, In andiiotd to dhyhmytoripsio hsit tpeniat ash dlmi aelrn a.uilefr hiTs illw rmpiai ecnixeotr of arvttpinaas, nialdeg to cdneiraes stiaapnatrv dan its tb,oimeetsla nirnsigace sti ptlneaoit fro iacngsu

B) shrieishapot-lNi lhewi eht ttineap is eiecarc,plcymh traptnasaiv dose ton aseciner hte deincneci fo ndiyek eotsns. C) ii-ateaPtncrs I od ont know fo nay sniaiintgcf aittrnseocin tbeenwe eht capraesn and aavatrspni.t D) iTcxo e-tptishia hwiel tanisst can sauec lldmyi eeadvetl vlier ocfnutin etst ,esorsc tehy rae gaeenllry not setocaidsa thwi hcexoitotip.ayt E) Tpey 2 betaDsei uelimls-t I do not nwko fo yna efetcf tath atisvrpatan ahs on iseebtad ro seitbdea snita.odmice

motherfucker2  Lucid. Nice +  
qfever  But isn't statin associated with hepatotoxicity too? FA 2019 page 320 +3  
srdgreen123  @qfever. I think thats why OP said that statins are not metabolized in the liver. +  

submitted by seagull(1405),
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Ddi oynnae ened to rdea htta lsta neestenc eilk 50 tmesi cbuesea het oauhrt eusersf to use teterb mmr.agra tsJu un.rgrtasfit

link981  Author rationale: "What is grammar?" +6  
qfever  Did anyone read like 50 times and still get it wrong? (LOL, me) +16  
drbravojose  Actually never understand what the author saying at any time. LOL +3  
alimd  Such a shitty question. Do we really have such questions on the real exam? In my opinion they just throw junk question to those assesments +  
nootnootpenguinn  Oh my goodness- thank you! I was so mad at whoever wrote this shitty question! (Got it wrong lol) +  

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meiPer sah no fcrauntats

nnitneigAos II - taneeregd ni halypemvioo

yloilmptiaD tlcinhie kaa lpahiysdihmcpoaphlooyeltldntii ngul santcrautf

lyiioistaPosdhonptlh 4,-osppihtsh5eba aak IP2P Gq cotprere ahpaywt

riinyslepePstdhaoh nvoeid-lv ni istiirncn ospsptioa wenh peedsxo on etxrealalclur frcsaues

hiSnylenmiopg - sposecmo ienlym nad alos has oselr in nsaigl snrua,ctiotdn st.ospaiop eintcLi:h eSmlnoyinphig aroit t2&;g asdcnetii mreuta fltae

endochondral1  how are we supposed to know that dipalmitoyl lecithin is the same thing as dipalmitorylphosphatidylcholine +6  
qfever  FA 2019 page 647 Pulmonary surfactant is a complex mix of lecithins, the most important of which is dipalmitoylphosphatidylcholine (DPPC). Also: Screening tests for fetal lung maturity: lecithin- sphingomyelin (L/S) ratio in amniotic fluid (≥ 2 is healthy; < 1.5 predictive of NRDS) +16