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Welcome to irgunner’s page.
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Comments ...

 +2  (nbme23#7)

I was thinking signal sequence on the N-terminal end that would direct the protein into the RER to be then implanted into the plasma membrane. I guess transmembrane region is the better more specific answer?

drdoom  A bilayer has hydrophobic tails (polar head + nonpolar tails). If the N-terminus could be embedded in there, it would also have to be hydrophobic; but if an N-terminus were hydrophobic, it wouldn't dissolve well in the cytosol (=mostly water). In fact, an N-terminus probably wouldn't dissolve at all. If it were hydrophobic, it would aggregate with other, nearby N-terminuses (or other hydrophobic motifs). But if that happened, shuttle proteins couldn't recognize N-terminuses in the first place (they wouldn't be sterically accessible), nor deliver them to the rER. +1

Subcomments ...

submitted by hayayah(1056),
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Cobmoalo si na eey tloarbanymi tath ocucrs borefe t.rbhi heeryT' gmnissi ieescp fo iutsse in utrucssrte taht rfom het ey.e

  • sCaoomlob ctigefnaf hte ri,is chihw tsuelr ni a kee"oyl"h apecaapenr fo teh ui,plp rneeyllag od otn elda to soiivn s.sol

  • loCosabmo vlnnivogi the nireat etrlus ni oinisv loss ni epicsfci atprs of eht lasuvi i.lfed

  • rgeLa nrielat oamblocso or sohet fceatfngi the tciop evern cna cuase wlo inoivs, chhiw esnma isoivn sosl htat tnonca eb telmecoply rtcreeodc whti aesgssl or tatoccn

mousie  thanks for this explanation! +  
macrohphage95  can any one explain to me why not lens ? +  
krewfoo99  @macrophage95 Lens are an interal part of the refractive power of the eye. Without the lens the image would not be formed on the retina, thus leading to visual loss +4  
qfever  Do anyone know why not choroid? +1  
adong  @qfever, no choroid would also be more detrimental to vision since it supplies blood to the retina +2  
irgunner  That random zanki card with colobomas associated with a failure of the choroid fissure to close messed me up +11  
mnemonicsfordayz  Seems like the key to this question is in what is omitted from the question stem: there is no mention of vision loss. If we assume there is no vision loss, then we can eliminate things associated with visual acuity (weird to think of in 2 week old but whatever): C, D, E, F. Also, by @hayayah 's reasoning, we eliminate E & F. If you reconsider the "asymmetric left pupil" then the only likely answer between A & B is B, Iris because the iris' central opening forms the pupil. I mistakenly put A because I was thinking of the choroid fissure and I read the question incorrectly - but it's a poorly worded question IMO. +  
mamed  Key here is that it doesn't affect vision- the only thing would be the iris. All others are used in vision. Don't have to know what a coloboma actually is. +2  
azibird  The extra section of that Zanki card specifically says that a coloboma "can be seen in the iris, retina, choroid, or optic disc." Don't you dare talk trash about Zanki! +1