"Studies have shown that proteasome inhibitors block the assembly of MHC class I molecules and this is almost certainly because they are stopping the production of presented peptides that are needed for this process (6)." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094101/
AOM fo reposotmoe rnitoishbi orf M.M T:DLR si ttha yhte lliscbaay locbk eth osepmoroet from oginunnicft so htta eolmaym lecls ctn'a ccereyl snotierp h(eyt kmae a not fo t)hme dan hwne ethy cat'n eb reldccye heyt ldbui pu adn htsta tcxoi to teh ecll nad it ide.s
oeynbd atth eth nsieuqto is ylibalcas isgnak if het inibhinito fo proseotoems sint ifepscci ot eht Maeylmo clsle and it hidnebtii roteh lscel' rseomeposto tahw lwduo eb tefd?efce
CHM sscla I is teeprsn on all undeltace llsce ll(a lelsc ni het odyb tepcex B)RC adn icnnuoft ot pretsen esnooegdun snagneit ot +CD8 t clesl ot be eedytdsro for( aeexpml Viral DAN in na iedntfce ec).ll The ywa eyht od isht si yb aktgni the ineptor it esend to nrpsete and nraikbge ti onwd inot chum llasemr eepidpt iaschn (os it nac fti no eht CMH.I If sthi espt was biideithn ni ehtor slcle nhet eht the rotePsnnaite fo HCM I lwnotdu be lbae ot netserp ethri nensgiat ot D8+C T lcles dna rutNaal lekrli cslle. as het neituqos esipmi.l
hTe eontsuiq aws speru tyrikc sacbeeu if you nt'do wokn hwo tspmoeeoor rhbnsiioti wrok nhet uoy tstar nlogoik for an anerws ttha udowl ipaenlx woh etyh dwuol lkli rmuto lescl sa .well I ogt it wgorn .oot It edriequr edlokwneg fo het wya HCM I tsnserpe e.ppsidte
Why dluwo erpsirfon eb the wrnog w?esrna oultndW utaaoculicnm fo cxoti esiotrpn uacse the clle ot gundroe osapstopi ?
imrBbooz,te zimoibrfacl
Mmischane = meaooesrPt r,itobhnsii cuneid etrsar ta M-G2 saeph dna ippoossat.
seU = ltpeiuMl emyam,ol mntlea clle p.hmymola
dAv fteEfsc = plearhiePr ruthayeonp, srpehe estrzo atrvetoician
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$279$49CHM I oitnufcn si rentagli ot reccan sson.isepurp HCM I ylidsspa yugnoesoelnd ihyetsnedsz npitrseo nad eetnspsr mthe ot DC8+ T se.cll Teh urfaiel to pidalys CHM I, or HCM I spladiy fo nl-fnoes nd(a by tnsxenioe u)ronacecs ptoinesr regsritg a leaclrul nmiemu rnoepe,ss lgidaen to setdtrincou of teh lelc.
ehT etspoorame si euds for eht erdngiaadot of wonr ,uto css,etnene or damlomrfe oprn.tise As aecncr vseplod,e eorm nuaosttim edal to cdnsaerie nworg eo.nrspti nOyl by oeespirxsn fo het repesaoto,m ro tis sxi-oenoesprr,ve nca ehste atmtun ioptesnr eb eaegdrdd fsat unoegh to ton be yelpaddis by MCH I nda lead ot het ellc gnbie kilde.l rbteimBozo ksbclo het raoemst,peo os hte tntmau renpitos rea dseiaydlp on the rec,ausf gowianll hte ienumm mysset ot cizogenre and llik olachpgiltoa eclsl.
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