"Studies have shown that proteasome inhibitors block the assembly of MHC class I molecules and this is almost certainly because they are stopping the production of presented peptides that are needed for this process (6)." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094101/
MOA fo mesroptooe rbsoiniiht fro .MM TL:RD si taht eyht ycablalsi clokb eth oeeptomosr frmo otgncfniniu so ahtt oyelmma ellcs 'atcn eryclec rsnoipte heyt( ekma a ton fo them) and hnew yeth 'tcna eb rccleyde ythe iubdl up dna ttash itcox ot het clle adn it de.is
yboedn htta eth sqnuoite si aiabsclyl aigskn fi eht itbinniiho of ssporeeomto tins ispicfec ot eth Myeaolm leslc dan ti tnbidiieh reoht e'lslc stepoesmoor wtah ulwdo eb ?efctefed
HMC lscas I is pertens no lal eeutnladc lecls (lla elscl in hte odby extecp CR)B nda ntcnuoif to etpesnr onnsogeued gentnias ot DC+8 t cesll ot be tereddoys (orf emexpal irlaV AND in na cedetfni lcel). Teh yaw they od ihst is by ntgkai het pterion it seend to entersp and airkgbne it wond iont uchm rmsalel eppdiet achisn (os it nac fit no the IC.MH fI itsh tpes wsa indeihibt ni rehto ellsc hent eth het saPtntnreeio fo HMC I ldtunwo eb blea to erstpen tehir teangins ot CD+8 T ecsll and altaurN illrke clles. as het itoeuqsn .iplisem
ehT stueioqn asw usepr rcyitk scubaee fi uyo t'dno oknw how toeosrempo borstihnii owkr ehtn yuo strta golokni ofr an renwsa atht dwlou lepniax how teyh lwodu klil rotmu celsl sa l.lew I got ti gronw ot.o tI deruerqi lnewokdge fo teh wya CHM I sepsenrt teipspe.d
hyW oulwd rnrfpsoei be eth rngwo rws?nea utndlWo uulccointama fo octix riptseno aucse the ecll to odgrnue pstsooapi ?
teBbziro,mo orimafblzic
aenhmiMcs = saeotPremo itr,obhnisi cnudei rasert at M2-G hsaep dan oa.opstspi
Use = iluMplet yemlmoa, lmenta llce .ylampmho
vdA efctEsf = rlpierhPae norhteupya, hrspee srtezo raticovietan
submitted by ∗sajaqua1(607)
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$279$49MCH I ntocfuni si ganielrt ot enccar .oepurisnsps MCH I adiysspl oeyugelnsnod eythiszesnd eniotprs and pneestrs tmeh ot 8D+C T lc.sel heT rieaflu ot paidlys CHM ,I or HCM I dplaisy of nlnsoe-f na(d by teiensxno rcsc)ueoan rtpsoien rriesggt a leaulcrl neumim enre,spos gneaidl ot urcieodttns fo eth el.lc
ehT seaoepmort is euds ofr the engdaaidrot of wnor uto, scee,nnste or oadeflmrm ro.pstien As ncreac eslpovde, more itauomstn deal to ediascern rognw ts.poiern Only yb oeinsperxs of eht mrpoot,eaes or sti sne,oxsieevrpor- nac eshet ttunma esnoprti eb dededarg ftas hgnoeu ot ont eb dypilsead by CMH I and leda to hte lecl ebing dl.lkei zmibreBtoo cbolsk hte or,smteapeo so the aunttm petroins era ydasipdle no the ,aecsfur nolailgw the neuimm tysesm ot rneoicgez and llki oialthcoplag lescl.
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