NBME 23 Presentation of antigens to CD8+ T lymphocytes (NBME Answers)

Retired NBME 23 Answers

nbme23/Block 1/Question#22 (reveal difficulty score)
An investigator is studying the adverse ...
Presentation of antigens to CD8+ T lymphocytes 🔍 / 📺 / 🌳 / 📖
tags: immuno repeat

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submitted by ∗sajaqua1(607)

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MCH I ofcniunt si riealngt to ecanrc suonperips.s CMH I spyalisd eysdugnnoloe itezhessydn sintepor nad esrsetnp ethm to 8D+C T .lelcs Teh leuiraf ot dsalpiy CMH ,I ro HMC I sidlypa of nfeol-sn dna( yb eeintnosx cosn)ecrua trnoeisp rgtigrse a craullel uemimn ne,erspos neildag ot soetdrtiucn of teh .lecl

hTe potesomrea si sude rof eht reaadngdoti fo rown ,uot tcsnseeen, or ermdofalm rt.eosinp As cncrae ldoe,vesp mreo mtutsaoni ldae ot dnaceires rowng enroitsp. ynlO yb eeprsnsxoi fo eht teorpmas,eo ro its spv-iroeernsex,o anc hseet anmutt iotepsnr be ddaderge tafs ghuone ot nto be elaipsdyd by HCM I adn aedl ot eht lelc bigen eilkld. tiozeBobmr skcbol het meesoatp,or so the tanumt trinopse rae eayldisdp on teh ecsa,ruf ngloawil hte umeimn stmesy ot eezrgcnio and lkil cghlapatoilo .lecsl

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catch-22 Aehntro awy ot pchpoaar ti is to nhkit botua MHC lcass I inosrpsce.g syBlic,ala if yuo iinbhti het matro,oeeps etpesdip will ton eb eeaenrtdg and tongnhi si vabeiaall to be dolead onot HMC I eebrm(erm CHM I sha to be eaddol rboefe is't rotnpseatdr ot eth ellc .uca)sefr llCes ttah nd'to xepsrse MHC I etg ldilek by eth luraatn e rslli.kt/mot62li4n.:/l/wcm/sP/hn.wbnhC/vs1ig.r2ewicatM3c.p7p +32

kai n"I nlccionu,so we hvae ddatemoetnrs ahtt hte peotaermso itrobhini eozbbrmtoi onwalgdrue-est sscla I dna saneehnc the svitteniisy fo lmyomea to KN –dtmlalieedec lysis" orfm eht ucnloscnio of het NHI prpae +6

maddy1994 arnoeth enmcahmsi is by kocigbln srmtopoeeo u veen rcsadeee erntgidao of tpcpooaiptro r..snespi.too ti naheecsnc ro(pissooftmap do)urwl +6

azibird tuB 8D+C and KN lclse lilk iva norepfir! hyW is tihs aswern wgn?ro sI ti acebuse t'si nto eht pmirray ?fteecf +2

testready he"T ormseptaoe is eht jarmo uocrse of ierotlyopct vyaitict vdveoiln in eht goetinerna of edtipesp rfo eeastntonrpi yb rajmo soyilttiitbahocpmi opcxlem cslsa I lulm.eoces eW eoprrt het enw nraotisbveo hatt brmezbtooi eostulaengrd-w ALH slsac I on MM llce,s elnusitrg ni indceares NK tlli–meedcdea lss" .yiws.4.n7mn/rtPhaclwmhwn/6l/22/C.ivMg./st/p1i:3eicbopct +

fatboyslim I tnihk whta OP isda scdtcoinrat whit twha ahtc2-@c2 ietdc ni teh ebPMud lrcatie. +

an1 OP dasi y"lnO yb rxeseoinps fo the eotreaosp,m or tis evnssi,proe-oxre nca ehset tamnut enrostip eb raeegddd saft hgoune ot nto eb epdlyadis by CHM .I" UW DQI 16174 says ttah a opertin enesogudr daentroagdi yb teh biuqintui taeposremo wtyahpa, fater ihhcw ti sgeo to hte ER nad hnet is seeerntpd to hte lcle ecsuarf rof HCM 1 spoeresn igaelnd to pasptsoio iva prseromf and snmyera.gz nivHag a oetsampoer oinhtbiri wdoul aacltuly teprvne hte HMC enpoessr abeeucs on rsetinop ear yde.slpida oAls noet atth hte onuiqets syas iwchh scresop lilw eb tfcfe,dea erteh si on oemitnn of nesaierc or eedacesr. oS e,ys het CHM /1 C8D yptwaahs si dfaecf,te btu st'i cauallyt wdon erdt.eulag nA abscnee of CHM 1 edals ot KN lelc deetadmi td.hae +

"Studies have shown that proteasome inhibitors block the assembly of MHC class I molecules and this is almost certainly because they are stopping the production of presented peptides that are needed for this process (6)." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094101/

+3/- donttrustmyanswers(74)

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submitted by ∗tinydoc(276)

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/e:5/pUsyuftJR.buhHItmo/h3tz

MOA of osetoeromp rtioiishnb rfo .MM DL:RT si htat tehy lailybacs klocb teh eoopsormte fomr cinftnunoig os thta eoyamlm clels 'tanc rleccey tnrsiepo yet(h kmae a otn fo )etmh dna newh yeht ntac' be dyelcecr tyhe diubl up nda tatsh oxtci ot het clel nad ti .ides

ydoebn hatt teh untsoiqe si alclysbia snigak fi eth ibiohntnii of eomosoprste stin icepsifc to het loameyM llcse nad it tdeiiihnb oethr sllce' moseorepots whta wludo eb tefefed?c

CMH cassl I is etrnpse on lal edtluaenc slecl lal( clles in het doby ecepxt )BCR nda tinocufn to neetrps seugonnedo stanineg to D8+C t cllse ot be stredodye ro(f lmpexae raVil ADN ni an cetinedf lc.e)l hTe ayw yhte do thsi si yb gnatki het rneopit it nesde ot nserpet dan rnkbgeia ti odnw tino cuhm esrallm dipepte caisnh (os ti nca fit on eth .CIHM fI sith sept was ihtiindbe ni rheto lescl tneh eth eht rPatentnieos of CHM I wundtol be able ot ntrseep ehtri atngiens ot C+8D T slcel nad arultNa leilkr lc.sel sa eht teonqsui lsep.iim

heT isneoqtu asw upres ktriyc ucseaeb if oyu td'no nwok woh eooemoptsr itihisnrbo owrk tehn you strat ngioklo fro na awesrn thta oudwl eniaxpl ohw htey udwlo klli mturo llecs sa elwl. I tog ti wnogr oto. It qudeerir kwelgdnoe fo het awy HMC I retnspse speipedt.

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submitted by ∗krewfoo99(116)

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yWh ldwuo fposenrir be the rowgn nwea?rs ulndWot cumniuataloc of txoci eipsrton esauc het lcle to ronegdu tppasoiso ?

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ergogenic22 bieBomzort deos tno eycritld taievcta pefroir.n tI eyltirdc bhstniii teh prmoeaesot cwhhi → nblasee D+C8 T lslce ot ieaniitt ioppoasst → aiv prefinor leeaers (ni eecness a toawmdesnr )e.ecftf +4

drzed ya,lctxE ti irsgregt hte slelc to enuorgd oatpoissp chiwh mnaes tath ti can itheer eb elcl maeeitdd errofpi(n dan aymgenrz vai FFL)A/SSA RO it cloud olas eb oruhhtg the tirinnisc atpahyw e..g( ;canidihoomtrl crhmecoyot c) +

powerhouseofthecell uoint:Qse Btu woh od 8DC lcsle heav a rloe ni tihs scorspe cexatyl in het iv?tetgen sI ti gysnia thta hnwe the irtpneso lidbu ,pu olyn hnet do DC8 eslcl coem adn sdneait of HMC I pnresnetig ot sesooratpme, ythe peretns ti ot C8D ot eantiiit tspsopai?o +

flexatronn ehtocl@lurpoofhseeew so ti lla egos cbka to biacs mimnuo i( gto thsi gwrno nda tup opitaspos sa elwl) tbu rfeat engirwvei taerlven aikn ds,rca i won tge ti.So aeteoromsps eabrk wdon gtedga sntoeirp iitwhn teh llec n)sugod(eeon. ehT akwbreodn curtpods gte aetkn up yb snrtrptoa tosasiedac hiwt etgnnai isgsrponec PA()T nad hutrbgo to het ghoru R.E eTh ndkrewboa cortdsup ear tenh ladeod oont MCH I lscomulee nad ubtgohr ot the serfauc fo the elcl. eWhn tnhnigki aubto MCH I, htnki otaub C+8D T leslc (FA CMH 1 x 8 = NwCDo8. to raumezsmi, enwh nsigu a oeesratomp oit,inbrhi yo'ure ckgnibol htat ngiatgg nad MCH I ganoild .ossprec As estdat oebfe,r D8C esocznigre HCM I cihw(h now't phenap hnwe insug heest ur)sgd +3

whosdaprincesss fnatl@ronex nhtka you !!!! +

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submitted by ∗abhishek021196(120)

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o,rebBoimtz boafrlcizmi

mhcisnaMe = Ptesooaerm ib,snirtoih eiudnc trreas ta 2-GM ephas and .tssaioppo

seU = lletipMu elmoma,y taenlm clle hmo.mylap

Adv scteffE = rehpPriela yhpouat,ner prseeh etrszo aconvtaterii

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tyrionwill nrdeu ,teobirBozm eth asotreempo canont gtdsie avrli Ag nad repnsste it ot hte -bdeomearbdennm -HMC.I eoTrrfhee C-Dc8T cntoan ceriegozn eth hsto lcsel ctiinaognn rdplaees .VZV That si lboybrpa hwy isnseglh si eno of hte lpaprou dsei fcefet of otbzmiBeo.r +

kcyanide101 heT urgd ntibihsi otoempreo.s ncHee rehte si on mgetrnfa beaallvia hhgutro TAP isdien C4D cell to loda tnuo CMH I.... sA husc teh CD8 ieproensttan to Tecll si vetderpen. ehT gilnccuamtua opintres niesid eth D8C ellsc hwihc era otn ibgen bonkre wond by eth pmeostoroe csuae ti ot rodngue toaspsopi +

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