"Studies have shown that proteasome inhibitors block the assembly of MHC class I molecules and this is almost certainly because they are stopping the production of presented peptides that are needed for this process (6)." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094101/
MOA of ptmroesoeo ohniirsibt fro M.M LR:DT si atht ythe ibylaalsc lokbc eth mtsoeroepo fmro itgfinuncon os thta oemmyal sclel 'tnca ececrly rotsinpe (teyh kmea a nto of ehmt) adn nwhe hyet ncat' eb yclederc thye biuld pu dna astth ctoix ot eth ecll nda ti ide.s
dyboen atht hte senouitq si siaclably anksig if teh inibiothin of oesotrospme inst ipciesfc to hte ylmaMeo selcl nad it itihiebnd torhe lsce'l mstoooepesr whta wudlo be ectee?dff
CMH ssacl I is epnetsr no all ladunecet lcsle all( llecs ni eht ydbo xctepe B)CR and notucifn ot etnespr osoengeund nnsetiag ot C8+D t lcels to eb orydestde for( elxepam rialV ADN ni na etcnifed )ll.ce hTe ywa yeth od ihts si yb inatkg eth eontrpi it esend ot trenspe nad agrbenki ti odnw tino humc slaerlm edtpepi ihasnc os( it cna tfi no het H.CMI fI isth sept swa ditheinib ni hreto clsle etnh eht hte sroetPitnean of CMH I dnowtlu be lbae ot reepnts teirh sneatnig ot C8D+ T elcsl nda rautalN ekllri es.lcl as hte oqiusten ipmseli.
eTh ntoiuqse asw rpseu itkcyr aecbeus if yuo 'tdno wonk woh sepormtooe initrisboh orwk etnh uoy tatsr onoklgi for na anersw taht ulodw naeilxp hwo eyth lwodu ilkl rmotu clsel sa wle.l I otg ti ogrwn .oot It eureqrid lenkodwge of eth wya MHC I sespernt sepe.itdp
Wyh uldwo eonfpsirr be the orgwn raw?nse dWnutol ointcaluaumc of icxto itsoenpr cuase the elcl to rugeodn sptpsiooa ?
bormzB,eoit imocfilbazr
msMhcenia = esaeomrotP nhtrs,ioiib dciune rsetar ta MG-2 esahp dna asotois.pp
sUe = tMeilupl emyom,la tmenal clel hapolmy.m
dvA efcftsE = Prapiherel por,hntyaeu epeshr steroz atrenoitvica
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$279$49CMH I tnucinof is atnriegl ot caecnr np.spousersi MHC I isaldpys nyeneulgoods edsyznsihet orpnseit nad ntpreses hmet to 8DC+ T .lcles ehT lrfueai ot ylsadip HMC ,I ro MHC I ipslayd fo flneno-s nad( yb neixsento ruceocsan) tseiporn tgriegsr a erclulal menumi rpesens,o eladnig ot ncttsudeior of het c.lel
The motaepseor is dues for hte raaotndeigd of wron ,tou ,ecstesenn ro oredaflmm orntesip. As cnrcea ,pesvlode meor naustoimt lade to sredeaicn rnogw peo.tnris Oynl by oeenspsrix fo het mpe,seoaort or tis roesve,npx-oisre nca eesht tanutm eopstnir be rddadege tsfa enoguh ot ton eb dlasdiepy by MHC I nda adel ot the lecl bngie lked.li zeooBrbtim csolkb het raestpe,moo os hte tatunm spoenrti are saydpidel no hte sr,eaufc wailnogl het muiemn etmssy to egizenorc dna lkli ohopctlgliaa ecl.ls
$279$49