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Retired NBME 23 Answers

nbme23/Block 1/Question#22 (reveal difficulty score)
An investigator is studying the adverse ...
Presentation of antigens to CD8+ T lymphocytes 🔍 / 📺 / 🌳 / 📖
tags: immuno repeat

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 +11  upvote downvote
submitted by sajaqua1(607)
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CHM I oitnufcn si rentagli ot reccan sson.isepurp HCM I ylidsspa yugnoesoelnd ihyetsnedsz npitrseo nad eetnspsr mthe ot DC8+ T se.cll Teh urfaiel to pidalys CHM I, or HCM I spladiy fo nl-fnoes nd(a by tnsxenioe u)ronacecs ptoinesr regsritg a leaclrul nmiemu rnoepe,ss lgidaen to setdtrincou of teh lelc.

ehT etspoorame si euds for eht erdngiaadot of wonr ,uto css,etnene or damlomrfe oprn.tise As aecncr vseplod,e eorm nuaosttim edal to cdnsaerie nworg eo.nrspti nOyl by oeespirxsn fo het repesaoto,m ro tis sxi-oenoesprr,ve nca ehste atmtun ioptesnr eb eaegdrdd fsat unoegh to ton be yelpaddis by MCH I nda lead ot het ellc gnbie kilde.l rbteimBozo ksbclo het raoemst,peo os hte tntmau renpitos rea dseiaydlp on the rec,ausf gowianll hte ienumm mysset ot cizogenre and llik olachpgiltoa eclsl.

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catch-22  rtoenhA awy to achappor ti si to tknhi otuba CHM aclss I .spensiogcr scyalB,ail if oyu ihnbiti hte ,pesrotaoem dipeespt illw not eb eteerangd dan ohitgnn is aebvalial to be ddelao otno MHC I emreebm(r CHM I sha to be elddoa oberfe s'ti nstdreraopt ot eth lelc freu.s)ca leCsl tath dnto' sprexes CMH I etg ilkdel yb eth traunal .erksill 7priP/.env/.nn/Chcwi/tmt/bcglMp143.2i.m26hw/swoatl:sc +32
kai  "nI cinslcun,oo we heva dtesdmoteran that eth omeptosera inhoriitb ztmorbibeo elodw-asutergn saslc I nda aeensnhc eht eiitssityvn fo maymeol to NK tmdlecl–adeie y"liss morf eth lcnonsiuco of the IHN epapr +6
maddy1994  aeonhrt ciehsnmma si by lcbgikon poeesomotr u enve escedare nidteaogr of ptooppcoriat o.espotr.nsi. it eccnsenah tasm(piosfroop uldro)w +6
azibird  But +CD8 dan NK lelcs llik iva rpnrof!ie hWy is htis rwsnae r?ngow sI ti usbeeac ti's not eht mpriyar fetf?ce +2
testready  "eTh opstamreeo si teh mjroa ruseco fo ecryotioptl tvctiaiy vnieolvd in eth greonteain fo pdetipes fro pornseieattn by rmoja imclyiostbttiaihpo oxemcpl lascs I eesumc.llo We proter teh wen tnoirosbave tath moorbbtzei reo-gdwlsuaent ALH class I on MM ell,sc lunrgiset ni aenesicdr NK –aetiedeclldm ssyi.l"c/hpC.sMwnim/2ho7a1P.sibtg6tc/t.el.pcwv2l4//i3mwr/nn: +
fatboyslim  I nhtki tahw PO dias icnscttdaor whti atwh 2ch@2cta- etcid in eht PdbMue ar.lecit +
an1  PO dsia "nlyO by xneesrisop fo het omo,eaperts or its orexoispr-ees,nv nca sehte ntmatu tosernip eb rdgededa fsat nhuego ot not eb pldesaidy yb HCM "I. UW IQD 67411 assy that a eprtino gsueerndo aednaogrtid yb eth uqtnuiibi eeaomrtpso atahpy,w reaft iwhhc it soge ot eht RE dan neht si eesndetrp to eht lecl arsfeuc ofr HMC 1 ssnopree alngied ot spoopstai iav omresrfp nda e.smraznyg nHviag a sarmtpoeeo ibtiironh oulwd ytacaull vtepnre hte MHC nsseoper escaeub on esoinrpt era sed.dpliya lsoA tone atth teh sneouitq ssay hhicw osprces llwi eb t,fcafeed rehte si on nmtnioe fo cerasine ro er.cedaes oS y,se eht HCM 1/ DC8 phaawsty si cdeta,ffe utb 'ist tlcualay owdn ealge.drut An nsbcaee fo HMC 1 ledas to NK elcl diemaedt hdeat. +

"Studies have shown that proteasome inhibitors block the assembly of MHC class I molecules and this is almost certainly because they are stopping the production of presented peptides that are needed for this process (6)." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094101/



 +5  upvote downvote
submitted by tinydoc(276)
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Ifs3tUu/Hpm.t/boJ:/uhyte5hzR

AOM fo reposotmoe rnitoishbi orf M.M T:DLR si ttha yhte lliscbaay locbk eth osepmoroet from oginunnicft so htta eolmaym lecls ctn'a ccereyl snotierp h(eyt kmae a not fo t)hme dan hwne ethy cat'n eb reldccye heyt ldbui pu adn htsta tcxoi to teh ecll nad it ide.s

oeynbd atth eth nsieuqto is ylibalcas isgnak if het inibhinito fo proseotoems sint ifepscci ot eht Maeylmo clsle and it hidnebtii roteh lscel' rseomeposto tahw lwduo eb tefd?efce

CHM sscla I is teeprsn on all undeltace llsce ll(a lelsc ni het odyb tepcex B)RC adn icnnuoft ot pretsen esnooegdun snagneit ot +CD8 t clesl ot be eedytdsro for( aeexpml Viral DAN in na iedntfce ec).ll The ywa eyht od isht si yb aktgni the ineptor it esend to nrpsete and nraikbge ti onwd inot chum llasemr eepidpt iaschn (os it nac fti no eht CMH.I If sthi espt was biideithn ni ehtor slcle nhet eht the rotePsnnaite fo HCM I lwnotdu be lbae ot netserp ethri nensgiat ot D8+C T lcles dna rutNaal lekrli cslle. as het neituqos esipmi.l

hTe eontsuiq aws speru tyrikc sacbeeu if you nt'do wokn hwo tspmoeeoor rhbnsiioti wrok nhet uoy tstar nlogoik for an anerws ttha udowl ipaenlx woh etyh dwuol lkli rmuto lescl sa .well I ogt it wgorn .oot It edriequr edlokwneg fo het wya HCM I tsnserpe e.ppsidte

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 +4  upvote downvote
submitted by krewfoo99(115)
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Why dluwo erpsirfon eb the wrnog w?esrna oultndW utaaoculicnm fo cxoti esiotrpn uacse the clle ot gundroe osapstopi ?

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ergogenic22  eobmrziotB sedo otn ydlriect itaectva reforni.p tI ieldcyrt ihbtiins teh toaperoems cwihh → enelsab D8+C T clsel to tinaeiit pspitasoo → aiv rofenrip eslerae (ni seseecn a aemwnosdtr tf.e)cfe +4
drzed  axty,Elc it sitggerr hte lclse to dgnruoe ipoossatp chihw asemn htat it anc hritee be ecll eeaidtmd fnir(pero dna aygmzner vai LSAS/FAF) RO ti ludco lsao eb hutgorh the iinisctnr wpyahat ..eg( mhditco;ilrano hycmeocrto )c +
powerhouseofthecell  ts:eQiuno tuB owh od DC8 lscel evha a lroe in hsti spcroes ltyecax ni hte ttg?nieve Is ti inagys atht nehw het pseniort iubdl ,up lnyo enth od 8DC eslcl emoc nda ideatns of MHC I gspiretenn ot mpstoeoeras, ehty epetnsr it to D8C to eitntiai paspisoo?t +
flexatronn  o@wflerclhsheteueoop os it all oegs akcb to iacbs onimmu (i tgo thsi nwgor adn ptu osapposti as llw)e ubt frtae wiernvgei etlrneav naik cda,rs i nwo gte i.S ot mooetssraep erbak owdn dggate inporets intiwh the ecll o.ngeeu)ns(od eTh doebwnrak uprsctdo egt tknae pu yb oatrrnpst ocsdieatas hiwt tigenan pesisorgnc (P)TA dan buogthr ot eth ruohg .RE The adoenrbwk tcpsdoru ear etnh dedola ntoo CHM I elslecmuo nda borhgut to het scfurae of the el.cl neWh gnkhniit utoba HCM I, ktihn oubat +8DC T lslec FA( HCM 1 x 8 = 8owD N.C ot maemizus,r ewnh sunig a atemrposeo broih,niti ry'ueo ibgnokcl ahtt tngagig and MHC I goanild poscr.es As stedta boree,f D8C geeosrnzic HCM I whhic( o'ntw pnhaep ewnh nusig thsee )drugs +3
whosdaprincesss  @rextlafonn knath uyo !!!! +



 +0  upvote downvote
submitted by abhishek021196(120)
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imrBbooz,te zimoibrfacl

Mmischane = meaooesrPt r,itobhnsii cuneid etrsar ta M-G2 saeph dna ippoossat.

seU = ltpeiuMl emyam,ol mntlea clle p.hmymola

dAv fteEfsc = plearhiePr ruthayeonp, srpehe estrzo atrvetoician

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tyrionwill  eudnr ooezm,brtBi the oreapmseto nacotn eidgts rialv gA and ertssnep it ot teh brde-mmaneeobnd -HIMC. eeoferThr T-DcC8 nontac grezcieon the osht lscle igcoanitnn rlsdpeae ZV.V ahTt si pyblbora hwy shniselg si eno of eth ouapprl seid teefcf fo or.Bbmtoezi +
kcyanide101  hTe dugr iisnibht etrm.ooseop eHnce rhete is on aetfgnmr ealbivaal ghruhot TPA eisidn CD4 clle to laod otun MHC ..I.. As cuhs eth CD8 aeoitrnsetpn to lelTc si nde.tpreev ehT lgcuuatminac streipon sdiien hte 8CD cslel hchiw rea ont ibgne bkreno ondw yb het eooepmrsot ucase ti ot orudegn ppotissao +



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