NBME 23 Presentation of antigens to CD8+ T lymphocytes (NBME Answers)

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An investigator is studying the adverse ...
Presentation of antigens to CD8+ T lymphocytes 🔍 / 📺 / 🌳 / 📖
tags: immuno repeat

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submitted by ∗sajaqua1(607)

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CMH I cntuoinf is argletni ot ancerc s.sporiunsep CMH I pdlsyisa gooudeynnsel eysthndezsi nritpose nda nepsestr htme to C8D+ T sclle. ehT ufiarle ot pdlaysi CHM ,I ro CMH I plaiysd of e-osnlfn na(d by snoetexni r)saunocce trionspe gesgirtr a lllcraue nmueim se,pnrsoe ldgenai to cotrusntdie fo teh lecl.

The toopemesra si usde rfo teh rgdioanated of rown otu, cnneese,ts or afmolmerd sreitn.po sA arncec pvel,dseo erom ttomuinas elad to aiceenrsd gornw .ipntoser ylnO yb oixneessrp of eth eeaoo,mrstp or tis rse,oep-vrsioxen anc htees anmtut eiptonrs be deragded fast hgouen ot tno be lpiadsyde by CHM I and alde ot teh clel bngei llkie.d zbrmoeoiBt bslkco hte teemaorso,p os teh tamtun orsntpie era plaedidys no eth ,sfuarce wlliagon hte imunme estmys to inczoreeg nda klli oolagcthalip el.csl

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catch-22 horAtne ywa to apacorhp it si to nhkti tauob CHM slcas I snpsgecir.o llcayB,sai if yuo nbihiti teh ptmrso,eaoe pepsidte llwi not eb ertgaened dan gntnohi si bliavlaea ot eb oddela noot CMH I em(brmree HCM I hsa to eb eoddla breeof i'ts dantrtpsore to eht ecll ae)r.sfcu lCels taht ond't eerpssx MCH I egt edilkl by the alrntau les.lik r.mltnt7oi:pvghi/sPwn2/aCn6.1/c.4sM2p/m3hw.l/erw/cictb +32

kai n"I suco,onncli ew vaeh omaesdrettdn atth het rmoaesoept birnitoih btreizmoob rsugalte-nowde casls I and snhacene het etstiinysiv fo lmyoame ot KN eltmlca–eeidd ysil"s mrfo the ncouicsonl of teh NHI pprae +6

maddy1994 noetrah nsehiammc is yb lonkcigb sreomopeot u vene escraede rientadgo of ocapptrotopi nospr.oie.s.t it cenhneacs oosippomsrfat( w)rdoul +6

azibird tBu 8CD+ and KN esllc illk aiv oiner!fpr Wyh is stih asnwre grwno? sI ti uebseac ist' otn het mprryai tfcefe? +2

testready eh"T rmopatosee si eth aojrm cesuor of rytteolocip titacviy voiednlv ni het eorninaetg of spetdpei rfo nenersaotpit yb aormj tcpiiboyoslaihittm mplcexo cssla I eucomlels. eW teorrp the nwe aoinvstbore hatt meoztbbiro e-wdtlsogunrea HLA lcssa I no MM lslce, gstilrune ni eaesrnicd KN ciltldeeedam– slsi y."trn//a/ibwiMplhswi.cneP:smn6pot..vml1h/w2gc/t/4732c.C +

fatboyslim I ithnk htaw OP idas tiradnscotc wtih hatw h@ca2t-c2 ceitd ni hte ebuMPd cltriae. +

an1 OP iasd yl"nO by oseisxrpen of eth opoetrmea,s or sit pxoi,o-revsnseer cna seeth mttnua estoinpr eb rededdga afst euhogn ot not be lpaedidys yb MCH I." UW IDQ 41176 ssay hatt a opitnre uosenrdge dtdrnaaeoig yb hte iiiutqunb poetmorsae wpa,haty tfaer chhwi ti gsoe ot eth ER dan ehnt si seepdrten ot hte llce eafusrc rof HMC 1 nesepros dlanige ot potssoapi iav srrpmefo nad zea.nrgyms vaiHgn a rpeosmetoa ihbntioir dowul lylauatc vetnper het CHM eeosnpsr aceusbe no itronpes are laie.sdpdy Aols neto atht het tnosuqie ayss hhcwi escrosp lwli be edfaecf,t eerht is no mtoinen fo sainrcee or decre.sea So sye, the HMC 1/ DC8 ahawpsty si feedac,tf utb 'sit lauayctl down ga.ueetdlr An nsbecea of HMC 1 dlsae ot NK llec iddaetem aedh.t +

"Studies have shown that proteasome inhibitors block the assembly of MHC class I molecules and this is almost certainly because they are stopping the production of presented peptides that are needed for this process (6)." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094101/

+3/- donttrustmyanswers(74)

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submitted by ∗tinydoc(276)

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tH/muh5p/ftRuos3yU/bt.:eJhIz

OMA of eopoeostrm niiitbrohs rof MM. DTL:R si atht heyt siaallbcy bkocl teh oeosmopret from ugonnficnti os ttha maelmyo slelc 'ncta cereylc oiptesrn (ehyt aemk a not fo t)hem nad enwh ythe at'nc be cceyrdle they bludi pu dna hsatt icoxt ot eht clle and ti .seid

nydboe atth eth uestqoni si ascbilyal sakign fi eth niibthiion fo tersoeopsmo sint ifcepsic ot the aolMemy lselc adn ti dinthbiie eorht c'lels prssoeotoem awth uldow be cetefdfe?

HMC clsas I is tepesrn no lal eltdueanc eslcl (lla elcsl ni eht ybdo pxetec RCB) and foucnitn to tsreepn sdongnuoee siganent ot 8D+C t slcle ot eb dsetoeyrd or(f amlxpee lrVai NAD in na tnifeecd e.l)cl hTe ayw yteh do ihts is by itakng the noieprt it deens ot rsepnte nda irbneakg ti ondw toni cuhm emasrll pedipte sncahi so( it nca tif on eth IHC.M If tihs epst was inihedtbi ni erhot ecsll nteh teh teh asteoetPrnin fo MHC I uldtnwo be eabl ot estrenp hrtie senntgai ot DC8+ T sllce dna aNtlaur lkleir lsc.el as teh iqesuotn m.ilpsie

The nosqutei aws rseup rtciky uescbae fi ouy 'notd kown hwo rseomotpoe shorbiinit wkor ehtn uyo tarts knioglo rof na wenars that oludw eilxpna how thye dlwuo likl utomr escll sa ellw. I tgo it wgonr oto. It qireerud leedongkw fo teh awy HCM I sseptrne sepdpi.et

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submitted by ∗krewfoo99(115)

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hWy lowdu rfrospein be het gnwro awnrse? Wntudlo uatimcanculo of toixc ntoeiprs ecaus het lelc to eodgunr ipstoosap ?

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ergogenic22 oeBtorzmbi deos nto liydetcr cttiavae ir.pfnroe It icrtdely itnhsibi eht semaoortep hichw → eebsanl 8+DC T lelsc ot aiettiin psiostpao → avi ifroeprn slearee (in eceesns a anmtrewosd ee).tfcf +4

drzed ay,lEctx ti irergtsg teh ellcs to ndrgueo tipaopsos hwhci easmn thta ti nac terehi be elcl tmdaeied rpfionr(e dna ayrnemzg via F/SF)ASLA RO it olucd olas eb uhothgr hte ictnrsini tawpyah (.ge. anroihloc;tmdi ocoytehrmc )c +

powerhouseofthecell oteQis:nu tuB owh od DC8 llecs vahe a oerl in hits rpsoecs xyatelc in the i?netvgte Is ti ygnsai ahtt ehnw het oprsneti bildu u,p olny ethn od 8DC celsl cmoe dna ianestd fo HMC I inptngrese ot eseso,poamrt ethy rsnpeet ti to DC8 to intiteia ospp?aisto +

flexatronn flehtseph@reueoocwlo o s ti all geso akcb to ascib umimon (i tog htsi wognr dan ptu osipsaopt as le)lw utb rtaef nwervgeii nvetrlea inka d,asrc i own gte .S toi stmseeraopo earkb donw egtagd nesitpro tniwhi hte clle ogen(.)nodseu eTh obwraendk cptuodrs gte nkeat up by rpatsrnto dtisoesaca ithw ngineta ocsprneigs (ATP) dan oturghb to hte ruhgo ER. hTe bodwakenr dtucpsro aer ethn doelad onto MHC I lceemsoul dna tgbhuor ot eht rfacesu of eth cl.le eWhn ihtkinng aubto HCM I, tkinh otbau D+8C T lecsl (FA CMH 1 x 8 = C8.NwDo ot miamsu,erz hwen iusgn a amroetopes rio,ithibn oe'ruy gclkiobn hatt igggnat nda HCM I inlgaod prs.soce As ttades obefre, 8DC izcenrosge MCH I hc(hwi t'own enahpp hnew sinug shete sur)dg +3

whosdaprincesss @rnonflteax hknta yuo !!!! +

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submitted by ∗abhishek021196(119)

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o,rezitomBb imoarbzfcil

seMmcanhi = rsmoPaeteo ,rbtohsinii enucid aetrsr at 2G-M saphe dna sipaposo.t

Ues = itllpeuM eoylam,m lmtean lcle lmyo.pmha

vAd ffetEcs = rihrePepla ar,toupnhey ehresp eosrzt antaoirticve

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tyrionwill nured rz,oBimtbeo hte ertesopaom nontca ditsge laivr gA nda sertnpes ti ot eth mdnbem-eaernbod C.-MIH ferToehre cCDT8- nctaon eigzoncre het thos esllc ocntingina edeparls VVZ. tahT is oyrbabpl hyw hnisesgl is neo of teh uorppla dise feectf fo .oozmeBtibr +

kcyanide101 heT rdgu istihbni mtroesoo.ep Hceen etehr is on amfnterg lavelaiab utohgrh TAP dnisie 4CD lcel ot aodl nuto CHM ....I sA cush hte CD8 itneespoartn ot llTec is tdeenevp.r hTe acucmnaltiug pnestiro ndiesi hte CD8 elcsl cwhih era not ibgne knbore wdon by the ortsmpoeoe auces ti to gdroune postapsoi +

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