"Studies have shown that proteasome inhibitors block the assembly of MHC class I molecules and this is almost certainly because they are stopping the production of presented peptides that are needed for this process (6)." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094101/
AMO fo repestoomo hibrnsitoi orf MM. RLDT: is atht hety cbiaallys kbolc teh oerpoetsom rfom iuifcnnnotg so hatt yelammo lcels ant'c clyecre ostpeirn hte(y akem a ton of mhte) and nwhe hyet cnt'a be creyedlc tehy iubld up adn tasht cotxi to teh elcl and ti des.i
eodnyb hatt teh usoiqten si sicylaalb agskni if het ibinoithni fo poooemstrse nist fseciicp ot hte lMomaey sllce nda it intidehib hetor cesll' ooeeorsmspt atwh udwlo be eectdffe?
MCH slacs I is pnseert no lal anulcedet lecls (all clsle in eth obdy ectepx BCR) and unofnict ot srnetep oogensnude iantseng ot D+C8 t sclle ot be dtdseyero fr(o maeplex lVira AND ni an itfeecdn )lc.el Teh ywa tyhe do tshi is yb taikgn teh irnteop ti dnees ot epnerst dna nrbekagi it ndwo toni cmuh lmlears pteipde hscnai s(o it can fit no the IH.CM If tish ptse asw ihdibtein in roeth sllec enht eth eth eiaeotnPnsrt of CMH I uwoltnd eb eabl to eeprnts retih nsaengit ot 8D+C T clsel dan taNalru ekllir clesl. as eht souqetin mepliis.
The nusotiqe saw pruse tykrci uasbcee fi ouy ndto' ownk woh toosempeor isnbirhtio work nhet ouy sartt gionlko fro an rweasn taht uwodl alinexp hwo yeht luowd likl mortu slcle sa lwle. I tgo ti gronw ot.o tI eqdurrei eodwlngke fo eht awy CHM I serspnet ete.dpspi
yhW lwduo iperfrnso be eht rgwno swe?nra dtWnuol niutacmaolcu of cxiot itrnopse eusac eth lelc ot godrune pitpaooss ?
mBtizoorb,e lczibroamif
mMeashcin = tsooPareem bioshntii,r encidu ertars at M-G2 ehpsa nad saoi.ppsot
eUs = llepuiMt malyo,em amtnle elcl am.lmphoy
Avd ctfesfE = hpiaeerrPl h,rneaoptyu erphes eotrzs aeacvtinrtio
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$279$49MHC I otnuinfc si etriglan ot eccnra soipepsnusr. MHC I apsdsliy yulogndoseen sdhetnzsyei sineropt dna enrptses temh ot +C8D T .lelcs hTe irlfaue ot aylidps CMH I, or MHC I salipyd fo losne-fn (dan by eoinsntex o)serncuca rinetosp gtrgresi a urallcle emmniu pse,snroe lnedgia to otsecudritn of eth l.ecl
heT sreoomaetp is euds fro eht ritdanoaged fo wonr t,uo sceteesnn, or rolmmadfe et.oprnsi sA ecarcn eld,vpose omre utanmoist dlea ot cendriase onwgr s.oinpter ylnO yb enprsosixe fo eth otmpees,aor ro sti pexos-s,ornervie cna sethe tntmau eroitnps eb aedddreg fast noehgu to not be sedidpyal yb MHC I and adle to eth ellc iebgn ikedll. biroteBozm sklcob eth pms,eteorao so teh ttanum spnetrio rae aedslypid on eth cseurf,a oiwlalng the einmmu sesmty ot enoeczgir dan llki aocogaplihtl slecl.
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