NBME 23 Presentation of antigens to CD8+ T lymphocytes (NBME Answers)

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Retired NBME 23 Answers

nbme23/Block 1/Question#22 (reveal difficulty score)
An investigator is studying the adverse ...
Presentation of antigens to CD8+ T lymphocytes 🔍 / 📺 / 🌳 / 📖
tags: immuno repeat

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submitted by ∗sajaqua1(607)

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HMC I ntuincfo si gnletari to arcecn rspu.iospnse MHC I lpssiyda ugelsdonnyeo dtyieszhsen oeiprstn dan netprsse mteh ot C+D8 T .lslec heT raefilu to yipsdla HMC ,I ro HCM I pydilas of elof-nns nad( yb noneitxse uon)casrce etnspior rtgregis a llelruca meimun seenrop,s ngielda ot scotdetinru of hte clel.

eTh eoeproatsm is sude ofr eth dtrngiadaeo fo rnwo ut,o teens,cens ro adlrfmome np.reisot sA crcean e,lepdsov emor nomttiuas elad ot snecdeair orgnw rsi.eotpn ynlO yb nxporeesis fo the o,aeospemrt or sit xr-v,sseeoirnope can these nuttma roeipstn be aeddderg sfat gouhen ot tno be ldpseydai by CMH I and elad ot het llec bgien dill.ke omriBzeotb lbkosc teh emooesrt,ap os the tumtan rsienopt ear spadydlei no eth sucefa,r giolnwal the mumein tesyms ot eozgnecri nad lkil cplhotoialga lsl.ce

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catch-22 onerAht way to ohcppara ti si ot inhtk btuao CMH lssac I gecsosi.nrp ,acalBysli fi uoy thbiiin teh oareoe,tpsm spdtieep iwll not eb atdenereg nda toginhn is aaliebval ot eb oedlda ootn CHM I mrbm(reee CHM I ash to eb loadde efrebo sti' srondateprt to eht clel .usr)aefc Celsl atht ndt'o xspeser HMC I get elldik by teh atarlun irk els.lv/6pCntm.i/eMPm//3t2ibls4wthnca.p2w.hwl/:ic71g/c.rson +32

kai n"I n,clnouisco ew eahv ettadenmorsd ahtt eht mrtaeeoosp ihtoibrni rombiebtzo -eoegdwntasurl sscla I nad shencnae teh yvtissetnii fo aoelmmy to KN mleadee–lctdi il"ssy omfr eth iuocslnnco of het HIN aeprp +6

maddy1994 rtoeanh hiscemanm si yb klobngic mtoropeose u evne cresdeae ieadntrgo fo cpottpoapiro oitnossepr... it cnhcanese p(otismpafroos )wlrduo +6

azibird Btu +DC8 dna NK sllce klil iva fenir!pro yWh is tish swnrea ong?rw sI it cbausee i'ts ton hte iraymrp efcetf? +2

testready heT" osarotepme si eth omjar rucoes of piotytloecr ayictvit lvdiveon ni eth neongrieat fo itdppees rof tensntairoep yb aorjm othatpociyiimslbti pcmloex lcssa I .euelsoclm eW rtpero the ewn saoriotnebv ttah bioebrzmto egslwua-onretd LAH slcsa I no MM s,lecl tnleigsru ni nairdcees KN d–lemedcietal s l".ysi/cmpmil2.Pnh/ascw/2eo4Ctisrncw/h6.M/tbwi:/7g.pnt.l3v1 +

fatboyslim I ntkih atwh PO disa taocnrdcist tihw tahw 2ca-h2@ct edcti in eth PdMeub teai.lcr +

an1 PO adsi nl"Oy yb oeenprsisx of the reotpem,aos ro tis vseexrosro,-enip can ehset ntuamt npriotse be eaddrgde stfa eougnh ot ton eb dladsiype yb MHC I". UW IQD 16417 ssya atth a rintoep uersgeond gtnddeoaair by eth nqiuibuti arostepemo pyahw,at areft whhci ti eogs to the ER dna thne is endsetepr ot eht cell uafscre rof MHC 1 nesoerps daiglne to spitaopso iav rspfemro nda .razeymsgn ivHnag a reoaptmoes iiionhrbt uodwl alyutacl rnetpev the MCH rponsese eeasbcu no intrspoe are yeslddip.a lsAo tnoe atht teh onietqus yass ihwhc srspceo lwil be atfefdce, teher is no oemnint fo recnaeis or daceere.s oS y,se teh HMC /1 DC8 awpsayth is effdat,ec utb 'its ylulaact odwn uelag.redt nA esncaeb of CHM 1 sedal ot NK clel tddeeima hda.te +

"Studies have shown that proteasome inhibitors block the assembly of MHC class I molecules and this is almost certainly because they are stopping the production of presented peptides that are needed for this process (6)." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094101/

+3/- donttrustmyanswers(74)

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submitted by ∗tinydoc(276)

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t.It3peR/hbhtUyuH5/z/:smofJu

OAM of smreotoeop ibrishoitn fro MM. DRTL: is tath yhet blliasacy kcolb teh roeoeoptsm ofmr ionfnintcgu so atth lmymaeo lecsl ntca' rclceey nptsoeir ehyt( akme a tno of me)th and hnwe tyeh act'n be elcercyd hyte udlib pu dan shatt xitoc to the clle dan it .edsi

bdnoey atth teh ioeunstq is ylicaalbs agknsi if eth iobtniiihn fo oesroetmpos tnsi icipsecf ot eth aeMoyml clesl nda ti iidhbiten eorth ellcs' oroptssmeeo what loduw be f?tfeecde

MHC cassl I is etprnes no all tedneuacl ecsll (lal elscl in teh odyb epxect BR)C dna notiunfc to erpnets sdugoneoen ginensta ot DC+8 t lcels to eb dyrdsoeet (for xealmep Vialr DNA ni na ncetidfe lle.c) heT awy yteh do isth si by taknig eth tpoiner ti eneds to nerpste nda gaekbnir ti odwn tnoi chum aellmsr tepipde hcanis (os it nca tif no eth HMC.I fI isth teps aws bdiienhti ni hoert leslc then eht het anroieetstPn of MHC I untdwlo be elab to eetrnps iethr nisgaent to D+C8 T ecsll dan rtauaNl kierll llc.es as eth ntsuqeoi milpei.s

eTh itenosqu saw ursep tciyrk eabceus fi uoy od'nt knwo ohw opesoroetm iihsrobnti owkr htne ouy tsrta kngoiol rfo na swenra taht ludow xilpnae how htye lduow lilk tuorm llecs sa lew.l I gto ti rngow to.o tI qerrueid wdkegnleo fo het yaw HCM I ssrtnepe eedtpisp.

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submitted by ∗krewfoo99(115)

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yhW wodul ifesnporr eb eth gwron ws?eran ndWtlou ualcaoincmtu fo xocti oiesptnr eusca het llec ot erndguo oppsaiost ?

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ergogenic22 imBtozeorb deso ton idylrtce eatvciat ipfonrer. It yilcetrd biithins teh ooasrmepte cwhhi → nablese +8CD T ellsc to eintatii aotisposp → avi freprino relasee n(i csesnee a dnrteomsaw )efetf.c +4

drzed txEy,lca ti trresgig eht selcl ot dogrnue oisosatpp ichhw amens tath ti cna hrteie eb clel deidtmea irerofpn( dna ymgrenza avi F/)AASLSF RO it duclo olsa eb hgtuorh teh iisnncrti wtphaay .(eg. ioihmntcd;alro retocohcym )c +

powerhouseofthecell suno:Qtie But how od C8D cslel heav a loer in hsit scpreos alyectx ni het ?tvnigtee Is ti nyagsi htat enhw eht epsontri dubil up, ylno then od 8DC llesc meoc and dseanti fo CMH I sepetgnnri ot sotaer,epoms yeth ptenres it ot 8DC ot iinettia sipapot?os +

flexatronn fwsuoleplreteoh@heoc so it lla gose bcka ot casbi ouinmm i( tog htsi grnwo nad upt aopopstis sa lew)l but etraf rewengvii envreatl aikn ,acsdr i own teg .Sito retpasmoeso karbe onwd etgdga osirentp thiiwn hte clle noo(gued.sne) hTe bedonrkaw pducrsto gte aketn pu by spnrtator aotasidcse ihtw ennagit spcrinsoge A(P)T dna urbgoth to het uorgh E.R Teh owkardebn oudsptcr aer nteh leoadd oont CMH I lelocmsue dna roughtb ot het rsufaec of hte ecl.l Wehn iinhngtk ubtao MCH ,I thnki uaotb DC8+ T lselc (AF HCM 1 x 8 = DwN8.Co to rzea,mmuis wnhe igusn a tpaersoemo ihoi,nbtri yr'ueo glcioknb that gaigtgn adn MCH I ndiglao sre.psoc As aettds f,rboee 8DC eczrgnesoi HCM I hiwc(h 'nwot ephpan ehwn nigsu tehse d)grsu +3

whosdaprincesss tfleaxnn@or htkna uyo !!!! +

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submitted by ∗abhishek021196(120)

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,tzrBoiombe iafzbcomirl

cseMniahm = oePosartem nsiitbi,orh uiendc rrstea ta G2M- hpeas adn oipao.stps

Use = Mluitepl myoamle, mntale cell opamym.lh

vdA fEtsecf = Parrlihepe ntopahur,ye heprse stroze tvcioaiartne

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tyrionwill rnedu teBb,ozrimo teh seeporotam ntnaoc tsdegi vrlia gA and ptreenss it to hte aodn-dbebnemmer CI.M-H roreehfTe cCD-T8 tnaonc nczgioere eht stho eclsl oangntcnii aeplsrde V.ZV tTha is arbyolbp ywh nisshelg is one fo eht raopulp idse eftfec fo oBebro.zitm +

kcyanide101 heT gudr binhisit prsetoeoo.m eenHc erthe si on nfmgaret abllvaiae torhguh ATP isdein CD4 elcl to olad nout MCH ...I. As shuc het C8D tnetarisepno ot clleT is edpen.vetr ehT tlimuncagcau senpiort sinedi teh CD8 lslec whchi aer ont ebing rebonk wndo yb het otpmeresoo acuse ti ot ogrnedu itopsoasp +

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