"Studies have shown that proteasome inhibitors block the assembly of MHC class I molecules and this is almost certainly because they are stopping the production of presented peptides that are needed for this process (6)." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094101/
MAO of ortpemesoo siibihntor for M.M LT:RD is tath yeht blaisyalc cklbo hte ooeprmoset fmro intncniugof so thta ylommae slcle acn't eecclyr rpstoien y(hte kmae a ont of te)mh dna nehw ethy n'cat eb eclcredy yeht lubdi pu and hsatt ctixo to hte lelc and it sie.d
odyenb that the nstuqioe is lsclbayia skgani fi teh inioihtbni fo toepeormoss tisn cefpisic to hte omaleMy lclse nad ti iihnetdbi ohret sel'cl rotposeosme twah wuold eb ffe?teced
HMC alcss I is erntspe on all tcnleedua lslec lal( elcls in eht odyb xcteep R)BC nad coiftnnu to seetrnp ongdusoene asitgenn to D+8C t secll ot eb oetrdyesd (rfo axmeple aVlri NDA ni na tieefdcn cl.l)e hTe yaw yeth do stih si by katign hte tnipore it nesed ot erenpts and nkrgbaie ti ndwo tnio humc mellras ieetppd chaisn (os ti anc ift on hte .CMHI fI shti pest asw idhienibt in retho cllse tenh het eht otesnitnrPea of MHC I wdntolu be ebal to srpeetn eitrh agntenis to C+8D T elcls adn autlrNa ellrki .lcsel as eht soentuqi mesp.iil
ehT eqstnoiu wsa ruspe ctriyk eucabes if uyo no'td wonk how ptoeoesmor hiriinbsot orwk hent yuo sttar gioklno ofr na snrwae tath lowud aeinlxp ohw hyet wdluo klil tomur sllce as .wlel I got it rgwno o.to It irudeqer glekdewno fo eth awy HCM I sreetnps esedpipt.
yWh lodwu enfprrosi be eth rnwgo wra?nse tnWdulo imnouauactlc fo ctoxi ospetrin euacs teh lcel ot oeudrng opopitass ?
ite,bBzoomr mbzraofiicl
hsnacMiem = oretmsaPoe itii,bnhsor ediucn tserra ta M-2G esaph adn .spaipotos
eUs = lteulpiM lm,oeyam etlman elcl ylmp.maho
Adv tEcfefs = ripaPehrle utea,rynoph eserph tszeor entrctovaaii
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$279$49MCH I nfcunito si raglenit ot acncre osp.upsesinr CMH I iplasdys oglunydeseno ssenhitzedy posnirte adn erntspse them to D+8C T cs.lel ehT fluarei ot spayild MHC ,I or MCH I sdpylai fo osne-lnf an(d yb enteixons csarn)coue tnporsie egrritsg a lcrlaelu imenmu peonss,re nielgad to tcnidtesrou fo het .ellc
ehT stmpaoeore is sued rfo eth ogeadairdnt of rnow ,uto sectnse,en ro elfrmaodm opeirt.ns sA carnce lp,ovedse orem numoisatt dael to edcnriesa nrowg rne.sotpi lnyO yb erpiesxnso of the oeerapmtso, or sit ier-,eorssvenxop acn eshet mautnt nitosper eb dedgared atfs gnueoh to ont be sdpeliyad by MCH I nad adle ot teh llec nbgie l.delki iBmtbrzoeo oclbks eht tropeesm,oa os teh mautnt tnsrepio rae ysaepdild no eht fr,caseu aollwign eth iuemmn esmyst ot rengeiozc dan illk polialgaocht lcsle.
$279$49