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Retired NBME 23 Answers

nbme23/Block 1/Question#22 (reveal difficulty score)
An investigator is studying the adverse ...
Presentation of antigens to CD8+ T lymphocytes 🔍 / 📺 / 🌳 / 📖
tags: immuno repeat

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 +11  upvote downvote
submitted by sajaqua1(607)
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MCH I nfcunito si raglenit ot acncre osp.upsesinr CMH I iplasdys oglunydeseno ssenhitzedy posnirte adn erntspse them to D+8C T cs.lel ehT fluarei ot spayild MHC ,I or MCH I sdpylai fo osne-lnf an(d yb enteixons csarn)coue tnporsie egrritsg a lcrlaelu imenmu peonss,re nielgad to tcnidtesrou fo het .ellc

ehT stmpaoeore is sued rfo eth ogeadairdnt of rnow ,uto sectnse,en ro elfrmaodm opeirt.ns sA carnce lp,ovedse orem numoisatt dael to edcnriesa nrowg rne.sotpi lnyO yb erpiesxnso of the oeerapmtso, or sit ier-,eorssvenxop acn eshet mautnt nitosper eb dedgared atfs gnueoh to ont be sdpeliyad by MCH I nad adle ot teh llec nbgie l.delki iBmtbrzoeo oclbks eht tropeesm,oa os teh mautnt tnsrepio rae ysaepdild no eht fr,caseu aollwign eth iuemmn esmyst ot rengeiozc dan illk polialgaocht lcsle.

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catch-22  nerAoht awy to prpoacha ti si to ntkhi aoubt CHM aclss I .gsosinprec cBlayi,lsa fi ouy iinhbit eht optse,moear edtsppei wlli ton eb ndtaerege and onhtgni is illaabaev to be doedla otno MCH I emebr(emr HMC I sha to eb lddaeo efreob 'sit rdtopntresa to teh lcle )eufa.rsc lCesl that dnt'o sxesrep CMH I teg lkdile by het urtnala .kllerist/w/.scr2n./miiovC7P/c2b:4lh6aw/wip.3n1en/slhc.ttpmgM +32
kai  In" lonn,osccui ew vahe dmotderanset thta teh mpaoreesto tinihbior boreboimzt asedgoteuln-wr sclas I nad anhcenes hte yitevtissni fo melyamo to NK eitd–eldecalm ys"isl mfro eht nunclscioo of hte NIH apepr +6
maddy1994  tahnero neammchis is by olcikgnb oroomeepst u vnee esearedc gtniarode fo croioppottpa eo.priosn.ts. ti cehenscna (ptfmropaoossi ul)odrw +6
azibird  uBt +C8D nda NK sllce lilk avi nrfroi!pe Why si sthi easwrn or?gwn sI it sebaeuc 'ist ton teh mrraipy fe?cfte +2
testready  "Teh posereoamt is hte oamrj crueso of oltoerpicyt iivtycta ilovvend in het ainrgotene fo pideespt rfo epentasotirn by jmoar btomihotpaictiilsy lempoxc lssac I ml.olsceeu We rorpte eth nwe oenarvboits ttah rtmoobbezi -sludneotgware LAH lssac I no MM sl,lec lrsntiegu ni csnaridee KN ceeld–idamtel is"y.lsg.thl/o3i/m14/b/Cm/tMrPwp2.6ascw/c7v:e.hlpnscit.2iwnn +
fatboyslim  I nhitk thaw PO adsi rtstanicodc ithw thaw aht@c22c- deitc ni hte duMePb iarlcet. +
an1  PO adsi y"Oln by osxrpsinee of hte ooampse,ert or sit epi,sxnveeorsr-o acn teehs aunmtt ospietnr be rddgedea astf goneuh ot otn be sliddpyea by CMH ."I UW DIQ 14617 ysas taht a tropnei srguenode adreongitda yb hte iqbtunuii tporoaeesm ywt,haap areft whchi it gseo ot het RE dan hetn si ertneespd ot the clel usracfe for MCH 1 sneoersp gandile to iapspsoto avi preomfsr nad sernm.zyga Hgaivn a esetopamor tiohibinr wduol ltuclaya ntevpre hte HCM srsnepoe eusabec on topseirn rea ylddpi.sae Aols ento taht hte euiqtons ssya ciwhh pescsor lwli eb dacft,eef heret si no ineonmt of snereaci ro saerc.ede So ,sye teh CMH 1/ CD8 pyahwsta is dfecftae, tbu t'is ycatuall nowd redt.leagu nA acebsne fo HCM 1 salde to NK llce tmdedeia dta.eh +

"Studies have shown that proteasome inhibitors block the assembly of MHC class I molecules and this is almost certainly because they are stopping the production of presented peptides that are needed for this process (6)." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094101/


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 +5  upvote downvote
submitted by tinydoc(276)
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tJ/hpteb:fmIhz3/uutyosR5/.HU

MAO of ortpemesoo siibihntor for M.M LT:RD is tath yeht blaisyalc cklbo hte ooeprmoset fmro intncniugof so thta ylommae slcle acn't eecclyr rpstoien y(hte kmae a ont of te)mh dna nehw ethy n'cat eb eclcredy yeht lubdi pu and hsatt ctixo to hte lelc and it sie.d

odyenb that the nstuqioe is lsclbayia skgani fi teh inioihtbni fo toepeormoss tisn cefpisic to hte omaleMy lclse nad ti iihnetdbi ohret sel'cl rotposeosme twah wuold eb ffe?teced

HMC alcss I is erntspe on all tcnleedua lslec lal( elcls in eht odyb xcteep R)BC nad coiftnnu to seetrnp ongdusoene asitgenn to D+8C t secll ot eb oetrdyesd (rfo axmeple aVlri NDA ni na tieefdcn cl.l)e hTe yaw yeth do stih si by katign hte tnipore it nesed ot erenpts and nkrgbaie ti ndwo tnio humc mellras ieetppd chaisn (os ti anc ift on hte .CMHI fI shti pest asw idhienibt in retho cllse tenh het eht otesnitnrPea of MHC I wdntolu be ebal to srpeetn eitrh agntenis to C+8D T elcls adn autlrNa ellrki .lcsel as eht soentuqi mesp.iil

ehT eqstnoiu wsa ruspe ctriyk eucabes if uyo no'td wonk how ptoeoesmor hiriinbsot orwk hent yuo sttar gioklno ofr na snrwae tath lowud aeinlxp ohw hyet wdluo klil tomur sllce as .wlel I got it rgwno o.to It irudeqer glekdewno fo eth awy HCM I sreetnps esedpipt.

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 +4  upvote downvote
submitted by krewfoo99(115)
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yWh lodwu enfprrosi be eth rnwgo wra?nse tnWdulo imnouauactlc fo ctoxi ospetrin euacs teh lcel ot oeudrng opopitass ?

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ergogenic22  boortBzime eods ton tilydcer civttaea fe.rnroip It eylrctid snhiiibt the aoeotpmres icwhh → seelnab 8+CD T eclsl to tiaeniti otssiapop → vai rofirpne aeeeslr (in eensecs a wrdtesomna etf.)ecf +4
drzed  c,ytExal ti rtgsgier het lecsl to gnruedo soaosippt hichw sname ttha it nac hetrei be cell eemitadd re(pofrin adn nreygamz vai /A)AFSFSL OR it dcluo olas eb uorhhtg het snrintcii yhtawpa (g.e. htrloaiid;comn recomothcy c) +
powerhouseofthecell  notiQ:eus But ohw do DC8 clsel hvae a olre in htsi sorpsce xelatcy ni hte igvntte?e Is ti ysgina hatt when eht rtpnesoi diubl pu, olyn hten do 8CD slelc mcoe nad daniets fo HCM I esrtnpngie ot arsoteops,em yeth rtsnepe it ot CD8 to iaiteint a?opssopti +
flexatronn  slet@upoolefhweorhec s o ti lal oges bkac ot ascib iuomnm i( gto siht ogrnw nda utp psosotaip sa w)ell btu freta gieeviwnr nrevalet kain rd,cas i nwo tge itS.o rseoopaemts kaebr odnw eatdgg itnopsre hnwtii the clle g.one(seodn)u heT nwkerobad courtdps get kenta up by atosrrpnt ceoiatadss thwi anetnig pgsscroeni PT(A) and uhobtrg to teh ughro .ER The aobedwkrn ucdrsopt ear nthe adleod ootn MCH I lelomuesc dna rguthob to teh efrusac of the .elcl ehWn nniigkth bouta CMH I, khnti atuob CD+8 T lselc AF( MCH 1 x 8 = oDNwC .8 ot ismueazr,m ewnh guins a eperotoasm oibrintih, or'yue nbcglkio thta ggigtna and HCM I dalnoig scros.pe sA astted before, CD8 reeonscgiz MCH I hcw(ih otn'w hppena whne ngisu etshe r)sudg +3
whosdaprincesss  ax@nltfenro knhta oyu !!!! +


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 +0  upvote downvote
submitted by abhishek021196(119)
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ite,bBzoomr mbzraofiicl

hsnacMiem = oretmsaPoe itii,bnhsor ediucn tserra ta M-2G esaph adn .spaipotos

eUs = lteulpiM lm,oeyam etlman elcl ylmp.maho

Adv tEcfefs = ripaPehrle utea,rynoph eserph tszeor entrctovaaii

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tyrionwill  nrdue ozb,tomeBri teh reapestoom ncoant stgdie rival gA adn rsteepsn ti ot hte dmeeberandmno-b .CM-IH eoerefhrT -DcCT8 anntoc ieoegnzrc the oths eslcl canitonngi srpeelda V.VZ Ttah si bayplbro ywh nslsgehi is oen of teh rloaupp side fectef fo .Bbiretozmo +
kcyanide101  The gudr ihistbin ospmoetroe. eHenc erhet si on rgnfmaet lbvaiaael uohhtrg TAP isined CD4 clle to odal otun CHM ...I. As cshu the C8D tontpaensrei ot cTell si rtenpede.v The tamauglnuicc peisntor sneiid eht C8D ecsll wihhc aer not bnegi erokbn wnod by hte rpmeooetos ceaus ti ot uordgne sspiooapt +


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