NBME 23 Presentation of antigens to CD8+ T lymphocytes (NBME Answers)

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nbme23/Block 1/Question#22 (reveal difficulty score)
An investigator is studying the adverse ...
Presentation of antigens to CD8+ T lymphocytes 🔍 / 📺 / 🌳 / 📖
tags: immuno repeat

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submitted by ∗sajaqua1(607)

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HCM I ocntiunf is lntareig ot ncacre oi.ssrppnuse MHC I salypids oloynngeusde hszetdsieyn opsetnir nad teessnpr mhet to D8C+ T ecll.s ehT ifalreu to asylidp MHC ,I or MHC I iyadspl fo lf-noens an(d yb nesnexoti arnuescoc) oristpne srregigt a ruclalel miumne eponre,ss ilgdena to nicdtesrout of het l.lce

Teh roeptmaose is seud orf teh arnagdedoti fo orwn ,tou esceen,nts ro rmmeladof eirosntp. sA rccean ldoep,esv oerm uansmoitt dlae to sedaciern orwng ineptos.r nylO by epxonirses of the teopmrao,se ro sit -pevooexrsin,esr nca htese nutatm ripesnto eb drdaedge ftas guehno to otn be elspiaydd yb MCH I nad elda to the lecl igbne dk.elli oremiBzbot solckb eth atepeo,roms os eth ntumat tpriosne aer diadlepys no eht fuear,sc lwlaoing hte ueinmm sytems to orecenzgi nda ilkl ahcloatgpilo le.scl

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catch-22 ertnhoA way ot hcarppao it si ot ikthn buato CHM sacsl I .npsrogscie icaBalyls, if yuo tbhiiin teh etoerps,aom tdpseiep lilw ton eb daeneregt nad ognnith is abiaallve ot eb odedla tono CMH I ree(mrebm CHM I sah to be loeadd rfboee 'ist sotperrdnat to het lecl acufs).er Clesl htta 'tdon srpeesx HMC I teg deklli by hte ralutna s.ierllks6occ23me/7//wg1.m:.2pl/tiwpri/4tihCsaMw.vn/htP.lnbcn +32

kai nI" noscnuic,ol we ahev temdosetradn ahtt the paeetmroos horibtnii zbmtriboeo oatgslrnu-wdee cssla I nad aenecnsh het syttvsieini of ommlaey to KN l–tleaddmciee yi"lss mrfo the iouclsnocn fo the INH repap +6

maddy1994 tanehor ieasnmhmc is yb loknbgci porteoseom u eevn decserea egtdaiorn fo ttoppicoorpa p.rsitons..eo it enncacehs ptoimoporfs(as oldwr)u +6

azibird tuB C+D8 dan KN lselc kill iva orrfpien! Why is thsi wsearn rgn?ow Is it ucaeseb si't tno hte riyamrp t?ceffe +2

testready eT"h oeasptmoer si the amorj usrceo fo ctipryoeolt tictvaiy vniedolv in eht neeanrtiog of eedippts rfo ntorpinaeets yb armoj isictlobmytaitopih eopxcml calss I ee.losclmu eW rropte het wen orainevsotb thta etbbozmoir eoea-gndrwtlsu LAH lassc I on MM l,elsc geltinusr in recdnsaei NK deic–llteeadm is"sy.l cwwa/gCi/7bsc/chi4.r3ln..M2twvilo2/t/pn1m/senpht6P:m. +

fatboyslim I ithkn twha PO aisd tcdtcsiorna whit htaw @22tacch- tdice in hte uMebdP t.aceilr +

an1 PO asdi "nyOl by enepsiorsx fo teh osae,rotpem ro tis ,essioner-evopxr anc teshe uanttm eptonrsi be gedadedr satf uehogn ot otn be ddpeylais by MHC ".I UW IDQ 17146 ayss atth a tenopir sgredonue ngaoditrdea yb the qiubnutii pesreootma h,apytwa ftrea hchiw ti gseo ot eht ER and neth si tpserndee ot hte lecl afersuc for HMC 1 neeprsso geianld to iosptosap avi erfmposr adn s.maryengz gnaHvi a rooetmseap trhnoibii dwlou aatlyulc etenrpv hte CHM srsneepo eusebca on reoitspn rae sypddal.ie lAso otne ahtt eth otqsieun syas wihhc rsoespc wlil be d,cfaftee erhet si on nenomti of saneecri ro edsae.rec So yes, het MHC /1 8DC wyhatspa si efdectf,a ubt s'ti uyctalla nwdo altdre.ueg An bcnseae of CMH 1 esald to NK lcel emtiedad date.h +

"Studies have shown that proteasome inhibitors block the assembly of MHC class I molecules and this is almost certainly because they are stopping the production of presented peptides that are needed for this process (6)." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094101/

+3/- donttrustmyanswers(74)

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submitted by ∗tinydoc(276)

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sIzou53p/hH/JR:tUbfyh/mt.ute

OAM fo esotoerpmo hbnrotsiii rof MM. :DLTR si htat hyet lycsilaab lbcko the soreetmpoo orfm nuficgntino so ttha memalyo clesl 'ntca cycreel pioernst ey(ht amke a tno fo )tehm and when ethy atnc' be rclyeced ethy dluib pu nad tsaht oixct to hte ellc and ti dsei.

bdoeyn hatt hte uqiteson si isacbllay aignsk fi eth btiionihin of teomoopsesr isnt iciscepf ot eth eoylaMm leslc and it henditibi herto s'cell seseotrpomo hwta ludow eb fdceef?te

CMH alcss I is teprnse no lla cdnlaetue llcse la(l esllc in teh yobd exectp CRB) dan innctuof to nerpest ongueodens ngensita ot C+D8 t elcls ot eb rtsodeyed o(fr pexlema rialV DNA in an fteiecdn l.lec) eTh ayw eyht od tsih is yb igntka teh irnetpo ti neesd to rpsneet and eikrganb ti donw inot cmhu aslemlr deptiep hsnaci o(s it acn ift no teh I.HCM fI thsi pets swa ihdnbitie in orhte lsecl ehtn the het nesonttaePri fo MCH I nultwdo be ealb ot eesrtnp rteih snnatieg ot CD8+ T lcels adn ltaaruN ielrkl scll.e sa het osnuiqte sl.ipmie

heT setnuqio asw surpe yrickt suebcae if uoy 'odnt okwn ohw smeptroeoo tionbrihis kwro nhet oyu tastr iloongk orf an nwsrae htat duwol xleapni ohw ythe ludwo ikll uomrt elslc as .lwle I gto ti ornwg ot.o tI erqiredu wendkolge of the awy HCM I nsseretp pepi.sdte

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submitted by ∗krewfoo99(115)

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Why owlud irpsonefr be eth orgwn enwars? lnoWdtu omantacuiucl fo ocitx reioptns useac eth ecll ot regound pspisooat ?

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ergogenic22 tBibmoozre eods otn litcrdey ttiaacve .fporrnie It teydlric htbiiisn eht mtresaeopo hihwc → lbseena CD+8 T celsl to iiatenit tsoaoppsi → vai fnepirro erlesea (ni scseeen a omdewtnasr efftec). +4

drzed cyExl,ta it rirgetsg the clesl ot goeunrd tpsooispa ichhw naesm ttha it anc rithee be ecll temeidda (opnerfri nad gnazmrye via SF/S)FLAA OR it loduc oals be tguhhor het rnnictisi ywpthaa .(ge. ;nhiaciotdmlro ychrtoomec c) +

powerhouseofthecell :istunoeQ But ohw do DC8 lcles eavh a rloe in shti scpeosr tlxceay ni eht e?vtitgen sI it gnyasi htta ewhn hte oseirntp iludb p,u olny nhte od 8DC elcls ocme nda etdsain fo CHM I nnpegrsiet to aprsmets,ooe hyte esnrpte ti ot DC8 ot niiiteta ao?tipsspo +

flexatronn ec@shwhelofouetrloep os ti lla egso akbc to cbsai onuimm (i ogt isth rngow nda ptu iasspootp as )wlel utb ertfa iwrgneive trenevla inak srd,ac i own egt io S.t aopesetomsr break ndow gdtaeg pstniore inhwti eht llce )g(ousnee.ond hTe owbrkdean uptrcdos etg entak pu by ontptsrra csaesatiod wthi tegnani sigcorspne T)AP( dna btghuor ot teh ohgru R.E ehT krdaebnwo ptrsoucd era nthe ddlaeo onto MCH I lueclomse nda ghorubt ot het uefarsc of hte cl.le Wnhe nhkngiit tuaob CHM I, think tboua 8DC+ T lcels (AF MHC 1 x 8 = CD.8Nwo ot ,zesaiurmm ehwn giuns a aomposeetr bii,nohitr eoru'y obiclngk that ggignat dna CHM I aldniog eocspr.s sA etdtsa ebfr,eo C8D szeoecrign CHM I w(hihc ntow' nphape nehw sngiu eetsh d)grsu +3

whosdaprincesss etlaornx@nf ktahn uoy !!!! +

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submitted by ∗abhishek021196(120)

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teb,zomBori ificmzolbra

sMimnhace = osroamPeet i,btnsrioih icudne rtraes ta 2GM- eahsp adn osospi.apt

esU = llMeiupt ,oymlmae lmtnea lcel ahyl.opmm

Avd sfEfcet = hlrapPeeri pruhneat,oy pehrse rsteoz tvntociareia

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tyrionwill dnuer obor,zetBim eth teosramoep ctaonn deitgs livra Ag adn teespnsr ti to hte abbm-endrnoedem -.MHCI eoefrhreT c8C-TD tcnnao zcireoegn eth tsho clesl natgniicon aelespdr ZV.V ahtT si yoaprblb ywh ssehlgni is one of eth poralup eisd tfeecf fo rozBe.moibt +

kcyanide101 hTe dugr iitbnshi terospoo.em ecHne eehtr si on efmgrant aelabialv huthrog TPA inedis 4DC lecl to aldo toun MCH .I... sA csuh the 8DC ntpetoesrnia ot ellcT si pvern.eedt The gatauicmcnul opinetrs dsniei het CD8 clles iwhhc are nto enbgi bknoer nwod by eth prmosteeoo secua ti ot rgounde otsposipa +

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