NBME 23 Presentation of antigens to CD8+ T lymphocytes (NBME Answers)

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Retired NBME 23 Answers

nbme23/Block 1/Question#22 (reveal difficulty score)
An investigator is studying the adverse ...
Presentation of antigens to CD8+ T lymphocytes 🔍 / 📺 / 🌳 / 📖
tags: immuno repeat

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submitted by ∗sajaqua1(607)

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CHM I ctifnnou is leinrgat to rcnaec onprss.uepis CMH I daysislp eseounlgdnyo deteiyshzns iptseonr and spesnetr hemt to C8D+ T .clles eTh eaurfil to lysdapi CMH I, ro MCH I liapsdy fo l-snnefo d(na yb etixoenns )ecosucarn ntsipreo rigetrsg a llaecrul umeimn nrso,pese nailged to usriedcottn fo teh cl.le

Teh speootrame si sedu ofr teh argitdedona fo nowr t,uo eecntnse,s or emmafrold poenisrt. sA cecnra ,svpdleoe meor noatsumit ldae to sieencard ngwro .npoistre ynOl yb erseoxpsni of eth ,promoeseat or sti ,xisnverpe-orose nca tsehe uattmn rpnsitoe eb gddaeerd fast huegno ot tno be lsyddaeip yb HCM I and laed ot het clle gbein i.ellkd iroztmbeBo csoblk eht e,rospoeatm so hte autmtn ipotensr rae ldeapiysd on eht sfa,eurc waillogn het nimeum smyets ot iegoznrce nda klli lchagiotlpoa cel.sl

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catch-22 Aonehtr yaw to pahrapco ti si ot nhitk tubao HCM sacsl I eo.srgpnsci aiBsalcy,l if uyo tinbhii eht espreo,mtao tdeeipps llwi not eb ergedetna adn otginnh is eavlliaba ot eb eodlda ootn MHC I eembrmr(e CHM I sha ot be dolade borfee 'tsi osretaptdrn ot eth lcel .aefr)suc slCle that d'not sxeeprs CHM I gte ileldk yb eht tanarul srl. elki:gmMC76t./cbvwn/tnc1.hc4tpprawwnois/.hieml23Pl/s/./2i +32

kai "In cnclsuo,ion ew veah rsmdetdateon that eht stmoepreoa iiohitnbr mebibzootr dtns-eaulwroge lcass I dna eheannsc the snitviysiet of oaymlem to NK eademelcdtli– lssyi" ofrm teh clonncsiou fo eth HNI pearp +6

maddy1994 oaerthn himnseacm si by olnkcbig oprtmeesoo u enev eescaerd gietnorad fo opitcporpato st..orieo.pns ti necshnaec m(osrfoapospti )wdrlou +6

azibird Btu 8D+C and NK llcse lkli avi onr!irfpe yWh is isht snwrae w?gnro Is it beaescu tsi' tno eht parrmiy cfee?tf +2

testready eT"h oapsemoetr is teh oramj scoure fo oreytcilpot iiattcyv ivvenldo ni eht goeatnneri of eeistppd rfo iaoepnsetrtn by mjroa isaobtpomhiitylitc elcmoxp lssca I .mullceose eW rrtepo the nwe ieovotasbrn hatt rtbomezibo sdotarlw-egune HLA lcssa I no MM ,slecl rsulntige ni derncesai NK l–mdelitdaeec is "ysl.inhl/2.p:C4mw7gsv.l3c/6wb1tM/ms./ipwtca/in/t2ecoPrn.h +

fatboyslim I hktin what PO isad dtcratsnoic thiw twha htacc-22@ eitcd in the PdMube .leactri +

an1 OP sdia lOy"n yb sreonisxpe fo hte e,meporsato ro its ,rxeniepe-sovros acn ehtes utatnm niostrep eb gedardde astf uhnego to nto be ydseiplad yb MCH "I. WU IQD 64171 sasy tath a oretipn esugdreno aoitngerdda by hte uutniiibq tasepmeroo hw,tayap aefrt wchhi ti esgo ot het ER dan tnhe si epreenstd to hte lcle eufrasc rfo CMH 1 soresnpe eadinlg ot aiopptsso iva ermfoprs adn myner.sazg nagviH a oatpomeers bitirinoh owldu cltalauy evtprne het MCH esnsorep cueebsa no epsriton aer dlpiysad.e lsoA tnoe htat teh oistuenq asys iwhhc scoerps illw be f,fedecat ehert si on etniomn fo scirenea or aecedrs.e oS ,esy the HMC /1 CD8 taaphswy is feca,deft but is't yltlauca dnwo d.aegrlute An nbesace fo CMH 1 selda ot KN lcel eaieddmt hate.d +

"Studies have shown that proteasome inhibitors block the assembly of MHC class I molecules and this is almost certainly because they are stopping the production of presented peptides that are needed for this process (6)." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094101/

+3/- donttrustmyanswers(74)

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submitted by ∗tinydoc(276)

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hepom/tUJh5uu/ItbR:/ty.f3sHz

MOA of stepreomoo ibnsiotrhi fro .MM TLDR: is ttah yhte aalcslybi blkoc eht remoeopost mrfo ntiguconfni os that ylamemo llesc ncta' ceyrlec rtepnsoi h(yet aemk a otn of mhte) nad hnwe hety na'tc be clrdeecy hety uibld up dna shtat cxiot ot hte clle dan it .ides

bdeyon ahtt the esqouint si sblaliyac ksgnia fi eth iinhnbtioi of oooemrepsts itsn ipifescc to eth aolmMey llsce and it tihibeidn etrho esll'c smoeestopor htwa oludw be tfe?dfeec

CMH lssac I is eetprsn on all dcnetleau llsce (lla lescl in hte dyob exectp )BCR and ufnitcno to tepsnre unenogodse gnaietns to D8C+ t lcesl to be yddtoerse (orf eepalmx rVlai ADN in na efcndiet .ecll) heT ayw htye do stih is by atikgn eth tpreino ti dnese to eeprsnt and nkbaigre it wdno iont humc ealmrsl dpepeti hsainc so( it can tif no the I.HMC fI iths etps was iiienbhdt ni ohetr clsle nteh hte teh iesPnantrote fo HMC I uwondlt be bael to rstepen etrhi tnianges to C+8D T eclls nda ratNual killre sel.cl sa eth nqsteuoi ilsiep.m

Teh sioetnuq was respu ykitcr ebeusca fi uyo ot'nd nwok how mtpreooose oibhnisrit wokr ethn ouy tstra lkioogn rfo na ewrnsa htta oudlw aniepxl who ehyt luwod lkli torum slcel as w.lle I got ti gwonr to.o It eudrqire nlgkdeoew fo eht way CHM I ptesresn ptsp.edei

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submitted by ∗krewfoo99(115)

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yWh wulod irseonrfp be eht nrogw narwe?s tlodnuW mcatuiauolcn of ioxct epritons aeucs eth cell ot egrdonu stsiopapo ?

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ergogenic22 ziroteBmbo dose not ledrcyti atiecavt enofr.rpi tI tlerycid ntiiihsb eht oratespmeo ichhw → neables +8CD T selcl to attineii sptpoioas → avi peirfnor releeas ni( cessnee a wdonmsaret fct.)fee +4

drzed lc,Etayx ti gertisrg teh llces to oerngud ptsoiaosp hhcwi enasm thta ti nca erteih eb llce deadietm (perfiorn dan aegzrymn avi LSAF/FA)S OR it cdolu olsa be ougthrh eht ciintisrn ptyhaaw (.e.g clnaoriidtho;m eoohcyrctm )c +

powerhouseofthecell Qsot:nieu But owh od 8DC cslel aevh a erol ni tsih crospse cyxealt in het egtevnti? sI it ingays ahtt ehnw teh oinetspr dbilu p,u olny htne do C8D llesc ecmo and iednsta fo MHC I ntigsernep to eoemoasp,trs yeth psertne ti to 8DC ot itieaitn otipsosap? +

flexatronn felsooe@ecetporwhhlu s o it lla osge kcba ot bsaic numoim (i got shti orwng adn ptu osptasopi as )wlle utb eatrf eiervnwgi veaterln kina ,cdsar i wno get toi S. msrpoesetoa rabke donw gdtgae oentsrpi wihnti eht ellc (o)unenedogs. hTe kwoneabrd ptruscdo get netka pu yb ttrsnropa oeiastsdca thiw eitagnn enpiscogrs )APT( nda hbogrut ot teh guroh ER. Teh adewkonrb tsdropuc era etnh edadlo toon CMH I lomlseecu nda otgbhur to eth ufasrec of eth .ecll nheW inginkth buato MCH ,I ikthn atbuo C+D8 T lelsc FA( MHC 1 x 8 = . wCo8DN ot ,uremimsaz enwh ngsui a poeteosrma ,nhrobitii yuoe'r lokbgicn ahtt aggntgi dna HMC I aognild rescs.op As asdett e,ferob CD8 oeeznrgsci MCH I iwh(ch 'wont aphnep nhwe nugis sethe )usrdg +3

whosdaprincesss anfonerl@xt atknh uoy !!!! +

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submitted by ∗abhishek021196(119)

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oeimzBb,otr iblrzaiofmc

mahMceisn = arotemsPeo b,sirntiohi uednic rreats ta M-2G ahsep dna iopoas.stp

sUe = tlMuepil eamomly, nmatle lecl holy.mpma

vAd ftEsefc = aeperPrhil eyrphnua,ot ephser stoezr rtonaicetavi

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tyrionwill rdneu Bboem,ozrit hte opeastomre onatnc tdiseg lavri gA adn terespns it ot eth rnemmdb-donaebe MHCI.- ofrhereeT CcDT-8 canotn iroegzcen hte tsho llesc intnnogaci eepsdlra V.ZV atTh si ablpyorb hwy sehgnils si noe of the paulrop sdei eftfec fo beizm.oBtor +

kcyanide101 ehT gdur isnhbiti oe.motrspeo cneeH eerth is on regfmnta lieaalavb uthghor ATP senidi D4C ellc to laod outn MHC I.... As hucs teh DC8 tonerpisante to lTelc is epvdenrte. heT lagcctmuainu psnroiet siendi eht D8C leslc which aer nto iebgn nekbor wdno yb het peromooets aeucs ti to edunrog iopsatosp +

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