Wtah rehwt me fof ni ihst qtsiueon is eht herasp l"lsce wthi titlel aymsloctp htat are eiwct eth zsie fo cms"ptyhly.eo I toguhh "asllm lcle onmaci"acr aotcnn eb that bi.g

hreTe rea trnacie situtioasn ni hicwh you nd'to eedn to oinfty tnsearp abotu nhyantig hnew grtetani a ci-hSsd-lTI era eon of tmeh. heT soeran ebign htta ueerntdta TSIs lwli aesuc remo spdera sa lwel as acn edla ot DIP

PIOLERS IEPLOSR EIRLPOS
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iThs si LLRYEIALT het asme othpo thye usde to dcebirse hte -ero-4ayld yob ithw sefiudf citlorca iecrsnos ormf BMEN .81 Can osnemeo ainexlp whs'at gogin no ereh

ehlWi het meiltefi iksr in teh rnegela ipanooptlu si jtus olwbe ,1% ti si 65.% in ef-rtsegdier vrsalteie of tsenatpi dna ti riess to emor hatn 40% ni tooynzciomg tnisw of dtfecfea ol.pepe yinzngalA islascc sdieust fo the ceesintg of oahzisrhicnpe done as raely sa in s,9031 erihFcs luccnodse that a arnceoconcd etra for icpssyhso fo tabuo 05% ni yotiocozgnm stwin sseme ot be a iarecsitl tms,iaete hwhic is iflnnisaycgti hehgri nhta taht in gcidzyoit ntiws fo baotu –0%911 (r//m4sct6pmcil.roen3cCngva9./6ben.3ilM/Phf#i25)

nca oemnose xinplea hyw ti yssa eh ash an tantic'' HTP .otntosc.iren.niac ti ot tle us wokn ahtt the PTH cenaintotnroc is a ltsrue fo gpoythdola ?na hatws' ihs ?xd ahnts!k

ishT is ervcetia pihcmeytlyao a,evr hwich is ude ot hhgi tliauted ro ulgn iess.ead 2aSO is ,olw dan PEO si iera.ecsdn

oAhnert yaw to rahcopap hte siotqeun is loinokg ta eth obldo .amres I'st ytpert nomlar (on k,tmcygaoarysee no sdreciaen rnbuem of l,tteeplas on ,sodr gtonhin ub,el cet.) A bodol measr form a ODCP pientta will eb mro.lna ustJ na cnsdeerai nmrbeu fo CRBs edu to teh eadrsncei EPO egndail to idrcsneae .gHb

ilaiCncl sue of -Ksganrpi rut:ciseid

• Hedoapyrtrlsonsiem
• K+ nlpetieod
• HF
• phieatc sceiast trelp(os)iocoann
• corehnegnpi ID mlidoei()ra
• naotirndaneg

Atg,hi ikd if mi' eht lnyo eno tub i dah NO edia awht hte g to aolceir neoovssicrn erew so erhe :gose

ePr 1g of

e:odybtarChra 4 acl Pn:ori te 4 lac tFa: 9 acl

eTh reom yuo n.ow..k

I hkint siht is iba,Bsae rattendtsim by hte o[Rnbi o]f dsIeox .iTck

71,5P F290A1

Wnhe uy'oer on Logn ad,nIls cdognriac to Gojnl,a eyo'ru IOGNG ot teg a tkci btei if ryuo sgle rea dpee.osx hsiT rigl saw igwonrk sa a gri.afeuld ehT xoeids ickt si ntivea to eth EN S.AU Wlieh we lltyiycap scoitasdea eth temales ossrc whit ae,bbasi etreh is loas na cyratiithrtrone nirg rof.m shiT gilr sloa adh a lo,yemnsptec ihchw ascnesrei eht iskr of sereev essadi.e

Tihs aydl dah prretem rtueamepr rpruetu fo .esmmernab She dah a galenit tatrc en,ctfonii ihwhc si a ksir aotcrf orf PMORP.

ormF d:Mteaa toypUn of the roimsoascngmri ttha oinzolce eht ewrlo aelignt arttc aehv het ptyccaai ot ucepdro pihesa,lhssopop hwhci nac mttilaseu eht dcotiponru fo arltsdinogpsan adn treyehb aeld ot eth oestn fo teirune oc.tiocnnsrat nI d,anitdoi eth s'shot mneumi erossenp to aeibtcarl siavnoin fo the rexoicvnde n/rdoa laetf emanrsemb adsel ot eth iptdruonco of euitpllm aaintfrlymmo rmoeadtis thta can acues oleacizdl ngaenekiw of eth latfe amnrsbeme nda eultsr ni PP.ORM

AF 0291 Pg 733
crhcnio irttisgas smlucoa ntliiafnammo daglein to ythroap

Thsi duwlo tsuj be het lmonar ssrneeop of uor neiysdk ot wneh ew d'tno rdnki tewra nghoeu a(ka jsut am)l.nor

mxaPirol tubleu si cnooisit bseeuca we ear bsriagbneor OBTH N+a and .2OH

aMucla aedsn si ihnopocyt useabec it is gsesnin het itdsla contvoelud ubeult -- eth toms IELDTU ratp fo eht nero.phn eermmeRb het rettouenccrurn gehxcnae ssemty - ictkh idnesgacn bilm si glosni lCNa enriu( setg less cdreteatnnoc as it scasd)n.e

Mrdlyluea clegnocitl ctud si hnioryetcp eeacbsu we rae earisbbgorn lla the retwa nkgiam teh runei omer ctea.ntodncre

loudC meseono palixen hyw iths chiceo is eth ebst rens?wa I ugsdtgrle nebewet A dna D, dna epcidk A iflyal,n icwhh si tenracia"s anileotuadc elvel and rpdeovi oi"latunspb.ci

I saw feocsnud eewebtn -ahAlp lcyeniuSn dna Tu.a s iTh tiaetpn ahs npnsasrkoi sdsaeies and suth ew wulod ese laphA nny.lcusei

uaT is eens in atpietsn hwit scikP e,essaid kaa tnloprmooareFt eamtndei DAN rmeelhszia ed.asise pae g 04.5 FA 1208

etyrtP esru tihs si a seca of o.leeignLal The fcta htat ti 'ditnd wohs up on ecutrul but a "hlhigy pedlsziai"ec miemdu (in dsihihngt eebdrfuf lahrcaoc ay)tes ielyded aiamrggne-etv rdos utp genlaeiloL on my aardr. ehT cahehaed dna ydr ouhcg oals lnie pu itwh it tub eht csreladomi thewr me off nesic I gtuhoht ythe ewer tdtaere iwth or.nooifulnoeuql B tu het ckeysht ivode for oiealsmrdc slncuedi nogaeeilLl sa a atrteg os ti derowk u.ot

tyucLekeo henoasid icfedenc,yi a ectefd ni trnegini AF.L1 pNsitueolhr aer eublna to edhera nda garietm to etnnoiicf ss,tie tiasnde agccamntiuul ni bolod. iTsh sainxepl the ascbene of ilosehrptun ta innfceiot sitse dna evaledte elnhsiortpu ni dbolo.

dSei neto: ePsyoh is a tgera reef rcseueor htiw -ckyselhiekt imagse to hepl eerebmrm oeimieiecucdismnnf nda .more Nto at lla no,sepdros utjs lumbdets unop ti nuidgr tideeaddc nad oschekd ti is'tn emro deliwy nokwn .utbaotm:s/omh.ngist/omlcpop/hy/yuoe

Waht uwodl a euuptrr fo eht foipnaall teub kool keli t?ehn mpCeraod ot rnlmao ..laispgle

sTih rylael dunsso leik ist' indcsrgbei oltpAr y,omndres tub ltorAp roemdnys si -iedlkXn N!OTMNDIA hWta si gigon no e?hre Is htsi a ?ekmasti oHw to eaxipnl ilnlgac ti nliXd-ek SEVIRSE?CE

tlporA tainrmtMSoyn eoud ni epyt IV laelgcon &tg;- innhngit dan tsitlnpig fo mrelaurogl eensbtam emrbenm.a tsoM lconmoym lXden-ik .daninmto Eye psrmbeol g(,e ,tonryhatpei oearinrt ns,tei)onlcu igptrne,remolihusol srrsuaeleionn sfeeda;sn c’na“t see, ’nact pee, tc’na eahr a k”M—.a”va-es“ebteEbeew peaenrcpaa ude ot alrrguire nntkchigei fo BMG

eth doereolnsAt was RCAIEDSEN ni the weanrs

hiTs sha ot od hitw teh hgoilmrat of neraittg scok.h tieScp a( ytpe fo ttirdbiesiv)u chosk as well sa vchmloypioe kcsoh are teeatdr tiwh VI lidfu rsisnctoetuia 0022F(A )p1.03 yislrCtdlao sfudli era iiftrsenl- ioc,ehc dna manlor nileas 90%,.( osinci)ot si etifin-srl cpsyfillicae ni eacss fo kscho.

5% tsreoexd in awret nad 5%40. enslia is yohnrtpcie nda tno usulfe ehe.r

5% dtxeesro oanel is isinooct in eth bga tub gillapsylyoohci nhopo.iyct It is omer otfen nvieg ofr udifl paclemenetr ftera seveer reidt.nahdoy

%.405 niaesl oyln is ihtnocpyo and ont eslfuu ehe.r

3% ilasen is rphnoctiye nda tno elufus rhee.

• erHe is a ctrha of the ilfud snsioctiraute orf teh fereinftd nikds of okhsc
• Heer si a acrht of eth rifneedft diksn of IV nslotsoui adn in leganre hnwe to use hmte
• Hree si tehrona catrh of IV soiolunts nad sues asecu I liek rsthca
• ndA erhe is na egami inwhsgo ni lerange ehnw ot ivge olmnar anisel .(9%0 eis)lan

keaoHyamlpi si ontfe omrf tcrisueid PE(XECT the K ngasirp dceisrtui no the olcnielgct ub,ulte STEA iopraeo,nSnlc[to lreonne,eep drilo,Amei edhrTmenHiailrataror,iczte])hdo ey a rdusiicet gcniat on hte CTD ssaecu eiyap.mlkhao

hreOt not:psio ilnCnieod al(pha ,)oklbcre nosrlLiipi Chrtin)(-iiAbE,o rtpMeolloo be(ta clokb,)re Tierneaemrt (K asnpirg )ieut.cdir

To olsw btecadii heprhopaytn, ouy acn iveg an AEC riitiobhn .e(.i, p)illnirios or an RA.B Thsi olduw ot drnicseae liiantod of hte ereffnet irltaoere nad revetnp eht lotaytnpiirrfhe njiryu acuesd by iticbead hhopptyr.aen

A ewf fo teh hsnit that ptoin ot atuhodreim trrahisti reov hte ehrot swa:srne

• eougnrY ega of tosen and elfmea - rteoahdmui htsirtria si an uuemmtiaon assieed and can hsut rnepets ni noygreu leefmsa eaehsrw rtitirshoostea is rmof rawe adn etar so it is ayulusl relod idsdnlaiivu 2A00(2F p466 rof soiorrashttite sv ioerhmut)da
• pSanrgi fo het aslitd eiltgrnhypaealn ntjois DIP( rae sprdae in oihrmudeta saiit)hrrt nda laelaitrb - ni eht reoth dossierdr eerht si otn eysnsrlecia itcetylvsie rof the PIP dna P,CM dan thye oudlw otn caseyinserl eb lablreait ie.(. otgu is otn riescnlyase aberltal)i eshwra maieoruthd ititrhars si eitlralab
• nuaPns ironmofta - eht niaoftrom of dorlanu nespausn is rcsthicacrtiae fo rduaemhito haitrsirt over roteh doresidsr (laclseeyip eocn gout si ilniaedtem the crneesep of selduno soitpn mtso to hrdoieamtu rrihtats)i
• SEL wuldo be iklyle be sadtescaio hiwt oterh etosdacias tsmpsomy (p)074
• lAso hte sahirittr ni upslu is coneesnivlte rof tijon ptey
• rSeoearmdlc odse otn oclomnym retneps whit riaristth or niojt pnai ()437p

ehT yke ofr iths egbin tisinsecgd enrmsauy si hatt i'ts a idndwee aoticr hcr.a l,oAs t'hrees neunve lspuse smiddhiei"n( psuels in het fetl epurp it"yx)meret miengan thta obdlo si otn sspaing mrof eth trioca rhac ot teh eltf vanbiacsul aretyr t's(i otn psinags hte irotca h).rac

Hree si ym kate: a vltceuiarrn pealts detefc ni fcnnayi sllwoa fro telf to hrigt gnhitsnu of dbool in eht lere.tvinsc shiT ueacss na diearcens prrsseue ni the hgirt lvtecerin eu(d ot erom doobl ngbie uspdhe otni ti) and a eeaerdcds seurpers in the etlf env.reltic ueBasec ehetr is remo bolod in eth aylopmrun utnrociclai ofmr hte hn,ust I kihtn eht ltef altria esrrupse ulodw salo eb sianreced ni an eaylr .SDV

OS wnhe ouy iperra het SDV, eth eflt veiltncre esrpures lwil eb icdaesrne oamrdcpe to ewhn eth thsun asw eeptrns t(i is on nrogel snolig od,ol)b the hgrit neevrctil erprusse wlil be scdedaree (it is on nleogr ettging odbol rfmo eht ,htuns) nda the left alrati rsseepru lwli eb edecdresa e(hrte si no nelogr reovodal fo the ropaunlym ymsets tnuniregr to eht etlf uam)irt.

022F0A 2p89

Tihs otnuiseq is ngiaks wtha tfle dmtnaoni nrutlccaioi namse. I ppseuos ti asntw us to iefnr htat eth DPA si yippsulng het mdgiaahrp rscfeua and AV dn.eo

tI si gcufinnso ot em eueascb oymlnarl eth igthR almaignr ratyer psleuips the hciaiaptgdrma bderor aetc(u )iamgnr fo eht .tehar I'm not ures htta ti cahnseg ni elft mntianod .tacrciiuoln reetoruFhmr it udlow tno abcrhn ffo teh ,PDA gtoluahh aebmy atprs of ti aer siepudpl yb het APD

Aosl het VA node is plpiduse yb teh rarloAinrvteiuct olnda ,trarye hichw nca be a bncarh ffo of the LCA or eht bLuXt C tno raylel teh DPA

eit5v//3itc9w.nlnish//M.ohb9.a7p/1l3Ctwscpmn:rg/.Pmwc

os fuoscnign etisunqo rfo em ubt het nopit is to knwo hte rucose of lfte nmaiodtn iccntraiuol ot eht APD

sadBe no het srtohiy ooiu(cmnpnts fo gelar tumoasn of hallcoo nad tadevele mesru /palmyiasesela iwth mycoap,ahicl)e hist nam lekily has cteua narstiicetpa F20(A20 )7.93p nOe of hte arjmo lcaiitospncmo is teiatusgnidoo of isse,ust such sa hwat si esne in hte iameg.