NBME 20 Hydroxylation of proline (NBME Answers)

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nbme20/Block 4/Question#10 (32.2 difficulty score)
A 65-year-old woman who has a 25-year history ...
Hydroxylation of proline🔍,📺
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+4
submitted by thelupuswolf(9),

Perifollicular hyperkeratosis and hemorrhage are seen with corkscrew hairs, that juicy buzz word for Vit. C deficiency. Hydroxylation of proline in collagen synthesis cannot occur without vitamin c

+2
submitted by epiglotitties(20),

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erheT si na yralmalnbo cseddeear nutcfnio fo het rxhynoldyoati of irolenp easbuec het dn2 steag in llanocge yehtisssn yxt(onaolihdyr of sefciipc rnoiple adn lysnie uidesrse) euerqisr mvianti C. cSeni ihts etpatin hsa cSyruv .(tiv C d),iccynieef itsh ocresps is ublean to o.uccr

+1
submitted by hayayah(1101),

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eSh ash a mviatin C ifi.ycecned crSyvu euasetrf lownsle gsum, seya nigbruis, ,peiaetech eolulfalciprri dna pitrbseoelasu s.geerhomhra

+1
submitted by lynn(12),

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A,F19 pg 69 - iilpllafurcreo dan sarepoeuilbst srere,goahhm pg 674 lilfcsyaepic slsit olmusca ndbigele

+0
submitted by stepwarrior(23),

Wouldn't chronic alcoholism also reduce available NAD and thus inhibit pyruvate decarboxylation by PDH?

andro It may also potentially do that , But that has no connection with our patients current symptoms - perifollicular hyperkeratosis and hemorrhages . Inhbition of PDH would be more relevant if they were talking about Alcoholic Lactic Acidosis or decreased energy in alcoholics +