I was confused between Alpha- Synuclein and Tau. This patient has parkinsons diseases and thus we would see Alpha synuclein.
Tau is seen in patients with Picks disease, aka Frontotemporla dementia AND alzheimers disease. page 504. FA 2018
Intracellular aggregates in neurodegenerative conditions :
Alpha synuclein- a protein mainly found in terminal axons which can aggregate and deposit intracellularly to form Lewy Bodies . These are associated with the neurodegenerative conditions 1. Parkinsons Disease 2. Lewy Body Dementia
Neurofibrillary tangles - hyperphosphorylated tau protein , number of tangles correlates with degree of dementia
Pick bodies - hyperphosphorylated tau . these are round aggregates though in contrast to neurofibrillary tangles. Seen in Frontotemporal dementia and other neurodegenerative conditions
Hirano bodies - intracellular aggregates of damaged actin filaments seen in various neurodegenerative conditions e.g AZ , ALS , Creutzfeldt-jakob Disease ( These are not really tested on )