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NBME 18 Answers

nbme18/Block 1/Question#45

55 yo man; father and brother died of myocardial infarct at early age

Increased transcription of HMG-CoA reductase

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submitted by famylife(37),

"Despite inhibition of HMG-CoA reductase by statins, cells compensate by increasing enzyme expression several fold. However, the total body cholesterol is reduced by 20%–40% due to increased expression of LDL receptors after statin administration."

https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/hmg-coa