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SeN Out (Snout) --> sensitive test; - test rules out
SPec In (Specin) --> specific test; + test rules in
can anyone pls explain why it is not << potential false- positive results >> ???
correct me if I'm wrong, but 'high FP (choice C)=low specificity (choice B)'. Whereas high specificity is required to rule in dz
picked positive predictive value myself. can anyone explain why not PPV?
The principle @hayayah is talking about (a negative test being relied upon to reliably rule out) is negative predictive value ("NPV"). I don't see why "uncertain NPV" isn't the correct answer, particularly because NPV is predicated on the disease having the same base rate in the person(s) being tested as in the population that was characterized for the test statistic. Given that the patient has a strong family history of colon cancer, the NPV of FOBT is uncertain. Said another way, the sensitivity of a test does not change with the population, but the NPV does. The whole reason the doctor is denying FOBT is because of bayesian thinking (a priori information related to family history), and from my point of view bayesian logic is more relevant to PPV/NPV than to sensitivity, hence my confusion over why NPV isn't the right answer.
Quick question: FA19 691 says Leuprolide ClINICAl USE is Uterine fibroids, endometriosis, precocious
puberty, prostate cancer, infertility...
I guess all except infetility(pulsatile?) are used as continuous?
GnRH is synthesized and released in pulsatile fashion , so if you give in pulsatile way you induce GnRH effect , and if given in continuous way it will suppress synthesis, depended the desired effect you want to achieve - infertility induce GnRH with pulsatile , stop synthesis for prostate cancer , testicular cancer , hormone dependent Breast cancer give continuous
How is one supposed to know this before having read this article?
This question falls under the either you know it or you dont category. It isnt in FA or Uworld
So why would these A-holes put it on there as if prepping for this exam isn't stressful enough :-|
and there's so much unnecessarily BS instead of real questions
i'm sorry guys it's bladder cancer blocking urine flow => reflux ureteral widening => reflux nephropathy.