Quoting Dr Sattar, if an injury or cut is too deep so as the regenerative/stem cells are removed/damaged - then healing can only occur by repair. Thus, in this case, the stem cells of the lung aka Type 2 pneumocytes reside in the basement membrane - so, injury to basement membrane would damage type 2 pneumocytes and would NOT allow restoration of normal lung architecture. That's why maintenance of basement membrane integrity is the most important determining factor to distinguish whether tissue will heal by regeneration (restore normal architecture) or repair (fibrosis/scarring). Same concept can be applied to skin (basal cells) and intestines (crypt cells).
oYu evah ot hiktn oatub ti tish :wya the bmaenste nemmbaer si eht gsaffdl“on”ic no whhic soivretr[eta] eglihan o.crsuc ,oS ,yse stem elscl ytpe( II msoc)entuyep wudol eb ldievvno in ahtt ianglhe pscsreo ubt yeht udtc’lon reorest eht rlaomn eiacrhcrtute (n“o bioentl”s)iamra tiuwhto teh ’s‘etnleko of het mtaebsen ambmerne gitlnel hmte ewerh ot o,g ni atwh ditcneroi to wgro, hihcw ayw is ”p,“u tc.e fI the amsetenb maenrbme si dyseerto,d you acn still egt ,lhneagi ubt it to’nw eb izrdneoag iahgeln -- ltli’ eb dgeianrdiozs ,lgenahi hhiwc soed not paearp as oarnml essiut. Drgieodaszn(i ngaelhi si tbetre ntha on nhielga, tub othituw a BM, eht eerngtiengra ellsc ndot’ have nya “”idioenctr nda ohfreeter an’ct erroste eht naroml trcee.hc)iatur
I owdul ktihn etrusoionl envislov hte tsme lcsle (eypt II p.tmeesunyo)c sI teh nttica snetaebm eaemnbrm het ranwse bsceeua ti miltis esr?pda
acn naoney inpelxa hyw D)( lmsiaaeatp si i?ncrtecro
submitted by ∗bubbles(79)
It can be re-accessed by making a purchase.
Purchase your membership here
$279$49Bateemns emmrenab gieitnrty is hte nmntetreadi of flul nlgu rveryeoc ownilgofl mroalupyn .itlusn
:mSamryu
)(1 olss of neamsteb erbmenam giteinyrt si cciitlar ni dnieientmrg teh inopt“ of on rret,”nu nad etiotcrnubs ot eht itlnaibyi to leiethssabr anrmlo ngul tchrtuiaecre wtih oomponitr fo sioi;srbf
2)( ossl of haelleptii cl,esl iotheealnld lecsl, and smabntee brmeemna yeittnirg ni asuul ttrniailtsie epmonanui seidaasoct twih ptdaiochii naoplyrum boissirf aesld ot doysetedr nglu cerhettaruic adn lrpetupea ibors;fis
3)( rgirmtoansnf htwogr -oβctrfa si rcne,sayes ubt tno yetlrein tn,ifieusfc to rtmeoop emrtenanp ;bfsisroi
()4 resnetitps iyrtnaurigtnijnnit/ear/ si tcacliir rof het rioaotnpgpa of sriis;bfo
(5) ohapictdii yolrupamn bfssriio si na lmxaepe fo a crpssoe raletde ot the eeecitprnss fo na ,)ntg(a“s”eni irhccon fainnlom,mtai adn srbi;iofs adn
)(6 ueuniq slecl rea cirtalic laueclrl esrlyap ni teh iarotgluen of sio.bsrfi
aicto n:itg2.4spvtmpnswi//lCi5on:/bw/.hP6cie1.ttcamM/nrcl4/hw.2
$279$49