Quoting Dr Sattar, if an injury or cut is too deep so as the regenerative/stem cells are removed/damaged - then healing can only occur by repair. Thus, in this case, the stem cells of the lung aka Type 2 pneumocytes reside in the basement membrane - so, injury to basement membrane would damage type 2 pneumocytes and would NOT allow restoration of normal lung architecture. That's why maintenance of basement membrane integrity is the most important determining factor to distinguish whether tissue will heal by regeneration (restore normal architecture) or repair (fibrosis/scarring). Same concept can be applied to skin (basal cells) and intestines (crypt cells).
You avhe to nhtik tboau ti isht ya:w eht mabnstee mbneream is het gfoafn”lscd“i on ihhcw srtee]trivo[a inglhae usrc.oc So, ey,s mets cslle teyp( II ynpceoset)um odluw be eivoldvn ni ttah ahileng orpssce tbu heyt oundl’tc eetsror hte rnoalm hitrrectucea o“n( ”mnra)atseoilbi wotihtu the eontelks’‘ of hte tsabemne amnemerb lgnliet ehmt hewre to ,og ni ahtw rodinitec ot ro,gw hcwih awy si “u”,p tce. fI eth sabmetne mbeanmer si deot,seydr ouy acn sllti get ein,lhga but it wtn’o eb airnodegz ihaegnl -- ’illt eb dzeisgdaroni il,hegna hwhci deos nto pepraa as lmanro s.tesiu dgoDienris(az neighal is trtbee nath on hignea,l tbu thutiwo a MB, eht eigrtneeagrn ecsll nt’do hvea yna o”rdeni“cit adn fhreeerto actn’ rosrete the mlorna etiureh.cat)rc
I odluw ithnk nouloistre enolvsvi eth mtse celsl e(pyt II psceyunm)ote. Is teh ttncai tabeesmn nmeearmb eth swearn bseeuca ti isltmi ?redpas
can aynoen axnelip ywh ()D ampetliasa is tcrercnio?
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()1 ssol of sanbteme eenbrmma ntygritei is latiiccr ni tnnrdgmeiie het tpoin“ of no t,”reunr nad irobntetusc ot eht aynltbiii ot baeerlhtsis lnrmao lung arcirehettuc tihw pnmortoio of ois;frsbi
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