invite friends ⋅ share via emailtwitter
support the site ⋅ become a member ⋅ unscramble the egg
free120  nbme24  nbme23  nbme22  nbme21  nbme20  nbme19  nbme18  nbme17  nbme16  nbme15  nbme13 
Welcome to blueberrymuffinbabey’s page.
Contributor score: 3


Comments ...

 +1  (nbme23#3)

I got this one wrong, but based on the ITT perspective others mentioned, maybe the "in their primary analysis" part of the question is a tip off. They'd start with including them in the original groups and then do additional analysis to try and tease out the impact? IDK





Subcomments ...

submitted by drdoom(647),
unscramble the site ⋅ become a member ($36/month)

ersHe’ noe yaw ot pto-ins-aesrfoelciem sedde“rcae -nnohgordybde tm”rfoao:ni ’mI not a gbi naf of tsih leni of si,gnonrae tub elhccatnlyi aanelin as a desi gourp ash rome sdyrogneh* rof taitonpel ndyorheg ongbnid nhta yceilgn:

nialan:e H—C3
yilec:ng H—

o,S e,nlc“”tilcayh aneailn oulwd treipm meor ddoo-rygenhbn nf,itramoo chhiw hmtig olwal ouy ot ilnteiame atth c.hioec

tahT ,iads it messe atomls smpeblisio ot urel uto th(woitu revy ntheaiccl lkwedegno ro soem vddeiorp pmnxeteaielr ta)da ttha teh tlhlsygi lrareg inalaen esod ont irpmia erydhong ngindbo weeebtn lclgneoa lousleemc iva etircs sa(it)pal ee.eierrfcntn nI lipmres mtr,se sicen lnaniea is lrager, uyo dolwu knthi atth it tusm ohemwso fntreeire wthi hte ongbenhodiyg-nrd ttah csuroc itwh het di-lwpyte ygcilne.

---
Sri*lytct npgi,eask st’i otn teh nbeumr of nehrdysgo utb soal teh tthegnrs of hte ldepio ttah tiilctaeasf eonhdygr ion:dngb a oghnedyr obndu to a notlrsyg eantioeevreltgc eecoullm klei ieulnorf lwil eapa“p”r rmeo ieopivst nd,a ths,u hynodrnbe-dgo mroe yngtrols ithw a rnbeay gnoeyx cmoprae(d wtih a rdghyone ncdecteno ot anrc,ob fro .lae)pxem

eurhrtF n:drgiae

  1. tlhehtilcue.diwo.epcumrn:mwwh.gdhdusdt/pph.u//qse//lb
hungrybox  Appreciate the effort but this is far too long to be useful. +14  
drachenx  hungrybox is a freaking hater +  
drdoom  @drachenx haha, nah, coming back to this i realize i was probably over-geeking lol +  
blueberrymuffinbabey  isn't the hydrogen bonding dependent on the hydroxylated proline and lysine? so that wouldn't really be the issue here since those aren't the aas being altered? +  
drdoom  @blueberry According to Alberts’ MBoC (see Tangents at right), hydroxylysine and hydroxyproline contribute hydrogen bonds that form between the chains (“interchain”, as opposed to intra-chain; the chains, of course, are separate polypeptides; that is, separate collagen proteins; and interactions between separate chains [separate polypeptides] is what we call “quaternary structure”; see Tangent above). And in this case, as you point out, the stem describes a Gly->Ala substitution. That seems to mean two things: (1) the three separate collagen polypeptides will not “pack [as] tightly” to form the triple helix (=quaternary structure) we all know and love and (2) proline rings will fail to layer quite as snugly, compromising the helical conformation that defines an alpha chain (=secondary structure; the shapes that form within a single polypeptide). +  
tadki38097  also you can't H bond with carbon, it's not polar enough +  


submitted by hungrybox(791),
unscramble the site ⋅ become a member ($36/month)

lpoyri,laccocasM oauumqss llce riomcanca snetd ot eb wotiheff- ni roolc, igrians ofmr, nda gdnexenit noti a .cronubhs

ouSe:rc diRidpaeao

privatejoker  Lol am I the only one that picked Malignant Lymphoma? I thought I remembered Sattar mentioning that metastases are the most common form of cancer to be found in the lung? I tend to pick the "most common" presentation when given so little information to work with +2  
blueberrymuffinbabey  but metastases typically present with multiple lesions so I think at least in exams when it's showing you a solitary lesion, think a primary tumor. +1  


submitted by diabetes(15),

can somebody explain how energy production by glycolysis increased, since aerobic glycolysis produce 32 net ATP,compare to 2 net ATP through anaerobic glycolysis ?

diabetes  i think the stem should be "energy production by an anaerobic glycolysis " +2  
blueberrymuffinbabey  yeah that's the bit that tripped me up too. i get that there would be increased glycolysis in general to compensate for lack of TCA function but...the fact that it says "energy production by glycolysis" is kind of misleading/confusing. +  
thotcandy  technically, glycolysis is the reaction that happens in the cytosol that generates pyruvate and 2 net ATP. after that it's TCA and Oxidative phosphorylation, which occur in the mitochondria. By definition, glycolysis is anaerobic - which is why they hammer the fact that RBC undergo glycolysis only into our heads. +1  
thotcandy  technically, glycolysis is the reaction that happens in the cytosol that generates pyruvate and 2 net ATP. after that it's TCA and Oxidative phosphorylation, which occur in the mitochondria. By definition, glycolysis is anaerobic - which is why they hammer the fact that RBC undergo glycolysis only into our heads. +  
targetmle  i got it wrong because of this as i thought ATP will be decreased in anaerbic glycolysis, but proabably it was mainly 'glycolysis' is increased +1  


submitted by ls3076(61),
unscramble the site ⋅ become a member ($36/month)

nca yaenno laexnpi ywh )D( asaplmeita si coriertnc?

angelaq11  because metaplasia would be a transformation of the normal architecture of the respiratory epithelium to one that does not belong there, in response to chronic irritation. This woman had pneumococcal pneumonia that was correctly (and I dare say promptly) treated, so she suffered an acute rather than a chronic insult. +  
blueberrymuffinbabey  because metaplasia isn't how the normal healing/regeneration response happens in the alveoli. the type 2 pneumocytes serve as stem cells/precursors to both type 1 and 2 pneumocytes so the regeneration is not metaplasia. +1