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NBME 22 Answers

nbme22/Block 2/Question#31 (48.0 difficulty score)
An unimmunized 1-year-old boy is admitted to ...
Phase variation🔍,📺
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 +23 
submitted by yotsubato(1086),
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whoissaad  is it the same thing as antigenic variation? +10  
dorsomedial_nucleus  No, antigenic variation involves genomic rearrangement Phase variation can be thought of as MORE or LESS of something. An on/off switch. No DNA is being rearranged, just under or overexpressed in response to the environment. +7  
makinallkindzofgainz  This isn't in Zanki, Lightyear, or First Aid, and I don't remember ever learning about this in class. Thanks NBME! :D +19  
jurrutia  You wouldn't expect the difference in phenotype of a given organism in a given patient to change because of mutations. It has to be something other than mutation. Phase variation is the only option that sounded like non-mutation. +