welcome redditors!to snoo-finity ... and beyond!

NBME 22 Answers

nbme22/Block 3/Question#30

Which of the following is required for the ...

Glutamine

Login to comment/vote.

 +9  upvote downvote
submitted by mcl(220),

The question is referring to the hexosamine pathway.

Carbamoyl phosphate and arginine are involved in the urea cycle. So is n-acetylglutamate (NAG) (regulates production of carbamoyl phosphate).





 +6  upvote downvote
submitted by seagull(437),

out of curiosity, how may people knew this? (dont be shy to say you did or didnt?)

My poverty education didn't ingrain this in me.

johnthurtjr  I did not +  
nlkrueger  i did not lol +  
ht3  you're definitely not alone lol +  
yotsubato  no idea +  
yotsubato  And its not in FA, so fuck it IMO +  
niboonsh  i didnt +  
imnotarobotbut  Nope +  
epr94  did not +  
link981  I guessed it because the names sounded similar :D +5  
d_holles  i did not +  
yb_26  I also guessed because both words start with "glu"))) +3  
impostersyndromel1000  same as person above me. also bc arginine carbamoyl phosphate and nag are all related through urea cycle. +  
jaxx  Not a clue. This was so random. +  
wolvarien  I did not +  
ls3076  no way +  
hyperfukus  no clue +  
mkreamy  this made me feel a lot better. also, no fucking clue +1  
amirmullick3  My immediate thought after reading this was "why would i know this and how does this make me a better doctor?" +  




If you want to take a look for the clinical importance of the hexosamine pathway & products: https://www.sciencedirect.com/topics/neuroscience/hexosamines





 -2  upvote downvote
submitted by meningitis(161),

Process of elimination on this one.

  • I eliminated Carbomyl phosphate, Arginine due to urea cycle.
  • I eliminated ATP because ATP alone wouldn't change F6P into glucosamine
  • NAG I got lucky and I eliminated it due to its use in ECM and collagen so I didn't think it was relevant and I kind of remembered it being in urea cycle.
dr.xx  you mean, pure luck? :) +7  
impostersyndromel1000  lol pretty sound logic here mate +  
nor16  same here, Glutamine is a NH3 (-amin) donor, so guessing made sense +