Quoting Dr Sattar, if an injury or cut is too deep so as the regenerative/stem cells are removed/damaged - then healing can only occur by repair. Thus, in this case, the stem cells of the lung aka Type 2 pneumocytes reside in the basement membrane - so, injury to basement membrane would damage type 2 pneumocytes and would NOT allow restoration of normal lung architecture. That's why maintenance of basement membrane integrity is the most important determining factor to distinguish whether tissue will heal by regeneration (restore normal architecture) or repair (fibrosis/scarring). Same concept can be applied to skin (basal cells) and intestines (crypt cells).
You veha to nthki uotba ti hsti yw:a the benmates eanemmrb si teh o”flscgand“fi on cwhhi o[vtretr]aeis ehlangi ucso.rc oS, y,se smte clles ytp(e II cenutmopse)y oluwd be nlvvoedi in hatt ehnliag osescpr utb yteh clo’tndu etsoerr teh almnro tarccheurtei (“no saaonib”tilr)em uwithot the setkle‘’on fo the esbemant ernammbe etnglil emth erewh to ,go in twah eidiotrcn to go,rw ihwhc ywa si p,“u” ect. If teh atsebnem arebemmn si rdoyst,dee uoy anc tlils gte ,nlaihge tbu ti ntwo’ eb grzaeodni haginel -- lti’l be adiizsgedron hlenag,i iwhch eosd not pepaar sa rmaonl seis.tu nriaizoe(gsdD nailhge si erbtte nhta on la,hnige but ithtuow a BM, eht ggrtaenenrie slelc ’odtn veha ayn trceo”ind“i dan rfrehetoe ntac’ retesor het maroln crehu)ettri.ca
I dulow hinkt oolesrntui ovsvinel teh mtse cslel e(tpy II cpes)myotu.en Is eht anttci nbesteam bemmrane het wasnre uscaeeb it tilims seprda?
acn ynoena pnlaiex hyw ()D mltpaiaaes si r?oiccentr
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