Quoting Dr Sattar, if an injury or cut is too deep so as the regenerative/stem cells are removed/damaged - then healing can only occur by repair. Thus, in this case, the stem cells of the lung aka Type 2 pneumocytes reside in the basement membrane - so, injury to basement membrane would damage type 2 pneumocytes and would NOT allow restoration of normal lung architecture. That's why maintenance of basement membrane integrity is the most important determining factor to distinguish whether tissue will heal by regeneration (restore normal architecture) or repair (fibrosis/scarring). Same concept can be applied to skin (basal cells) and intestines (crypt cells).
oYu aehv to nhkti tauob ti shit y:aw teh ntseemab aembmner is hte “nodgcf”falsi on hhwci [v]oresiettra naighle corcsu. So, yse, estm ellcs tye(p II yec)emnsutpo wdluo eb vevnidlo ni ttah nehilag sesrcop utb etyh ’clduton orstree hte nmalor utcrhartciee (o“n btmsolai”ina)re wottiuh teh leek‘ns’to of eth mneeatsb ameernmb nlgetil hmet eehrw ot ,og in thwa etniidcor ot rwgo, whchi ayw si u“p”, cte. If eht seanembt amreenbm si rsotdy,eed oyu can lslit teg elah,ngi but ti ’ownt eb raizegodn helagni -- ’ltil be sednzdiroaig in,lhega whchi seod not eapapr sa alromn eistus. geDrizadinos( eahnlgi si beetrt hant no eahgnl,i utb iotuhtw a ,BM teh riegtnrngaee lsecl notd’ ehva nay etnd“o”icri adn therrfoee ’cnat oeersrt eth namlro )c.echaurrttei
I dwulo hinkt nruiloetso sivoenvl hte mtse celsl t(epy II euespcn).tyom Is teh tnatic nmseebta mrbaeemn eth wresna uebesca it stlimi sp?drae
cna aynnoe xnepila hwy )D( ptiaemasal is ntcriecro?
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$379$49aesnmBte bnmameer iiryttgen is eht eardntmntie of llfu ulng yrvoerec oolgfwlin luomyparn sn.ltui
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1)( lsos of bamtsene rememban irnetytig si itccrila ni ntirngemied het ipot“n fo on ,nerut”r nad sctuitnoreb to teh ibtiinlya to brhatileess lramon nlug rehcetaciutr hwit oonmptori fo issf;rbio
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3)( gminrfratnso owhgtr raf-tβoc is scsaen,yer ubt nto etneylir euncsif,fti ot mrptooe mnetperan fssiio;rb
)(4 nttreepiss rtg/erniat/ninntiriyuaj si iccrltia fro hte oantiparpgo fo irssfo;ib
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(6) qeuniu lselc ear acrcliti cullaelr erapsyl in the gailonertu of rii.sbsof
oct iiat:n:4b4.se/cv/Can/grwh2phi6tnwmc/.c.n/Ml51/iittpPowl2sm.
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