NBME 22 Answers ↦
endochondral1
any FA or pathoma or uworld correlation?
+ 2019-07-05T21:58:47Z
taediggity
Type II pneumocytes serve as the stem cell precursors, w/out those you're more or less fucked: FA 2020 pg 661
+4 2020-01-18T22:42:05Z
drdoom
by "restorative" i mean healing which restores the previous (and normal) tissue architecture. for that to happen, you need an intact basement membrane!
+2 2019-06-08T21:01:03Z
nwinkelmann
Yes, this a great summary to the post by @bubbles and the article he posted! Another way to think of the question is not, what causes repair, but what causes irreversible injury/fibrosis. That article explained an experiment that showed TGF-beta was necessary to initiate fibrosis, but if BM was intact and TGF-beta was removed, the fibrosis didn't persist, i.e. intact BM is protective against TGF-beta. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645241/
+ 2019-07-07T01:07:08Z
aesalmon
I would also like to know if anyone can answer this question - I saw it as a Sattar "one day, one week, one month" kind of question. Its probably very simple but I still don't get it
+ 2019-06-05T19:11:29Z
bubbles
I posted a new comment explaining: basement membrane integrity is the strongest determinant of full fx recovery following pulmonary insult :)
+3 2019-06-08T19:00:20Z
drdoom
You have to think about it this way: the basement membrane is the “scaffolding” on which [restorative] healing occurs. So, yes, stem cells (type II pneumocytes) would be involved in that healing process but they couldn’t restore the *normal* architecture (“no abnormalities”) without the ‘skeleton’ of the basement membrane telling them where to go, in what direction to grow, which way is “up”, etc. If the basement membrane is destroyed, you can still get healing, but it won’t be organized healing -- it’ll be *disorganized* healing, which does not appear as normal tissue. (Disorganized healing is better than no healing, but without a BM, the regenerating cells don’t have any “direction” and therefore can’t restore the normal architecture.)
+7 2019-06-08T20:58:53Z
nwinkelmann
Yes, this a great summary to the post by @bubbles and the article he posted! Another way to think of the question is not, what causes repair, but what causes irreversible injury/fibrosis. That article explained an experiment that showed TGF-beta was necessary to initiate fibrosis, but if BM was intact and TGF-beta was removed, the fibrosis didn't persist, i.e. intact BM is protective against TGF-beta. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645241/
+ 2019-07-07T01:09:25Z
angelaq11
because metaplasia would be a transformation of the normal architecture of the respiratory epithelium to one that does not belong there, in response to chronic irritation. This woman had pneumococcal pneumonia that was correctly (and I dare say promptly) treated, so she suffered an acute rather than a chronic insult.
+ 2019-08-20T20:28:47Z
blueberrymuffinbabey
because metaplasia isn't how the normal healing/regeneration response happens in the alveoli. the type 2 pneumocytes serve as stem cells/precursors to both type 1 and 2 pneumocytes so the regeneration is not metaplasia.
+1 2019-12-08T23:49:33Z
submitted by bubbles(63), 2019-06-08T18:59:34Z
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