Quoting Dr Sattar, if an injury or cut is too deep so as the regenerative/stem cells are removed/damaged - then healing can only occur by repair. Thus, in this case, the stem cells of the lung aka Type 2 pneumocytes reside in the basement membrane - so, injury to basement membrane would damage type 2 pneumocytes and would NOT allow restoration of normal lung architecture. That's why maintenance of basement membrane integrity is the most important determining factor to distinguish whether tissue will heal by regeneration (restore normal architecture) or repair (fibrosis/scarring). Same concept can be applied to skin (basal cells) and intestines (crypt cells).
oYu avhe to nthik butoa it siht w:ya teh smetabne manbrmee is het ncf“daflig”so on hiwhc tr]serev[taio hgienla sccu.ro S,o sey, smte elcls (ytpe II uoseymc)petn wulod be vnliveod ni atth lnheaig crseosp btu heyt udlt’onc erosrte teh nolmar rrtthecuceai “n(o basaeim)ilontr” huwitot the lkn’t‘oees fo the sntaemeb emmerabn llntige emth erewh ot ,og ni htaw dnitrecoi ot og,wr wchih awy si ,p“u” cte. fI hte esntmbae rembeanm is oydse,drte uyo nca lslti get l,ehigna but it tow’n be gnoriedaz nhligae -- it’ll be nddrazieiogs gae,ilnh chwih does nto aeprap as ralnmo itses.u seairD(goizdn helagni is trebte ahtn no einl,ahg tub wohtiut a M,B het irgteagenenr scell o’tnd vhea nay tr“codniei” dna rteehreof at’cn troesre eht alrmon rteuca.ci)erht
I uodwl ikthn norleituso nolisevv eht estm lclse (ptye II onepuse.tym)c sI eth tcntia tnbsaeem nmaeerbm eht rwsaen ubeesac it ilitsm rade?sp
cna oennya nalipxe yhw (D) aeslmiatap is ecnr?icotr
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metanBse nrmeemab nyitiegrt is eht eenmnardtit fo lful glun vrerceoy ilofnolgw lnauypomr ts.nuli
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)5( chidoaiitp nyropamlu iissfbro si an xameple fo a pscerso eredlta to teh itsecsneper of an ,g“s()tn”niea noihccr tiomf,mninlaa adn fss;ibori dan
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