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Retired NBME 22 Answers

nbme22/Block 3/Question#23 (reveal difficulty score)
A 45-year-old woman comes to the physician ...
25% 🔍 / 📺 / 🌳 / 📖
tags: biostats

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 +8  upvote downvote
submitted by ∗b1ackcoffee(115)
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I ghhottu rnrdagegi sith enosqitu sa HLA gene dtruioitsinb ne( l.)ocbk

nevE fi ew adcdirs gitrnveyhe dan ujst htnki tboau the stal ncsnteee (tisnuq,)eo orf nay eeng, hcnaec fo inlgsbi aivnhg etxac mesa lleael is 2%5

sueopps eehrt are 4 lelalse rof a enge in sper,nta A,a, B, nad b h(wat I mnea ot ysa is all 4 rea ftefeidrn in tobh .ra)nsetp

owN eupposs noe edaghrtu ash aB o.otTepye gn veha axcet asem selae,ll eroth tehdurag ustm evah

05% cnehca fo a m(agon a dan A ormf lihumei )eotrmdtpl 5b %y0 cceahn fo B namog( b and B rmof hft)ear

bdecnoim iytbblioarp fro ayn neeg luwod eb .25%

eseP,al notip tou ayn utalf in het .eiaogsnnr

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cjdinurdreamz  i ueds teh esam xetac raesginno +
skonys  Snirffgeu mrfo secscsu voer heer aubesce I sjtu daer ti as herte oen csuol 6"*" dan sehs omzsyuhgoo aa. hTsu her isessrt has a 52% ncaehc fo igben aa too escbuea nnuetp reqsau. Mots alpbrbyo het rwngo colgi but ye,h ew tuo e.hre +



 +4  upvote downvote
submitted by ∗bubbles(79)
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Can snooeme eailnxp loprprye ohw ew know that isht ttira wollfos niledMaen integces adn is olauatmos rseveeics adn mrfteheuorr owh teh peatrsn wree ygsoueozhtre?

I dugssee a lto on ihst eniutosq adn tog ukylc :(

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niboonsh  lsmotuoAa nDnamoti driesdsro suulyal reestpn as steedfc in aucrutlrts eeng,s ehwre as usAoamtol Rscseveei rdieorsds uysallu epnrest as ymenze edesiifcinec. P054 si an nemzey, os we aer oayrbpbl gadnile itwh an tulasaomo risceesev esdrrio.d rftohrrueem, teh nutioeqs taetss etehr wsa a gzsouhoy"om nsecpeer fo ....5.p40." nI tloasuoma esvicsree e,opormsbl epnarts are sluylua gtzrsoeouyh,e imgaenn htat /14 of erhit iskodd ilwl eb aceffdet aka( oho,gusy)moz 12/ of het diks wlli be sr,eirarc nda 14/ of tireh sikd wlli be afc.efutedn +38
nwinkelmann  sI tshi how we lhsdou takatc shti erb:l?omp rtsFi celu agsittn denifeoxn is veacti abmeeltito fo xoaifmTen lduhso akme us iezcrgeno iths nirgedun tfrsi pssa picaeht 04C5YP bmlieoa?smt neOc we wkon h,tat het fcta htat eth meatbetlio si eerdesca usgssgte an zmneey efdect, ichwh si rudeptosp yb ttepna'is somgzyuooh ezynme eal.slle eTnh use eth regnlea uler htat nezemy tfseedc rae AR heraews caturtlsur pnioter stecdfe ear AD riacnithene ettpasr. neOc we kwno eth rpnaet,t iknth taht otms nocmmo srsimniasont of AR ecmos mrfo wto iecarrr psen.tar So pfrsfongi lsealel = 2%5 ymghuzooos olanmr, %50 eyousoghetrz rci,aerr and 52% ozmohuygso fefad,cte usth rtsesi sah a 5%2 of ihavgn teh easm alleles as atnpeit (ie.. zugoohyoms 4C5PY0 )6?24D* +6
impostersyndromel1000  ew hda eth tecax mesa huhtgot ,rsocpse so i oot am hinpgo siht is eth rocetrc wya to rapopahc t gite aringenso inderf +
ajss  aknths for shti t,alpannoxie I tloltya ogfrto tbauo AR aetpstrn rae stmo lyeilk zymsnee s,feeciiidecn htis idkn of ekam the eiqnusto eeairs if oyu oppacrha it htta wa,y tnksha +



 +3  upvote downvote
submitted by ∗dentist(94)
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  • yeenmz icceefsydni = AR

  • gsumoohzoy eeepscrn fo "CP..Y.

QED: syuzghoomo + RA = 52%

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 +1  upvote downvote
submitted by ∗its_raining_jimbos(29)
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xoTmeanfi ahs ot eb abzldoemiet aiv isftr pass mmleoitabs ot na cvtiea itlbemtaeo ixe)n.dnfo(e hTe etnpita ahs ecredsdea tsnoaonetcricn of eht bleeziomtda opudrtc tndiingaic that teh naitep’st piar fo cmyoecroht P504 allelse enat’r ztinaegimblo nfoaxmite eyrl.rtcoc heT sonqteiu is gsanki twah the ashccne era teh trssie sha eht maes oyepngte, hihwc ludwo be 52% g-t&-; 2/1 * /12 = 41/

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medschul  Hwo od ew owkn eth eanrpst aer not gmuyozohso +8
yotsubato  Cachnse rea eyht aer ont unsels eyth ahd ro rae nosctsueiu +



 +0  upvote downvote
submitted by 07chess(3)
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nnirhtgOivek cerwdse em. heT oinequst estm akss orf a eccnah for a etissr ot egt het seam l,sleael otn tath hse si zuymogoosh itwh met.h So I icdekp 7%5 ndeisat fo 5t.%A2 teh opt fo i,t heyt put 24(6I*D thuoght ttah msena taht .tp has 4 pocsei fo atelwoesll( mfro chea ternap ekil . eHhL)TyA heva to maek unqseiots emisiolbsp ot dn.sduenrat

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 +0  upvote downvote
submitted by g8427(0)
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If osme noe can elhp em edtunrands cb im a tib ecudn.osf I dsendurtna eth huotght rspeocs and I draiezle that ihst aws an RA eissade adn I aosl tgo teh 4/1 fd,feetac /21 rrcriae adn 4/1 nutfcd.afee tuB I cheos %0 cb I durifge fi ti swa na AR esisdae het 1 lhcdi dalraye sadedeis swa uyoshozmgo afdetcef 14(/ dfee)fta.c hWihc eadl em to nikth tath teh trheo ssreit asw reteih a raerrci ro otn aceffdte ta a.ll mA I tjsu vero tnnhiikg htsi ro am I nto lyful unsrngtdaedni sawth gnogi on?

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rush  you ehva ot ntkih autbo ceha dilhc ,adliydnviliu n'tedso ermtta ahtw eth ssblnigi hea.v ehT ouneitsq tsseat thwa ear eht sodd fo teh hicld egtngti eht eadises. So esragsdlre of teh hetro nisibslg ti listl si omM )(2/1 add /2)(1 hciwh samke ti /14 AR +
titanesxvi  tBu hwo od ew nokw htat eth tsernap rea zuoeoyhrgset rfo teh atinmuto +
need_answers  we onwk thta eth neptsar ahev to be uerhestgooyz aA X aA ubsceae no a 2x2 bealt, het ylno wya teh hadertug culdo eb szhmoguyoo fro an AR is by avhngi bhot tprsane be ceriasrr (A)a os teh qsuentoi saw skiagn wtha ear eht ahcsenc teh issrte ahs eth esma allesle a()a nda herte is yoln a 2%5 fo igavhn the amse .ellalse +



 +0  upvote downvote
submitted by timekeeper36(0)
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So I haet shti tenuiqos beecusa yuo 'tanc tlel hwta hte rapnte's nygtpsoee r.ae ihsT yzmeen tecfed ts'ni teogmhnis ttha you nca tell lgiceyoatplhon so ew tc'na ujst emuass eht rntasep are gteuo.snreheeo

tI hslonyet 'edsto neev tmaetr if it is astaulomo cessireve or not enics ew ynol hvae to oyrwr oautb yoogomuzsh fof srpn.gis ereH si het h.mat

earsPnt sibsloep peoeg:nsty

A - Naorm;l a - o.rnambal

oMm: Aa d:Da Aa w(tha teh tuqosine si g)usasimn

om:M Aa Dad: aa

o:Mm aa :dDa aA

:mMo aa Da:d aa (how si to yas tsih i'snt boe)psil?s

m(Mo AA ro aDd AA si eiossbmlip neics eht nipsfgorf nct'a be aa)

morF othes netgyope isplisosibeti ew can lcacautle etrtbe ietbpo.riilsba

ncieS i'st sopisble for ntrpsea to aveh nay fo eshet 4 tongesepy we juts aessum ttah aech iypsotsilbi is 41/.

:Mmo Aa + D:da Aa ;-&tg orinpfgfs aa = 14/ pyimltu(l tsih yb 1/4 icnse ewer' giumssna eqlau lsobisitipy fro horet n)eegstpyo t&g;- 1/61

:mMo aa + :Dad aA g;-t& fsonpifgr aa = 21/ -g;t& 4*1/2/1 = 8/1

mM:o Aa + :aDd aa -g&t; ifsnrgofp aa = 21/ g&-t; 1*/421/ = 8/1

:moM aa + D:da aa -t;g& oprsffngi aa = 1 ;g-&t /114* = 14/

nheT we dad all eht brltioaisebip o1t1e/h6 regt + 1/8 + 18/ + 4/1 = /691

I wnko eth tnie'uqsos awsner si %.2.5. os I sguse tpu %25 on eht tte.s TBU fi oyu tnwa ot aycatllu asn,eunrddt thsi si a bretet ataooxipmin.rp eTh ynlo prebolm is ew 'ondt nowk eth egen rbuidtontisi of the lesllea or I nca give breett amth :P

oyrSr 'tis onlg and sgnnoifcu

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 +0  upvote downvote
submitted by fukprometric(3)
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erehT swa a uwdrlo tnusiqeo no i.ths LHA rae sepasd wnod to pisfnfogr in hleas.tpopy Prenta X has A and B yohe,taplp natepr Y has C dan D .alpohtpey ehsTe vaeh diaelneMn nheri,ntaeci .ei. A.R fI eth antetpi is ooshgoyzmu fro pyD6C2, ahtt anmse tath rPaetn X dan tnPrea Y hobt haev a ytpeplhao with cYP.D62 :ie. A yeplothap sha 6c,yD2p C theyoppla hsa y2Dpc6

oFr erh is,tesr eerht si a %05 hnacec omm eassps dwno rhe A oa,telhypp nad a %05 cehcan the dda sspsae dwon his C op.ylahpte 12/ x 21/ = 4/1

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