inlenadMa nGec:seit
aMn hsa 32/ achenc of nibge a rcre.ari He( odes tno vahe the sdi).ease W noam crreria kirs smut be dltcacuale thwi 2p^ + q2p + ^.q2 2^q = 014/000, q = 1002,/ p is yoglruh = 1q2p = 110/0 = rrearCi cenyerufq .
skRi fo ivhgan a chdli sthu luqsae 3/2 x 11/00 x 1/4 = 001/62 auc:s3/eeB = naM rriCear rski 1/010 = eFmlea eCrrira k1 i/sR4 = cCneha hety ehca spsa on the sierseecv enge to ihter fgs.frnopi
hTsi eht msae sa so@kymn'pceay aoplxinante thwi moer iantenolpxa stohe atht eden it...
The ittpaen is tnaeuffecd by het ipataurrlc aamolutos vecesiesr eassdie nda sih hrotebr sah hte aatomoslu ssieeevcr eiesads -g-t&; stih nemas aehc of itrhe nrpaste sicarer eht RA all.lee Now, ofr hte eiaptnt to be anfcftedue vgnei ttha htob hsi repntsa ehav eht RA l,elael it easmn atth eht tntpaie ahs a /23 accneh tath he is nyesotuumialsl ffctendaeu adn a ic.rarre
The tseanpit' atrpner is eftecuandf dan olrman raeWeyidrgHn-b tesgcnie sa( dtsaet ni eht ).hepebrnlow.m tshi is lyicfipelsca in,eodntme uoy rea ot uamsse ttha hte reprtna hsa a errraic eyercfuqn fro eht AR eall,el iwchh qeual to q.p2
hTe deasise sah a uyrqfeenc ni the toioppulan fo 14/00.00 Tihs si q^2 g;--&t 2q^ = 0/.00104 vgSlino for q, oyu get q = ./1002
rrreCai ceneyfrqu is .2qp eeHwovr, for a arre esa,sdei qp2 ≈ q.2 So, eth iarrcer ynurefqce orf het rantepr = q2 = 2 * /1200 = 0./110
Nw,o eth Q kass toabu na gisnforfp fo hte eittapn nda ihs ntrraep gnbie tfacdeef, so ot vahe na dfctefea di,lch rhete is a 14/ acecnh of ihgavn na eedtfcaf idlhc assbceu(e hte nitpaet and eth atnrrpe btoh vahe a 21/ heaccn of pgasnis eht laelle -tg;&- oyu lulmepit ethse eehotrtg 1/2 * )2/1.
o,S tlpimylu /23 * 100/1 * 14/ = /0.160 hisT si iaPpentt( ngieb a )ireacrr * tPa(prrne biegn a i)arrrce * vihng(Pa na ffeaecdt gonifsprf eot.thegr)
hTe iplaboitbry of het erhatf gibne a eirrcar si /23 since ti is nnowk tath eh node’ts aveh het i.aeessd hTne teh aibrtpbyoil fo ihm sgiansp it on ot hsi dik si:
12/ * 32/ = 13/
htWi het ryWieagr-eHbdn rcnPilpei, uyo can erifgu out hte rbatyiboipl of hte omerth ngbie a crairer:
q = r0t00,s10/)q4( = 0210/
o,S 2pq = 2 * 02/01 * /109092
, cihhw xopapr si 001/1, adn eth biopyltraib of eth lhidc negitgt isht aellle is 0/110 * /21 = 210/0
Tsu:h
/0102 * /13 = 1006/
hwy eerht si tyrbbolapii fo heratf bengi a reaicrr is 3/2
We assume this is a recessive disease. In other words, you manifest the disease if you inherit a disease allele, d, from your mother and a disease allele, d, from your father (giving you the allele pairing denoted by “dd ”).
dd = you have the disease.
The father does not have the disease; this means his genotype cannot be dd and thus must be one of 3 things: DD, Dd, or dD.
That is,
Notice that in only two of these 3 possibilities (⅔) does the father (potentially) have a disease allele, d, that he might pass on to his progeny.
submitted by ∗drdoom(1206)
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$279$49 65% OFFuoalcatinCls ofr dda. Teh atiolbiyprb of eht fterah nbeig a recrrai si 32/ sneci ti si wkonn thta he ’sodetn ahve eht siee.sad hTne eht oipabbiytlr of ihm inspsga it on to ish kid is 1/2, s:hut
isanucollCat rof omm. With het gHrWan-yeeibdr ,nlierpicP ouy nca uferig uto teh itbipalbroy of hte hrtmeo negbi a irc:aerr
q = 400)qst,/r100( = 0021/
So,
pq2 = 2 * 12/00 * 90219/0
, hwhic is xorpap /0101.Fro teh hdicl to teg het lelale from mmo, two gtihsn dene to phepa:n (1) omm tmus be a criaerr e“zoh[trtg”]oeey adn )(2 mom tmsu sasp het laleel ot :lcdhi
uPntgi ti all erhtetgo. N,ow bocmnie lal horetg:et
= bbirapoitly( of add igebn ec)arrri * io(laytibrpb fo add psansig on seedais llaee)l * iitbrlbpoy(a of mmo bnegi )rcarrie * ybb(ritopila of mom nssapig on esaesid leleal)
=
2/3 * 1/2 * /1100 * 12/
=
1 ni 006
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