dieaanMln seteGni:c
Mna ash /32 aehncc fo nbegi a rrar.cie H(e oesd not evah the aiee)ss.d nmoWa rrecari isrk mstu be aacdtullec iwht ^p2 + 2qp + .^q2 2 ^q = 010/40,0 q = 210,0/ p is yrloghu = q21 p = 1100/ = rraeirC necfreuyq .
sRki fo aihgvn a chdli huts qlause 23/ x 011/0 x 14/ = 06/10su 2c3e/:aB e = aMn arirCre skri 1100/ = emlFea reairCr R ki/4s1 = Cnheac tyhe ecah pssa no the ieseecvsr enge to heirt g.ipfonsfr
iThs teh mesa as @'eaockmyynsp nxatlineaop twih meor axnpanitoel oeths taht eden ..t.i
Teh neattip is etnfcuadef yb eth riuacaprlt otmsaaoul icvrseees essedia adn ish brteohr ahs het ouatoalsm ersvcseie seiesda t-;g-& iths ensam ache fo tirhe enraspt erraisc het AR llee.la Now, ofr teh npiteat to eb eeuatcfnfd ievgn atht thob sih traspen evha hte AR el,alel ti amsen atth eht iptaent sah a /32 chneca ttah eh si uismoentulsaly tfeeuadcfn adn a rrceir.a
ehT epsi'tnat atprern is ctnaefuefd adn alnomr WHaygn-eierbdr nceesgti a(s tdstea ni hte lpnebome.).rhw tish si ilccspafieyl nenmoei,dt ouy aer to sauesm tath eht nprrtae sah a arerrci cnurqeyef ofr eht RA lalel,e ihcwh uaeql to p.q2
The edeassi sah a fqreecnyu in eht tapuioolnp fo 000041/. hsiT si 2q^ &--;gt 2q^ = /040.001 nlgoivS for ,q you get q = .0201/
rreairC eqfecynru is 2.pq vworHee, orf a arer sseide,a p2q ≈ q2. oS, hte ecarrri eefrcqnyu fro eth aerptnr = 2q = 2 * /0120 = .1100/
,woN eth Q assk uabto na gofnrisfp fo eht tientpa and hsi rtnepar bigne dtfeface, os ot aevh an dfeaetfc i,dchl heetr si a 41/ neccah fo hnaigv an tcfedefa ldchi sb(aecsue eht tnaitep nda eht narretp tbho heav a 12/ cahnce of npisags eht lleela -;gt-& uyo lielmupt seeht oeegttrh 2/1 * )1./2
o,S litpulmy /32 * 10/10 * /14 = 0106/. hsTi si tPaie(tpn geibn a ic)rrrae * aprePt(rn igben a ierracr) * nivag(hP an eeffcdta iropffgsn )t.goerteh
ehT rpiybbilaot fo the frteah ibneg a irracre si /23 sneci it si nkwno hatt eh ods’ent ehva hte deaes.si hTne the yoalbbprtii of mhi ngasisp ti no to hsi kid i:s
21/ * 32/ = 13/
hWti teh -WbedrngyairHe rnlipP,eic ouy nca giufre tou the abrlipyiobt fo eth mroeht ibneg a crierra:
q = ,0q100r)(s4t/0 = 1/002
oS, pq2 = 2 * 021/0 * 2901/90, ciwhh paprxo si 0,1/10 dna eht oprbtyailib of teh ildhc iegnttg hist leeall is 0101/ * 21/ = 02/01
ush:T
/0021 * /31 = 1/006
wyh rethe is plbtibroayi of afterh ngebi a rrcaier is 2/3
We assume this is a recessive disease. In other words, you manifest the disease if you inherit a disease allele, d, from your mother and a disease allele, d, from your father (giving you the allele pairing denoted by “dd ”).
dd = you have the disease.
The father does not have the disease; this means his genotype cannot be dd and thus must be one of 3 things: DD, Dd, or dD.
That is,
Notice that in only two of these 3 possibilities (⅔) does the father (potentially) have a disease allele, d, that he might pass on to his progeny.
submitted by ∗drdoom(1206)
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$279$49lnostciaauCl ofr dda. The oiaytplrbib of eht tarefh nibeg a iarcrre si 32/ senci it si owknn atth he snt’ode haev the .iesesda ehTn the ltbyipoarib of hmi gsiaspn it on to his idk is 1,2/ th:us
cCouilalsatn rfo mmo. tihW the HWyrdiea-nbgre pirlncPei, uoy nca frugei tuo the itbirpbylao fo eth mhtroe nebig a irre:rca
q = s(,)rtq04010/0 = 0012/,oS
pq2 = 2 * /0201 * 099/210, hihcw si ppxroa 1.0/10Fro eht dhlci to gte het lallee mofr mom, two tsghni ened to pneah:p ()1 mom mtsu eb a irrearc eeoy]o[t“zghtr”e and )2( omm tsmu saps hte lelale ot ih:lcd
nuigtP it lal geroteth. owN, bciemon lal etr:tehgo
= pbrt(yilaiob of dad ebgni ircaer)r * baotiiyrpl(b of dad sinpasg on issedea el)eall * yabit(birpol of mmo bneig ceairrr) * boirp(blyiat fo mmo nipagss no sideaes alelle)
=
/23 * /21 * 1/001 * 1/2=
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