alMaiendn sGnie:cte
Man sah 2/3 cnaehc of iebng a crrriae. e(H sedo ont ahev the esad)e.si m naoW arcreri ksri ustm eb leadultacc wtih 2p^ + 2qp + ^q2. ^2 q = 1/0004,0 q = ,0210/ p si hryuglo = 1qp2 = 11/00 = raeCrir efcrynueq .
siRk of nvhiga a hldic thus qulaes /32 x 1100/ x /41 = 0/016 e:uec as3/2B = naM ierrCar kisr 0 11/0 = eaemFl rCreair 1/k 4iRs = Cachne hyte hcea sspa no teh reseeicvs ngee to iehrt gopsf.finr
isTh eht smae sa sy'ancemyo@kp xoenaltainp twih orme ixneolpntaa esoht atth eden t..i.
Teh tenatpi is cuadfetnef yb eht ailrarucpt amauolsot eecesrivs esdaise nda sih toerhbr ahs het osatlomua reevissce eeasisd gt&-;- stih amnse aehc fo hiert pstanre aciersr eht AR lleela. ,owN ofr teh eipntta ot eb nduefeafct vgeni tath tbho ish ntsraep haev teh AR la,lele ti nemsa thta eth npateti hsa a /23 ahecnc hatt he is uuonatsiyllsem uffetdncea adn a rair.rce
hTe eisatt'np rateprn si cneuftaedf dan ramoln igbryWHedner-a ctigesen as( stdaet in hte ehn.rbewp.m)ol isth is cepcifysiall mneeti,odn uoy rae to aseums that the reatnpr ahs a irrcear ernqufeyc orf hte RA lea,lle wichh auqel to qp2.
The easdesi ash a qneecfryu ni the tuaoppionl of 0/00401. hsTi is q^2 &-g-;t 2^q = /01004.0 vgiSonl rfo ,q yuo gte q = /.2001
erriaCr qcyreunef si 2q.p voHeewr, fro a rare asdes,ie 2pq ≈ q2. So, hte rcirear urnecfeyq for het trnpear = q2 = 2 * 20/10 = 1/.100
o,Nw hte Q sksa utabo na sropfingf of hte attpine dan ihs npterar ngebi fdafetec, so ot have na catdefef ,hilcd ethre is a /41 ahecnc of nvihag na dfcetfae lcidh eacses(ub het aptenit dan eht enrprat otbh evha a 1/2 hcacen fo apigsns the elelal -gt-;& yuo mtluelip eehst hgterote 12/ * /.1)2
,oS lyltpium 2/3 * 101/0 * /41 = /060.1 shiT si eaiPnptt( ebgni a rciarre) * pern(taPr gnibe a ierc)rar * ihv(ngaP na tefafdce pisgffrno oh.tr)geet
heT bpabyotriil of eht tearhf neibg a cairrer si 23/ ecisn it si nokwn htat he oe’dnst heva teh sdaes.ie henT eth aytlbripobi of ihm nasigsp it on to ihs kid s:i
21/ * 32/ = /13
hWit eth dngHry-Wbeaeir ,irncPelpi ouy can iuferg uto the rtaioybipbl fo hte mrhtoe bgnei a raecrri:
q = s40()1/0qr0,t0 = 002/1
o,S qp2 = 2 * 0/012 * 9/20091, ciwhh oprapx si 1/00,1 and het ryopbbiliat of hte dlihc teggtni siht llelae si /1001 * 21/ = 0/210
h:usT
20/10 * /13 = 6/100
wyh ehret si aribbotpyli fo ahfetr nbegi a ecrarri si 32/
We assume this is a recessive disease. In other words, you manifest the disease if you inherit a disease allele, d, from your mother and a disease allele, d, from your father (giving you the allele pairing denoted by “dd ”).
dd = you have the disease.
The father does not have the disease; this means his genotype cannot be dd and thus must be one of 3 things: DD, Dd, or dD.
That is,
Notice that in only two of these 3 possibilities (⅔) does the father (potentially) have a disease allele, d, that he might pass on to his progeny.
submitted by ∗drdoom(1206)
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$279$49talcnuslaCoi rfo add. ehT rtiyoblpbai fo het rthafe ngebi a rcriare is 23/ nices it si knonw ttah he ’dsnote have the d.issaee eThn eht oipbbtaiylr fo him anpssgi it no ot sih ikd is 21/, :suht
nllotacaiCus orf mmo. tWhi eht -rgeybarinedWH erPpicn,li you cna ergfiu out eht tylipriboab fo het mretoh ignbe a i:rcerar
q = (00s/rq4)00,1t = 0/102S,o
2pq = 2 * 2/001 * 209/190, ichwh si rpopxa 001/.1oFr teh ldhic to get het elaell omfr mom, tow gstinh ende ot e:phpan )1( omm tmus be a reirrca ort]zetheoge”“y[ nda )(2 mom sutm ssap het llleea to hdl:ci
igPnut ti lla tgohreet. oN,w mibecon lal egt:hoert
= ayritlb(ibop of add igebn rearrci) * byrip(oatilb of dad sisnpag on dieseas lllea)e * raib(pityolb of mmo genib earrcr)i * ay(otbrlbpii fo mmo snipgsa no seiseda lealle)
=
2/3 * /21 * 1/010 * /12=
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