dinnMeaal iestenc:G
aMn sha 3/2 cnceha of being a .rcrerai He( deso ton eavh het d)i.eseas nmoW a reircra kisr must be cculaetlda iwht p2^ + qp2 + q2.^ 2^q = 1/4000,0 q = 12/,00 p si luhoyrg = 2p q1 = 010/1 = iCrarer ufeyrcenq .
Risk of hniagv a dlihc uths qusael 32/ x 01/10 x 41/ = 00/16ecu / 2e3:asB = Mna errraCi iskr 00 11/ = mleaFe rCarire s 4/iR1k = anehCc etyh ehca spas on the essvercei gnee ot thrie fopnfsrig.
iTsh the mesa sa ckao@epynmy's pneatnxilao hwit meor ixlpoanntea eshot that eden .t.i.
heT ntiaetp is edfuatefcn by het arlcaturip msaoltaou eissecerv easdise dna hsi rbtorhe has the toalmauso cesveseri dsseiea -gt&-; htsi smaen hcea fo hrtie nstepar sirearc hte AR llaele. wo,N for the ittneap to be nadufecfet eignv htat bhot shi atnprse vhea eht RA allele, it menas ahtt eth aptient ash a 32/ aecnhc atth eh is lusotileyumsna atucfeednf and a ecr.rrai
hTe 'ptiasten trrapne is nfdauftece adn ronaml Hegydi-nWebrra neegtsic a(s dttaes in eht .h.rolem)bpenw sith si lcylfipeaisc nteni,emod uoy rea ot ueassm taht hte anrptre hsa a aercirr qncfyruee rof the AR ,llaele cihwh uleqa ot pq2.
The deeissa ash a euqynfcer ni eht ouoatnppil of /10400.0 ishT si q^2 -t;-g& q2^ = 100.04/0 nlvgioS fro q, uoy etg q = 0/2.10
airrreC cyurneqfe si .pq2 eervwHo, rfo a rare eeis,asd 2pq ≈ q.2 ,oS eht arircer ueeycrnqf fro the reartnp = q2 = 2 * 2/001 = /11.00
,owN eht Q sska ubaot an spgfrnofi fo the teaitpn adn hsi erpntra gibne fdetfcea, os ot heav an efadectf hlidc, rehte si a /14 hecanc fo hiavng an dtcffeea ldcih easube(sc the eaipntt dan eht nperrta obth aevh a /21 enhcca of psagins the leelal -;&-gt uoy miuelplt eshte othertge 21/ * 1./)2
oS, lmilyutp 23/ * 110/0 * 1/4 = /10.06 ihTs is tPine(tap bnige a r)ricare * rprea(ntP iengb a rcir)ear * viag(hnP na ftcafdee ronspigff gero.tet)h
eTh pbtrialbyio fo het ahfetr negbi a aerirrc is 2/3 ciesn it is nwnok thta eh eson’dt evha the i.essead hneT eht rbbpytoliai fo him saisgnp ti no ot ihs kdi i:s
/12 * 3/2 = /13
tihW the r-dnyeeiWrgbHa rceiplniP, yuo anc griefu uto the bbliyptrioa of eth rmeoth being a irrcae:r
q = 04,t0q1/r)s0(0 = 10/02
oS, 2pq = 2 * /2010 * 109/092, hichw oxrpap si 110/0, nda hte patrolybbii of hte chdli tgengit tish lleale si 01/10 * /12 = 0210/
h:uTs
21/00 * 1/3 = 016/0
ywh herte is libobipatyr fo eafhrt eibgn a arrcrie is /23
We assume this is a recessive disease. In other words, you manifest the disease if you inherit a disease allele, d, from your mother and a disease allele, d, from your father (giving you the allele pairing denoted by “dd ”).
dd = you have the disease.
The father does not have the disease; this means his genotype cannot be dd and thus must be one of 3 things: DD, Dd, or dD.
That is,
Notice that in only two of these 3 possibilities (⅔) does the father (potentially) have a disease allele, d, that he might pass on to his progeny.
submitted by ∗drdoom(1206)
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$279$49notCuisclaal for add. The lytipirboba fo hte arhetf egibn a rrrieca si 2/3 nscei ti is wnnok atht he edots’n heav eth ideeass. nTeh eth ltibpirabyo of mih isnpgas ti no ot his dik si /1,2 :uhts
tuaiascClnol orf mom. tWhi eht ndHrWbre-aiegy lcineipr,P uoy acn irfgeu tuo het boiaytiblrp fo het tmhoer egibn a i:arrrec
q = 104tq,000r()s/ = 002/1,So
pq2 = 2 * 021/0 * 19290/0, wichh si praxpo /100.1Fro eth ldhci to get teh leaell mfro mm,o otw htngis dnee to penh:pa 1)( omm tmus eb a rrecari zeeeho][tg”rt“oy nda )(2 mmo tsmu psas teh alleel to c:dihl
uigntP it lla trtegeoh. ,oNw bcniemo lla :toetherg
= bl(toriaiybp of dda ibgne rrcair)e * t(porbiabliy fo add sniaspg no edisaes alee)ll * p(libyaiotbr fo mom ibegn ri)crera * aybbirloipt( of mmo agsisnp no esdaeis aelel)l
=
23/ * 2/1 * /0011 * 1/2=
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