naldanMie Gestn:ice
nMa has 32/ acchen fo nigeb a ei.arrrc H(e dsoe otn aehv hte )seiedsa. Woanm rrciare rksi utms be ldulcaacte whit 2p^ + 2qp + .2^q 2 q^ = 100/4,00 q = 0,10/2 p si uhlrgyo = 2qp 1 = /1100 = Crairre feuyncqre .
iRsk of hginav a diclh tsuh ueaqsl /23 x 1001/ x 1/4 = 001/6sca2/u :ee 3B = naM rrraCei krsi 1/001 = aFemel Caerrri kiR1s/ 4 = aCcneh tyhe heac psas no eth vseeceris nege to trhie prfnfosgi.
sihT eth asem as y'skyoncap@me xonntaipael itwh mero itnlaxoepna eoths hatt need t...i
heT ttipane is eecftunfda yb eth pacrurlait otomlusaa iecseervs dseesia nda shi roetrhb sah eth otoumlaas reevessci dsiseae -&-t;g sith nmsae ahec fo rhiet asprten csreair eth AR .alelel ,wNo orf eht tieptna ot be cetfdeunaf vieng htat bhto shi pnrtesa evah hte RA alee,ll ti esmna htat het ateinpt hsa a /32 cnecah tath eh is msllnauistueoy tfdneafecu nda a .ecairrr
Teh ietapt'ns pearrtn si futcedafne adn rmlnao d-WyrgirHeeabn gseecint s(a ttdeas in hte ph).rwnbmeeol. tsih is paclfyesilic meoi,ntdne you era ot samseu htta eht ernartp has a icarrer eryuncfeq ofr teh RA elell,a hwihc qaleu ot p2.q
heT esaieds sha a uqereyfcn in the toupnpilao of 004./010 hTis si ^q2 g--;&t ^2q = /040001. gnioSlv fro ,q uyo gte q = 100/.2
ieCrrar eycfuqenr si 2qp. roHewve, for a rrae saes,ied qp2 ≈ q.2 oS, het rrierca cynequerf rof teh rntrpea = q2 = 2 * 2/100 = ./1100
wo,N het Q ssak utaob na ringfpsfo fo teh eitapnt and shi retarnp gneib efdctfea, os to ahve na adtceffe d,lcih hrete is a /14 caecnh of anvihg an ffceaetd lcdih bs(aseeuc eht taitpne adn teh nartrep btho heva a 12/ nhacec of piagnss the lelael &-tg;- uyo muileptl seeht hretoget /21 * )/.12
oS, pmlylitu 23/ * /1001 * 41/ = .0/061 hisT si et(taiPpn enbgi a rriac)er * trPapnr(e geibn a rrcraie) * ghniPv(a na fceeftad fofrigspn toree.g)th
eTh tbybioiaprl of hte harfet genib a rrieacr is 23/ cneis it si onnwk htta he neotd’s ehva eht ee.iadss eThn hte bopbiytaril of mhi gspnsia ti no ot ish ikd i:s
/12 * 23/ = 13/
htiW hte ng-WeyHbdrraei iPp,cernil uyo nca iferug otu teh opibrbitlay of het ohetmr neigb a r:aerirc
q = (t04/sqr0,001) = 10/20
oS, q2p = 2 * 210/0 * 902/910, ihhcw paxpor is 1010/, dna eth aibibyorlpt of the ildhc enitggt hits aellle si /0110 * /21 = 00/12
uTh:s
010/2 * /31 = 100/6
hwy hetre si yprblibtoai of aehtrf ebgni a rcrreai is /32
We assume this is a recessive disease. In other words, you manifest the disease if you inherit a disease allele, d, from your mother and a disease allele, d, from your father (giving you the allele pairing denoted by “dd ”).
dd = you have the disease.
The father does not have the disease; this means his genotype cannot be dd and thus must be one of 3 things: DD, Dd, or dD.
That is,
Notice that in only two of these 3 possibilities (⅔) does the father (potentially) have a disease allele, d, that he might pass on to his progeny.
submitted by ∗drdoom(1206)
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$279$49atiauosCclnl for dad. Teh bblptryoaii fo eth etarhf bneig a arrrcei si /23 cseni it is wnonk thta eh eotdn’s ehav eht dsei.aes Tneh eht lpbyobatiri fo ihm gnapiss it on to ihs idk si /21, :suht
tculoilasnCa rof mmo. hWit the bdierrH-gnaWye liPp,nrice oyu acn riuegf tou eth ibiplbaytor of eht oetmhr eignb a eiarc:rr
q = 0041)s/(,qt0r0 = 0021/So,
2qp = 2 * 12/00 * 90/2910, hichw is appoxr 1/00.1rFo hte dchli ot teg teh lelela mrfo mo,m wot ngtshi dene ot aphnp:e (1) mmo muts eb a cerirar oe]gz[reto”h“eyt nad 2)( mom tsum assp teh lelale ot c:ldih
uiPtgn it all ehrgtteo. ,wNo nomceib all :gthoeetr
= biboilp(arty fo dad egnib i)rarrce * ibybp(ltroia of dad igpsans on eaidsse alle)le * bobptiya(ril of mom eigbn ia)recrr * bbarly(tpiio fo mom ssaping on iedssae l)aleel
=
/23 * 21/ * 110/0 * /12=
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