aManinlde :teceGisn
aMn ahs 23/ eacchn of enigb a ri.rcaer eH( sedo not veah teh disee.)sa ona Wm ciaerrr skri msut be ateldlcacu iwth 2p^ + qp2 + .q2^ ^2 q = 010/0,04 q = 0021/, p is ulogrhy = q 1p2 = 1010/ = rCierar ercnefquy .
Riks of ivngha a hcdil hust eqauls /23 x 00/11 x 4/1 = 0061/u3:Bsee2c / a = naM erCarri sirk 001/ 1 = amleeF arCerri 1Rsi/4k = Chncea yeth chea asps on eht evricesse eegn ot hteir .fifpnsgor
shTi het asem as y@nysekaopmc' oanaxpelitn twhi mroe aaoiptxlenn ehsto thta edne .ti..
The ipeatnt is cnautfedfe by teh prtuaicral tuaaoosml iveserecs asdeeis nda hsi rerthob has het uatamoosl erscseeiv sdeiase -;tg&- stih esanm ahce of trehi tnsearp ciarser the AR lellae. Now, fro hte anttepi to be aneecdfutf vigen that ohtb sih pnesrta vhae teh AR el,leal it nemas atht eth aenptti sha a /32 achnec htat he is suaounmtselyil ceutadfenf nad a eacr.irr
ehT ipsetnat' erptnra is fnfecutdae nad ronlam ayberegHirWnd- iectensg sa( aesdtt ni eht nmwhbep)leo..r shit si ecilpflsiyac oteednmni, yuo are ot essmau ttah eht retanpr ash a arrceir nruqceeyf ofr the RA llleae, iwhch aqeul ot p.2q
hTe aeisesd sah a fequyrecn in eth tuaooplpin fo 0/10.400 ishT is q^2 tg-&-; ^q2 = 001400./ oSlvgni rof ,q you tge q = 021.0/
Crraeri qfeurcney is p.2q eervHwo, orf a erra ,asiedes pq2 ≈ .q2 ,So eht arriecr euncqfyer rfo eth aerrtpn = 2q = 2 * /0210 = /1.100
,Nwo eth Q saks bauto an iorffpsng of teh teiaptn adn shi ratrnpe ibeng aecfdfet, os ot vhae an efdfceat d,cihl hrtee is a 1/4 chaenc of givhna na deatfcef child c(baeesus teh entipta dna teh netrrpa othb heav a /21 ehcnac of giasspn eht ealell &g-t;- ouy etillpmu seeht trgeehot /12 * 1/2.)
,oS yilmltpu /23 * /1100 * /41 = 061.0/ hTsi is p(tnatPei enbgi a ar)ercir * rpPter(na einbg a r)crarie * n(aiPhvg na efcadtfe risgnpffo ehgtr.toe)
Teh yrpltbabiio of eht atfrhe ginbe a erricar si 3/2 ceins ti is wnokn tath he ’otnsed eahv teh dsasei.e neTh teh baoitlripby of him spnsiga ti no to his dik :si
21/ * 3/2 = 13/
ihWt het rg-nbeaerWiHdy piPen,rilc oyu nac erguif uto hte pioltbiaryb fo eth mthreo igben a :rarrcei
q = 14r/00,0st0()q = 021/0
,So 2qp = 2 * 02/10 * 29/0190, ichwh ropxap si /110,0 adn het oaybiprbitl of eth hdcil gteingt tshi llelae si 0/101 * 1/2 = /1002
hsT:u
21/00 * 1/3 = 0/601
hyw tehre is yobtlraibip fo rtfahe bnegi a acrerri is 32/
We assume this is a recessive disease. In other words, you manifest the disease if you inherit a disease allele, d, from your mother and a disease allele, d, from your father (giving you the allele pairing denoted by “dd ”).
dd = you have the disease.
The father does not have the disease; this means his genotype cannot be dd and thus must be one of 3 things: DD, Dd, or dD.
That is,
Notice that in only two of these 3 possibilities (⅔) does the father (potentially) have a disease allele, d, that he might pass on to his progeny.
submitted by ∗drdoom(1206)
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$279$49tilscCanlaou rof dda. ehT ryiboabtlpi fo teh tfeahr ibgne a ecrrair si /32 scine ti si wonkn ttah he od’stne evha teh ei.ssdae eTnh hte ioaybrpbtil fo imh ainssgp it on to ihs idk si 21/, shu:t
uoncliaCsalt rfo mmo. hiWt het eHygeda-nbrWir Pirip,nelc uoy nac gefuir uto the pblirbatoiy of hte tohmer engbi a crr:erai
q = 0t,4)(0r10/q0s = 0/021o,S
p2q = 2 * 1020/ * /290019, whhci is orpaxp .00/11oFr het hdlic ot teg eth eleall rmof mo,m owt snhgit ende ot nhe:ppa ()1 mmo mtsu eb a errarci ogez”h“r[]teyteo and (2) mmo tusm spsa eht lleale to hlcdi:
Puitgn ti lla hroeegtt. oNw, beominc all :toehtrge
= r(iblpyibtoa fo add gnibe r)rcaier * ilabyibp(rto fo dad nissgap on eisdesa eal)lel * bi(oyaptlrib of mmo ibnge rr)eicar * plioart(biyb of mmo igssanp no deaeiss leel)al
=
32/ * /21 * 10/01 * /12=
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