lnadaniMe tci:seneG
naM ahs 32/ cehanc fo bineg a carrr.ie H(e sedo ton have het ae)sdes.i aWnm o rricrae srki sutm be tleualadcc twih ^p2 + 2pq + q^.2 ^q2 = 00010/4, q = 002/,1 p is glhyrou = 12qp = 0/011 = errCair ecfunrqey .
Rsik fo ivhnga a lhdic tsuh equasl 2/3 x 0/110 x /14 = /0160 ecB 23e:/asu = Man rarrCei rski 001/1 = maelFe earrirC kR14 /is = acnCeh htey ceha asps on eth eieecsrsv enge to htrie gsfip.onrf
Tish teh esam as @mnp'eakoyscy aeopatilnnx ihwt erom aixetnnlopa htseo ahtt nede .t.i.
hTe ettpain is taenedffuc by the puiracaltr atolsuamo cssereive dseesia dan ihs roebhtr ash the asloumota esrvceeis idsaese &g;--t sith nsmae hace fo hiter rapestn arrisce het AR l.ellea N,wo ofr eth apetint to be etfefnadcu egnvi ttah othb sih tsrnpea vhea het RA ,eellla ti measn ttha hte ptaetni hsa a 32/ acnhce atht eh is uyalmotnuelsis uteafncdfe dan a erriarc.
ehT t'iantpse tnrerpa is ffnateuced nad onraml ai-enHrdbyrgeW necisget sa( tedtas ni het hnp.rme).lbweo stih si peisiccalyfl m,ditneoen ouy are to easmus taht eht aprtren ash a cairrer qyruneefc orf het AR ,lleale wchih elaqu to pq.2
hTe easeisd ahs a cuenryqfe in hte tolupopani fo 14000.0/ iTsh is 2^q -;t-&g 2^q = 01040./0 Svoginl ofr q, ouy tge q = .1200/
riCrrae ceeuqnyrf is 2p.q ewHeorv, rfo a erra is,sdeea p2q ≈ 2q. So, teh recriar ncefeyruq ofr het prntear = q2 = 2 * 1/200 = .1100/
oNw, teh Q kass otuab an fsigrpofn of eht ipatent and shi raeptnr gbien fefeacdt, os ot vahe an deafetcf ,lhcid terhe si a 41/ anecch of gavhin an efftaecd hlcdi ecs(sebua teh aenptti dan eht trepran ohtb ehva a 2/1 checna fo gsansip teh ealell -tg;&- you letlumip eehst eotrghte 21/ * 2)1./
oS, miltlpuy 32/ * 10/10 * 1/4 = 1/.060 hTis is aepiPt(tn gbnei a rr)arcie * nrtrp(eaP igbne a rr)arice * ihavn(Pg na ceaefftd fsipngfor hg.)rteteo
Teh rlobibipaty of the htrafe egibn a ricrrae is 23/ esicn it is nkown htat he sn’teod heav eth edissea. hnTe eht riboblitapy fo mhi sgnsapi it on ot his ikd :si
12/ * 3/2 = 31/
iWth eht y-rbarigdnHeWe rpPnlciie, you acn iufegr tuo eth plaobibtyri fo eht tomher binge a a:crrire
q = 0tr0q10,s04)(/ = 002/1
,So q2p = 2 * 1/002 * 9102/09
, ihwch xoprpa si /,0101 dan het altpribbiyo of the cildh tntigge tsih ealell is 0101/ * 21/ = 2010/
Tuh:s
/2001 * 1/3 = 6/010
hyw ehrte si liyoprbbiat of ferhta gbnei a eriracr si 3/2
We assume this is a recessive disease. In other words, you manifest the disease if you inherit a disease allele, d, from your mother and a disease allele, d, from your father (giving you the allele pairing denoted by “dd ”).
dd = you have the disease.
The father does not have the disease; this means his genotype cannot be dd and thus must be one of 3 things: DD, Dd, or dD.
That is,
Notice that in only two of these 3 possibilities (⅔) does the father (potentially) have a disease allele, d, that he might pass on to his progeny.
submitted by ∗drdoom(1206)
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$279$49 65% OFFaaucltsiClon orf dda. Teh biypiaroltb fo teh teharf nigbe a rrriaec is 32/ iescn it is onnkw taht he ondes’t eahv hte dieaes.s Then hte iiybboralpt fo imh apsgins it on ot ihs dki is /,21 us:ht
oauCicnstall ofr mmo. tWih the re-riedgHanyWb inpcPil,re uoy nca eigrfu tou teh obriilybpta fo hte ermhto ingbe a eric:arr
q = r0(1s0q0,t/)04 = /1002
S,o
p2q = 2 * /1002 * 92001/9
, hhciw is ppaorx 1/00.1rFo the lidhc to get teh alelle mfro ,omm owt gihtsn need ot ap:ehpn )(1 mmo utsm eb a icrrrea eyg”[z“erootth]e adn )(2 mom umts sasp hte lleela to icdhl:
iugnPt ti lla getroeht. N,wo mnbceio all trtee:hog
= (piblytboari of add gineb r)ecairr * oyiblab(trip fo dda asnsgip on seadsie llle)ea * lrpyatiobb(i of mom egbni aecri)rr * (bbartpiloiy fo mom ipasgns on sdeaies ellel)a
=
23/ * 2/1 * /1010 * 12/
=
1 ni 006
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