nMlaienda sGti:ceen
aMn has 3/2 caehcn fo ngbei a air.rrec eH( esod tno vahe the s.idesae) Womn a reircar irks usmt eb cadlelcaut htwi ^2p + 2pq + 2.^q q 2^ = 00,0410/ q = 1/0,02 p is glurohy = 1 2qp = 0011/ = rCrreai ceuqenryf .
siRk of inhavg a dhilc htus elqaus /23 x 01/01 x /14 = 10/6023 Be/ suec:a = nMa eriraCr sikr 11/00 = eelmFa iarrerC R/ik s14 = ehCacn htey cahe saps no hte csesverei eneg ot ierth .fsfnogrpi
isTh hte mesa sa o'ackymye@nps onianpltaex thiw orme annpixeotal thoes ahtt edne .ti..
ehT pnittae is uecetdfafn yb the iraptuarlc otmaolasu ercesevsi deassei dan hsi hbretor hsa teh laaouosmt eiservsec sesiead t&;-g- itsh snema each of eriht snptrea craeisr eht AR alelel. wNo, for eht atepnit ot be nfteuedcfa engiv thta htbo his trnaspe evah eht AR ea,elll ti mensa htat hte anetipt ash a 2/3 nccahe atht he si tsnsuaeymiolul eunaedcftf nad a r.eriacr
ehT ti'antesp ptarnre si tfeucdeafn dan rloamn ineerWy-adbgrH isgetecn s(a tsdeta in hte rmehlw.neob)p. siht is flclaceiipys entedin,om ouy era to amsues atht the neparrt ash a iraercr yeecnfuqr orf eht RA llalee, cwhih qulae ot q.p2
ehT eesasdi has a rfeueqync in eth ponalupoit fo 4/010.00 hisT si ^q2 &-;gt- 2^q = 4010.0/0 lnSigov rfo q, oyu etg q = 001/2.
aeCirrr fqecrnuye si 2qp. eervwHo, for a raer s,iseeda 2pq ≈ q2. So, eth rrcriae efyrncequ orf teh nreatrp = q2 = 2 * 012/0 = /1010.
o,wN eth Q assk obatu na finsorgpf fo eth eanttip dan ish ternpar gbeni detafecf, so ot haev na effadtce dicl,h rteeh is a /14 hcncea of gaihvn na feedatcf cihld seue(sbca teh tpntiea adn het rerpnta hbto eahv a /12 hnecca fo sisgpna het eelall &-g-t; you luteiplm teshe hgoterte 21/ * 12.)/
,So tylupmil /23 * 100/1 * 14/ = 06/.10 ishT is aentp(itP gbien a c)earrri * a(rertnpP bgine a a)ercirr * vgPna(hi an eftfdeca sfprniofg h.etrotge)
The ilirbyoptba of eht refaht giben a raicerr is 23/ inces it is knwno ttha eh deot’sn have eht sesd.iae henT teh birbayptlio of imh ssaipgn ti no to his kdi s:i
/12 * /32 = 1/3
thWi eth niaerb-gdeyWrH ilrPep,nci yuo nca egufir tuo teh opbritaibly of the meotrh egnbi a arrre:ic
q = 0/0s),0r4(1t0q = /0102
So, 2qp = 2 * /2001 * 19/0209, hhicw oxparp is 0/011, dna the rbiptaybiol fo eht ihcld ettingg hsti aeelll is 1/001 * 12/ = 1/002
sTu:h
210/0 * 3/1 = /0016
hwy rhtee is riblipoybta fo ahefrt negib a cirraer si 23/
We assume this is a recessive disease. In other words, you manifest the disease if you inherit a disease allele, d, from your mother and a disease allele, d, from your father (giving you the allele pairing denoted by “dd ”).
dd = you have the disease.
The father does not have the disease; this means his genotype cannot be dd and thus must be one of 3 things: DD, Dd, or dD.
That is,
Notice that in only two of these 3 possibilities (⅔) does the father (potentially) have a disease allele, d, that he might pass on to his progeny.
submitted by ∗drdoom(1206)
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$279$49lCuitlconaas rfo add. The albyipborti of teh erhatf ibneg a acierrr si /32 inces ti si okwnn tath eh e’ndots aehv het ea.idses heTn eht iltoarypbib fo hmi aipsgns ti no ot shi kid is ,/12 u:hts
aacCitunsoll rof mmo. Wiht hte dgHebriarnW-ye ei,Prlinpc ouy cna eirguf out eht bryolaptibi of eht rotmeh giebn a e:riracr
q = q00,4(ts/0r10) = 20/10,oS
p2q = 2 * 2/001 * 99200/1, ihhcw si rxpoap .1010/orF hte cdhli ot get teh eallle mfro m,om wot stngih eedn ot :pehanp 1() mom tusm be a acrirre [oze”ehre]t“gtoy and 2)( mom tmsu ssap the lelael to :chidl
Pngiut it lal gethroet. N,ow emconib all g:teoethr
= itil(aboyrbp of add bnieg )irrarec * babiroyil(pt fo dad aigpnss no sasedie lalel)e * loairitpy(bb of mom bieng aer)crir * pyb(ilaoirbt fo mmo nsgiaps on ideases elal)el
=
/32 * 2/1 * 010/1 * 2/1=
1 ni 600$279$49