Mndneaali t:esneciG
Mna sah 32/ cheanc of ibnge a ira.ercr (He odse ont heav eth sdie).aes aWmno rcairre sirk stmu be eudclactla hwit p^2 + q2p + .2^q 2^q = 400100/, q = 00,12/ p is hluorgy = 1 2qp = 1/010 = erarCir erunqecyf .
skiR fo vihnga a ilhdc thsu qelaus 2/3 x 1001/ x 1/4 = 10/06B: 2 cuese/3a = aMn arirrCe krsi 1 010/ = leFmea Caerrri 1s4iR k/ = Cenahc yeth chae saps on the ieescrves neeg to rhtei fnsrfgpio.
Tish eht eams as aeosmyc@'npyk nopxaentail htwi mero etlaaxinopn hoets hatt edne ti...
The tanpite is fctuedefna yb teh tuarpalcri aomoutasl ceeerssiv daeises dna ish hotrber ash eht usoaltamo esirvcese diesase g;-t&- tsih neasm caeh fo rihet aptsner riaescr the RA .llelae wNo, ofr het itnpeta to be ftdecanufe ivgen atht hobt ish etaprns hvae eht AR ,llelae it mnase taht the nptiaet hsa a /32 hccnae thta he is sayeuusitlmnlo entdfuefac nda a crr.riea
ehT ipnttase' rnarpet si eaudfctenf dan rlmnoa -egybHWredanir tneesgic (as satdet ni the lhermnop)..bew shit si pelcaiifscyl tinedn,oem uyo rae ot saemus thta the etanprr sah a eacrrri runefqecy rof eht AR lele,al whihc qaule ot 2qp.
The deseisa sah a urqceeynf ni hte uoapoptnil of ./014000 hsiT is ^q2 -&-gt; 2q^ = 4000/1.0 Silgovn ofr ,q yuo tge q = 201.0/
rriareC yueqecfrn is q2p. eHroewv, rfo a erra saedsie, 2qp โ 2.q o,S eth ceairrr ecefrqnyu rof hte petranr = 2q = 2 * 1020/ = 0/11.0
,woN teh Q saks otabu an nfigfrspo of eth ettinap nad ihs nrrpeta inbeg fteaecfd, so ot have na tecffaed hcil,d trehe is a 41/ echcna of vhgian na etffedca dilhc scb(seaeu eth tnpetai dna het earprtn bhot vaeh a 2/1 neacch fo ginspas teh eellal -t-;&g ouy ilmleupt shete throgete 21/ * )/2.1
o,S ipltumly /32 * 010/1 * 14/ = /0.061 Tshi si Pteaitpn( neigb a rca)rire * eptPrra(n giebn a erc)arri * vgPa(inh na dafeftec snifrfogp ehg.erott)
eTh ilatboibpyr of hte thfrea igneb a rarcier is 3/2 neisc it si owknn htta eh tsoendโ hvae hte a.essied nTeh hte aborbiitpyl of imh apsnigs ti on ot sih idk si:
12/ * 3/2 = 13/
Whit eht y-raWrdbiHnege il,Pcrpein yuo cna efugir tou het lbibotpryai of eht emthro gbein a rirc:era
q = r4(q)00,s0t1/0 = 210/0
So, 2pq = 2 * 200/1 * 0219/09, hihwc xprpoa is 100,/1 adn teh ibtibrapylo of eth dhlic gettgin ihst llaeel is /0101 * 1/2 = 010/2
:Tshu
20/01 * 1/3 = 0/061
ywh rhtee is boaipiybtrl of fareht ebgni a arerrci si 32/
We assume this is a recessive disease. In other words, you manifest the disease if you inherit a disease allele, d, from your mother and a disease allele, d, from your father (giving you the allele pairing denoted by โdd โ).
dd = you have the disease.
The father does not have the disease; this means his genotype cannot be dd and thus must be one of 3 things: DD, Dd, or dD.
That is,
Notice that in only two of these 3 possibilities (โ ) does the father (potentially) have a disease allele, d, that he might pass on to his progeny.
submitted by โdrdoom(1206)
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$279$49cCitunallsao orf add. eTh aoytlibirbp fo teh trhfae giben a areircr si /23 ceisn ti is wnonk htta he nโsdtoe aevh het eaisse.d nThe eht lyoatiirbpb of ihm gspsani ti no to his dki is 21,/ tsuh:
ulicCnlatsoa rfo mmo. tihW the r-eayWdbniegrH Pnp,icrile uoy anc uegrif tuo eht iatypbrobil fo teh othrme geibn a icerr:ra
q = ts,1r0004)(q0/ = 02/10,So
2qp = 2 * 001/2 * 9/20910, ihchw si oaxprp 011/0.Fro eth hdicl ot gte hte lealle form m,mo wto gtnhis need ot heppna: 1)( mom stmu be a rriarce htzeotg]eo[yโerโ and ()2 mom mtus assp eth lleale ot :lhicd
nitguP ti lla rotghete. ,owN nbmoeic all hgoeert:t
= tb(lriyiaobp of add nbgie )rrracie * lribbp(oyiat of dad siapngs on adsesei lelale) * iy(tobaiplbr fo mmo enbig rrecai)r * bitlopbr(ayi of omm ginsaps on sieades le)lale
=
32/ * 21/ * 0/110 * 1/2=
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