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Retired NBME 22 Answers

nbme22/Block 2/Question#34 (reveal difficulty score)
A 30-year-old man and a 24-year-old woman ...
1 in 600 🔍 / 📺 / 🌳 / 📖
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 +27  upvote downvote
submitted by drdoom(1206)
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lCuitlconaas rfo add. The albyipborti of teh erhatf ibneg a acierrr si /32 inces ti si okwnn tath eh e’ndots aehv het ea.idses heTn eht iltoarypbib fo hmi aipsgns ti no ot shi kid is ,/12 u:hts

  • ibolrtbyiaP of dda eignb rreicra = /23
  • tPioarlibby of add ssainpg no sdaeesi leella = 1/2

aacCitunsoll rof mmo. Wiht hte dgHebriarnW-ye ei,Prlinpc ouy cna eirguf out eht bryolaptibi of eht rotmeh giebn a e:riracr

q = q00,4(ts/0r10) = 20/10

,oS p2q = 2 * 2/001 * 99200/1, ihhcw si rxpoap .1010/

orF hte cdhli ot get teh eallle mfro m,om wot stngih eedn ot :pehanp 1() mom tusm be a acrirre [oze”ehre]t“gtoy and 2)( mom tmsu ssap the lelael to :chidl

  • riatibbyPlo fo mom inbge eiarrrc = 0/110
  • toPlairbiyb fo omm asigsnp on daeesis leella = 12/

Pngiut it lal gethroet. N,ow emconib all g:teoethr

= itil(aboyrbp of add bnieg )irrarec * babiroyil(pt fo dad aigpnss no sasedie lalel)e * loairitpy(bb of mom bieng aer)crir * pyb(ilaoirbt fo mmo nsgiaps on ideases elal)el

= /32 * 2/1 * 010/1 * 2/1
= 1 ni 600

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kernicterusthefrog  oT euotq rgyhoT o,Trh agdr eqe:un ew", ess,uJ orsg"s +52
niboonsh  ihsT oquentsi kseam em twan to iotvm +14
drdoom  lol +
5thgencephalosporin  oayk wow +
tekkenman101  You cna maek sith a lto eirqkuc yb iguns ilpsme srelu orf oalusmtoa eievssrce das .ies)es1 ntUfecdafe enrtpa wiht ctfdfeae ieagnle iwll eb a rrracei 23/ of eht emti )( a)A2 rqeencyfu ni opotpalnui is perus wlo os you anc regnio P nda stju esu (2)q ni roedr ot caacelutl rrraeic erfycqeu.n So tkea teh rqesua otor of the usoozmygho esvseriec rcuyfneeq (140/),000 dna sjut glup it in: (05).02 = )103. ehT sddo fo tehri dhlci ibgne edetafcf whti teh tow rtnespa bgien uaemssd tteliphycaho csrriaer is 1/4 (aa) ro d'2 5Dsa.. aeircrr ahcenc 3/(2) x s'oMm arrrcei ecahnc .0()1 x h'dslic ancehc fo bnegi vesserice ()52. +1

Instead of doing all those calculations for the mom, you can also just multiply the dad's probability by 1/200 → q, the probability of the allele in the general population

+1/- hungrybox(1277)

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 +4  upvote downvote
submitted by keycompany(351)
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nMlaienda sGti:ceen

aMn has 3/2 caehcn fo ngbei a air.rrec eH( esod tno vahe the s.idesae) Womn a reircar irks usmt eb cadlelcaut htwi ^2p + 2pq + 2.^q q 2^ = 00,0410/ q = 1/0,02 p is glurohy = 1 2qp = 0011/ = rCrreai ceuqenryf .

siRk of inhavg a dhilc htus elqaus /23 x 01/01 x /14 = 10/6023 Be/ suec:a = nMa eriraCr sikr 11/00 = eelmFa iarrerC R/ik s14 = ehCacn htey cahe saps no hte csesverei eneg ot ierth .fsfnogrpi

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hello  eSe my aienlxtpnao if uoy eedn omre osrdw to lnxaeip shti oeplnanxita +2


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 +3  upvote downvote
submitted by hello(429)
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isTh hte mesa sa o'ackymye@nps onianpltaex thiw orme annpixeotal thoes ahtt edne .ti..

ehT pnittae is uecetdfafn yb the iraptuarlc otmaolasu ercesevsi deassei dan hsi hbretor hsa teh laaouosmt eiservsec sesiead t&;-g- itsh snema each of eriht snptrea craeisr eht AR alelel. wNo, for eht atepnit ot be nfteuedcfa engiv thta htbo his trnaspe evah eht AR ea,elll ti mensa htat hte anetipt ash a 2/3 nccahe atht he si tsnsuaeymiolul eunaedcftf nad a r.eriacr

ehT ti'antesp ptarnre si tfeucdeafn dan rloamn ineerWy-adbgrH isgetecn s(a tsdeta in hte rmehlw.neob)p. siht is flclaceiipys entedin,om ouy era to amsues atht the neparrt ash a iraercr yeecnfuqr orf eht RA llalee, cwhih qulae ot q.p2

ehT eesasdi has a rfeueqync in eth ponalupoit fo 4/010.00 hisT si ^q2 &-;gt- 2^q = 4010.0/0 lnSigov rfo q, oyu etg q = 001/2.

aeCirrr fqecrnuye si 2qp. eervwHo, for a raer s,iseeda 2pq ≈ q2. So, eth rrcriae efyrncequ orf teh nreatrp = q2 = 2 * 012/0 = /1010.

o,wN eth Q assk obatu na finsorgpf fo eth eanttip dan ish ternpar gbeni detafecf, so ot haev na effadtce dicl,h rteeh is a /14 hcncea of gaihvn na feedatcf cihld seue(sbca teh tpntiea adn het rerpnta hbto eahv a /12 hnecca fo sisgpna het eelall &-g-t; you luteiplm teshe hgoterte 21/ * 12.)/

,So tylupmil /23 * 100/1 * 14/ = 06/.10 ishT is aentp(itP gbien a c)earrri * a(rertnpP bgine a a)ercirr * vgPna(hi an eftfdeca sfprniofg h.etrotge)

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 +0  upvote downvote
submitted by beastfromtheastx(0)
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The ilirbyoptba of eht refaht giben a raicerr is 23/ inces it is knwno ttha eh deot’sn have eht sesd.iae henT teh birbayptlio of imh ssaipgn ti no to his kdi s:i

/12 * /32 = 1/3

thWi eth niaerb-gdeyWrH ilrPep,nci yuo nca egufir tuo teh opbritaibly of the meotrh egnbi a arrre:ic

q = 0/0s),0r4(1t0q = /0102

So, 2qp = 2 * /2001 * 19/0209, hhicw oxparp is 0/011, dna the rbiptaybiol fo eht ihcld ettingg hsti aeelll is 1/001 * 12/ = 1/002

sTu:h

210/0 * 3/1 = /0016

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brill45  You idd hist tgirh ubt I kithn dmae ti a itb oerm caldpceiotm hnat ddeeen to b.e oT irfuge uot het oldekihlio fo a rnaomd eonspr ni the ptinoluaop ianspsg no a cseesierv lla,eel uyo sjtu nede to od q)2oqstoua(rre ot tge to q. dnA jsut use that q to lultipmy whti eht 1/3 you gto riearl.e eTh q vaeul leslt uyo the llelea qrfcenuye ni eth puonapliot, hhewter eth nrspoe si a rraecir or ouhmoyzsgo rveiscsee bo.th uoY tllis ogt it, btu just nigttle uyo nkwo hte ieesar utroe in asce oyu ese it aign!a +2


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 +0  upvote downvote
submitted by kdckjn(0)
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hwy rhtee is riblipoybta fo ahefrt negib a cirraer si 23/

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drdoom  We eausms siht si a ercvieess issdae.e nI oterh wrods, you emiftasn eth asedsei if you hintrie a esdeias ll,eale ,d mrof rouy etohrm nad a eidasse lleae,l ,d from uyor hert,af vigign uoy na elllae ignirpa oendted by d.d dd = yuo aveh teh seida.se heT hratfe esod otn aevh eth ies;ased tsih msane ish epotenyg cna ynlo eb 1 fo rehet itgsnh: ,DD dD, ro .dD tTha i,s DD = D mfor sih dd,a D mfro hsi o;mm Dd = D rofm hsi a,dd d rmfo hsi o;mm or Dd = d ormf sih dad, D ofrm shi .mmo etociN hatt in lnyo wto fo eeths 3 seoisilispibt deso the artehf y(ptolaelnt)i aehv a eadiess llaele ()d hatt he hgmit pssa on to shi rpon.eyg +

We assume this is a recessive disease. In other words, you manifest the disease if you inherit a disease allele, d, from your mother and a disease allele, d, from your father (giving you the allele pairing denoted by “dd ”).

dd = you have the disease.

The father does not have the disease; this means his genotype cannot be dd and thus must be one of 3 things: DD, Dd, or dD.

That is,

  • DD = D from his dad, D from his mom;
  • or Dd = D from his dad, d from his mom;
  • or dD = d from his dad, D from his mom.

Notice that in only two of these 3 possibilities (⅔) does the father (potentially) have a disease allele, d, that he might pass on to his progeny.

+1/- drdoom(1206)

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