denianlMa Gnes:ietc
aMn sha 23/ cnceah fo inebg a rrarc.ei (He esod ton aveh eth a)sde.esi anmoW ciraerr risk ustm eb tauclalcde ihtw p^2 + pq2 + q2^. q^ 2 = 001040,/ q = /0,201 p si hyulgor = qp12 = /1001 = Crirrae yunecrefq .
skRi fo ivnahg a hidlc suth laueqs 23/ x 1001/ x 4/1 = /0061B ee3:/u ac2s = nMa aCerrir rksi /0 011 = lmeaFe reCairr 1/4 isRk = cChaen tyhe ehca sasp on teh ecrivesse enge to rthie fogrf.sinp
siTh eht easm as ys'caeknp@ymo opinataxnle tihw mroe oetalxpnina estho hatt dene .ti..
ehT apntite si tuafecfden by eth icplaartur otaauslmo servsiece eaeisds dan ish hebrtor sha teh luosoatam seeicevsr edaseis &-;g-t tish asnme ahce of erith eaprtsn csirrae hte AR aelell. wN,o fro the npaiett ot eb cedetnaffu igevn atth tboh ish ptnaesr aehv hte AR ll,elae ti asemn that eth teanipt ahs a 2/3 cceanh taht he si ulmoetlsanyisu eecffdantu adn a a.ierrrc
hTe p'ntseita tnerpra is ecdeafuftn dan nomral aeyr-bHnirdWeg gienstce (as daetts ni het wmobl)ee.np.rh isht is eylsplcfacii ne,etmdnio oyu aer to saesmu atth eth ptarren sha a reairrc qyecrnefu for teh AR ,lelela ihchw ulqea ot .qp2
Teh easeisd hsa a yuefercnq ni hte ioalnuoppt fo /0.04001 hsTi si ^q2 t&g;-- ^2q = 10000/.4 vgiSoln rof ,q oyu tge q = 00/2.1
Carrire qenecuyfr is .q2p Hverweo, rfo a erar eai,ssed pq2 ≈ q2. o,S hte rricrae yeqefrucn fro eht prnaret = q2 = 2 * 1/200 = 00.11/
wN,o eth Q sask taoub an npofrigfs of het ntaeipt and his nptrrae negbi dtfeefca, os ot veha na catffede ,ichdl htere si a /14 caehnc fo gnahvi an effatdce lhcid esabceu(s teh aetntip dan the trperan btho eavh a 21/ ccaehn of gssipna the elleal -tg-;& uyo meltulpi etshe gteeorth /12 * 2/.)1
o,S myutllpi 32/ * 010/1 * 14/ = 6.1/00 sTih si i(ptanPte ngbie a rc)rraie * enparr(tP ebign a reraric) * (gnviPha na dcefeatf ioffgrpsn horg)e.tte
eTh oiybilrbtap fo the rafeth inebg a irarerc is 2/3 isnce ti is kwnno atth he tdno’es ahve eht .eaiesds heTn hte bliribytaop fo mhi sgnipas ti on to his dik is:
12/ * 32/ = 3/1
Wiht hte rer-HbadWineyg eclipr,nPi oyu acn ergiuf otu het lyobpiribat of eht oehtmr geibn a recr:ria
q = 400/q0s1tr0(,) = 1/002
,So p2q = 2 * 0/210 * 01/9092, hchwi aoprxp is 0,101/ dna het bbltipryioa of eht ilchd ingtgte isth elalel si 1010/ * /21 = 20/01
uhsT:
/0210 * /31 = 60/10
hwy trhee is boapibtriyl of thaerf nebgi a ricarer si 3/2
We assume this is a recessive disease. In other words, you manifest the disease if you inherit a disease allele, d, from your mother and a disease allele, d, from your father (giving you the allele pairing denoted by “dd ”).
dd = you have the disease.
The father does not have the disease; this means his genotype cannot be dd and thus must be one of 3 things: DD, Dd, or dD.
That is,
Notice that in only two of these 3 possibilities (⅔) does the father (potentially) have a disease allele, d, that he might pass on to his progeny.
submitted by ∗drdoom(1206)
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$279$49cloinatCsaul rof dda. hTe plabtioyibr fo het rfhaet nbgei a cirerar is /23 ensic it si nnwko taht he tendso’ vahe eth ed.isesa nheT eht librtyopabi of imh aspigsn ti no ot shi ikd is 12/, h:tus
aouscnlClait fro mom. ihWt the eWdregbir-anyH Pcpirilen, yuo nca iegfru uto eth rlpyboabiit fo eth oehtrm eibgn a rrrc:aie
q = ,qt)000/(410sr = 01/20,oS
2qp = 2 * 1/200 * 2/09190, hwhci si rxppao 10.10/orF teh dlhci to etg teh elella rfmo mmo, owt ihtsng need to :nppaeh 1)( mom umst eb a arirecr g[oeher”]z“tyeot and 2() mom tusm assp eth leeall to dih:cl
Ptingu it all ghtoteer. oN,w bimnoce all :rgteehot
= ibpi(byoatlr of add enibg rerciar) * lr(opbiatiyb fo add psgains no iseaesd )lleela * itprbyoail(b of mmo nbige )arrirce * bpiyra(loitb fo omm sniagps no saseeid elll)ae
=
2/3 * 21/ * 0/110 * 1/2=
1 ni 600$279$49