aMlinedna :tinscGee
aMn ahs /32 chacne fo einbg a e.rarric (He odse ont veha eht )e.dessia nmWa o erircra rksi tusm eb llaudtaecc iwth ^p2 + qp2 + q2.^ ^ q2 = 1/004,00 q = 02,1/0 p is ygruolh = 1p2 q = 11/00 = rreiCra rqnufeyce .
Rski fo haginv a idchl tush slquea 32/ x 1001/ x 4/1 = 160/0Bas2u:/ ee 3c = naM rCarrie sikr 11/0 0 = maeFle eaCrrri iskR/4 1 = enChac hety heca apss no teh veciserse enge ot ierht .gnfsrifpo
Tshi het asme sa mnyoycp@ek'as npieaxotaln itwh omer tonixaaenlp sheot htat deen ti...
The ttnepia si fncuefedta yb hte pircrtuaal aoouatmls rivseesce isasdee and his bhtorre ash hte sltamauoo eievesrcs esidesa -&g-;t itsh nsaem aceh of ihert etprnas asrreic hte AR .lealle ,oNw for hte ttiapne to be fdneecaftu nivge htta obth ish nrtsape hvea the AR elael,l it emsan atht the enapitt has a /23 ncahec hatt he si oissutnuealylm cuadefntfe dna a eirracr.
heT ettias'np ertnarp si duaneecftf and oanmrl yn-egedriWrabH etcseign (sa edstta in eht eemr)b.lo.hnwp thsi si faipllcysiec oiem,tnden oyu ear to esusam taht hte aptrner sah a rcaierr frncyeqeu rof teh RA ea,lell hhciw uqela ot p2.q
ehT sdesaei ahs a nrueyfqce in het ounpoiplat of 0014/.00 isTh si 2q^ g;-&t- 2q^ = .0001/40 lSgvnoi ofr q, oyu egt q = 001/2.
rCiarre ceqrfenyu si p.q2 ervewoH, fro a raer iesd,ase p2q ≈ 2q. ,oS the crrarei eqyufcnre for hte prratne = 2q = 2 * 10/02 = /.1001
,oNw het Q kass obtua na fprofsign of het ianeptt adn hsi arprnte beign ctefdfea, so ot eavh an fcdfaeet ildhc, hrtee is a 41/ ceahcn of vhaign na cedfeaft clhdi scaeeusb( het atietnp dan the npatrer tbho ahev a /21 enccha of pgsanis eht eelall ;&g-t- oyu utiplmle eehts tohgeter 21/ * )/21.
,So yllumitp 3/2 * 0011/ * 41/ = 106/.0 sihT is niat(Ptep nibeg a iecrarr) * ntrrPpea( begni a rearir)c * igPhv(na an fatecdef spforfngi eetgt)ohr.
eTh riayiobbtlp fo het rfehat egbin a cerriar is 3/2 ecnis it is wknon ahtt eh neot’sd veha eht sedi.aes nhTe the btbpilraoyi of mhi inapsgs it on ot hsi dki i:s
2/1 * /23 = 13/
htWi teh raHeergnbyW-di ileripncP, uoy cna rigeuf out eth ltoiaibbypr of het romeht iegbn a :rrarcei
q = 0ts0qr0)(4/,10 = 1002/
S,o 2pq = 2 * 012/0 * 0/99210, whchi apropx is ,10/01 nda the oitpbrlbiay fo the dcihl getngit ihst lleeal si 0101/ * /21 = /1002
hsTu:
/0201 * /31 = 1006/
wyh hrtee si iblrapbtyio fo rhfate iebgn a reriarc is 23/
We assume this is a recessive disease. In other words, you manifest the disease if you inherit a disease allele, d, from your mother and a disease allele, d, from your father (giving you the allele pairing denoted by “dd ”).
dd = you have the disease.
The father does not have the disease; this means his genotype cannot be dd and thus must be one of 3 things: DD, Dd, or dD.
That is,
Notice that in only two of these 3 possibilities (⅔) does the father (potentially) have a disease allele, d, that he might pass on to his progeny.
submitted by ∗drdoom(1206)
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$279$49nlslotciaaCu fro dad. eTh rtlboipyaib fo the hfreat iegnb a rcaeirr is 2/3 cesin ti is nkwno taht eh ’onedst vhae hte issd.eae nTeh the ityaoblbpir of imh pgssani it on to his dki is 1/2, :stuh
sntlcalioaCu rof mom. htWi hte ngbyH-eWairdre ePcriilnp, you nac fugier tuo teh iypailbtrob of the mthreo inebg a :arircer
q = 4/0)0s10(,rq0t = 010/2So,
pq2 = 2 * /0012 * 02/1099, hhciw si axprop 10/10.Fro eht lidch ot gte eht elleal rmfo mm,o tow sghnit ndee to a:pephn )(1 omm smut be a cirraer y]“oght[”ertzeoe nad (2) mmo stum psas the lelael ot hidcl:
tnuPig it lal ohegtrte. N,ow ocnimbe lla tghet:eor
= (lbyrptiiboa fo dda ginbe c)rrraei * pilaryt(iobb of dda sisagpn on eassied le)llea * rtl(byioipab fo mom geibn icarer)r * tiori(ylabbp fo mom sisgpna on sadeise leae)ll
=
23/ * 21/ * 1/001 * 21/=
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