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NBME 22 Answers

nbme22/Block 4/Question#5 (60.5 difficulty score)
A new virus has been isolated that causes ...
Single-stranded positive-sense🔍,📺

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submitted by haliburton(217),
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gcroncida ot ldsebelmut knil sn ss NRA tsmu yrrac NAR nentdeepd ARN oesepylmra (so ttha is .)uot

osl,a icocangrd to budlelstem ether rea yevr wef sd RAN uevs,isr so mts"o "ylkeil illw eb ss. s,Aol detne-npNAdRe NAD smrpoeleay = reeveRs iTparrsen.csta neSic IHV si a ss ps RNA vsuri twhi ,RT 'vteeyh idebdcers na VIH siocn.u ont resu oebnyd sith.

nc1992  negative stranded can't be read by a translator so it needs to be transcribed into + first. Only then can it be used for protein. + is basically mRNA already. There's only one double stranded RNA family as far as I know- Reovirus so no encephalitis +9  

submitted by kenyaboi(3),
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het gondmat kitcr eher is IVH si senlig snddaet + essen p".iddoli" BNEM twiesrr aer sjut cerfu.ks hghuhh

submitted by welpdedelp(242),
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Ok, so NRA pedtnndee NDA arlopmeyse is for evesrer icrnpsrs.ea..att lgines ansrtdde + seu ANR dtpneeedn NAR .lomayerspe anC enmesoo exapni?l

hyoid  The only thing I can think of is that HIV is a (+)-sense single-stranded RNA virus that relies on an RNA dependent DNA polymerase (reverse transcriptase) to synthesize DNA. +1  
haliburton  according to [medbullets link]( ns ss RNA must carry RNA dependent RNA polymerase (so that is out). also, according to medbullets there are very few ds RNA viruses, so "most likely" will be ss. Also, RNA-dependent DNA polymerase = Reverse Transcriptase. Since HIV is a ss ps RNA virus with RT, they've described an HIV cousin. not sure beyond this. +  
some0217710  Can’t think of any retroviruses outside of HIV and HTLV and they’re both +ssRNA +1  

submitted by b1ackcoffee(59),

my problem with this, why can't it be similar to Hep B (circular DNA)? virus is new or hypothetical.

andro  Hep B - is " partially " Double stranded and not fully double stranded . Double stranded Circular does not necessarily denote Hep B even though the virus has a reverse transcriptase . I think they wanted you to pay attention to this . And besides the obvious fact that Hepatitis viruses cause inflammation of the Hepar ( liver) and not encephalon ( brain) +  

submitted by niboonsh(369),
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My gsues si htat eyht ear rngrreefi ot Rerstiruov TH(/IVH-)VL a sgnile dsardten evtiopsi esnse eanlri NA.R tiosvreuRres aer onnwk ot yrrac seeervr tanispcatesrr p-(eednnRdAetN repe.a)yA-osDNml heT aiciplnteshe si htaw wrhte em fof uzc I oamytallacuit ttouhgh of eth namy neitvega nsees RNA esivsur ttha uaces hcielteispan eil(k erarsauniv ro )abvryuisnu. lAytenparp reteh vahe been a few ecauss of VLHT gciasun .e.schleantiip. aeybm sith si awht ethy erwe yingrt ot etg ta? Idk tub i sjut nsetp way too hucm tmei no this madn soiuqtne M/s8itw/h.iswe1th8lmlov7mcwc/.n/pC//n:.7ganc.8rip5tbP

submitted by drschmoctor(106),
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RAN ddnedepe DNA mpseolyrae = rvresee patrnitecassr (F A 02 p 38, enurd e)rlmeoesa.t

nveiG the rsivu ahs versree ae,tnscrarspit it is elkyil a rotrvsurie (ervnsiaupdah salo ash eeerrsv .e)astcrarsitpn

Rrrivtesesou rae S+S NAR eus(iAsrF v 20 p 17)6

submitted by meddeku(0),
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epaseaJn inshleptaeci ruvis ccdograni to .rD geGolo b(c)ni


submitted by hipster_do(6),
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I itkhn tish wsa nifrgreer to erserev nticesatarrps, nad hte loyn otw rusiesv I kenw hatt sued hmet weer HpeB and etIoH.err/uVvssir eGivn the toectnx I dkcpie erutsVHIir/revso ciwhh era SS + .snees iThs aws kdin of erwid uthgoh cisne eth ursiv swa ”en“w ... utb evI’ aneedlr tath “wen” ylualsu sanem very leittl no ehset tsts.e

yotsubato  "New" means made up fantasyland virus +5  
yotsubato  Also Hep B is a ssDNA virus that goes to RNA, then is reverse transcribed to dsDNA +  

submitted by jcmed(19),
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sA osno as I asw icplntaihees I gthuoth fo sreiusFvlvia chwhi :ear

SS ⊕ lraien erlaahcosdI cliun:indg

wCelVYH,ol ev,efr e,guDen .tS oLuis ieentlh,pcsia West lNie svuri aka onsgeinhetlaimcenpi nad iaZk ruvsi

.p 167 tiFsr Adi 8120