NBME 20 Increased osteoclast maturation and activity (NBME Answers)

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Retired NBME 20 Answers

nbme20/Block 2/Question#7 (reveal difficulty score)
A 30-year-old man comes to the physician ...
Increased osteoclast maturation and activity 🔍 / 📺 / 🌳 / 📖
tags: endo PTH

+11 upvote downvote
submitted by cafeaulait(11)

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I lvbeeei siht smte yam eb nfnrgeiri ENM 1 nomsdrye - lsoebpsi nogrmasait ptep(ci urcle diesaes d)x, rdtayhipaor one,aamd adn attpuyiir enadoma s(ncugai A).HDIS Bu,t ouy t'nod eedn ot neev nowk ihst to etg tihs gitrh - sjut snakgi the feeftc of high HPT on hte ysmset - uescas aiedcersn tcsoloates yttviaci as elwl as taaimrt.onu

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fatboyslim ehT osmptysm fo htsi ptenita rea ude to arliaehpcmecy s(,tseon ,osbne onrg,sa NOTSERH een[darsci iss,edu}ir dna iisrcpacyth e)oso.nertv leaymaHrcicpe anc salo cuaes epitpc ucrle dsiase.e oS the rmyirap hloogyatp si iaytphardro pldnymirhaaeaaseop/ sgiuacn eht eclimpyhraeac +6

beetbox eDso ynaeon kwon w'hats up hwti eth o'n lsiairnoaebtm in ueuhmrs yXdD?'ria eyht usjt trowh thta in ofr no o?arsne I gto oheodk on t,i I hutghto ereth aws on sneradcei telocstaso ctva.iiy.t. iwsorehte teh trclicoa bsneo wdoul ehva nbee lddyo hitn or oshnetigm +4

topgunber EMN 1 - P P P . hy,atPdarior rangstspcaair(ne ni ihst )eca,s irttayiup eol.sin not yek to egsrnawni hist itupns.tq oe cemso ihtw ympsmost of hareecaclipm,y saomn, sonra,g shonret ee(ipn,g) ypchs esL norvekooot. at htp adn ucmal.ic ew see hhig ac and high .tph eW kwno atth hhgi amcucil owuld rlewo ihts.hp.t. msnae eth hhig ciaulcm wsa eud ot the high pht ei(.. ridaphaytor oQinmsuaot) nadee is auatlycl isgka:n wath era the ceteffs of ?HPT a, c, tospopie of D PTH and E i iedeevbl 'tnrea edlaetr to uos-PSdBHT n henotgsim leki teh atssihonepeg of spoueiFhatirh-md doypsyaper ew ifdlteneiy wkno taht THP sinecesar Ca , os yb rnncegiias ltassoteco t/rtioinvmuciaytaat ouy iretelba cimlcau onit teh bl.doo htis si eth sbet .resanw +3

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submitted by ∗laminin(18)

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cna seoemno panxile wyh ti syas he ahs na ''cttnia PTH soitnoe.cni.r.actn it to tle us nwok taht teh TPH teotnncacroni si a lstreu fo g?ptnahaod oyl hst'wa ihs xd? hatks!n

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yotsubato I aewrs ythe kaem up eosm of isth .tusff Leki wtsah pu with the rits,th nui,roanit dan pctpei luerc sd.saiese +9

redvelvet erhyepilacmac cna sceua opnrhneeicg atdeebis uisnpsid; so h,stirt an.untiori lyerhaemapicc anc lsao uaesc pticpe lrcue .eeisdsa iHs tomsmyps rae all uaotb lyaahprcimece edu to r.drtparsheyahypimoi +4

namira lcyc"emraHpiae nca cuesa eanlr osndcytiufn schu sa eocrhiegnnp betasied siidnsuip I),D(N tub het ehasnmmsci gynneldiru pdcndmeieruaacyic-leh IND ear ton lelw o .dorudnst"ellasn-.08f/a0t:olk0n5i///8lwet7i1wwotate29(/33gyirrh5pd.nt0rteSx4c6e)n-uit- +2

dulxy071 Wyh nt'ca teh retocrc aenswr eb )C hcihw ipsotn tawdros nerla e,lariuf hchiw aym edal to ynadecsro aihodyarmprsetpiyhr inahgv eht mase tuslers I eievlbe +2

pmofmalasia The cdaosrney harisapodyemytrphri in lrnea aeulfri si deu to lsos of maciluc ni het ticnnfoui-nnngo endk.iy nI hits qsuetino hte mclcaiu wsa le,aeetdv so you anc rlue tou alenr earluif. +1

sars ceem-prHcaaliy seusca seonst mclaiuc( )nst,soe sanorg (ainsoctont,ip) rnhtoes eadce(risn iiu,t)orann oensb seecr(ndia ostatocesl tci,)naotiva nda crspihyiact neervsoot n(i)e.srpesod +1

epiglotitties botyuosa@t sloa sa eomeons meiotnend in terahno cotem,nm i nkhti yeethr' nntgiih that the xp ithmg ahev E1NM. hriPrtadayo ei-syahlaprp amipycac,elrhe aptirityu maado-ne AHSID i(tru+no)ttaiir,hsn nad aptinracce u-mtor astmrnaoig icptpe( rluec sa)eiesd +

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submitted by killme(14)

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Teh oncetpc eginb dsteet si w"ath edso PHT do ttha ldase to recyle"amipch a3hP/bpng.sta:/eiii/jp./dVmtoKsgcb.

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yotsubato gu,h lsh.tblui I saw yrgtin to eugirf uto na atlauc eesadis peocrss e.reh +7

rio19111 tsi yamrirp irphdsaayrrthmpyioe uaedcs by aydthrrpoia n.omdaea dtdniaio of hte itcppe lceur uggstes grllonZie -t;-&g- ENM1 utb noen of thta si pim beeusca tst'ha tno awht hyet aer .aknsig lAl tehy era aingsk rof is eth icountnf of .TPH +3

topgunber MNE 1 - P P P . hP,otrradayi nargts(cnisaerap ni hist ca)se, itaypruit lnie.so otn eky ot gnnearsiw siht sttpeiqu no. mcoes hwit soptmsmy fo rhpyiecaem,alc nsmao, rn,oasg rtnehso ()eein,gp spchy Lnvorteoos. eok at thp adn mulci.ca we ese ighh ca nda ighh .pth We onwk ttha hghi mulacci owlud wloer tthip.s.h. eamns teh ghhi cumcial asw ude to hte ghhi hpt i(e.. toiyraardph set dnQnoa)omauei is ulycatal n:aisgk wtha aer hte tscfefe fo ?THP ,a c, ptpsoieo fo HPT D nad E i beedveil en'rta atrleed to uPHT Bd-Sons moteshgni elik het hnaesgeposit fo oatase-rdoiFehyphduympir ps ew ilfdenytie wonk hatt PTH saiseercn aC , so yb arginciesn soclstoate iv/aatittaoyiuncmtr uoy eeiblatr ulmiacc nito het .bolod hist is teh setb .anwres +1

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submitted by ∗sympathetikey(1600)

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In ndtiodia ot PHT = tsoetloacs avitycit = aceidnrse c,lcamui isth srpnoe uldoc saol be xtegnbhiii pssmyomt fo 1NEM.

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topgunber NEM 1 - P P P . ohaPardry,ti asrarnsgeica(pnt ni this )e,asc itpayitru slon.ie ont yke ot snaiengrw tish totsq nup.ei oecsm iwht pmtoymss of rmelhi,cpayaec san,om ar,ngso nrhoset e(eg,)npi chspy re ekovostn.oLo ta pht dna .lucmiac we ese hihg ca dna hhig tph. eW kwon htta ghih aucmlic dwoul olewr hs.t.hi.pt maesn hte high ilcamuc swa eud to the ghih pth .i.(e aythripdora )utsedonanmQeaio is laytaluc an:sigk atwh are het ectfefs fo P?HT ,a c, epsptoio fo H DTP dna E i eelvbied artne' retldea to sunTB PS-odH estighmon keil het niestaopehgs of smrayher-iidotso dpFepauhyp we ifedynitle nowk that HTP eesrnasci Ca , so yb ceninsagri oolcasttes ayurttiiinoatvcmt/a oyu aebiertl amcculi iont eht do.lob hsit si eth tbes ernsw.a +1

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submitted by rio19111(16)

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ist apmirry rsipdohrrtyhaiaympe auecds yb tirhpoyarda anaemo.d tdaiidon of the iceppt ucrle ggessut elngriloZ t--g&;- MN1E

utb onen of that is pim suecabe ttah's ont hwat eyth ear as.ignk All tyeh rae ksgnai rfo is teh tncoinfu of H.TP

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rio19111 sSoetn, a,onrsg o,strhne hcirptisyca ovteserno -;tg-&- mmotysps +1

topgunber EMN 1 - P P P . arriaPot,dhy (acsigarsetrnnpa ni shit )sa,ec uytiprita elosin. tno kye ot gsweniarn sthi qe sointut.p smoec whit ypossmmt fo eahmcyp,rcelai anos,m gsnor,a ronhset n,ieg)pe( shpcy Lnoksroo eoev.t at hpt and lauc.cim ew ees ihgh ca dna ihgh t.ph We oknw tath hihg icalmuc dowlu erlow pih.h.tst. emasn eth ihgh iamlcuc wsa deu to hte ghih pth ..i(e rtrapidyaoh s Qndutooimeanae) si acautlyl king:as what aer eht fsfceet fo PHT? a, ,c tpeposio of TD HP dan E i leebevid nare't trelead ot BP-nHsdoTu S sgehoitmn iekl het enspetishoga fo oema-hrtrud Fsdosapipieyyhp we tynieleifd owkn atth THP ceiessanr aC , so yb esnnrigcai eoacsstolt irayviumtntacta/ito yuo eiltbrae ialcmcu toni hte odl.bo hsit si the tbse swrae.n +1

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submitted by ∗nwinkelmann(366)

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Does yeonna wkno eth ngicicenifsa of eomtncoy ltmy?tioi

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submitted by arthur_albuquerque(1)

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tahW heeldp me ot aresnw tsih eon etiqu lisaey wsa eth wollgnoif oeiarl:atn

cpimlecaayerH + hhgi PTH ;&-gt ymrpair" rrsoypyiiear"hahdmtp

How od hgih HPT elad ot aei?rclycmapeh ragienIncs lsoetaostc yi!aticvt

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submitted by ∗topgunber(68)

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NEM 1 - P P P . rPtaiydo,arh rgrtnac(aensispa in ihts )se,ca tpyurtiai nleo.is nto eyk to ainnrswge itsh uti.nqoes

tp mcseo wthi ytssommp of h,ciyealrpcema a,mnos ,nrasgo nhetsro ene()gi,p pyhcs nesrv.oeot

ooLk at htp dna cauimc.l ew ees hghi ac nad ighh htp. eW wnko ttha ihhg cmiclau oldwu elwro h.t.phs.it amsne eth ighh camilcu was ude ot the hihg tph e..(i diryartopha omae)and

Qniteosu is tllacuay akn:igs hwta ear teh cfteefs of T?PH a, ,c soptepoi of THP

D and E i levideeb tnae'r deerlat to THP

oBusn-Sd msiteohng leik the toehnpassieg fo hdosameapesorydpyiuithrp

-F ew etnyedfiil wkno thta HTP sncsareie aC , os yb scniaegrin ltscotaseo tait/iaantyrtcmvoui uyo rtbaelie ualiccm iton the .oblod itsh is eth bste sawr.ne

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