NBME 20 Increased osteoclast maturation and activity (NBME Answers)

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Retired NBME 20 Answers

nbme20/Block 2/Question#7 (reveal difficulty score)
A 30-year-old man comes to the physician ...
Increased osteoclast maturation and activity 🔍 / 📺 / 🌳 / 📖
tags: endo PTH

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submitted by cafeaulait(11)

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I ilevbee ihts tmes may be girrnifne EMN 1 drsyenom - eloibssp tmoingrsaa e(tpcpi erulc sdieeas dx), yhtoaapdrir a,ndmaeo dna iyarttupi aeanmdo ncsigau( I.ASD)H uBt, ouy 'dnot eden to eenv knwo iths ot get shit grtih - jtsu gniksa eht fteefc of gihh THP no hte tsemsy - ascesu rsanceeid catostosel vtciytia as lwle as tiuanrato.m

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fatboyslim Teh omspmsyt of iths atenpti are ued to iaermcclyhpae es(o,tns b,neos asrg,no HESTRON andec[esri ssdeuri,i} nda syhipicrcta seer.ovtno) Heceilcmpayar nac osal eausc cieptp cruel .eaeidss oS eth mrairpy phaooylgt is yorhiapradt m/peapaaadnorelsiyh scuangi het crmcepiaeahyl +6

beetbox Dsoe neoyan okwn hsa'wt pu ithw eht 'on bloeiaastmnir in umhurse XyDa?i'dr they ujst rwhto ahtt in rof no ?anoesr I tgo hkooed on ti, I thohugt trhee wsa on earinceds olettcsoas yva.i.tcit. wiehorset the citloacr ebsno odluw heva ebne dydol nith ro othmnegis +4

topgunber EMN 1 - P P P . roid,thyaraP anrs(artcpiasneg ni ihst esa,c) itpryuait lines.o ton kye to iagsnerwn this ut.nposi etq seocm hiwt msptmoys of eymehcapar,cli m,sano snor,ga rethson e)gn(ei,p ycsph Lneeorto.ovko s at thp nad cmialc.u we ees ihhg ca and high hp.t eW onwk ttha hhgi aiccmul olwud loerw ..htsip.th nasme het hhig uilmcca wsa deu ot eth hhgi pth (e..i rtoahaypidr nteQmoaanuides)o si tcuaayll gasnik: thaw rea the ectffes of H?PT ,a c, soitpeop of HP TD dan E i deeevibl re'tna trleaed ot oHPTudnsB- S niegmthso kile het nagsetosiphe of prmeatdeorFou-ishsyppya hdi we fnyldeieti owkn atth PTH senascrie aC , os yb ceiasgnnir ssleooctat r/ioitcamayitttnavu uoy btilerea umalicc into hte bl.odo htsi si teh ebts nwera.s +3

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submitted by ∗laminin(18)

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nac omsnoee enaxipl hwy ti says he sah an ttc'na'i TPH nnticatni.ecr.o.os it to etl su owkn hatt the HPT nrnencaicotot is a lutesr of oothplya?angd hwtas' shi ?xd akhs!nt

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yotsubato I aesrw htey mkae up emso of tihs sufft. kiLe htwas pu htwi eth rt,hist naniituo,r nad tpicpe ucrle s.dseseia +9

redvelvet rmepcyheicaal anc eacsu ecneogrhipn beetsiad undsi;sip os r,hstti irtuonain. rlmiaaeyhccpe cna laso eusac teipcp urelc adesi.es sHi yptsmsmo era all tobau eccaymiehlpra ude ot mesdhyraipyaiorthp.r +4

namira ylmeie"caapcHr nca suaec eranl utnycdnofsi shcu as poehriengcn dbiteesa nupsidiis D)I,N( tbu eth ismsnacmhe nnuldregyi yhidcncadeerl-ipcameu IDN era ont llwe uoso.t"rdnd e3e2fs3kn/6ea/rl.halt1dnt(cwtieiat//e407r005o/9owxtn5g-i-)ily-ut0prSlt:.w88n +2

dulxy071 Why n'tca eth rcoertc sewarn eb )C chihw tposin darswot nelra fiurl,ea hchwi amy dlea ot ndrcoayse timrdryrepiahshypoa avnghi hte seam elsrtus I eeivlbe +2

pmofmalasia The ydaorescn prpyamhihtosrreayid ni alren ruaflei is deu to osls of uccilma ni het uonfiigon-ncnnt kyn.ide In sith uitosqen eth umiclca aws ,aeetveld os ouy acn elru tou alern u.irfela +1

sars ilcarypeeamHc- eacuss nostes l(cmiauc essn,o)t norgas ni,(taopion)cts nhersto dersa(ienc )ounatrii,n esnob idens(raec slsoaotect otat,iai)cvn nad apiscyicrht vsoenreot epi(.sdros)en +1

epiglotitties stbotoauy@ olas as neoosme eniodtmne ni hrtoane teomc,mn i tikhn yh'etre nnhitgi atht eth px mtghi ahve NEM1. htrayPdoiar epralaiys-hp pya,mcheilcrae tpatiryui aonmea-d DIASH nn,)+utthtiiis(roar and parceaicnt outm-r oamtgisrna t(eppci eulrc )sisedae +

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submitted by killme(14)

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Teh opccetn bgine tstdee is htwa" edso PHT do tath aldes to hi elarm"ccypeaKV/b.hgjbsmp/ts./in:/i3apiedotP.cg

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yotsubato ugh, uhb.iltls I was ygrtni to eriugf uot an cutlaa sesdiea reocpss rehe. +7

rio19111 tsi pyrirma hramyapeyisrdhproti eudacs by irayphadrto aenoa.md oadtdini of hte peipct rlceu ssgegtu nlroleiZg gt-;&-- M1NE u tb nnoe fo ahtt si mpi eabceus 'hatst ton wath tehy aer k.ngias llA teyh rea angkis orf si hte finucton of T.PH +3

topgunber MNE 1 - P P P . dPyiht,raroa srpann(arsacetgi in hsti ,)easc ruaiyptti ils.noe nto yek ot grnnwaeis hist t untoeqip.s msceo hiwt tmpmssyo of ma,aheielcpyrc so,mna osr,ang orehsnt npe()gie, sphcy e Lsvtk.nooreoo at pth and ccmiula. we ees high ca nad hghi pth. eW nowk ahtt ihgh acumlci wdluo oewlr s.i.t.thhp snaem eht ihgh mcuical wsa edu to teh hihg pth ei..( itophayrard muaetinoQdneo )sa si lalcyatu in:agks wath are teh tecseff of ?TPH ,a c, iseotppo of TPD H dna E i bevidlee ntar'e redltea ot H oBdPT-nsSu gnmeioths iekl the oneagphsties of oysphirydih- umraadFtspeope ew eeiiylfdnt onwk thta PHT cesraensi Ca , os yb esiigcrann lctosesaot oyviitatmrtaa/tcnui ouy elaibert iuccmal inot the ood.lb iths is eth esbt rn.awse +1

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submitted by ∗sympathetikey(1600)

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In dntiiado ot HPT = ottoeslsca tyvaitci = nisedcear a,mlucic hist enrops olcud laos be hnxibigeit tsmmopsy fo MEN.1

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topgunber EMN 1 - P P P . adory,ihrPta nraasnecagr(sipt in ihst eac,)s tptyiiuar osen.il otn eky to gwsnneari htis oeits. qunpt ceoms wthi ostmpsmy of cylrpaamhiee,c anms,o r,angso reotnsh npi)ge,(e cspyh .okoLsereto vno at pht dna uaiccl.m ew see hghi ca dan ihgh .pht We owkn htat ghhi ulacmic uwdol eolrw ht.psh..ti eamns hte ighh mcacilu swa ued ot hte ighh tph (ie.. irdophytara )omoaneaQs duneti is tcyaulal aik:nsg ahtw rea eth tefsfec fo T?HP a, ,c pptieoos of PHDT dna E i ieledvbe 'anter deralte ot dTBo-PsunH S etmnhgosi leki teh neoepasisgth of ip-dt pemshysprdaaueihForyo we lfeinitdey wokn ahtt PTH aceeissnr aC , so yb iicensnrga otoslceats iivtymutatartaoicn/ you bteleria luicmac iont hte lbodo. ihts is the stbe rsea.nw +1

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submitted by rio19111(16)

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tsi rmraipy dpmsyorarhtpayierhi cadeus yb rohaytairdp deaomna. odatindi fo the picpet cleur tgugses rlngoilZe gt-;--& NEM1

tub neno fo atth is imp csaebue sh'att nto ahtw ethy are n.aiksg llA heyt rae agknsi fro is eth tinncufo fo HPT.

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rio19111 eStnos, sr,goan htnrs,oe yicsaitrpch stoneorev ;g--t-& tsspommy +1

topgunber MEN 1 - P P P . ,orhatayrdPi trsnaapsng(icare in sthi ac)s,e auirttpyi slnioe. tno key to irwgsnean this iotqsneutp. coems thiw topmsmsy of pcchaieemrl,ay m,noas nso,gra tsnheor ge,)(pein schpy .otoLrese vookn ta hpt dan calcimu. we ees ghhi ac dan hgih pht. eW wnok tath gihh aicmlcu dwuol erolw .titps.hh. aemns teh high mlaiucc asw eud to the hhgi thp .(i.e raahrptyoid aemad)ntQeinu soo si lcatauly ags:ink whta ear eht fteefcs of HTP? a, c, oioptsep of HPT D nda E i vbideele r'tnae ardleet to HBuSPond-sT smegionth keli het pentegsoahis fo yrshudy paa-odsFpemtehpioir we idtiefynel wnok hatt PTH cresisaen Ca , so yb gisninarec teclsotosa atruiiacmtantiv/oyt you itleebra lcamiuc oint hte dlo.bo hist is eth etsb .nreaws +1

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submitted by ∗nwinkelmann(366)

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oesD nyeoan nkow het isciieagcfnn fo tnmocyeo mitiyol?t

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submitted by arthur_albuquerque(1)

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thWa dhpeel em ot wrenas sthi neo tiequ esyali wsa het igolflnwo :tiaolrena

laycpicraemeH + hhgi PTH &g;-t maryp"ir yhohrmasrpdtpeiryia"

Hwo do hhgi HPT edal to arhlyi?cmcpaee neinsIcrag oslostctea tcityiav!

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submitted by ∗topgunber(68)

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ENM 1 - P P P . ahyPridto,ar i(sntpsnrgraaeac ni sthi c,)eas ptrutiyai eio.lns ton key ot rigawnens shit equ.ositn

pt smceo hitw tsmpmsyo fo ,mcrelaiahcyep a,mnso anr,gso tserhon i(ee)gpn, ypchs roet.snove

okoL ta thp and .acuclmi ew ees hgih ca dan hhig hp.t eW onkw hatt hghi muiaclc owdul olwre ttpi.s.h.h emasn eht hghi uclacim saw ued ot hte ghih tph (.ie. adpyhroatir )aonmdae

isteounQ is ctualayl aikg:ns ahwt are hte ftecesf fo ?PTH ,a ,c oepisotp of TPH

D dna E i beedvlei rn'ate ertlead ot HPT

nos-BudS ogniemtsh ilke the sstpoeeniagh of hyprarpuiopyeddistsohaem

F- ew lydeiteifn oknw htat THP escnsraie aC , os by incagnesir tcosaetosl oti/imyacuatnrativt uyo tlaeirbe claumic iont the ob.ldo htis is eht tbse anwrse.

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