NBME 20 Increased osteoclast maturation and activity (NBME Answers)

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Retired NBME 20 Answers

nbme20/Block 2/Question#7 (reveal difficulty score)
A 30-year-old man comes to the physician ...
Increased osteoclast maturation and activity 🔍 / 📺 / 🌳 / 📖
tags: endo PTH

+11 upvote downvote
submitted by cafeaulait(11)

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I ebeilve this emst yam eb fnrrnigei NEM 1 mnyorsde - obspeisl mnigsaoatr te(pcpi rlecu essiade ),dx rtryaiaodph e,maando dan iytpuitar adenoam caginsu( SI.HA)D B,ut oyu 'ntod nede ot nvee wnko sthi to etg hits tgirh - tjsu niagsk the fetcfe fo ghhi THP no teh smseyt - sescua rdnseaiec claeostsot iyvctita sa wlel as tn.mitoaura

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fatboyslim Teh pmymosst of this tapetni aer due to iymepahcelarc eo,s(tsn ebns,o nags,or OHSRNTE reeas[nidc sedsi},iru dna cariitpschy toeeronvs.) ceaymrpeHclai nca aosl sceau tecppi lreuc aiessd.e So eth ipmryra aypgotlho is rdaaprhiyto emnisroyaapdahe/alp cusigan the cehapyareciml +6

beetbox Deso eayonn onwk thwa's up tiwh eth 'no lriaoeanmbsit ni suumehr aX'?yriDd eyth jsut hrwot tath ni rfo no onsera? I tog edohok no it, I hhtugot rthee saw on cdeeasrin lsaottseco y..vta.icti heetsroiw eth citocalr oebsn udwlo veah ebne dyodl inth ro tmsneogih +4

topgunber NME 1 - P P P . oPyairtdha,r nstapr(anscgerai in siht ,csae) typatiiur es.lnio tno yke ot wsianrneg isth ittseo nuq.p ceosm hiwt yssompmt of macrypchieela, m,snao gosarn, rneotsh e,)gn(ipe pcsyh ko eoe.tsroovLn at htp and umc.acil we ees ighh ac and ihhg pht. eW wkno atht hghi milucac oluwd erlow sh.ihtt..p eansm eth hihg caclmiu saw edu ot hte ihhg tph ..ie( aahpoitdryr nouitsde)mQn eaao si ltylacua kg:asin ahtw rae eth sefcfte of ?PHT a, c, sptopieo fo P DTH and E i dveebeil nta're traeled to duHs-oPS BnT gmoehinst liek eht pingtehasseo of dhmediyo oaie-ruprapsyFtshp we yflteniedi nowk ttha PTH seiaernsc aC , so yb eisnaringc asoctleots ttaiayutcoa/tvnmiir uyo eealrtbi ulmccai iton eht dloo.b thsi is the tbse rswn.ae +3

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submitted by ∗laminin(18)

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can emoeosn xeplina why ti sasy he has na ''ncitta TPH eotcntnoi..cais.rn it ot let us nkow atth eth THP nnooatercitcn is a urslet of nytaagoo? pldh wat'sh his d?x tnk!sha

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yotsubato I waesr tyeh akem pu esom of itsh usfft. iLke hwtas pu itwh eht sr,hitt ura,niotin and ppitce lurec assdse.ie +9

redvelvet ilcharecpyema acn seauc ihecongernp eaeitdsb s;npsudii so ,hitsrt nuiort.nia pyealhecaricm cna aosl uaces ceitpp lruec sei.eads Hsi spymtsom aer lal oautb pmereacycihla eud ot aaiprrymhsr.eyhptoid +4

namira mialrcaH"cypee nca saceu rlnae nsocfdyuitn uhsc sa nenephcorgi tsideeab psuindsii )DN,(I ubt eth enmssicmah ngnieruldy cepeldminacdruah-ciye IND aer ton llew ".rnosuddeto 2artttir07/:/nl.ku0wleytpf-5ttesw/4(de)n3og.l0ao-i8n96hc35-8lStir0ewxa/1n/i +2

dulxy071 Why 'ntca hte otrecrc nrewas eb )C hhiwc inpots rwtsdoa nelra iurfe,la hwich yma dlea ot eydrcanos hmepayiryhripdorast agnhvi eth mase utelssr I vlibeee +2

pmofmalasia Teh ynedarosc perphsoaamrtyyhridi in reanl flueria si edu to slos of calicmu in eth nuon-incgtnifno .nyedik nI isht suqentoi eht umcialc wsa aete,lvde so yuo acn lure uot earnl ei.uarfl +1

sars earcclH-aiymep uassec otsnse cmcliua( )sston,e gnaors naos)ocn(itp,ti tnoeshr dn(sceraie iiu,onnatr) onebs seieda(cnr stosltoeca coanvtii,)ta nda iycastpcrhi ovonsteer es(dpseron.i) +1

epiglotitties o@tabuoyst alos sa oseenom demientno in roaetnh m,neotmc i hiktn 'eethyr gthinni thta hte px hmtig heva N.E1M Prdahrtoyai e-hpylaarisp cecyiaa,rmehpl tirpiaytu eaod-amn IADHS tti,(inuhso+ni)trra dan ceactripan r-outm sirnaamotg p(petic ecrlu eisdse)a +

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submitted by killme(14)

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eTh tcconpe gneib tetdes is ah"wt odes PTH od atht edasl to repmhe"icay lcan.ihg//bpco3V/i:pagdt/Ktj.s.beisPm

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yotsubato hg,u thbillsu. I wsa rtgyni ot furgie uot na cautla aesised cpessro hr.ee +7

rio19111 ist rrpiyam iphiaoryrayprethmsd acdesu by droariyapth adonm.ae dionadti fo the itecpp ucerl tsuggse ognrlilZe --&g-;t NME1 tbu enon of atth si mip ebceusa athts' nto thwa tyhe ear asgi.nk lAl htey rae isgnka orf si hte uicfnont of H.TP +3

topgunber NEM 1 - P P P . ayirPhrdat,o erac(pnnatassgir ni ihts cea)s, rattypuii .eiosln tno yek to wrnnigesa tshi pn e.tsqutoi csmeo ihwt symmospt fo earh,ycecplmai sman,o ,orngsa srohnte npee()g,i cyshp eor.voLsko onet ta thp nad cmui.cal we ese ghhi ca dna ghih t.ph eW kwon thta ighh aliucmc wudol lrwoe .h.hstit.p aensm the ghih acmclui asw deu ot het hghi htp ei..( partayoirhd sdnomeQaoenu)ta i si caytllua kgan:is hatw aer het eteffcs fo ?PTH a, c, opsoeipt of TPD H dan E i lveibeed rt'aen eltdrae ot SoBsn-uTdP H hgnemitos klie teh aitesopesghn fo eiepp ayFdhdur-pmaooystsirh ew nlieydftie onwk atht HPT sneascrie aC , so by nnciieasrg esoctatsol a/avotiyittimcutran ouy ibetelar mccauli itno eht ol.odb tihs si het esbt aenrw.s +1

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+2 upvote downvote
submitted by ∗sympathetikey(1600)

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nI ndtiioda ot PTH = tstocolsea ytaticvi = deesnirac cium,cla this nsorpe doucl lsoa eb tnighxiebi mymtopss of .1MNE

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topgunber ENM 1 - P P P . atiaPryhd,or tscingras(narpea ni hits e,cs)a aitpyruti eo.snil ton eky ot ienwnsgra sith q.etsoipn ut esmoc whit mmosspyt fo caaehrcliye,mp anso,m rngos,a rehsnot in(e,gpe) hscyp esookrnoto.vLe ta htp and ilmcc.au we ese ghhi ac dna hgih ht.p We wonk hatt ghih amcclui uldwo lroew .ttshhi..p measn hte ihhg camculi wsa eud to the ihgh thp e.(i. otrdryihapa teQsoadann ouei)m si yulaclat ka:gsin awht ear eth festecf fo ?PHT ,a ,c etippoos of PHDT adn E i levdebei er'tna dtreeal to uTS-BoPHsnd somteinhg eilk eth asthesgeionp fo uprsmesdFpi-aoiyrhhop dtaye ew flnyieetid owkn atth HTP naisserce Ca , so by isgnneairc seooalsttc nimiyotcutit/vtraaa yuo rlaeetbi cluacmi toni teh ol.dob tsih si het ebst awse.rn +1

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submitted by rio19111(16)

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tsi yirparm hayrdistmipryepahro aecdsu yb rdhpatoyiar doe.anma doatiidn fo hte ietpcp elucr ggtseus lgnieorZl --g&t-; MNE1

tub neno of hatt si ipm cseaueb h'ttas ont whta ehyt are gaink.s lAl they era inkgsa ofr si the nitocfun of PT.H

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rio19111 no,estS nogasr, srot,neh cypcsthraii ntoorseve -&t--g; tmompssy +1

topgunber NEM 1 - P P P . drPoiyhaar,t iea(aanrrgtpscsn ni shti sac),e uayirtipt os.ieln nto yek ot ngsaewrin siht u.otneq tips somec wiht ysmspotm of rpche,elyimcaa onam,s ,gsroan senhotr n)ep,(gei syphc eLvsornto koo.e at tph nad .iccalmu we see high ca nda ihhg thp. We nwok htta ighh cmiucal uodwl reolw tp.h.t.sih asnme teh ihhg ilcuacm wsa ued to het ighh tph i(e.. horradtiyap iotmaanu on)eesQd si ylalcaut :nsagki what rae hte ftesfec fo ?THP ,a c, spooiept fo PDHT and E i leevdeib arten' elrdeat to uTsodHP- BSn ghtonsemi ikle hte pigotaesehsn of potu essrpmiahiyFpyoeradh-d ew flinteidey kown ttah HTP sieesracn aC , so yb rnigeiancs cltstaeoso antmtrviyutiao/aitc ouy brelitea cmliuca niot the oo.bld sthi is eht tebs .wesrna +1

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submitted by ∗nwinkelmann(366)

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seoD oenyna wkon eth cnsaiinfiecg of otmynoec tolii?tmy

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submitted by arthur_albuquerque(1)

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haWt lpeehd em ot wsrena hist neo uqiet eyisla wsa hte floglwoni atanelo:ir

ryiaHmeecpcla + ihgh THP -t;&g mpayi"rr yyrrhaeoippdta"ismrh

oHw od hgih HPT leda ot hearymaec?lpci rsncgeaIin lotsosacet tiv!tcayi

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submitted by ∗topgunber(68)

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EMN 1 - P P P . rPr,ahaytiod nngaaspsciearrt( in hsit )c,sae riattpiyu no.lesi tno key ot wgsarnnei sith .seiunqot

pt osemc tihw oymsmpst fo permeiclahca,y mn,sao aos,nrg estnrho gi,)e(pen pschy .tnooresve

kooL at htp dna acm.uicl we see hihg ac dna gihh htp. We nwko htat ihgh iulmcca duolw eolwr ti..tshh.p neasm the hihg accilmu asw due to the ihhg htp i(..e ihaapodryrt a)aonemd

nuetQiso si ylcaluta ksg:ani tawh rae hte etfescf of T?HP ,a ,c etppsooi of HTP

D dna E i iledeveb aetnr' rdeatle ot PTH

SnodBus- tehignmso kiel the hpaensigsoet fo pohtsihdrisyorypedmpaaeu

-F ew dfelyniiet kown hatt THP esnsercia aC , os yb iancgensir tetlaososc aitvitay/arimcnotut uyo trlebeia clcauim otin the d.oolb this si hte estb ws.eran

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