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nbme22/Block 3/Question#40 (32.8 difficulty score)
A 49-year-old man has had the gradual onset ...
Essential thrombocythemiaπŸ”,πŸ“Ί

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submitted by link981(163),
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Per tiFsr iAd 8012 pg( 12)4 &a;pm Mckre nMuaal

a) CLM is not eht newras eesucba in MLC ouy heva HIGH sWCB ma;p& aetlstleP. In hte mets ehrte si olyn hghi pett.slal )eb Is hte nearsw eabeucs in anleistsE tmomaceTbriohhy ew evah rmnalo BCsW nda RC,Bs ustj ihhg tet)lpla.cse Melodyi amiltaseap resrfe to well a ataampilse ni ydelmio clsel hhwic are ib,splhaso inolshpeoi,s )dc.te nI omeyilyaPhtc erVa ew hvea IGHH Bs,RC sWB,C nda lea)l t.etPes tvcieRea sot-rtmsoybihoc si a vledeeat taeepllt otcun taht srucoc ancredoys ot etoahnr doerdirs e:lki

ori-nChc fymlmnariaot srrdsoied ge(, redotuahmi ttiahr,ris rfmaintmoyla lbwoe s,iaesed ebt,usislrouc sosis,caorid stoolrsuiangma iwht cl-)iasuAiytnetio pg ofetiicnn


-Ionr neyieficdc



tnmoeceylpS- or smhyppsenloi

impostersyndromel1000  perfect response right here +  
paloma  Essential thrombocythemia presents with platelets > 1 million, not reactive thrombocytosis +  

submitted by lola915(39),

Just want to add that the pale, blue mottled finger is a symptom of essential thrombocythemia called erythromelalgia. Also a symptom in Polycythemia Vera but this dudes erythrocyte count is normal.

submitted by bubbles(70),
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keTa a kool ta hatt ssaeimv etaellpt ntuco -- ervo a lniilom rpe m3m! hTat usodhl iptno oyu trswaod a toleyvripaelrimfoe drirdeso of omes sotr encis ihts flale tnis' neildegb tou sa rfa as ew cna eltl rofm eth obldo lpena (hciwh dulwo tpu aivtecre yooismrtocbhst on eth dx.)d

oNw t'lse kool ta esoht scret.oryyteh mrNlao -- so it's tno iaoemyhtplcy ar,ve dna nnoriscgdei the lcka fo ioocytekul,ss abrbyolp not LMC ro emoylid talaameip.s

oS uor rwanse mstu eb liastenes yrohh!meocamtibt

submitted by haliburton(215),
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AF 02:71 tehracediraCz yb isavems oolerrtfainpi of aactyrogyeskem dan p.atleeslt mmyoSstp nileduc leegnbdi nda hss.toomrbi Bdolo saerm howss lkadmrye rnsecdaei mnureb fo taleltsep, cwihh aym be grael or wtersheoi bmyanorlal .dmefro hrgeyrlmEaoalti amy

submitted by djinn(6),

Essential thromcythemia is a neoplastic proliferation of mature myeloid cells, especially platelets.

High neutrophils and eosinophils