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NBME 22 Answers

nbme22/Block 4/Question#15 (reveal difficulty score)
A 24-year-old woman, gravida 1, para 1, comes ...
Release of stored thyroid hormone from a thyroid gland infiltrated by lymphocytes 🔍 / 📺 / 🌳 / 📖
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 +36  upvote downvote
submitted by liverdietrying(111)
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sihT eno swa a ittlel .iktcyr For ihts neo eth eky is eht low ioddinoarei .etapku hsTi atptnie has ghhi T4 dna wol HST wihch smaek seens ni a eyrhtrpyohid tpat,nei hpperas yuor sitrf gouthth is that tshi nattepi ash r’aeGsv edea.iss eowHve,r ni vrGeas’ yuro hiydtro si ngibe ttliumdase ot eakm rmoe thdyori ohmonre orfm thscacr and sa cush ludwo ehav na iscenared daieiirndoo ekaupt seuecba het ioytrdh si ignnirgb ni eht reeuqdir wo(n eibda)lrdaloe iod.ine hsiT is yhw it si tno aGsrve “(reaeles of ihrytod neoohrm rmfo a trdoyih ldteuismta yb ateioin.bds)”

So fi ist nto esavG’r wath lduco ti eb? rFo hits yduo’ evah to wonk ttah atomoh’Hsis odihyrisTit al(so wnokn sa cnroiCh Lphycticmoy diroitihTsy nda is nfeto redrfree ot sa such no rdoab amxse ot hwort yuo ff)o ash hteer spseha - rfsit heyt aer tyipe,oyhrhrd then ,yiueohdrt hten the sscacil oirhtyohdpy ttha uyo udlow peecxt tiwh olw T4 adn hihg S.TH shTi aws eht yke to tish ueq.osnti eTh renoas ofr htis is ttha tdanohiyitr rdepxesioa ieasnoditb in shtmoisao’H ceuas hte diotyhr ot saerlee lla of sit sreodt rhdioyt ehonrmo kmanig eht aintept oehtdrpiyrhy rof a sorth eopidr fo mtei. frAte siht evmaiss aereesl of hyiodtr nhormo,e het istdniaboe akme mteh nableu ot amek enw TH dna freoerhte ehyt cmboee itoeyrudh rof a trsoh irdpoe nad ethn oitrpyyohdh hcwhi ouy uolwd x!pecet encSi hety ’cnat aemk wne HT, hte ihtdyro lliw ton take up teh eondaidiiro nda treeehorf heetr liwl be lwo oriaiddione etup.ka e,nHce srae“eel of dsetor orthiyd nehomro omfr a hroidty gland ietndlfatri yb eclysym.tho”p aak ypcmyco“Lhit shta(oohim)s hiridttosi”.y

I hnikt e“rsleae of dohyirt orneohm romf a tuyomhlpmaso iyhodtr lagnd” si grerifnre ot emso ndki fo tdorhyi aencrc ni iwhch sace uyo wluod tpceex ehtm ot be cdsnibrgie a olndeu on aderdniooii .pateku

amy​Smru vdeio hree dna alos a rgaet eits ni laegenr: rhludtqe/dtp/iadoi/nd/oepetonsrmsg/hi.rynneeir/oaecc:

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aesalmon  gp 338 of AF isstl it erudn roysyptdmoihih utb it deso npretse as aneinrtts drsyrehiohiyptm trfis +9
hyperfukus  epy tath aws teh !eky erGoit is "OTH" tub eth nraiimegn nsreaw csohcie rwee isllt idnk fo elbh D wsa rsnttiigadc eht lleh tuo of em i petns os lnog to vcnocein sfemyl ot cipk C adn oevm no +3
hello  gasinPt wnsealnki'nnm mocmetn sa na daitid:on hCcoie D"" si rwngo /cb mltuo"aohspmy ohyrdit l"dgan = iampryr yrdtiho mlmyapoh tlialyy(cp NHL, ichhw si yrev rare) or atioHshs'mo orhyidt srrgenposo.i 'atsmoHiohs riothiytsdi = cylcpomhtyi iflienartt ithw ganmrile B cllse nda trHeulh clse,l hwchi pnuo ncdtnuoei nitisal,mtuo anc leda to lutmt/aanganitmoin snrfamoirattno to B elcl p.myaomhl hBot of ehste spretne twhi trympoidyoshih twhi owl T4 and ihgh HTS toppo(ies fo tihs ean)t.tpi +1
taediggity  I oluaebsylt evlo your ditigliy,nvrre@e eewhrov eth tssgihpneoae of pmpoastrut oidrhiytist si lismira ot sosa',iomHth os I itnhk isth pseonr ahs rmpptosaut rditiostiyh and rouy aoaxleintnp fo istaretnn hososictirytxo is opst o,n whcih ludow saol rocuc ni pasuptmtor tihtodiiyrs +16
pg32  I gaeer thiw g.iid@tegtya loAs otne atth wnmoe aelnyveutl coeevrr mofr posrputtam tdsyiihrtio nad ylpictaly comebe tihyeudro ag,nai cihhw doent's hnpaep whit saooHmsth'.i +
vulcania  nI FA (2901 p. 8)33 it sysa atht tidhyro is luuyasl lnrmoa eisz ni tpotusmarp dhtii,rostyi tbu teh itentap in hist tuenoqsi hda a hroiydt cw"iet eth onarml ie.z"s I gsseu at het end of eht day it dons'et mtreta cwhhi gadisnios is irhtg fro tihs tqsiuoen easuc hety htob esem to edal to eth asme otrcecr nesraw :) +2

This is definitely not Reidel's thyroiditis. I remember getting a question wrong on UW, in regard to subacute granulomatous de quervain's thyroiditis. The pathogenesis is granulomatous inflammation destroying the thyroid follicles and releasing stored T4/T3, with a LOW radioiodine uptake. I think this line is super important to get the diagnosis right. Like liverdietrying mentioned, you need to understand that in thyroiditis of basically any cause (postpartum, hashimotos, subacute), there is a release of thyroid hormones leading to a transient hyperthyroid state which then BECOMES hypothyroid later after a brief euthyroid phase. Hence the term thyroiditis, inflammation of the thyroid gland, with release of it's contents.

+/- imgdoc(183)


 +23  upvote downvote
submitted by hayayah(1212)
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ihTs is a neiaptt cesa of tmpuasrpto dyiotishrit. anC arsei up ot a raey frtea ldveyier dna has imcylyotcph rnti.talfie

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almondbreeze  AF 9120 gp 383 +1
waterloo  olhuhtAg ytrhiso sesem ot tnipo twaosrd taht, ehs hsa na erdlenag td,orhiy nad ni sutrppoatm r,sidotitiyh htiyrod alsyuul rlnamo in izes rf(om F)A. slgearrdes tereih wldou aevh loesmhtcyyp tirfig.inltna +



 +4  upvote downvote
submitted by nwinkelmann(366)
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hTe xaaentonpli by erityrvgedinli lspu eht netploixana in het crieatl edopst woelb (c/gnCw899/9isp./omw4laM/psPn4c:t6mrib/h.lc.wt.eh/vnit) ear the sb,et tsuj eend to be mcnbieod :.) Teh eldtniiafrfe idgsinosa lteba 1 (la9ict-a1ohS.=t:mi-/vn/wTpneloBn.08?4gthstm/sy/lwt/roCc9rrPbM1n-e1M9w/jcc4O.00b4Lp/tl./io6pbee) syclaeiicflp fsindiiete eht nctodnioi in hsti qeitonus as aptptsourm syio.itrtdih

eaylm,iUtlt if uyo knwo htat dtmiiyhyosrohp sha a enitstnra shipmyhteyidorr saphe u(de ot oteaniumum ecoudrtistn of hte llces whihc ylaerad had rdeerofpm HT dna os it asw eesredal uopn iudes)cnottr foeerb sroyyophthmdii ncugi(fninontno eclls os tac'n etak up )enodii dna hatt tpymdohyrhiosi si a motpclyciyh iaftrntligin rotiis,dhyti oyu iwll oknw eht anr.ews I ahd a hard imet asgdnundiernt htis ta fstir eecbsua we e/sanilgueoataedv dbaes on the sreepcne of -tTOinaP Ab, ubt teh rgnyulendi tposengaseih of teh rhdytio rneocsuidtt si dctlmaileeed- tey(p VI tpyi)etsrniesviyh ton bA imedtaed pe(ty II )siitsperyhtviyne leki agrsv.e stoHo'shima = ptmlcohycyi toanlrftinii hwit irlnegma cretens hc(iwh can fortrsnma ot B ellc p)mmyalho wthi ruethhl elslc nrk(pie otlpcmyas lcle).s

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 +1  upvote downvote
submitted by niboonsh(409)
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naC moeeosn exlapni eth nrfdficeee twebene .C rasee(el fo dretso iorthdy enmhroo rfom a dotiryh anldg trdafitilne by chpysemly)ot nda D. (alReees of hditroy reomnoh ofmr a mytaumlhpsoo hitdyro .dalng

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drdoom  bnoho@,ins nndgie a mnocetm whti a eniousqt kram iwll eakm it rpaape on teh "msceotnm nskgiee r"aswnse lsist +4
nwinkelmann  A ushloyampmto ythodir lnagd acn hreiet eb ued to mairyrp idrohyt omayhlmp ih(hwc si mostal lyasaw L,HN tub si evyr r)ear or ude to amhio'stsHo trdhioy .esnsgoroipr assot'oHihm oiisyittrdh = ocytlcihmyp felnaitrti iwht glrnamie B lclse nda threluH lc,sle wchih oupn tnnoudiec siilounta,tm can dale to t/onagtmlamiintnau arsnootamntirf to B elcl .ymalmpoh ehTes, I eevleib, duolw tlsli rnetpes whti ryop,sihoihtmdy nda thus oudwl veah lwo 4T nad ghhi HST (oioptspe fo isth ttaien.)p +1



 +0  upvote downvote
submitted by seagull(1933)
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p/.96phce/9vtgi.8wsamn/bPlmt.iw//wo9h:.t4sCMrlicc4/nn

dogrnccAi to htis pe,rap omrutapsPt hTidstiyrio espnesrt wthi -iPnTOta oniabisdte. The reswan ochiec ssue eycsotmp.lyh So htis si a ansrtetin moatioshsH iHedt.rioyhprsym oGdo ucLk with ttah !eno

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seagull  E:IDT etscyhmoyLp rae aosl trsenpe ni htsi as .elwl My bad +1



 +0  upvote downvote
submitted by hyperfukus(111)
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I nihkt ttah sicen theeyr' nskagi orf an opniexaltan fo eht 'tnetapsi ruectrn SxS hwhic swhos ttah esh's ni eth setta fo anresTtni htydei:smorHiryp chiwh si due ot :C eslaRee fo dsrtoe htrdyoi nhoemro fmor a oidyrth ldgan elnrtiifadt yb elytshocmpy

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 -1  upvote downvote
submitted by mdmikek89(6)
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ucetaubS oypmccliyht uihttosub Scrtiyaide lichptmcyoy diihsitotry is cadaeeircrhzt by dgamae to afluliolrc slcle htiw ioymtcpylch itnainrflito ibngmrlsee 'shHatosoim ttdrihyiois tdensai of ngalumaro afo.inrmot urDsg : ne-iernt,frαo iut,imlh i,maeordano e-tlikrnieu2n, oreinyts snikae s tuinotAubmimohienri dsseiea tr pmastPou orthstiidyi: tafcfse %5 fo eownm dinugr eht pptuoramst iepdro nda is 3 tsime mreo nmoocm anmgo mnoew tihw ytpe 1 ebsedtia lelium.st

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