The neoctcp si a dlncvootue ywa of ikansg fi oyu kwne how VDJ inobiaoercmnt r,kwso iwhch is atth it si yluaclta na xemeapl of anitlrge hte DAN of hte TB/ ycmlyp.thoe

outnSrhe blto eun:chteiq So nweh yeht sue a eobrp anstaig mseo ,goirne dna iugouttptn a szei fo .15 kb or 6 b,k sthi is ligltne oyu teh zesi of hte AND tfenmagr in hace llec (de’tnos amettr fi yeht sya J opbre or ntnscato noeirg r,bope ryeeht’ utsj nsygia eyehr’t giargettn smoe nedleciout csqeneue dfuon ni hte Ig s/CRTlocu etab ihnac lcsou cleepsrtvyei rfo BT/ llsce.)

I tinkh hte uoncgsfni patr ucdol be ndiwegrno hwo ouy wokn trehewh ryo’ue ayrltp thhogur enragnearmert (nerasw scioche B utrh D) or if it nsta’h oecdcrur at lal yte cr(rteoc n.ra)sew Heer, the topcecn si htat B lclse onuderg (DV)J aeanegtrerrmn in het nboe o,wmrra ielwh T lcsel od ti ni eht ,uhysmt dna it lal pahpens at noce. oS a lmpasa ellc in eht olbdo kiel in eullptiM lyeMmao owuld aevh uflyl gonndreue irtoioca,nmneb ewilh a T llec ni eht dlboo duclo terhei eb llyfu tedeudac an(d avhe neihdsfi VDJ nor)mciaeibotn or itemmaur s’nhta( rtseatd VDJ).

niSec het T ellc egen was 6 bk dan fydletenii biggre ahtn eht .15 bk eeng, eht T cell htns’a nereogdun oiinnarcmbteo .eyt

toShr es:anrw lAl seeng aer nsetrep in hbot B dan T lsecl, tbu htey earrngrae nad rssexpe oetrpescr htta rea csiicfpe to irthe aele.gni hTeri rea tdpnieedenn VDJ rgiosne for B lcle etoercpr toeainnrge nad T cell retporec ae!grinento hiTs iiwk rietalc sesdh ihtlg no :ihst

/te.htcpcsTeeiVk_iagrJ_#p:olwi/_(nst.now/eocrdrr/eoibin)lpakiiDtme

I too garcailytl mdsesi hi.t.s tub ti is lclautya os lepism tath we aer ginmiss the tfsoer uthrohg eht ester i--h elW boht B adn T csell duroegn DVJ renramgreat,en het ,V D, adn J ngees era FDNTFIERE GENES pideste egbin dozerniag dan etreroefh aciifsslde ni a irimlas haiosnf due ot heitr hsrdea nede ot neraeteg desvier rruettu.scs To amke taermst eorm infug,ncso tboh tses fo VDJ ngees rea on rmocseoomh 4.1

shTi is why het BNEM iieepfscd tath heyt aer gngagti TEH ASEM J OERNIG hhiwc is ttha fo eth B elcl erprtcoe eneg J o,ngeri otn het T lcle otpercer nege tJba-e eonigr se(e wkii arl.)ctie ehT B lecl etporrce gene is ont aeergrrdan in a T l,lec fi it ,was T csell uwodl aveh eatiiod!bsn

heT ywa I hhugtto auobt hsti uiqstnoe asw taht ni MM erthe si a NTO fo bdineiotsa gebni ,dame os eht VJD gteensm si gibne kebnro urdseac/eetgdnprlaee/r myna items adn sah bene roethdesn ot kb..15 As rof het T esCll, atht nrgeio itns’ eibng udse seinc( three si on alnloc xpiaonnes ro c)lioeetns os ’ist lsilt ogt hte lful kb6 lnhteg dn.chutueo

hiWle T lslce do seu the JVD mi,cibonenotra the T ecll eoetprcr nsaich ear dtefienrf egsen frmo the B 'elslc vheya and higtl ihcnas. inSec eyht ueds a B ecll Jige-nor orp,be het T c'elsl bnda wlli be hcum rrleag sa shit eara fo sit AND (teh B ellc eayvh or gliht nacih eegsn) heav nto bene egrdaanrre -- tnsiaed its T ecll erpeotrc gnees eavh ebne eag.draernr

oor/wnr_zete_mn/wbi2tre/stmcux/t/som_//tpe/rb12hqp.un7icl.awnns_tiiletoeaoedes_tsee_qbd:hpm4snppl