Teh noptcec is a ocouvnetdl way fo inskga if uoy nwke who VJD citemioarnonb sokrw, chiwh is ttah it si ualylact an leempxa fo glniaret the ADN fo the T/B lomyy.thecp

trSneohu tobl hnc:eueiqt So wehn yeth esu a epbor taignsa emso og,neri and gtuntouipt a iesz fo 15. kb or 6 ,bk itsh is teilgln you teh esiz of the DNA remfgant in aech cell dn(etos’ emratt if yeht ays J rebop or tntcnsao egiron ,orpeb t’ereyh sjut inyags r’eythe nttegragi esmo leneictoud nesqeuce dfoun in eht gI Rosu/TlcC teba nciha lsuoc yvstcpeeelir for TB/ ).ellsc

I kihtn eht iunfcngos atpr docul be nideogrnw who uoy nkow eethhrw ey’rou tyarlp urghhto eeatgnremarrn nrswea( hccosei B rthu D) ro fi it nsaht’ ecrorcud ta lla yet c(rroetc )en.wars H,ere the tnpcoec is ahtt B lselc duengor ()JVD rrtgeaeeannrm ni eth beno mrro,wa iehlw T llcse od ti in teh hys,mut and ti lal pnasehp at .eocn So a amslpa ellc ni eht olbod keil ni ipleutMl Mmoyela wulod ahve llfyu eodnnrueg oe,biocntmrain elhiw a T ecll ni hte oobld ulcod iehetr eb lyufl eucdeadt nd(a eavh fnisihde DVJ aniroonmetic)b ro rmtiamue ah’t(sn eatrstd VJ)D.

icneS eth T lecl neeg wsa 6 bk dan tnldfyieie iregbg atnh the 15. bk egne, hte T clel nah’st oeneunrdg iennbcomroiat ty.e

rShto :nwsare All egnse are nstpree in btho B adn T cle,ls btu ethy aareerrgn nda xpsrees rpreostec taht rea eificcsp to ehtri enelag.i iheTr are tdpnindneee DJV igeonsr rfo B elcl croeprte eenaontrgi and T clel crreteop ingea!teorn ihsT wiik aretlci esdsh ghilt no it:sh

l.p/_JepD(icVeaTdelior#oiect/kingrwmnrb/iiw_aokis/ehopcrt)st_ne.:t

I too ltalgicray mdsesi ..this btu it si atcayull os miplse tath ew rea ssiimgn eht tosfer hthroug het seert l-hi-eW hbto B nad T llcse uregndo DVJ raege,nanerrmt eht ,V ,D nda J egsen rea IERFNDETF GESEN eepdtis giben gorezndai adn teeorfhre ledciaifss in a iilsram osfnahi ued to hrtie srdahe ened to eaneterg iverdes srustruc.et oT kema tsraetm orme ,sinufngoc thbo esst fo JDV eesgn rae on rocseomhom 4.1

iThs is yhw hte BMEN edsecfiip atht etyh ear iggtnga EHT EMAS J IGROEN ihcwh is tath of the B cell eoprcret eegn J ngiroe, not hte T clel oreetpcr gnee aeJ-tb roigne (see iwki c)eairt.l The B llce orercpet neeg is not erdraaengr in a T ,lcel fi ti s,aw T lsecl oluwd evah !intieasbdo

eTh awy I ttohhgu oautb stih queiosnt was ttha ni MM reeth si a NOT of otedinbsia gbeni made, os het JVD mngsete is bgeni okrben rrl/adetpesgauener/cde nyam itmes dan sah eben derhtenos ot .5k1.b As rof the T ll,esC htta neorgi ’nist iebgn duse (neisc theer si on lnoacl xasnpinoe or cesntlio)e os ’tis still tog het lflu bk6 etglnh ehut.cudon

eihlW T lecls od esu eht VDJ ,tbanncmriooie het T llce petorcre scahin aer dntfirfee eengs mrof eth B llse'c vyahe dna lhitg i.hcnsa einSc htye esud a B lcle J-reoing or,bep teh T l'cels dbna lliw be mhuc rrlgae as hsit aare of its DAN e(th B lecl hyave or hltig ianhc s)enge veha ton been geernrdara -- diesatn tis T cell rrcotpee nseeg veah bnee erarr.aedgn

/1eeqope_ta/rirten7udmtso2hszs/otnbb_l/niwrn.c:rstdx/_n/spsiee/4pcn/al.uow_h_imbmlttwqemoeptpe2_e