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Retired NBME 22 Answers

nbme22/Block 2/Question#35 (reveal difficulty score)
A 45-year-old man with Li-Fraumeni syndrome ...
Decreased binding of RNA polymerase 🔍 / 📺 / 🌳 / 📖
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 +67  upvote downvote
submitted by ∗seagull(1933)
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iDd onyean ndee ot rdae ahtt tlsa enentsec klie 05 eitsm uabesce eth oruaht rfssuee to eus tteber ar.rmmga stuJ traf.iutrngs

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link981  Aoutrh ortanae:il tWh"a si m?rrmaga" +6
qfever  Did ayenno edra leki 50 mtsie dan itsll etg ti gro?wn ,L(OL m)e +22
drbravojose  ulcayAtl eenrv asetndudrn what the hutaro ysaing ta nya time. LLO +3
alimd  cuSh a shtyti .oteunisq Do we reayll vaeh csuh usiostqne on het aler ?xmae nI ym nioponi htey jtus orthw ujkn nqoueist ot theso enatsesmss +1
nootnootpenguinn  hO ym sogne-dos tkhan !oyu I aws os adm at eehowrv erotw hist ytthis ei!oqstun t(Go it rowgn lol) +
xmen  TYEH IGEV OMESTEMI EDIRW SNIUOEQST RUDNGI THE LREA MAXE DNA!!! T'IS XPLENRMTEAIE +


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 +12  upvote downvote
submitted by ∗hello(429)
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hTe marrgma of teh ucaatl Q was no.cunifsg

oT keam etbetr eessn, it sudohl asy "hiWch of hte giwofnllo is the sotm ylikel utelsr on hte orisptintrnac fo gnees htta iiinhbt cell visoinid adn thta incntoa teh ceussnson seunqecee ."T.A.TA

S,o eht Q si isagkn toabu the pt35 gnee dan acfielpisycl butoa eht 5t3p eegn emorprot rgieno.

Pmororte ogrenis ahve a TAAT xob oyubislv(,o ainnmeg rchi in TA- esab ap)isr. T-A abes npaigri sah 2 rdhoyneg bnds,o wichh mseka meth raesei ot eevlac &-g;t- solalw orf ADN rintnarcipsot to uccro orem isy.ael NAR loP deso iniaconrrsttp of ADN oitn RA.N

The etnire Qetms- kltas tobau hwo uremiLnFi-a is ued ot a toitmuan ni 53pt neeg, gdnelai to a alck fo mutro snsoepiuspr .itaytvci

So, if hte otpermro enogir ATTA box of het 3tp5 ngee si dt,mtaue neth hte 35tp ngee will tno egt cabnitsderr t&g-;- tish si wyh ehrte lwil be ddaeercse ARN lPo igbind.n NAR Plo lwil hvea a ecduder tibaily to ibdn tp35 tg;&-- lsse routm rrupesoss eegn rnasrttniocpi g-&-;t less utrmo urinpspesos.

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jcmed  tath duowl be relvoy easy of ehtm htgouh eye olrl +
whk123  eBst .apnnoeltiax +
fhegedus  dan enduydsl tnrygehevi esmka snsee D: haTnk oyu orf a trage nexnat!opial :) +


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 +8  upvote downvote
submitted by ∗fenestrated(32)
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roF tshi noe I thkni wath uoy had to kwon si atht Tnctiroapirsn -R&Ng;tAND-)A( si deoepmfrr yb ANR rtoy lse.pamIe saw otn AND yrmaepselo ucasebe htis neo psreletiac -N&AN()DtDg;A-

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fenestrated  etenewb ernacesdi or eeadrcdes gibidnn I cipedk aeedsdcer ucesaeb it saw a atutinom icwhh faeetcdf eth ongdhrey dobsn cihwh si who nicotesedul dinb ot haec oehrt +1
makinallkindzofgainz  stih is hwo I gto ti ihtgr +


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 +4  upvote downvote
submitted by ∗yotsubato(1208)
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p53 is tmueatd dna ncat dibn eth TATA ,box os tawh hsepapn to osrrtintnpaci of hrotiinyib ont?erspi

Is aicblsayl twah tish eusoqnit si nrytig ot as...k

So on TATA xob errtoomp &tg=; sDeecerad nigdbin fo ANR meerpsayol

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link981  uYo idsa ,it yteh era girnyt"" ot s.ka Sduloh seu ebrtet maram.rg +3
titanesxvi  Tshi si on tfsir d,ia nad sasy ttha teh oprerotm oegrni is hrwee oeelrmARpsaNy dsnib +1
nootnootpenguinn  nakHau TATANO- .o.b.x ahtnk you orf sthi !aoelnnpatix +


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 +3  upvote downvote
submitted by ∗d_holles(218)
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This si a gdoo upietrc of an empniteexr sihgnwo :stih

/1e10r.ap2owtlatfeung92is:w/rc/ct1rms6.i//wstueh/

Oeecnong umvole ,62 epgsa 2221912–2 )(0207

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 +3  upvote downvote
submitted by dantescuttlefish(7)
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hWy si thsi not cdsneerai dbningi fo NDA leopramy?se

shiT aumtiont uodhsl esuac craluell divinois ei AND nopielartic dna asecu denaseirc gnidnbi to oigirn epcitlaoinr eesquesnc ie ATAT by NAD seam.oerylp

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brise  'stI tlnikag tboau oatntusmi on eth nocirtpistrna of ngese that iibntih eth llec nisidoiv. Aols NAR oemyrepals indsb ot the oropetrm goe.nri +
nwinkelmann  ,oAls eth souqetin epicllycifas h(hogtu in a revy r,dowy nudlvoteco w)ay dseka whta teh tefcfe fo hte oitmunat on csrnpiatitnro as.w AND opl si tno sdeu ni si,apnrintortc it is dseu in tpciroian.el RAN plo si duse ni rsprncn.iioatt nI tmesr of icrasedne or rsddaceee ngnii,db gnraigni is aiprvtyl/pelioso dcehrag and rpnoiel is lrrnntao,eau/opnl so eehtr ear ewfer nnboi-dgH itses, adn suht sdeceader dnbiign fo teh ANR opl. +1
medn00b  uoCld ihts cntdevuolo suitnoqe alos ...t..a. .h..mtn.ae icesn teh eneg ot meak 5p3 si sdseme up due to het dernyogh bo,dns ANR palyemesro lwil tno eb blae to ibnd ot mkea teh RmNA ... So ehetr lliw eb cacer?n eausceB 5P3 si a murot ro.p..sesupsr eemml kwno htskan sugy +


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 +3  upvote downvote
submitted by ∗jessikasanz(9)
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lot of owrd omitv ot ask hwat" dnibs ot teh AATT xb"o

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 +0  upvote downvote
submitted by pipter(10)
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soeD aneyno avhe nay pfscieic eadi on the icenhamms fo hte p35 tiutnaom qounseti idgagnrre the TTAA oxb t(eh neo with eht legsin omani dcia soncinvoer nda eht dneterffi rodgnhye nbd?n)iog

I hecso hte cesdaeder bndgini of RAN yrpoeaemsl no het TATA cqsuenee fo eensg ttha nihiibt llec ivsndioi edbsa syloel no teh cfat ahtt 3p5 is a rmout rorpepsssu aka( tdmueta ls3;5et&sg-p itnhinoibi fo gtei;ptivd-ilsm&lionu )vni.oiissd

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joha961  rFom a amrond reppa I f,dnou l“yubargA ’ps53 omts imroaptnt tfnnucoi si to atc as a trprnisacnoti rotcfa tath lerdcyit eraltuesg aspehpr relveas nhueddr fo eht ’slcel NRA smrpeoayle II ANRP( )ir-nserIabtdcI eesn”g. oS yromlnal it rncseeais NRA opl ;indibng a tinmuota wodul dcaseree it. +1
estsosa  heT TAAT oxb si tpra fo eth moerotpr nioegr ties heewr NRA elsomparye II nda thore pctriiorntsna rocftsa nibd to D.NA A tecdef wuldo orferethe rcdeeeas nnigdib fo NAR el.ameosrpy +7
mnemonia  sAlo yuo anc eorasn ti out (I got shit rongw besuaec you veha to eb yerlla su)temoiluc iesnc we wnok thta sols of p53 = acnre.c Cecrna = ntwa emor cell dsioniiv = don’t antw iioinrhtby gene = lsse rorcsititnpan of sdai ee.ng +1


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