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NBME 22 Answers

nbme22/Block 2/Question#35 (reveal difficulty score)
A 45-year-old man with Li-Fraumeni syndrome ...
Decreased binding of RNA polymerase 🔍 / 📺 / 🌳 / 📖
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 +67  upvote downvote
submitted by ∗seagull(1933)
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dDi enynoa ende to raed tath tlsa cneesetn ielk 50 mtise eueabsc het uahort esusref to seu rtbtee .ammrrag sJtu r.rgtnusatfi

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link981  thourA lnitoaaer: ah"Wt si ra?m"ramg +6
qfever  Ddi aynone edar leki 50 tmise dan istll get it gnro?w (LL,O em) +22
drbravojose  ltAlcyau rneve netdunadsr twah hte trhoau nsiyag at ayn mie.t OLL +3
alimd  uShc a ytiths t.isueqno oD ew eylalr ehva shcu uoetqsnis no eht rela ?axem nI my noiipon ethy tsju rthwo jnku oeutqnis ot stoeh atnmsseess +1
nootnootpenguinn  Oh ym sdeo-osng nkaht yo!u I swa so mda at verohwe ewrto hsit syttih nosuie!tq Gt(o ti wrgno llo) +
xmen  TYEH IGEV IEOMEMTS IRWED NSIQSUEOT NDUGRI HET ERLA MXEA !NAD!! 'STI RENIEAPXMELT +



 +12  upvote downvote
submitted by ∗hello(429)
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hTe mgarmra of hte lucaat Q wsa inncgsou.f

To mkae reetbt ne,ess it olsudh asy Whcih" of eht nwglliofo si hte osmt ylleik lruest on het itcnnpatrosir fo nsege thta hiibnit ecll odnsviii nda atht cotnain eht ncnsesuso eesequnec "A.T.TA.

So, eht Q is ngisak utboa the t53p nege nad elicpciafyls ouabt the p53t nege peormrot gioren.

romeProt niersgo haev a ATAT xbo yuolovsib,( iemangn hicr in TA- seba irpsa.) -TA abse ripigna ahs 2 hyogrdne s,bndo hiwhc samek hetm irseea to eclaev -t;&-g salwol for ADN iottrispracnn to rcocu omer ei.ayls ARN lPo eods tcrniitrsonap of ADN onit NAR.

heT eienrt Q-mset slatk ubato hwo i-FnmLueria is ude to a ttmonaui ni t3p5 eneg, alniedg ot a alck of otmru uinspsorpes .ttiacvyi

,oS fi teh orormept ngeior TAAT obx of teh t35p egne si eum,ttad thne hte t5p3 neeg llwi ont etg aridtsbnecr g-&-t; ihst si ywh eterh wlil eb adeseedcr RNA olP ii.nndgb RAN lPo lwil vhea a deducre iyiblta ot bndi p5t3 ;g&-t- sels tourm psussrroe egne nrtaciiosptnr &--g;t slse tmoru uiprpne.soss

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jcmed  taht lowud be lerovy yesa fo mthe tuoghh yee rlol +
whk123  tesB axalentpo.in +
fhegedus  adn sdneydul vtrenegyih mkeas esnes D: aThkn oyu orf a tagre nioxpaltae!n ): +



 +8  upvote downvote
submitted by ∗fenestrated(32)
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Fro isth one I nikth tahw oyu hda ot nokw is ttha oniprtscTianr )(;NNg-A-DRt&A is pdrefrmoe yb NAR .omIrtslpea ey saw not ADN ealemsryop euebasc htsi eon srpieceatl &N-AD;g(A)DN-t

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fenestrated  between sercniaed ro recdesade nnigidb I ikcedp dedrcseea scubaee ti saw a outtimna whhic daetceff het gyhrnoed odsbn ichhw si hwo tdceileuosn ndib to cahe rteho +1
makinallkindzofgainz  hits si owh I tog ti trihg +



 +4  upvote downvote
submitted by ∗yotsubato(1208)
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p35 is atmtdue adn ncta nibd the TATA xo,b os hatw nphepsa to risrcoainnptt fo tyroiiibnh pinort?es

Is cblylaisa ahwt tsih utseqoni si ingtyr to ka...s

oS on TTAA oxb eoprmrot =&tg; csedeDare gibidnn fo RNA rlaemyosep

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link981  Yuo adis it, yhte ear "gintyr" ot .ask luhdSo seu brttee gmarr.ma +3
titanesxvi  hsTi is no rifts dai, nad syas htat the pmtoeorr ieongr is erwhe malersAoNRyep sbnid +1
nootnootpenguinn  aknuHa T-NOATA x.ob.. hantk you fro iths txnaloieap!n +



 +3  upvote downvote
submitted by ∗d_holles(218)
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Tish is a odgo tcirepu fo na eixenmetrp hoinwsg i:ths

u96pliw//ete/tg/sare0t2//owcrs2ta.rhsuf:nmc1i1.w1

ogenneOc lvumeo 62, espga 2222–2911 0720)(

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 +3  upvote downvote
submitted by dantescuttlefish(7)
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Wyh si siht ton sienecard nidnbgi fo DAN pseoyelrm?a

ihTs attominu ulsdoh euasc ulecrlal iidvions ie NDA oapleicintr nad eacus rdeaiscen inidbng ot ingiro oilpenriact eeeunssqc ei ATTA yb ADN osm.leyerap

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brise  I'ts kailgnt tobau untmotisa no the rtnrnstpaioic fo negse ttah ibtnhii eth llce siivo.ind slAo ANR lysrmepeoa sbidn ot eth reormpto e.ingro +
nwinkelmann  s,Aol the nuosietq ifslcaecyipl (guhoth in a rvey odw,ry loovecndut w)ya dksae what eth efefct fo hte itatuonm no ionpsartnrict s.aw DAN opl is otn dues in ,nsnictrtporai ti is edsu ni rnciaeoipt.l RAN opl is sdue ni optans.rintcir In remst of renecsiad or reddcseea nbidig,n rniaggni si o/pilvaosyreptil ahrgcde adn inpeolr is lraa/oolneu,npnrt so tehre rae ewref oHndb-ign tseis, and tshu cdsadreee ingnbdi of the RAN o.lp +1
medn00b  dloCu thsi ledcovtnuo usnqteio laos mt..aeha...n....t. ecnis teh neeg to akme 53p si mesesd up eud to teh odynhrge dsb,no ARN pomeserayl will ton eb lbea to bdin ot eamk eth RmNA ... So tehre llwi be e?rcanc ucsBeae 3P5 is a truom ssu.pe.p.rsor mlmee nokw ankhst ugys +



 +3  upvote downvote
submitted by ∗jessikasanz(9)
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lto fo rdow toimv ot ask wah"t ibdns to het ATAT o"xb

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 +0  upvote downvote
submitted by pipter(10)
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Dseo ynonae vahe ayn epscfiic aied no teh ahicnmesm fo eht p53 mitnotau tionesuq nirragedg hte TAAT xbo he(t oen thwi the giesnl onima dcia ionrnvscoe nad hte inedftefr eyrnghod ?nng)idob

I hoces the edrcdesea iingndb of ARN syrepolame on teh TTAA eeeunqsc fo segne tath inbhtii lcle dnvosiii deabs soleyl no hte fcat htta p53 is a mrotu ouprrssesp aak( deatutm s;g5&3-epstl otibniniih fo tsdemti;liigplon-&viu oidsii)nvs.

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joha961  oFrm a danorm pepra I ud,onf aygulArb“ 5’3ps mtso ptrtnmioa onunicft si to cat sa a tsoninaptrrci cftrao htat reycditl ltersgeau phpersa eerlasv rdudhne of the lecs’l ANR ryeeamspol II (NRAP rctebiIn)rdIsa- gnse”.e So oanlylrm it raceienss RAN pol ;bnidgin a tountiam wuodl saeedrec .it +1
estsosa  Teh TTAA obx is aprt fo eth roemprot inergo site hwree RAN pelsameyro II nad tehro trrtoinscapni roftcsa nbdi to A.DN A tfcede duolw eofterreh esaecerd dinngbi of NRA ayeoprl.mes +7
mnemonia  losA yuo cna anseor ti uot (I otg stih gownr caseube uyo avhe ot be ryleal eoultics)um sicne we onwk that slos of p53 = nc.ecra necCra = twan reom lcle idsioinv = don’t tnwa norihbtiiy eeng = elss rnaritciptnso of dasi ng.ee +1



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