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Retired NBME 22 Answers

nbme22/Block 2/Question#35 (reveal difficulty score)
A 45-year-old man with Li-Fraumeni syndrome ...
Decreased binding of RNA polymerase 🔍 / 📺 / 🌳 / 📖
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 +67  upvote downvote
submitted by ∗seagull(1933)
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Did yenano eden to arde ttah salt eteecnns ilek 05 esitm bsucaee eth ahrotu ueerfss to ues tbeert marm.gra uJst risgtntrfau.

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link981  Atuohr tel:riaaon at"Wh is rgrm"m?aa +6
qfever  Did noeyna rdae ikel 05 mtesi nda lilts teg ti ?gnwor ,LO(L m)e +22
drbravojose  actyAull evern aduntenrsd awth hte athuor igansy ta nya .mtie OLL +3
alimd  huSc a htsity enqt.isuo Do ew llarye vhea hcus otqssuine on the elra ?mxae nI ym ipnnioo yeth jtus owrht jukn otisqneu ot oesht enmatsesss +1
nootnootpenguinn  Oh my oosgdn-se athnk y!ou I asw so mda ta eorvehw otrew shit hytsti on!eistuq otG( ti nwgor l)lo +
xmen  HTYE GIEV EOSTIMEM DERIW ITSSENQUO IRGNUD ETH ELRA AEXM D! AN!! STI' EMLAEXITPNRE +


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 +12  upvote downvote
submitted by ∗hello(429)
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eTh rmmraag fo het taaluc Q asw gonsfncu.i

To kmea rbeett ess,ne it usodhl say "cihWh of eht ioolglnwf is hte tsmo yiklel retsul no the tapcriitrnnos of enges that iiihntb ecll isvnoidi dna hatt onactni the unosesnsc eqcseneeu ".AT.AT.

oS, het Q is ansikg tuoba het t3p5 enge dna fsypacieicll taobu eth t3p5 eegn otpomrre nerigo.

rrtoemPo ogseirn eahv a TATA xbo ubylov,s(oi ngainem rich ni T-A aesb ira)ps. A-T abes iiapngr has 2 ndygeorh bdsn,o hchwi mesak them eieasr to eecvla g--&t; lwolsa for ADN ontrntrasicpi to crouc mero lsy.eia ANR loP oeds tporirnisantc fo NAD iont .NRA

hTe ieenrt t-Qems alskt utoba how irFmianL-eu is edu to a maottinu ni 5t3p geen, dgeinal to a aclk of mourt resisosppun tat.iyvci

,So fi hte epmtoror ioengr AATT oxb fo eht 5pt3 gnee si me,taudt ehtn hte p3t5 egne lilw not gte tnidascrerb t-&;g- hsit is yhw ehter llwi be cseedadre NAR loP bnidi.gn ARN Pol lwil haev a ddueecr iailtby to dnbi 3t5p >--; slse tmoru prsersous eegn rcttansnriiop -tg-&; ssle mtuor orsnup.piess

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jcmed  htat oudlw be yvelro syea of emht hhtgou eey lorl +
whk123  teBs o.enlanptxia +
fhegedus  adn ensdydlu itvnhygree eamsk nsese D: naThk ouy ofr a aegrt ipaonet!lnax :) +


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 +8  upvote downvote
submitted by ∗fenestrated(32)
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roF htsi oen I nhikt hawt uoy dha ot nkwo si tath anpiinrscortT g)D;AR(&tNAN-- si fmrdeepor by RAN oIemtyresl .pa wsa nto DNA eraespylom suceabe htsi one lpearistec NA(-);NDADt-&g

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fenestrated  eenbewt eracsedin or cerddeaes iigndbn I ecikdp dedeacser esbaeuc it wsa a inotuatm hiwch ecafdfte het ygohendr nsodb hiwch is woh esudcetlnio nbdi ot chea hreto +1
makinallkindzofgainz  siht is ohw I gto it ghirt +


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 +4  upvote downvote
submitted by ∗yotsubato(1208)
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p53 is uattedm nad nact dbin hte TATA obx, os hawt hsnappe to snanroiipctrt of ihnotbriiy pesinotr?

Is callabsiy atwh htsi osueiqnt si itryng to s.k.a.

So on AATT oxb roroetmp ;tg&= daeeDrsce bigndni of NAR lpasmyeeor

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link981  uoY iasd ,it etyh era y"i"tnrg ot k.as udSlho eus ttbere mrga.rma +3
titanesxvi  hsTi is no rtfsi i,ad dna syas htat het pormteor gnorie is hweer lsoNayReemArp snbdi +1
nootnootpenguinn  ankuaH AT-OTNA .b..ox nkaht ouy rof isht ointlaa!enpx +


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 +3  upvote downvote
submitted by ∗d_holles(218)
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siTh is a good pricute of na xteeinprem winsogh h:tsi

fm0/o1i1iusarp9/ae.n/1wg2/.r/wl6et:c2wstrucsh/ett

ocnOeneg oemluv 26, epgas 221–92212 (0)072

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 +3  upvote downvote
submitted by dantescuttlefish(7)
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Wyh is this otn nisaecdre dbiignn of DNA yesm?epolra

iTsh nottmuai husdlo caeus lulrelac oiiisvnd ei NAD ailretcinpo adn aeusc neradesci diinngb ot rongii elnrpcoaiit cnseueseq ei ATAT by AND erm.lasyope

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brise  tI's ltgaink obaut sttuonami no eth potrsciarnint fo engse that tniihib het lcel iidns.ivo Aosl ANR eloesprmya idnbs ot eth mootrepr nir.ego +
nwinkelmann  l,soA eth eotqsuin ialypsfcelic ut(ghho in a evry d,ryow veouncdtlo yw)a kedsa thwa het tfecfe of the tnomutia on ntsptrnicraoi wa.s AND pol si ont seud in ar,tinsincprto it is udse in i.taiorpelnc RAN lpo si udse in ato.irpctnrnis In merts fo esnariedc ro ddaseeerc ngb,dnii iainggnr is sopopyei/ltvirla gceadrh and lirpnoe si aonarnunlro,/tpel so terhe ear ewefr gH-ndboin ssit,e dan tsuh eaededscr inngdib fo eht ARN .lop +1
medn00b  oCudl thsi lecvoudtno enqtsiuo slao a....n.t .h..a.etm. enisc het neeg to meak p53 si deessm pu deu ot hte denrhgyo obd,ns NRA rampleeyso lilw ton eb beal to ndbi ot mkea teh NAmR ... oS ehert liwl eb ?nrecac eaeBusc 5P3 is a ortum pussr.opr..es meelm owkn kshtna ugsy +


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 +3  upvote downvote
submitted by ∗jessikasanz(9)
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tol fo wodr ovtmi to ksa hawt" dbsni to the TAAT "box

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 +0  upvote downvote
submitted by pipter(10)
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eDso nonaye vaeh yna cciisefp edia on eht scnemmiha fo eht p35 nuatitmo nqtsioue rgredniga eth ATAT xbo the( noe with eth gniesl iamon diac ronosnevci adn the ienrtdffe ynrhdego )i?gnbodn

I secho eht caderedes dbngini fo RNA lysmeeropa on eht ATTA qseecneu of sngee ttah nthiiib cell nosiiidv sdaeb yeolls no eth cfta atth 53p si a oumtr purossepsr ak(a mtdtuea ;lssgep-5&3t niihitibno of gipeidll&in-;uttoimsv si.svnodii)

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joha961  mrFo a rmnaod eappr I u,fdno Abarguly“ ’sp53 ostm ntirmpota nounicft is to cat as a ipcsorantnrti octfar atht dleyrict eulsgetar spephra esvarle udhnerd of hte l’slce RNA yspaemorel II NPR(A derIsncIb)rta-i sne.ge” oS mlornyal ti reeasnsic NRA plo dgnibin; a tnutomia dwuol eaercsed .ti +1
estsosa  heT ATAT xbo is arpt of eht roemrotp iegron teis ewreh ANR rslyaoempe II adn ertho iprnttnocairs rsaocft dnbi ot N.DA A teecfd wdoul feteoehrr desereac igindbn of NAR mproe.alesy +7
mnemonia  losA ouy nac nsaore ti out (I tgo hsit nrgow aecsebu ouy vhea to eb yrella e)tosuicmlu censi we wnok htta sols fo p35 = anc.rce Ceancr = wtna roem lecl ioinisdv = no’dt atwn itbnhoriiy egen = essl nrtiiosparntc of sida .geen +1


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