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Welcome to pipter’s page.
Contributor score: 9

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 +0  (nbme22#35)
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joha961  From a random paper I found, “Arguably p53’s most important function is to act as a transcription factor that directly regulates perhaps several hundred of the cell’s RNA polymerase II (RNAP II)-transcribed genes.” So normally it increases RNA pol binding; a mutation would decrease it. +1
estsosa  The TATA box is part of the promoter region site where RNA polymerase II and other transcription factors bind to DNA. A defect would therefore decrease binding of RNA polymerase. +6
mnemonia  Also you can reason it out (I got this wrong because you have to be really meticulous) since we know that loss of p53 = cancer. Cancer = want more cell division = don’t want inhibitory gene = less transcription of said gene. +1

Subcomments ...

submitted by medstudied(1),
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aCn mooeesn lpeesa eaxlnip hyw hte eanwsr to sith si yjunri to eht proseriot rcdo erhtar ahnt teh ldiraa ?enrve

pipter  because raising the arm above the shoulder suggests abduction which would mean the axillary nerve is also involved. the lesion would be more proximal. +7  
kchakhabar  I thought "up to the shoulder" is done by deltoid muscle (aka axillary nerve) and above is done by trapezius. +4  
forerofore  as far as i can find, abduction ranges of motion, per first aid are: 0-15° = supraspinatus 15-90° = Deltoid 90° = trapezius 100° (over the head) = serratus anterior in this question, they are directly telling you its not the serratus (long thoracic), because no option compromises it. Also, trapezius is innervated by cranial nerve XI, which is not a part of the brachial plexus, so, even though its worded weirdly, you can assume they are talking about deltoid disfunction. so deltoid disfunction (axillary) + radial disfunction = posterior cord +3  

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anisegmnimo utnoc sa cgenannhi s?losnei ihts( cmneomt eedns to be remo hnat 05 htcrarseca pyeapr.tna)l

goldenwakosu  I think it’s because meningiomas are able to calcify (aka sometimes they have psamomma bodies). I got this question wrong too but I totally did not completely register that the tumor was in the dura (interhemispheric fissure + central sulcus). Hope that helps! +2  
pipter  the only reason I got this right was because they described the tumour as being near the falx cerebri. +2  
fcambridge  Other hints include being described as round and seen in a female. Both indicative of Meningioma +15  
niboonsh  also meningiomas typically present with seizures or focal neurological signs +  
suckitnbme  I thought enhancing meant it uptakes contrast. Meningiomas are commonly enhancing lesions per Radiopaedia. +