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NBME 22 Answers

nbme22/Block 3/Question#37 (19.7 difficulty score)
A 35-year-old man with bronchial asthma ...
Increase in cAMPπŸ”,πŸ“Ί

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submitted by mcl(601),
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a2eBt- reoscretp aer pcuolde ot Gs ,ptsinoer which taetcavi edynlaly ycslace dna eeianrcs PcMA. ciyCcl PMA tneh erassceni aycttvii of ntierop aiekns ,A hiwhc htlshepsyoorap nosiym thgli ihacn inakes, lttiymueal terluigsn ni ohstmo seclmu xoeanral.ti tAbl,louer a B2 tsan,iog si teeferhor ulsfue in rantetgi hscpm.bnorosa

impostersyndromel1000  are you able to clarify that phosphorylated myosin light chain kinase from cAMP/PKA and dephosphorylated myosin light chain from cGMP both cause smooth muscle relaxation? saw this on another Q with the nitrates causing headache so now im confused +  
dubywow  @impostersyndromel1000: Here is an image that summarizes cAMP and cGMP actions in smooth muscle cell very will. Hope it helps. link +2  
iwannabeadoctor2  cGMP is the use of Nitrates for endothelial vasodilation; B2 is a different action, similar end result. See this diagram for the adrenergic receptor actions. +  
castlblack  cAMP INHIBITS myosin light chain kinase causing relaxation according to FA 2020 pg. 317 +3