NBME 22 Answers : Block 3 : #37 = A 35-year-old man with bronchial asthma ...

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submitted by mcl(501),

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impostersyndromel1000 are you able to clarify that phosphorylated myosin light chain kinase from cAMP/PKA and dephosphorylated myosin light chain from cGMP both cause smooth muscle relaxation? saw this on another Q with the nitrates causing headache so now im confused +

dubywow @impostersyndromel1000: Here is an image that summarizes cAMP and cGMP actions in smooth muscle cell very will. Hope it helps. link +

iwannabeadoctor2 cGMP is the use of Nitrates for endothelial vasodilation; B2 is a different action, similar end result. See this diagram for the adrenergic receptor actions. https://s3.amazonaws.com/classconnection/769/flashcards/5928769/png/screen_shot_2014-11-04_at_92935_am-1497B7358A4552ACB39.png +

castlblack cAMP INHIBITS myosin light chain kinase causing relaxation according to FA 2020 pg. 317 +2