Alkylating agents (merchlorethamine) (the other drugs listed are microtubule inhibitors) increase the risk of AML.
Procarbazine side effect is leukemia. FA 2018 page 428
AML is an aggressive malignancy of myeloid cells and commoniy presents in adults with pancytopenia and circulating blasts on peripheral smear.
Gingival hypertrophy is not an uncommon finding and represents infiltration of the gingiva by malignant cells.
Depending upon the types of mutations present, patients are divided into good, intermediate, or poor risk subcategories. Those with poor risk disease invariably go on to stem ceil transplant after induction and consolidation chemotherapy.
submitted by โd_holles(218)
Goljan stresses the Boards giving the leukemia questions away based on the age given in the question stems.
ALL = 0-14
AML = 15-39; 40-59
CLL = 60+
CML = 40-59
https://forums.studentdoctor.net/threads/goljan-on-leukemias.303605/