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Additionally, AML is the only answer choice that has multiple blast forms (myeloblasts, promyelocytes, etc.). ALL is characterized by a single blast form (lymphoblasts).
CML has blasts too but they tend to favor mature forms.
You see numerous blast forms == AML, which is characterized by >20% blasts
The answer choices are all of lymphoid origin except for AML and Hodgkin Disease. We know Hodgkin Disease is a lymphoma (not leukemia) and would present with lymphadenoapthy. So the answer must be AML #testtakingstrategies
@atstillisafraud thanks for mentioning the merchlorethamine increasing risk for AML, i was trying to make a connection with the drugs but couldnt. Had to lean on the test taking skills just like key company
Procarbazine is alkylating as well.
@keycompany how did you know the phrase "multiple blast forms" meant literally different types of blasts and not just many blast cells were seen?
@keycompany, how did you know it had to be of myeloid origin?
I think they are talking about the GHRH receptor on somatotrophs, which works through the cAMP pathway.
I don’t know how it relates to GH/IGF-1 in particular, but the question said there was a mutation in the alpha subunit of Gs, which activates adenylyl cyclase.
I agree the patient does have Acromegaly, but in the question it talked about how the patient had a mutation that prevented the GTPase activity of Gas. So Gs would be overactive --> excess adenylyl cyclase
ugh i was so excited too bc i thought i remembered jak stat epicfail