,So rfo smeo ,earosn noiutraernsrtmets si igetosmnh ve'I LAYAWS ruedglstg w.iht.. lbpaobry sebeuac I watns' uthtga ti lewl so erven raylle elaendr ,ti tujs lndreae ugenho fro arhewevt x.ame I usjt unodf hsti boo hroghut BCIN and tis ASTI!NAFCT tI's ofmr 0210 so mhigt eb l,do ubt it swa r.tgea oYu acn hraecs othgrhu het okbo dna ifdn eht echstap.r I petytr umch ustj entw huohrtg all of het uetitaorrmntnsre c.tpaerh .Nvslww/w/so/0KghBiicb/h1pktmbt.o:97nn9.o/.n

yM imna tyGkeaaltae:am tuwas- = rmoaj raitextcyo rrr.nseaoemtinttu Two eytsp of ee)rc:t rpo1s aetibcom,rtop msto fo hwihc are etnpypscair Gi icwhh dales to rsaddeece MADN prcrteeo vycittia dna sirk fo y,ctcoxiieixitto or asisptyptnoc qG cpteesror atth adle to rcaesnei aN,+ +,K and eaesdrdce gmluateat uasesc oepnlztridaaio dan erdnsecai +M+g deceitslanpm and DNMA ceerotpr ivtcatiy nad ikrs fo txoxt,itocyecii adn )2 iotciprono nchealns lgcdiuinn NMAD dan /neiAaaPtAMk ,alsehcnn ichwh lla owlal oecifcnnpsi nitoca ,ixufnl but olyn MNDA llowas Ca++ nlxfui (dan oyln ni a atlvgoe pentdened nremna retfa ifefsuinct rzoineatoialpd has sldpidcea eht ihoirtibn g++M nio in the ).achneln

BAGA dna yleincg = hibyiionrt nrersotinsr.teumat 1) -ABAAG and B-ACAG = toripnicoo ncahelsn htta dale ot eufxl fo -,Cl adn setdiep shti giacsun ezrpilodia,onta the onrnue lstil ssaty boewl tirngse eapnio.ttl AGBAA- nidnbgi ites for riurbab,teats dressot,i A,GAB nda ocrntipixo = ednisi eopr fo n.clehan AGA-AB nibidng ites of eionnedzsepbazi = sidoeut of eorp of nne.lhca ) 2 lycGien acnelnh is a vrye riilmsa lC- ufxel hcnle.an )3 B-AGAB si a tmooctpiebra nlehanc hatt atcaevtis Gi adigeln ot dsdceeaer cMPA iwhhc atestvcai fxflue K+ nhlcanse and tniisbhi Ca++ uxilfn escnnhla dgealin ot .razipaiheolroyntp

Begoinic nemasi = hesimalotancec naeodpmi nnro(tiooiacd of obdy veome,mtn ,arrdwe tni,tvmaioo ,trm)neifencreo oniehrpnperine leep(,s fskeslnu,wea oet,intant ndgeife ,hovreabi ipeerheipnn swt(eol aetnoortnncci ni C,SN) lpus roninoets s,l(epe sunaeklfs,we ,snreodepsi ,tienyax aae)uns nad taeishnim a(r,luoas tio,aenntt regl,ayl tesusi da,eamg nad amy lnenuceif bodlo anirb .o)lwf Osyiuvobl, lla of isth si in dnoidtia to eredigancr iuaotnsmeosinrsrn nad hlf,tgi htf,irg and fghit .peosnesr

TAP dan rtheo srniupe = aretyxiotc ssomsnran,iti ceealsder-o htiw rohet llm-usocealelm rtsentiensrrtma.uo eiAnodnes t'nsi lssiaaclylc icosdedern a rntoimusneretart uebceas it 'inst edrtsles/doreea ni a++C eendtpdne nren,am tub evdride ofmr PAT ebrfoe nagivh na atryxicoet paot.lient

eAiclcyteohln = ojrma rtnrsnitrtmeaueo nvvodlie in suranmsneiroostin vai suacmirn adn iicncoint sotecprer.

eePtdip ntrneeorasirtstmu = myconlom lrseeead sa pediroppet reralg rosspuercr atht are cvdelea yb csciipef ezymsen atth reew ni eth saem mtrrstnaeroietun leievcs noup sereea.l Fvei tyspe = tg/arubni pd,eepits iopoid eds,ppeit yiputtria pp,sidte ihaamtloyhcp eairsglne no,oermsh nda oseth ton sialscf.ide Esaexmpl = sropruerc ahtt sigev srei ot neabtcsus P osppch,aumpi( oexe,nortc adn GTI and leeedasr mfro lsaml teaedmir SNP C eifsrb htta strmnita pian nad earpteumtre oafimotinnr, plurowef ehnse,viotyp dbniheiit by piidoo ip)e,setdp irnnikoeun ,A puteienpeodr K, dan reepdnteopiu agm,am nad iooidp tdseppie cnulgidni alntp ilaslokda keli( em,)ionphr cntshiyet opdoii ivrisetdeva, and hs,nrienopd phyos,dnirn dna nehis.lknepa In ergaeln ooiidp spdeptei ear snteepsadsr i(.e. gaenasila )i,esmhacmn vvnioeld in xecomlp iaehvbosr ulsxa(e ,attonrctia mggieeiusrs/veasvbssi hiv,)raoseb dna mtecpidali t(gouhh otn d)iteivfein ni ypicacisrth edrssidor.

vl,erOla mrnseteitotsrruna = tepy se:ytp colmuemelasll- tneasrrtsimt nad dspeeoiruenp,t wrehe lmesleaus-lolmc aetismrsnrtt era eftrsa adn aeeidtm apdir acpyistn siiomntrssan e.(.i nngodera SSN gihhrfftgtg/il/hfti ciukq p,rsnoee)s ehrew sa penrsoitdeepu lgn(ao thwi cbioiolg niaems dna soem slmal clueomle tenirtsta)rsm aer swoelr nda tedimae gald,rua nogpdorle rismriuonotsen.nas

mSoe setu:ircp imsmap_rh.uwftdttomvwpe/.vnpouekere:isw.on_ceita/drko/bretap_heht/nstuludn/ier, eag2n0oeiap2fa6e4trBdn/sp2or/iecP1ua0rcAd6.g63a0mcgs/lb-i1rhTdf-hrer:lpe-w/4h.dtr4u3tfB-5srsr1bct-e1f-0/7aptues9eRGe/w8ei/o-il3ta-sno1i3bp0bgAg68aw, adn w7/3ihar0pfd./g-fsee5wst9emlbibeh6sufgaegU5at/ld_/l&i-aaa-r2.ao8d-31epl=-rex--nhnf/=-nt.1wtb/eb6dg1tea1:#x0g2c4iw;db

gohuT tqeoun.is

ceRlal ahtt eeainnmtM zeih('rlasme rd)ug si a DNMA coperetR antiostAgn thta lesph tveprne xcoticteoixty by oikgBncl +2Ca rtnye. saht'T hwo I mebreerm .itsh

• A) AB-AAG rotpresec lte l-C in
• B) nGycile si sdeu ni teh nsipal rdco sa na hniyoibrti rstetto;urmianern aosl lets Cl- in
• C dna E) aotetorpcibM auetaglmt esrrcoept rea eropGitn- oeuclpd
• eeh,rrTeof teh lony hgint hatt lduco elt 2+Ca in si ADMN srpreteoc

DAMN eoprsrtec in this saec era nigbe sdeu rfo lngo rtem iitoonanetpt ihiwnt het nibar nda otu of all of rteeh schoeic noyl sith eorctrpe usse Ca+

uYo anc asnerw yb eossrpc of mli.neoitnia ipeim"tvoteC nitet"csianor mskea uoy tikhn tomyiutrlas .TN roCss otu GABA dna ny.gilce In eth texorc os uamglat.te abiepttrMcoo wuldo emna 'shtree ceonsd esmenergss ldvvieon dan teh rpoecter uwold nto tismtnra icmu.acl eencH D.AMN

sdeu ni onlg remt aienpitntoot ,gn(lgaaue )yomme,r Mya sloa alyp a eolr in gnee nstpnroicrita in reounsn

1) MNAD si a uteamtGla etrpecor tys)e2p ub AAMP is a ysebtup fo AMND htat is iailniylt dactvtiea yb eagltutam sr )el3aee AMDN posreetrc ear dufno rnae APMA portesecr tub ear otn cdvataeti yb owl llvsee of eagalumtt reelase ued to a Mg oni libokgn’‘c hte ln) aen4ch trnueFeq ctiAno lneipoatt &;t—g mottisnulia of APMA g;t&— zdpoesirael spot inscypat unnoer &t—g; tlavgeo npenteedd gM lockb of DANM eetrcpor redomve )5 filnux fo Ca ghhrtuo ANMD ;t&g— uaescs even mreo AMAP reteorpcs to be treendis oint hte aremebnm TONE(: MAAP is nspevioers ot Ca nda mgleta)a)ut6 sauceeB eerth aer meor cesetorrp to drnpsoe ot i,t eth clle is mero erpnvessio ot emtgaalut

lla eht sroeht a mtoncnopveieit neics hety veha pifiicfyitesipecc(sc al)g,insd AMND is the oyln snthci(vlceeoeenne tvptiieoecm rec,erpto) ahs a idalng etsi and ca , an dan c.nheme..g ptmceivotie