S,o rof eosm anr,eso sunnitreermstrtao is thmsnogei eIv' WAYSLA gdretuslg ...htiw bbaoplry seabceu I nwas't tuhtag it elwl os evner aylrle edenral it, utjs erdlena ueognh orf evehwtar .maxe I tusj ndufo tish boo gtouhrh BNIC and sit TAS!IATFNC I'st mrfo 1020 so tmgih eb old, utb it aws r.geat Yuo nac shreac huhgotr eth obko nad fidn teh crpha.tes I peyrtt cmuh stju wnet grouhht lal of teh trmenirtnuroseta hprt.aec Kohvb:Nkt/7/b1s/i/moBhg.9n9wic.wot0nn.pw/s.l

My main as:eauyaltaat-mw Getk = oajmr aeiryttcox rutnemsetortrai.n owT ytpes of :cerore1p)s t oitr,moabtepc tosm fo cwihh ear sptiaypnrce iG ihhwc asdle to ecseadred NAMD eeptcrro cviyatti dan irks of excxcttiyitiooi, ro tpncstspoiay qG srcoetepr ahtt eald ot crneaeis ,a+N +K, adn aecrdesed tgalaemtu cusase notepliarazido dna aneredsci +M+g dlacnsemtepi and ANDM pcetrreo cvttiyia nad skir of otxetcticoix,iy nda 2 ) ortciipoon halecsnn cdniniglu DMAN nad n/ieAaAtakPM ,nanclhse hcihw lal wolla oienpsnccif nocati x,nluif tub lyon NDAM loawsl ++Ca lixnuf n(ad nlyo in a ealgvot edtpdenen maenrn teafr icfunesitf eznoioaailtdpr sah selacdpid het thibriion g++M oin ni het n.lcen)ah

GABA nda cnyileg = hiirtnobyi tasrsmnruno.rteite ) 1 AAA-BG dna GAABC- = pntiiocroo hnnsalec that edla ot fxule fo -,Cl dna tdsepie stih sugcian pnoaoezti,dairl hte eonnur tslil sytsa wboel setgrin ttoa.plnie BAA-GA dnbiign esti fro trauertbb,ais sdiro,est GAAB, dna xrtoconipi = inesid pore fo chenn.al ABAGA- nidngib teis of eiopnaszdbeienz = tosidue fo reop fo .anlhecn 2 ) nGlyiec lcnhean si a yver ilriams l-C leuxf c.nlneha )3 -ABAGB is a eiobcprtatom hnenalc ttha esiavtact iG dlniaeg ot sdaceeder AcPM hwhci vsaactiet uxelff +K acsnenhl dna itibinhs +aC+ xnfuli hcneasnl nelidag to tonhrrapypi.izleao

oegncBii iaesmn = nsmciteohlaeac pnaodemi nontico(oadri fo doby ,temomven d,rwera omti,vtanoi n,fr)terinecome neinopnhererip ,ese(pl u,efasnlwkes neoitattn, deegfin evoabirh, ppiiernenhe os(ltew ctitcorenanno ni S,)CN plsu nriotonse ls(e,pe elenwua,kfss ospened,ris ,xatiney ea)uasn dna neihtmsia rlsa(,aou ntia,netot ,alrgley ssutie dg,amea nda aym nnceeiulf doolb anbir w.)ofl Oo,svulbiy lal of shit si in ontiadid ot cairnerged ounrsienioanstmsr and ,lhfigt ,ighrtf dna thfig noeerssp.

TPA dan horet eunrpsi = xytertaoci rnim,ntassois eecsadlo-er hwti hoert uale-mollclems emrnunerto.strsati neAidnoes 'sitn aallcsislcy inrdcosdee a nrrrueatesomintt seuaceb it n'sti elrdoseds/earte in Ca++ depneendt ,annrme tub vdidree fmor TAP ebrfoe hgivna na tearxoicty it.nlpoate

ccnliletAyohe = mjora rntoteanmrusriet oindlvve ni nosuirrennisoasmt aiv irscumna dna iinoccint teospre.cr

Pedpeit tnuiartomrseernts = nmmocyol elredesa as edpitoprpe earglr seprrursoc ttha era dvlcaee by pficesci zeemnsy that were ni het saem aiumontrtrteners celvsie unpo esaler.e Fvie ptesy = tgrau/bin ,depsiept doiipo tpp,deeis itprtiyua dpits,ep iayphomlatch ngilseera oehmrosn, and htseo ont scls.dfaiei Expesaml = pcruseorr htat seigv sire to nsecbutas P po(simh,uacpp rc,teoenxo dna ITG adn leeraesd form lalsm aitmdere PNS C irsefb tath rtnitmas nipa nda ptremareetu onafimionr,t pewufrol stohyn,vepei nebidthii by ioodpi )tsi,eedpp uinkeoninr ,A eoutnrpepdei ,K dna euendtripope m,amga nda iooipd spetiped diulcnign lapnt ialdsaklo lik(e on,phi)rme tehcstnyi oodpii veidav,rstie adn ,hospninedr s,npndrihyo nad iae.knhlsnep In arglnee opdioi ideseptp era aresndsteps ..e(i selaaanig ea,mshcnmi) eodnlvvi ni epxcolm vbhiaorse (easxlu otraatcint, segsivsasimbgeuvries/ rsboeh)a,vi dan catidmepli gu(ohth tno ti)iindvefe in ysihptrcica .risdesrdo

ealrl,Ov nertrtreasouinsmt = pety s:etyp sul-caelomllem trasnrtimste and pdte,neispoeur where uceomlmsesllla- eritamsrstnt rae erfsat nad tediema pardi pniasyct mrnsssontiai ei.(. drnageno SSN i/rghgt/ffitlhgihtf qckiu oen)sersp, heerw sa dispoetrpneeu nlaog( hwti ilbcooig smniae dan oesm slalm ecolleum nreimrtsat)ts rea lersow dan etmdiea adlga,ru onedglopr uosoannmr.srntsiie

oeSm pietscr:u eeiortde/ppermdt.rif/loee_o:whnvrvahted_hs.cmtwn/eusri/nknupmpsuo/_utitbwtk.aa, t/3saasr-fd/l/srd---0-1.rgo2rtic004nppwrh/6prsi0o5eedee6mgBdAc33ti/gel/ub2a1a1wPa/gtt1i-6fi4hne293lp41eboratugceeape8rRcobw0e6AfhnTs-Gb8f:.7aBi-usr, and i//tx-26fipdf-esg-65b0hg-5-t8w/lxa1l.er#t2b39abge7_dd4dltfofd=u.-&w/ggshi/b3ael11epmcewnnas0a1ti:aeae=b/r.ea--Uhwr;n

ogThu qe.siunot

eRlacl ahtt nnietemaM (i'elhzmraes dg)ur si a AMDN tpRreoec tgtnosinAa htta lhspe ntpvree ocitteioycxxt yb lcBnoigk C+a2 etryn. tTahs' hwo I rembeemr s.thi

• )A -BAAGA rseeportc tle lC- ni
• )B cnlGiye si desu in eht inapls rcod as na itinibyorh ets;eniumnrtorart oals eslt C-l ni
• C dan )E obrtatocepMi maettgual rpsecrote ear r-ieoGtnp olpudec
• ferhroe,Te het oynl gthin htat lcudo tle a2C+ in is NDAM ecepstrro

AMND ercsrpote in sthi seac aer genib dseu for olgn mret ioaintotpetn tiiwhn eth abinr nad uot of lla of rhete osehcci lnoy htis ortrpeec euss +Ca

ouY anc wsrean by pscoesr of oiineali.tmn iveeip"tCotm "sotniiretanc keams yuo nikth oaistyutmlr TN. srCos tuo ABAG dna ynlgi.ce In teh xroect os atglmae.ut irctaobpetMo uwlod eanm seht'er ocdsen egrmesesns oevnvdli adn teh rproeetc ouldw nto tnirsamt .uccamil ecHen AND.M

esdu in ngol trem tipntaooient nage,(aglu momre),y Mya asol apyl a lroe ni gene pnsotircirant ni srneuon

1) ANDM si a attmlGeau oerterpc )etp2usby APMA is a ubepyst of DAMN taht si llatiiiny aaidcttve yb aaeltmtug rel aes)3e MAND terpceors era nufdo rnea PAMA cepesrtro utb ear ont vtdteicaa by olw seevll fo lgetumtaa aseeerl ude ot a gM nio o’‘ckiblgn teh 4hnn)laec rFtueeqn Atinoc ntpetolai &g—;t tutonimaisl fo APAM tg&—; ezaiodrslep sopt itacysnp nrueno ;t&g— otaglve pedentedn gM olkbc fo DANM tecoperr oevderm ) 5 luinxf fo aC otuhhrg NMAD —t&g; cesasu evne mreo PAMA trscroepe to eb nesiedrt iotn teh nmemebra EO(N:T AAPM si ersseivnop to Ca adn tl agt)6emua) acseeuB trhee ear orem rosprceet ot sroendp ot ,it the lecl is eomr nirovesesp to etuaamgtl

all eth oehstr a empocinttinvoe isenc etyh ahev (ycietpicpscifiefcsi s,in)lgda NMDA si hte loyn nince(cslhntveoeee meivetcoipt re,op)erct hsa a ilangd iets dna ac , an nda hen.m.ge.c ivptteicome