effect of glutamate antagonist on pt with acute cerebral infarction = targets NMDA receptor
decreases calcium entry into neurons = decreased excitotoxicity = promotes recovery from acute cerebral infarction.
Touhg nsi.uoteq
clRlae ttah eietnnmaM a('remhlizes d)gru si a ADMN Rcpteore nAngsattio atht leshp evprten ieoticytxxcot by kigBoncl +a2C rteny. h'tasT hwo I ermmbeer .htsi
a picture for better understanding https://2e.mindsmachine.com/asf04.02.html
^ link is dead :( (they published a 3/e) but here is the re-route to the new site if anyone wants to dig in https://learninglink.oup.com/access/watson3e-student-resources
NMDA cpreesotr in tsih caes rae nbige udse orf glno remt pioniettntao ihwnit eth ibnar dan tou fo lal of ehtre hsicoce only htsi opcrreet ssue aC+
I ipdeck DMAN ueasbce t’si ruytomltsa,i tub si terhe ayn edeepr noaesr ofr hts?i
uoY can esnarw by ecporss fo nmaeto.ilnii "eomCtvpieti saeirtonn"tic amsek uoy nihkt yloirumttsa .TN Cosrs out BAGA nda n.cyileg nI hte cxoret os ulatg.etam ptcbeaoMorti owlud mena ehse'rt coedns gserenmses nvidvloe nad eth toperecr dwoul ont rimtstan a.imulcc nceHe DMAN.
duse ni nogl ermt atiooinnetpt ,na(elugag yr,mo)me May sola lyap a olre in neeg atornrtciipsn in srunoen
)1 DNMA is a mteatalGu ectoprre ubt)ysp 2e PAAM si a tsbpeyu of MNAD taht is iiylaltni eicdvttaa yb laumgteat )eaes 3rle NADM trepecros rae ndofu aern PMAA etrorcspe tub are tno cvitaatde yb olw evlles of algtumaet eelersa deu to a gM ion ‘gonlbick’ teh 4an)elnh c ntreqFue coitnA ianltopte t—;g& iaotmutslin fo AMPA &;gt— eroladpzesi ptso ncapsyit uenron —;gt& tlgaevo entpdeden Mg koblc of NADM rprtceeo oemrevd ) 5 xiulnf of aC ohguhrt NMDA g—t;& sasuce eevn eorm APAM oteesrcrp to eb nedrtsei ntio teh nrambeme N(EO:T PAAM si ovsierpnse to aC nad ))tu6aaet lgm ucesaeB rtehe rea emor eepotcrsr to esnrdpo ot it, het elcl si rome iresnsveop ot taeulmgat
lal eth hoetsr a ioeevcminpntot escin htye vhea sfistceiepicfi(cypci ig)ansdl, DMAN si teh lnyo evelehnse(encotcin ecpitvmeoti )rpetecr,o hsa a ganldi iets dan ca , na and .ee.mnc.gh vpectoemiti
submitted by ∗nwinkelmann(366)
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$279$49,oS fro smeo rasneo, rtnnisoatuetersmr is tionghems eIv' YSAWAL gltursged h.ti..w yroabbpl esaucbe I nw'tas gautht it llwe so rvnee arlyle enedlra t,i stuj edernla onguhe rof vewetarh .meax I ujst fduon siht oob hrhugot INBC and its FTATINS!CA Its' form 1020 os gmhit eb l,od btu it aws rateg. Yuo acn ehcsra hgtruoh eth boko nad fdni hte sr.thpcea I teptry hcum tusj went ouhgtrh lla fo eht nriarnroeeumttst ptca.her nbth..lbswp/ock0iwoKNBhm/v///g979wo:ni.sn1.t
yM main kauemGyalswat et:aa-t = jmoar xaterocity mtnuear.oteirnsrt oTw sptye fo prr 1:seoetc) ,otreimcatpbo msto fo ihhwc aer rpantpyscie iG ihwch adsel to deedresac ADMN cperrteo aiyicvtt dna iskr of yittioxcioex,cti or opsysptancti qG eptsreorc that dlae ot crsaniee aN,+ K+, adn dcesrdeae tuagematl cseasu elaioiztrnodpa dan sanrdeice ++Mg dspliemcenat adn AMDN erteprco tictaivy adn risk fo cy,ixtttxoociei and 2) otrionciop encalnhs idningluc DNAM nda iA/tnkaaMAeP heac,lnns iwhhc all loalw scnfpcnioei cnotia lxuin,f but onyl DNAM laswlo aC++ fuilxn ad(n nlyo ni a eaovtlg pdedenetn amrnen afetr tsicefuifn tooeaziliprnda has dedcpisal eth otibriinh ++Mg noi ni het a.lchnne)
GAAB and clynieg = nriitbhioy rentsn.imatserruot 1) AGA-AB nda A-GCAB = onctiopoir lcennsha thta dela to uflex of C,-l nad disetep ihst asingcu ,anielropizotda eth urnneo lstli tyssa lwoeb nertigs l.optatine AABG-A igibdnn tise ofr st,rbiaeutarb ir,doetss AABG, and oiicrtxonp = iiends erpo fo acl.hnne BA-AAG ibdingn seit fo sbinoazepzenied = iduesto of pore of alnh.nce )2 cinGlye nhnelac is a eyvr siilamr C-l uexfl hae.lnnc 3) ABBAG- is a tcimpteraoob nlhcean htta avcteista iG gneidal to dedeesacr cMPA which vacttaesi lxffeu +K elhcnasn and nibitsih a+C+ flinux ncsnehla eigdnal ot le.oioptarnpzaryhi
igecoBni naiesm = aecsmnocalihet ondeipam donrion(aicot of obyd mne,movte raew,rd ivimo,ttoan mfrneoert,neci) neireenopnprih ,plsee( ulsswafkeen, enaoit,ttn gfeined r,bavhoei enrpienheip est(wlo cconntroetain ni S),NC ulsp etisoornn esp,(le fenlaw,kuess seoirnspd,e xtyi,ane nuas)ae and neihmtsia al,ro(sua ,ateonttni ,lgrealy eistsu gaa,dme and amy nnleeicfu oobld biarn fo)wl. i,uOovbsyl lal fo tsih is in iitndado ot drgranecei mnnessostniuraoir dan itfhl,g tigfh,r dna gthif rspeoe.sn
APT nad tehro neiupsr = taryixtcoe osinin,tmrssa -redlsoacee twih hoetr a-scllmeuollme intrma.sretrteuson dsneiAeon 'nist alsslcyilca rnceosided a sntmonrureearitt caubese it tnis' roe/rtsdsleaeed ni C+a+ ntpedneed nnme,ar tub eerddvi fmro TPA eboerf nvhaig an oattrecixy at.lieptno
ihlAloyetccen = major rtsuienotmrnreat divolven in nssoaneniirosrtum iva nmuraisc adn cniintcoi e.prrecots
iePptde ttraertsuneinosmr = ommynlco rseeeadl as irepptpedo arrgle cserrospur thta aer edvaelc yb iiscpefc zmneesy thta were in eth aems eirnntomaertrust slevcie onup s.leaere eiFv teyps = n/utgbria dtppies,e diiopo isedeptp, tatiyirup isp,dtpe cophaliyhmta eligensra r,mohesno nda tehso tno difsaescli. xeEpalsm = resucoprr thta sgevi ries to ntabscues P cuhppis(op,am xtco,eroen nad IGT and seereald frmo allsm atedeimr SPN C ibrefs atth mristatn apni dna prmerutteae afiirn,otomn fowpruel ptenis,oyveh niibihtde by poidio s,pi)tepde runnioiken ,A trindpeoueep K, dna topeueerpdin g,mama dan oodipi tesepidp innicdugl pltna laikaosld (like nrimop,eh) hesctytin odipoi virtvas,edie adn nehrd,pnios nrdphs,oiyn nad a.lkpeenishn In anrelge oiiopd pepedtsi are dnatepssers .(e.i asngeiaal ne,mmic)ahs ovdvlnei ni lmxcoep hboavrsie (xsaeul ttrca,taino eiissmiggureb/vssaesv )heriasvb,o adn aciilpetmd g(htuoh not i)fievditne ni phsacictiyr s.rrodsdei
a,Olerlv nermittoarnuetsrs = eytp t:eyps cmeslllmoelau- rnsatmtteirs dan ,esertdounipep eewrh scl-lellaummeso rneittstrmas rea tafers nda dieaetm pidra pcysiant itnomrsssina .i(e. nadenorg NSS t/hgifgfihgttirfhl/ kicuq e,roensp)s ewher sa putidseneerop go(nal tiwh ibcoogil nseaim dan omes llams uelelmoc nemrtisttsar) are eosrwl dan eaemdit laagr,du polndgroe nsitosnrnuroe.msia
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$279$49