effect of glutamate antagonist on pt with acute cerebral infarction = targets NMDA receptor
decreases calcium entry into neurons = decreased excitotoxicity = promotes recovery from acute cerebral infarction.
uhogT n.qeuosit
calleR tath etnaiMmen srme('zlaehi rdu)g is a MDAN ocRperte tgnsAtnioa ttah epslh vntpree eyotxocictxit by licokgnB +2Ca tnyre. saTh't who I rbmeerme ht.si
a picture for better understanding https://2e.mindsmachine.com/asf04.02.html
^ link is dead :( (they published a 3/e) but here is the re-route to the new site if anyone wants to dig in https://learninglink.oup.com/access/watson3e-student-resources
NMAD espetrorc in htis seca are gbein usde rof ogln emtr otieaipnontt niiwth teh nairb nad uto fo lla fo treeh oehcisc nyol hits rcpteoer suse C+a
I eikdcp MDNA seecbau st’i tuyirmst,alo tbu si erthe yna dperee rseoan fro i?hts
uoY can nswrea by ecpross fo ninim.eaotil tmveoeii"ptC nnartiteoic"s mkeas you tiknh otasumltryi T.N Csrso otu GBAA dna gcniel.y nI eht eoctrx os metu.alatg coieotMarpbt wlduo mean eh'tres snedoc resemsesgn donelviv and eth creperto dlwuo nto nitastmr ui.clcma eHenc D.ANM
eusd in lnog rtem anopiiotntte ngega(l,ua yome),rm yMa osal ylap a lero ni gnee totanrnicsipr in nesruon
1) DNMA si a tmtGeaula troecepr pute2)ysb MPAA si a etsbyup of MDNA thta si lntiyaili eaivtdact by agutletam lseee)3 ra DNAM retporesc are dounf nrae MAAP rrtocesep utb rae ont datvetcia yb wol velsel of euamagtlt eraesle ued ot a gM oin ‘blok’icng eth ah) nec4ln etFuernq tnocAi liaptoent &;g—t islmitounat of MAAP g;&—t aoliepezsdr spot nyctsipa nnoeur —;gt& loeagvt ptndendee gM obclk of NMDA ocperert vormeed 5) uxlfin of aC othughr DMNA >— ueascs eenv oemr PMAA cesrtopre to be sitnrdee nito teh abmrmene NT:E(O PAAM is iseevposrn to aC and )6lamta)uegt aeuecBs etreh era eomr rsecrtpoe to spndeor to ti, teh lelc is orem enispesrov ot maattugle
lal het htsroe a novpmoittcinee escin eyht aveh (ycpcitffieicspciesi ,adsgln)i NMAD is eht ylno vh(sleceeietnnocne ivtcpeeoitm rr)otpe,ec has a idlgan siet nad ca , na dan .n.ge.mhec pctmtevioei
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$279$49So, rof esmo raneo,s erumserinntotasrt is oshnmeitg 'vIe AALYSW lesgrugtd iht..w. pbbroayl uebasce I stw'an guatth it llwe os envre yllera lednaer i,t jtus rendlae unoegh for evwetahr .xema I utjs noduf ihts boo hgurhot CNIB dna sit TNFATCA!IS Its' ofrm 0201 so thgim eb dl,o ubt ti wsa tega.r oYu nac chaers oughhrt het obok adn fidn het shcp.erat I eyttpr chum usjt nwet hguorht all of the rsineuttrmarneto tephrc.a g.K.c/bo9/t/wb7w1t.o0p.shihosknm/ln/:nvN9wiB
My inam mtaystetakaua:ew-Gal = jrmoa yxrietacot tertiesnouat.rmnr Tow ptyse fo :pt) eecrr1so ipate,omtcrbo mots fo hhwci ear spyepnrtcia iG hciwh dlsae ot eereadsdc AMDN oreercpt iicvttay dna ikrs of cceitiitxx,yoiot or ptsatconiysp qG ospceterr htta dlae ot crinesea ,Na+ +K, dna deeseracd telaatmug cssuea zopoideranalti dan ernaeisdc gM++ estclmneapdi and NDMA precoret cittviay adn skir of cxoe,itytioxtic and 2) roiitoncpo ansnhlce duinclign MDNA dna aakietMAnPA/ slhca,nen hcwih lal ollaw pcsfoicinen aonitc ulin,fx ubt yonl MNDA slawol C+a+ xuifln ad(n olny in a oglteva eetnnpded nnmare rtaef uitfsniecf rdloizponateai sha pddceiasl eth hbrtinoii Mg++ oin ni eth ncae.)nhl
AAGB nda ilencyg = htoriiybni attensinos.rruremt ) 1 BAA-GA adn A-BCGA = oiciporont ahnsnecl htat aedl to ulxfe fo -l,C nda piesdte sthi usagnic lnoaiire,pazotd eht nreuno ltlis sasyt wlebo eitgnrs itaolp.ten -ABAGA ngbndii siet rof urestb,tbaari orst,edsi AAG,B nad xnirptcioo = isinde poer fo eanlhnc. GABAA- bnidnig tsei of ioenpzndzaebies = seiodtu fo preo of al.hnnec 2) ycniGel cnlaenh is a yver isilram l-C lefux nhlecn.a 3) GA-ABB is a otobacrmteip cnehnla that tviacesat iG endigal ot dderacsee MPcA chhwi estvtcaia xluffe K+ hnlnecsa and btnshiii a+C+ lniuxf easnchnl ngildae to hirpnioalzyoear.pt
iBeocnig amenis = ceahtlnomscaei dpnoamie onradotcnoii( fo ybdo veometmn, ewdarr, amtvi,oonti creio,)mtnrenef hienreenpinorp (le,pes sslkfnea,weu ,ttnainote eifedgn e,ohvaibr reipehinnep oswtl(e tcootrenicnan ni SCN,) puls srtneoion ,pe(lse s,ukfnwelesa reosiendp,s yta,xein en)aasu adn nthsiaemi as,uorl(a eto,antitn lag,yler esitsu ad,geam dan aym leneciunf dolob rnbai owf.l) blOosyui,v lla fo isth is in tadnidoi ot dgnreciera nsnraossmioutneri nda tglh,fi hfgrit, nad hitfg .sepsnoer
TPA dan rteoh uiernps = aiyecxtort snsmoan,tiirs a-eeeocrlds thwi horet eoeaslll-lucmm tearoustrinrn.mtes sAnindeoe 'snit lsayalccsli ecndidrose a orutrmsetainrnet becusea it tsi'n arsltreeeddso/e ni +aC+ deeedpnnt amnne,r btu iderved mrof PTA erebof gniavh an roiyectatx tnopa.tile
lAinetcelhyoc = ojamr urtnortramneiset nvlidvoe in nuntsmeriorsoasin iva mscruani dna iicncoitn por.tceers
ePdtipe raotriuntnessemtr = myolmcno rsedeale sa pppdeieotr graelr eusrrpcosr thta era cdelave yb pesifcci ezesnmy ttha reew in teh sema suntireaoettrmrn slcevei oupn learee.s evFi sypet = /gtriubna ,tpisedep oioidp septpie,d ttuiypira pidp,tse hmtaolyphiac ireglsnae ,rhesnoom nda hotse not clseidfis.a xmpElsae = proercurs atht geivs iers ot ucestsanb P m(saopuiph,cp eonxrcte,o and GIT adn esreaeld mrof lasml atiemder SPN C iersfb atht imsanttr nipa dan ereautptmer o,nmnaroitif reufwpol hst,oyeevinp ithniebdi yb oodipi pte,esd)ip nieoiunnrk ,A rdtiuenoeppe K, nad ppdieertnuoe a,agmm adn odioip pstpieed ilnngduic lptan alaiklsdo (elik erh,nmpio) cthyisten oodpii dt,aviseevri adn rophsdenni, s,ypohnirnd nda seni.anlpekh In nageerl odipio dpeptesi era sdaprneesst i(.e. lagiasane e,mnmhc)sai onlvedvi ni oxpmecl ivbaeshor eaulxs( orcnitta,ta eigssrvbisvuesiesagm/ b)ahvor,sie dna cdimltiepa (uhhogt nto edeiif)nvit ni taiycshprci sdseio.rrd
Ol,revla nrsotteeaisnrtmru = type pesyt: celluasleolmm- aminetrssrtt dan dopesree,ptnui erweh mcllmluseola-es mrtessriatnt aer atesrf adn tmieead dipar psaycint triasnsismon ie..( aoednnrg SNS i/ilf/frtthifhgtghg kucqi nse,)poesr where as redptenoesupi olga(n htwi ociigbol enisam adn mose llsam lmeuolce rtmnat)tesrsi are wrosle dna diteeam lgru,aad drogpnloe o.onrimtsansursine
mSoe eupictr:s empev_ihta/tdk/peirt/enlbwtomoenh_ukei/wtr:_auota.espfuvd.nirsepdrco.tmurw/nhs, r6of-icfa2s./gRtrer7iee1beaaB64b2.8cp/g0tr-m-siTtgfsB41Aedodcc3tu51ph--a-iwr/u6gpbae0:2ole3sweehlAgaf/4-bp8tea3er00ir/9/-niro1pt/udG1lPh36srdasnw0n, nda =/3b1f-cbeaa=gf6-dbw&.rx7a/0rweepUt-8erdgwaoifldnaiel.i-x-tsplnh6b/hm_dadfew.b5/01;1auta94g/gst2g1#3/sle5:nh--ee2t-i
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