o,S for meso oesran, enstinrtsruotrmae si tesnhomgi e'vI SAYWAL geslugtdr t..hw.i paybrobl ebusaec I t'snwa taghtu it wlel os enver aerlyl ldaeren it, jstu eldrnea hugeno fro twhvreae ae.xm I ustj udfno hits oob rohhugt ICBN adn its T!INATFSCA 'sIt romf 0120 os hgtmi be d,ol tbu ti aws .terag uYo can csaehr rohuhgt eth koob dan fnid the sae.hcrpt I yteptr cmhu tjsu enwt othugrh lal of eth ierurntrnatostem .hprceta 1s/wt:onBoKo..snmn//ibN/0.9lgi7wh/wtphkbcv9.

My nmai aasamu let:-taeGtakwy = rjmoa rycoaeittx rrttre.stuennmioa oTw ypset fo t:serec)1 pro irtmo,epotabc tmso fo wcihh aer eiatnprcpsy iG cwihh edsla ot ddaeecesr ANMD otrreecp vtcatyii dan srik fo otcyietotxx,iici or pyptnosictas Gq cteeprors tath laed to areecsni ,Na+ +K, and escdadeer tamltaeug scuase airaienoopdltz and andesriec +gM+ ctedmiapslen dna DANM proceret aviictty adn srik fo exioxttciyco,it dan 2 ) ioinroctop eahlnncs inindclgu NDMA dna neAAMitkPa/a ,nenchsal hihcw all wolal nincsocpfei ciotan nux,lfi tub lyon MDNA lalows C+a+ infxul d(na yoln ni a vgolate pdedntnee nmnare rfaet nfsetiufci inaeotozridapl ash apsdldcei teh biiinroht gM++ nio in eth hnnec)al.

AGAB adn yglicen = oiintrhbiy ssuemtta.rnnroriet 1) GAA-AB and GBA-CA = riioncotpo cshanenl htta adel ot xfelu of -Cl, dan tpsiede iths gnuisca oontazierp,idla the nenrou llsti yasts loewb itgsnre npolit.aet AABGA- idibnng stei orf asabbtiurr,te dsei,tsor GBAA, and onpioxrict = sidine poer fo .hlnncea -BAAAG ibdignn iset of zdnneboeizsipae = diosetu of epor of claehn.n )2 leGcyni hncalne si a vrye slmiiar Cl- feulx h.cnlean 3) ABBA-G si a tarcmepoitbo lnanech thta iesvaattc iG geialnd to csdedreae cMPA hhwic aeisvtcta lxufef +K asenchln and iibhsitn C+a+ ilufnx nscalenh idnaleg ot ezrahnpirt.alpoyio

giiBneoc asnime = ohcatleeiancsm nimadoep oritninoacdo( of dboy meotnm,ve era,rwd oattiom,inv temcrif,eoenr)n iinhneperrneop pl(,ees wkuee,lsasfn taeton,tin fieendg oia,rhveb eipreenphin wsoe(lt nrannccottoie ni SC),N ulps nroiotens ,lps(ee ku,swseeanlf osee,nsripd ,nxaitye ua)anes dna teismhani su,a(alro tatntonei, grealyl, stieus dgme,aa and amy lninfueec blood irbna .wlfo) lbiyvOsuo, all of siht si in iddinaot to rerincedag souonnsnersimtira adn ihf,tlg t,ifgrh dan gftih epe.osnsr

TPA and erhot ipersnu = ritcoayext itsmo,rnisasn lo-esradece iwht rheto melmsc-luolael stetraoreursi.nntm nAesednio t'sin cslclsaylai erdnseoicd a enierrstatunromt aesebcu ti 'tnsi erdeeldstaesro/ in C+a+ eddepentn ar,nnme utb dvderie fmor TAP erefob iganhv an ttxeycario t.potlenia

inhcotcleyleA = raojm trenmtoterurisna dveloinv in nitemonosraussinr vai nsumrcia dna innitcico ptsro.eerc

Ppeitde nrstrniaotetserum = clommony darseeel sa irdeppeopt arlegr crsrsporeu htta rae eleacdv yb cifescip yneesmz ttah weer in hte seam soemeuriartnttrn selvcie unpo e.rlasee Fiev tsepy = batg/inru spiptde,e poiido spi,eptde yapitrtui d,ipetps hmacylpaoiht galirseen eo,mhorsn dan soeth tno sasli.fdcei mepxlEas = urroespcr htat sgeiv esir ot ussbecatn P ahpp(pc,omsiu noce,toxre dan ITG adn erdlsaee ofrm lsmal eemirtad SNP C refsib that irastmtn apin nad reeptmuetra fiin,atmoorn urfpewol ,evtniopyhes iinithedb by odpioi ,estdei)pp nnurinokie ,A eipnprdeoteu ,K nad tinoeerpduep aag,mm dna dooipi pspiedte gidnciunl pnlat kdailaosl kei(l ph,rnm)oei ncytethis ipodoi ,viiederavst and oiesphn,dnr rspynodin,h dna phk.nlneiase nI eaelgnr iooidp dtippsee aer ptreensasds .(ei. eignlasaa nmm,)iceahs ivlenodv ni oexpmlc bhoerisva uax(els otnaatir,tc seiuavrgiseig/sbsvmes ha)erisb,ov adn itapcleidm guhoh(t not vt)fiidneie ni yirchcaipts edor.risds

lvaOle,r nruatrstmseenrito = tpey pey:st llumaoesmcle-l sreansrmittt dna rtiseeu,ppdeon rhwee ml-sameslcolule tttanrriessm ear asrfet dna dmieaet dprai iypnatcs ansnorsstiim ei..( androegn SNS fghglii/f/htfigtthr cukqi ep)rnse,so weerh as deuntreopespi l(oagn twih clbogiio seinam nad esom slaml eeuclolm tsettrmsnari) aer wroels dna miteead glaaurd, olnoergdp mnostsorieasnin.ur

oSem sicue:prt utv/rkopir/laudmomiodwedasths_nniti:fttthurpewunet/_epvrwb_/nmkeeraeoh/.se.c.p, worBesur60bsa/rA3h/3Ai4-2.oph0ntludebm-es-i1i1c68neheeo70/l109a:42af/sTct1pia-tgr5/6s.irgb1rd0w3/ulresie-rna-egrBttfp-Rpdpaacgf6ed/bwf8Gog3ae2-tcP4, nad hpgm/ahU7-=n3wll=1it:-6r&u1dbehf4xaiest0-g0#ab6.dsea-x-bb-tf8eledple/grts2ei3ndaba.a_t9fw/e/1dwewgf-rog5a/51;i2n/.-c

hTguo ne.iutqso

ealRlc ahtt nitemeMan marilh'szee( )gudr si a MDNA ctpoeRre Aontniatgs tath sephl vpreten iixxctotyocte by ikcognlB +2Ca netry. t'sahT hwo I ereebmrm .shit

• A) ABAA-G epscrtore etl l-C in
• B) elcyGin is dseu ni het asnilp ocrd as an hibitnyiro nomistrtetrranu;e losa lets -lC ni
• C adn )E ociaoetpMtbr lategmuta rcrstoepe aer G-nteprio cpeolud
• ehfroT,ree hte yonl gihnt atht ulcdo lte C+2a in is DNMA reectsrop

MNDA sorreptec ni iths asce rea ibneg dues orf gnol rmte atittopnoine iwnthi eht irban dna uot of all of reteh ischoce only tish roerectp seus a+C

ouY anc earwsn yb prcoses of nioiiltnmae. "tmviepieCto itnresat"inco mskea oyu inhtk saymluoirtt .TN srosC otu AAGB adn nyl.geci nI het cortex os telatu.mag batceproMoit uodwl amen h'setre ensodc smrsneegse ivovednl adn het roetcepr uwlod tno ntitmasr lmacciu. enHec DNM.A

sued ni onlg mter ttptaoeionin (,lguaagen ,ero)mmy yaM aosl lyap a rloe ni neeg corasnipintrt in ruenosn

1) MDNA is a mlutGeaat opeertrc 2u)sbeypt MPAA si a spyebtu of DANM atth si tiayililn daatievtc yb elgamttau rae3ese l) MAND ercreostp aer doufn nrae AAMP ocrrsptee tbu era otn decaiattv yb low eevsll of temugltaa aereles due ot a Mg nio blnc‘i’okg teh nnhc4al )e qteneruF nAcoti nilattoep g&;t— otasnuitlim fo MAAP &g—;t izpoedelsar spto ypatisnc uneonr &t;g— algeotv tdpndeene gM clkbo of DNAM eterrcpo dremevo ) 5 lnxufi of Ca outgrhh MDNA ;—gt& esscua vene orme MAPA scteporer ot be dneetris oitn teh enerbmam (TNO:E AAPM si eresisnovp to aC dan a)lg6eu mta)t usaeceB trehe rae erom crsrpteeo to pnsodre to t,i hte lelc is more nosivsrepe to gtultamea

lla het srhteo a inttmpecoeiovn cisen they ahve eiccipi(cesffytiispc daigl)ns, MADN is eth lyno hotevne(lnsiceence emovptiitce o)crterpe, ash a nlidga site nda ca , an adn ee...cgnmh tcivotipmee