effect of glutamate antagonist on pt with acute cerebral infarction = targets NMDA receptor
decreases calcium entry into neurons = decreased excitotoxicity = promotes recovery from acute cerebral infarction.
Thuog s.euiqnot
laecRl thta anemneMit ehzares'ml(i r)gud is a ANMD eerpcRot staontnAgi thta lhpse neveprt ttecixyoicoxt by ilgoBcnk aC2+ renyt. ah'Tts ohw I bmeremer .sthi
a picture for better understanding https://2e.mindsmachine.com/asf04.02.html
^ link is dead :( (they published a 3/e) but here is the re-route to the new site if anyone wants to dig in https://learninglink.oup.com/access/watson3e-student-resources
DANM rtpsoceer in shit saec aer inbeg dsue rfo olgn tmre oottintnapie iihnwt the niabr nda tuo fo lla of eerht hoscice lnyo tish eopectrr euss +aC
I icpekd AMDN aebescu ti’s smloaiur,tty tbu is erthe nya peeedr earnos orf isth?
You nac arwsen by scsoper fo oinmeat.liin ottpC"ivemie nrii"ntcteoas ekams uyo ihntk taitsolrumy N.T Csors tou BGAA nad eg.cylin nI eth txeocr so ttm.eglaua ceaptrotiobM woudl nema ht'eers soecdn ngmeseessr dovnlvie and het cterpoer wulod otn isntatrm ca.mucil Heenc MAND.
duse ni nlgo trme oietinpoantt ugae,a(gnl my,)emor Mya olsa yalp a elro ni gene tapinscrnorit ni erusnon
1) AMND si a etamutalG epreoctr ype)ubst2 AMAP is a sptbeuy fo ANMD that si laiinitly cviaadett yb gaetlmuta l3 re)seae DAMN poreercst rae uodnf nare AMPA eeorptrsc tub are not dtvaecita yb wlo vslele fo mutagtlea aserlee edu ot a gM oni ki’bnocg‘l teh ca)nl4neh qneturFe oAinct atneioltp &—;gt iisaotumtln of AMAP tg—&; rdiospelzae opts niystapc ernnou t;—&g taegvlo teenpnded gM blokc fo ANMD etrocper remvdeo 5) ixfnul fo Ca uthogrh NMAD gt—&; ssacue evne meor MAPA srtproeec ot be idesnret noit hte rmaenbem OE(N:T AAPM si srivenspeo to Ca nda latat6g)e)u m aecuBse tehre era erom eptorrecs ot nrepdos ot i,t eth llce si omer vproiesens ot uttaleagm
lla hte ehorts a vtiotimcepneno ecsni yhet avhe (fccisteieipycfpicis ani,g)lsd MNAD si het only necti(nhseenecoevl vtcoemetpii p,eerrcot) ash a danlig tise dan ca , na adn ..chee.ngm ecettpvmiio
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$279$49,So for semo ern,aos rnietstaoermnrstu si eihgtonsm 'Iev WSALYA geutrsdgl .w.hi.t lrbboypa ecusbae I ntwsa' guatht it lewl so nvere reayll dnaeelr i,t juts enldrae ougehn fro erhvwaet xae.m I jtsu onduf tihs oob gurthoh NCBI nad its TASNITA!CF s'tI ofrm 0021 os hgitm be dol, utb ti wsa gera.t You nca hsraec hogurth het book nad ndfi eht aes.pcrth I yprett hcum stju tewn otuhghr lla fo het aiontntusretrrme rahtpce. wsno./bN.bs7ti.w:h9m/ochw9tgB/1//livknKn0.op
My inam akuyaG-tes tmlweaat:a = armoj oeirxttcay n.otteemrrutanrsi wTo peyts of r:o tc)psree1 tbeca,omirpot sotm fo hhwci aer npitcsreayp iG cihwh slaed ot ecdreaesd NMDA coteprer ttiiycav nad kirs fo titexxoityci,ico ro yipaposnstct Gq oerterpcs hatt dela to sincraee +aN, ,K+ dna ercsaeded egttlaaum seausc dnitraiolezoap dan escerdnia +Mg+ ntcseeplmadi and ADMN rortepec vcyatiit dan risk of xioticteicyotx, nda )2 icnroiotop nneaschl digunlcin NDMA adn tMaaPkiAen/A elh,anncs whihc all woall ncnoiseipfc ctoani unl,ifx tbu lony MNAD aslwol +Ca+ nfliux nda( olyn in a oevltag tddennepe anmern reaft usfientcif rodzlaiiatpoen has spcdiedal het iobiirtnh +g+M oni ni het .ec)nanhl
BGAA adn gilcnye = irtnbyiioh aetnmtsst.rouinrre )1 AABGA- dan -AGBCA = inopcoirot hclnenas hatt edal to lfxue of -lC, dna epsidet isth acsungi alzrpo,anoideti het nurnoe lilst atssy olebw isrnetg ien.aptolt BAAAG- inigdnb siet for batr,tribasue soresd,it G,BAA adn nriopcxito = iinsde peor of nna.chel A-GABA ngibidn esit of sedaezzipebinon = edituso fo epor fo nae.lnch )2 cinGely nnalehc si a yerv rialims Cl- ulfex cnh.lean 3 ) BBAG-A is a mecotrapboti nhalecn htta tvtaaseic iG nligdae to eedcsared cAPM whchi ctavsitae uxfefl +K slneacnh dna ishibitn ++Ca iufxln nhcnales deanigl ot lazoeptioarnr.hyip
egiinBoc ieanms = ocemheilcnatas anedpimo tancodioroi(n fo bdyo t,menmveo daewr,r no,itvoatim c),inrnmrfeeeot rnpernpnoeheii ep(,sle aelswk,sneuf noe,titnta iegnefd orvab,ehi iipenrhnepe (sewtol neatconortinc ni N)S,C lpus rtnsoenio ,eepls( newssf,kealu idenroe,pss iyxat,ne nu)aaes nad ehminasti r(l,usaoa int,tneato yal,ergl siesut amdeg,a dna yma ceulnfnei dolbo nrbai )w.flo syov,Oubli lal fo htis si in iaddtnio ot gicraeedrn oiosstmrenanriuns and thlg,fi fghit,r dna tgihf srseenpo.
TPA and threo iuprnse = taetcrxoiy saninrismst,o car-lesoede twih hetro lellmolu-eacsm stsrtmo.rntiunraee edAnesoin 'tsni clcsylsaali iseroedcdn a rtesomneuranittr beuasce it tns'i /taseddeeoeslrr in ++Ca petenednd nramne, tbu ddevrei rmfo TPA ebfore gvhain na ytaitxcreo aeotp.itnl
otyecellcnhiA = joamr mtiastrrennureot oivelnvd in rosiasnmoniuentsr iva smaiuncr nda nctcioini ose.certrp
eeptPdi emrtnranorstiteus = omlnmcoy eeedalsr sa eriptepodp raerlg sersocrrup htta rae evclaed by pcifecsi zsymnee ahtt ewer in hte smea rtntoaetersriunm scivlee puno s.earlee Fvei pseyt = gbtnia/ru ptpie,eds ipoodi estpdepi, tayiitrup itpes,dp htipyaoahcml iaesrlneg ,rhnsooem nda tohes tno ea.iislscfd smaEelpx = ursrcreop hatt iesvg esri ot etucbassn P ,opmsichpau(p xeerocton, adn IGT nad eesadlre form sallm amdtriee NSP C ersifb that rasimttn ipna nda eueprerattm mr,finioaton wrupefol nseetyivhop, ditbiienh yb oidipo ie)es,dppt riinnneuko A, rpioepdetenu K, and eonptdruepei am,mag dna idpioo epeitpsd dingniucl alntp aloldasik iek(l i,ohme)rnp tintychse pdoioi rtevv,eiadis adn rhpoend,ins nipysrhon,d dna nap.klnieseh In geaenlr idpooi istpedpe era dsesptesarn e.(.i laiseaagn ,mnecahi)sm novveldi in loemcxp svarioheb x(saule nc,atiaotrt uissgse/eibavsmvesrig ihose,)bvra dna cidamlpeti ghuoht( ont iieetfnd)vi in icyptcraihs rosdired.s
rlOlav,e eerrsmstitnnuroat = epty e:spyt umm-ecllealosl imstarnstter dna trenpuodiep,se heewr seaco-ullselmlm reiasmtstrtn rae srfeta nda idtmeea adipr yapncits asntrmssnoii .i.e( neadonrg SSN gihhhtg/lft/iftrfig iukqc ,soerpe)sn rehew as psituderoeepn (lgano htiw oiiclobg isnema nda seom sllma uoelmcle ttnrsrs)emtia aer lresow and aiteedm alua,grd roleongpd irnmtesoun.srinaso
Soem pui:tresc nolrvbe_disp.wa_erndv/.ou_tpr:rmmutpnwefreuo/eh/wthuetp/ke.daikihtce/osttnsima, 5060gdune3-AGrPbc2mbBT/8ihtta6a/gu3frce1o10r3ioauecge-dsd2i08--rsca-rere0s-lptaee-:tpss7oeliipAra1fhdt1p1ae4ltawb/n3bw-sg/fw.oh/4/g6rf.29p/RiB4en6r, adn blhd:a2--ep-a/7/5l;axa01=egne4-es-=pwt-w1fcan9/_alaw2m-hwrur0gg.r.eeitehtds6es/3&n/gf8a#/ide1lbtfi6b31tdxio5bfUd.bg-
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