effect of glutamate antagonist on pt with acute cerebral infarction = targets NMDA receptor
decreases calcium entry into neurons = decreased excitotoxicity = promotes recovery from acute cerebral infarction.
uTohg eiq.ustno
lelRac ttha nitMaeenm ahr(e'zmelsi r)udg si a DNAM ptcRreeo agtsnAtino that plhse tnevrep ctoieixoxtyct by ngcoikBl 2C+a eytnr. h'saTt ohw I beermrem .hits
a picture for better understanding https://2e.mindsmachine.com/asf04.02.html
^ link is dead :( (they published a 3/e) but here is the re-route to the new site if anyone wants to dig in https://learninglink.oup.com/access/watson3e-student-resources
MADN creoprset ni hist seca rea geinb eusd fro nglo emrt ieitponottan ntiihw eht irbna adn otu fo all fo teehr esccoih yonl hist ertrpeco sseu +Ca
I cipked DMAN cseaeub it’s tya,soultimr tbu si hrtee yna reeedp sronae rfo ht?is
oYu anc rwneas by rpecsos fo il.itnnamioe iiCtp"meovte "anictrsenoit easkm oyu nhtki iulaomtstyr .TN Cssro uot ABGA and .ilecgny In teh otcrex so tgl.atuame opeMobttrica wulod eanm es'hret doesnc srsenemgse vnldievo and teh oceperrt woudl tno tmatrisn calc.umi neceH MAD.N
udse ni onlg mret topttianieno u(,aenaglg mey,o)mr Mya aols ylap a leor ni eneg tirprcnisotna in urnneos
)1 ANDM si a aumlatGte peercrot ybeusp)2t MPAA si a euyptbs fo NAMD ahtt si allnyiiti vaaietdct yb mtauetgal r)s laeee3 DNMA cperotesr rae fudno aern MPAA prcrtseoe but ear nto icdetvata yb low vlelse fo amutlteag aerlees ude to a gM noi g‘kiconb’l het nh4anlce) equnerFt oAinct pltaenoit &g—t; nttasmoulii of MPAA tg;—& aperesolzid otsp iancpsty oerunn t&;g— legoavt depteennd Mg okclb of NMAD reprceot oeremvd )5 nilufx fo aC grhthuo DAMN —g&t; scsuea nvee mreo MAPA sperotcre ot be eedrtnis oitn hte emnaembr EO:NT( PAAM si nseevoirps ot aC nad age)ltat) um6 escaBeu terhe era orem soptrecre ot enosrdp ot ,ti hte lelc si ermo iepevsnsro ot ugttmleaa
all teh hsotre a meitpvetiooncn ncsie yteh hvea pfy(ecictcesficiispi s)dalg,in ANMD si hte ylno ensnecveteloech(ni eoetvticmpi c)otpe,rre ash a gdnila teis nda ac , na adn .ehcen.m.g eovciietmpt
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$279$49,So orf omse ,arneso ormanttuentriesrs si gheinostm Ie'v YSLAAW ulsgedrgt .hi.t.w abbplryo beseuca I st'anw ughatt ti lwel os vener aleylr aedlern ,ti sjtu lederna ugnohe for rtvwheea x.mae I sujt ufnod hist boo thrhuog BINC dan sti S!FATAINTC It's mrfo 1020 os itghm eb ,odl btu it wsa rgat.e uYo cna esachr tguhroh hte kboo dan nfdi hte hptar.cse I tptyer uhcm tujs wtne ugthohr lal fo the rsrteurinntmotea .pahcter w/.mob/./0/wns.stNoh.:ilng17/in9hpbt9cvowKBk
My iamn kalayaaut-G :estaetwm = omjra aytrctoiex .eunnrtaiosrmrett woT stepy of )rcese :p1rot omatrebco,pti tmso fo wihch rae ynirteacspp Gi ihchw lsade ot decdaseer NMAD teroerpc vtiyitca nda kisr of xytocoixei,itcit or tonypascipst qG rstpoeecr atht aedl to caserine +Na, K+, dna eddsearce tlaegtmau euscsa noaairtoedzpil dna reasicedn ++Mg ldmetspaenic nda ADNM roptcere ivtcaity dna skir of e,tioiocxityxtc nda )2 rpintocooi enalchns gldcuinin AMDN and AniMataPAke/ a,lchenns ihhwc lal aollw psieccinfon citano fliun,x tbu ynlo ANMD lowsla +a+C fnluxi (and lyno ni a vlotega etnndpede nmearn rtfea tfiscnufei otadinlziarope ash cdeaplsid teh nbhiotiri +gM+ nio in teh nceahn)l.
AGBA nad gyecnil = hnbtoiiyir ets.reonmrrastuitn 1 ) BAG-AA and CAB-AG = conotropii slchenna ahtt adel to efuxl fo lC-, dan seetpid tihs iguacsn aotaoidil,eznrp eth uonrne tslli ystas leobw gtsenri olait.nept ABAA-G ibinngd eits fro asbtaeirut,rb esosdr,ti ,BAGA adn picotnoixr = sndeii opre of lnnhc.ea A-BAAG nginibd etis fo izsoipneneebzad = ouedtsi fo orep fo .lennhca 2) nciyleG nacehnl is a rvye lirsaim C-l ufexl cnn.heal )3 -GBABA is a obttcoarpime hanlnec taht vaetatsci iG nileagd ot arddecese PAcM hhicw stcaviate flxfue +K enslncah dna ibsitnih ++aC nlfxui hlenasnc dnaielg to ynzohrpprtoi.aliea
eoBiginc imaens = ceseolatmnahic eiopndam rnai(tindooco fo dybo eoentmvm, ,weardr itimovtoan, ernmteieocf)r,n hnieepponnerir lsep,(e kseafunwl,se ttienaon,t fengied vieabho,r ieniehnpper (wtseol oriacntenoctn ni )C,SN puls osoinrent p,el(se ua,slefsenwk osr,sniedpe ti,xynae nsau)ae nda imatniehs olaar(s,u nntttie,ao egar,lly usetsi ,eagamd nad amy encifnule lbdoo aibnr .wo)lf Ooulysv,ib all of htsi is ni onitiadd ot reenigcrad snmsnniourtaiseor nad fti,hgl gh,itfr dan hgtfi s.nporsee
TPA dna rhoet reiupns = xytcteirao miissa,rnnsot l-reeedocsa htiw rtheo mulce-eollslam u.tmrotnessnartrei senideonA snti' ilcalalscys rceeosdidn a rsrrtaeueinnottm eceubas ti n'ist etraslds/roeeed ni C+a+ tnnepedde r,amenn tbu derivde ofrm ATP efebor avhign na toctexyrai .aileotptn
ectlhcilynAeo = rjmoa eeratnrttomursni evvlinod ni utsnsoiaorimrnsne vai scunriam dan ncnitoiic respreotc.
Ptdeepi ensmourrtaritesnt = mocymnlo laeesrde as ppeipderot lrarge ecrrspsoru htta rae vadecle yb efpcisic zmneyes ttah rewe in het maes unetotirentmrsar csvelie poun reesea.l eiFv tsyep = t/anrbugi seipde,pt iipodo ,tipesdpe pauryitti tpe,dpis ilhthycamapo rensaegli ohesmo,nr adn etohs not sdciea.lsif lsaEpmex = orrcusper htta gsvie eris to ebsaucnst P (pmcios,phapu rctox,oene dan ITG dna esaredle mfor samll tmedaier PSN C bfires ahtt niamttsr pani nda etrrpmeaeut nor,tmoaiifn ufoewlrp se,teihypnvo itiindbeh yb dipioo tpesid,)pe nrnkiinueo ,A reepdeoutipn K, dan niroeduepetp ammag, dna idoiop tiedppse iudinlngc natlp dlsliokaa (elki menh)rp,oi nhtetiscy oidoip sar,ieievvtd dna ,nnrhdsiope ropd,hnsnyi dna pnsalheeikn. nI gerealn opidio eppdsiet aer adtpssneres .(i.e ieaagnsla can)smme,hi vvldieno ni celxomp sahverobi ls(uaxe ittacn,raot bguiamiessvsveger/ssi a,rbh)iveso nda ildtimecap guohth( ton idneftievi) in ciihyaspcrt esddr.srio
velOr,la eratrsmstenrnuito = tepy yes:tp lmsucllle-aemo tmternsastri and pniorputeseed, eherw asmleclmlelu-so ireattsmsntr aer seartf dan ameeidt rapdi anyticps imntisnaossr .(.ei aneongdr SNS ifgttifrghlfghti/h/ ukicq o)ree,npss eherw as eputpieonresd ao(gnl htiw gobiilco esnmai nad emos mlsal coulemel em)irtnsttsra ear wolers nda teemadi lrgu,ada ponolgder m.tinnosonrrsiuesa
eSmo reus:ticp aeeh__nkro/imcusi/edprrwvappfw./.w/ttmouuitvnehrdtnahksloen_prisde/uo.ttbetem:, dotctr:eld.3tt-/eisscee40ha/Toh.itB7eeeppgAG6a1resbtaoacaP8hb9lrusBgie//1/0w-frfi300pnu5d-23ar61ufmi-64/-6sfeR3rd/bpgb-gpc1arn2rwaiw1sore8g2nl-04-A, adn _emt&h/1-plsnU=9g4xtr:da#5n/fdge;abwewr6-8xl-/dhfe=rtgphe-7el3-nabe-f116iai2afabd.st-ee0/5/s2g3c.i1-al.0bwbuo/awditg
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