oS, ofr soem oasrn,e naemtnsrsrrtutoie si mensighot Ie'v AYWSAL luredtgsg .ithw.. parlbybo uceabse I ns'wta gtahtu ti lwle so nreev yrllae aeelndr ,ti tsuj dealner hnguoe rof twverhae .axme I ustj doufn sith boo urghtoh ICBN adn its IF!ATCNTAS 'tsI fmro 1200 so ghtim be ,old but it swa rat.ge You anc acesrh ohghrut eth kobo dan dfni hte sehctr.pa I tprety hcum ustj enwt guohhtr all fo hte mnriotsturearnte acetpr.h k/i1.slnn0o/mw.wnvNpKhbit/o97.c.:Bg/ot9bwh/s

My main ttmGluk asaw:aeeytaa- = jramo tctyaeoxri .ttiamtornrueesrn woT pstey fo : otspre1e)cr btmarocoei,pt tsmo of wichh aer pcnypasriet Gi ihwch leads to dsdcaeeer DANM epcoertr iivcatty dan ksri fo xcitoietxyi,tioc ro ttposnciypsa Gq ecetprsor htat edla to sneciear N,a+ K+, and rdeadeecs atglmtaeu cussea arianeoidtolpz nda encardies ++Mg esidlnpatmce dna MDNA epctoerr yvticita adn rksi fo c,tyiexxcoittoi nda ) 2 nootrcoiip achnlnes nidglcinu DMNA nad Aie/ktaAanMP ,elhscnan ihhwc lal alowl icnencpfios icotan ,inuxfl tbu ynol NMDA wllaso +a+C lunxfi (dan ynlo ni a aoevtlg tedenedpn raemnn after tiuifcnefs alnzodaieoitrp sah sdadeplic eht ithniirbo ++Mg ion ni teh laenn).hc

AGBA dan ycilegn = rnitibhioy as.untnorrsiettrme )1 AAAB-G dna B-GACA = nooiripotc lnhnaecs that edal ot exful fo C-,l adn teiedps hsti siuangc ,pztdoiiraonlea eht ounenr tilsl ytass owebl ernsgti .tatieplon AAAGB- bningid iets rfo ,rataisubrteb s,srodeit GAAB, dna iopntrciox = enidsi pero of aehclnn. -AAABG nnbgidi eist of zeeidnipaosenbz = eoisdtu fo rpeo of nhl.aecn )2 elGnicy lhceann is a yver smaliri Cl- lxuef enn.hacl 3 ) ABAB-G is a ptmbcoitreao nelahcn htta tecasvait iG idelgna ot edraecdes MAcP hiwhc eitcvtaas xflefu +K acnhlsen dan iinsitbh aC++ niulxf aechlnns diganel to .atropainzeoilpyrh

ciBoineg inames = ceantisolehacm imdponea itdnocoarno(i fo odby evn,mtmoe ardrw,e it,moinotav citfomee,)nrnre npronepenehiir e(,pesl afensl,ekswu noaent,tti dinfege hirabev,o ipineprhnee oltes(w ctcnnareontoi ni NS,)C puls ootneisrn ep,sel( enws,aleusfk ,nessdeopir ,naeyixt usnaae) nda nemihaist (o,aalsru oetnniat,t glrl,yea uisets ed,agam nad may nlnfuceei lobod rnaib wfo.l) lysuoib,vO lal of isth is ni noditiad to erarcdgnie niortisunanosmers nda ,lhfigt rtifgh, adn hgitf or.pessen

APT nda etroh sniupre = xericaoytt ,stmianrsnosi eeorlaes-cd hwit reoht aoleclmluemls- rartnt.meusoitnsre eneosindA si'nt ycliasllsac oridnsceed a rtoninarurtemset eeascub it stn'i deeoredlsrt/sae ni a++C etdndpnee meanr,n but ddivree ofmr PAT oefber gnhvai na actoeyirxt eopi.ltatn

heAeloiylcnct = mjora mtitrneoesrnrtua vdinlevo ni stmnoiisraunnrose via cimrnasu dan nciocinit p.srreceot

eepdiPt rirstaoteemrtunsn = ymolcnom releades sa dpepiotrep lraerg csrrspureo htta era ledveac by icipsefc ynzmese ttha ewer ni teh msae rentaiestruntmro vcesile npou elas.ree vieF tespy = gatnr/biu dpei,tpse oipido ,edieptps tuaitrypi dtpsie,p tylcaphimoah rsilnagee hoomrn,se dan oseth tno e.dislscfai peaxElms = prrseucro hatt igevs srie ot catenbssu P auoi(,cphsppm rxcoeenot, and IGT nda edaslree rmfo lmasl dmeiraet PSN C sfebri ttha sntiramt anip and rmeruapeett ia,onoimnrtf eopwlfru s,etohenvpyi iehbidnti yb iidoop i)dets,pep nnrikoeuni ,A nedporpiteeu K, dan rednotippuee a,mamg and oidopi dptepise luindnicg ptlan laoiaklsd ki(le pioh,)ermn tyheiscnt opoiid reitiadsvev, adn roph,ndneis ophsr,dniny nad nkie.nlsehap nI lgernea ioodip spdetpei are stadsrenspe (.e.i elagaians emc,aisnmh) vnlvoied in xcmlpoe horvasbei a(xlsue ratticaont, euvivsbesr/eiigmassgs hra)s,eoibv nad tipalidcme t(houhg ont neiiedvtfi) in sycaithpicr od.rsdesri

ealrlv,O mntsruesattrioenr = peyt syet:p lmlleomaeu-lsc ersitasmtnrt nda d,otnierepueps hewre cssmalme-elulol nemtriatsstr rae fesart nad aeiedtm praid yptinsac smasnsnritio e.(i. enarnodg SSN //ghtftlgighfirthif quick npo)esr,es ehrwe as presoeutnedip (galno whit iigclobo einasm dan osem aslml ecellmou imtstrnsr)eat era sworel nda iaeedmt gl,daura pldonogre srmniisotearn.sonu

Smoe spte:ucri ohdmb/erwat.oretkr.eo_/.sr:pneftemueuelasicndpiewnnuarhvwtp_t/vit/smutp_oh/idk, .Rptit/ee3t1sturhr1r/p/6td6sePlwts-p-fbg8r:3ginib4cgecnen3irehfiT0.guw2do-1/l6a1f-pGea-adera08-d-Ace0e0/iafBom2B04proo3crg/au652wss7bahbeArsl1-4a/9, and /5.f2gbin15/arh4/fpdiofb7/./wma3:deles-tltg1rwx-n1e=gw13iUhwd0tcsx_e0#led;dgt6u/a--pgfa2raebba-i&ee.e96nba---sta8=hl

ghouT nqots.ieu

Raellc taht inmMeanet sheieaz(mlr' ugd)r is a NDAM eocteRrp atioAsnngt tath plhes etpenvr ioxoectcttxiy by iBoknlcg +Ca2 ynter. saT'th hwo I reeermbm stih.

• A) G-BAAA etporsrec tle lC- ni
• B) cGeliny is udes ni het lspian rdoc sa an iytbhionir etsmtn;reaoiturrn olas ltes -lC in
• C and )E topioberctMa uegtaatlm erpsteroc are tr-Goepin dolcpeu
• eohT,rreef the lyno ghtni htta codlu elt aC2+ in is NMAD esprtceor

AMND recsptoer in iths csae era bigen edus rof glon emtr tnitooanitep tihwni teh arbin dan tuo of lal of hrete cshieoc loyn htsi ocpetrer sseu aC+

Yuo acn ewsnra yb sceprso fo nlia.ioeimnt otv"iepetCim cnisoitntre"a skmae you kntih urltoatymis TN. Csrso uto BAAG dna c.gynlie In eht oxertc os etmal.tuga Motrtopiaebc uwldo enam see'rth coesnd gesssmrene evovdiln nad het peecorrt oulwd ont itnrtmsa c.liucam eneHc A.DNM

eusd ni glon ermt notpteniotia agna(luge, em,)rmyo aMy loas plya a lore ni gene rrcatsopntiin in onenrus

1) DANM is a tametlauG troercep tyspbe) u2 MAAP is a spteuyb of NDAM tath si tiilaliyn atitvcead by luetmaagt seare)le 3 MDNA tescroper era nuodf raen AMAP reetropsc tub era nto icvettdaa yb olw llvese fo gaetmtlua asrelee eud to a Mg oin klo’ngbci‘ hte nh)enalc 4 uneqFter Anciot aptolenti t&g;— otnumatliis fo AMAP &g—;t daeosperlzi stpo icnytasp reounn &—t;g alovetg pneeedtdn Mg olckb of ADNM ecopretr meordve 5) fuxinl fo aC rohtuhg ANMD g—&t; asseuc neev roem APMA csreprote ot eb dinretse iotn the ebmmenar EOT:(N MPAA is oveipssenr to aC dna 6l)tmeagtua ) seBeacu ehert rae omre ercprteos to donresp to it, teh lcle si rmeo nsirvpeoes ot ageuttlam

lla eth srheto a icvtpoimnotene sncie ehty heav icfcisftyiepce(sipci ,sidl)gan NADM is eht oynl senevcenl(contheei evemtpiciot e,cptoer)r ash a anildg teis dna ac , na dan gn..he.mce imocttpeive