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Retired NBME 23 Answers

nbme23/Block 2/Question#32 (reveal difficulty score)
A 2-year-old girl is brought to the physician ...
N-methyl-d-aspartate (NMDA) 🔍 / 📺 / 🌳 / 📖
tags: pharm neuro repeat

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 +19  upvote downvote
submitted by nwinkelmann(366)
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oS, ofr osme nerao,s rseuetonrrttinams is omghstein ve'I YSWAAL uregtdgls tw.ih.. blayprob eusebac I st'wna uhattg ti wlle os neevr ylrela radelen ,it ujst rndaele gohnue orf warvthee ex.am I juts fdonu ihts boo htoghur BINC dna its NTFSCTA!AI I'st mfor 2010 os mgthi eb d,lo tub ti aws r.aget uYo cna raches hohutrg the okbo and dnfi the .scpaetrh I terpty mhcu tsuj wnte hrhtguo lla of teh rreostrtmnaitnue .etahprc sKo/nnhomv7/w0wBpbb.n/N.hwc:tls..1oiit9/gk/9

yM iamn kwa-Gealtae:stauya tm = rmajo yrcioxtaet t.etmteiorsarnnur Tow tepys fo p)cror1:se te oopc,abimettr stom of ihcwh era rptscypnaei Gi hwihc adels ot ddecaeres MAND oecreptr cvayitit dna rsik fo iyticixixoco,tet or cysitostnpap Gq rpeeorsct thta dela ot secranei Na+, ,+K dna dceerades etulagtma uasces depnoaotalzrii nad sdraceine +g+M esdetcminpla nad MADN roeprcte tvyactii dna rski fo yxcoc,itxietoti nad ) 2 ocinooptri nalcnshe lgudniicn ADMN dan k/eaMinPAAta ,ecnslnha iwhhc all lwoal fceipcsonin iotnca ufxi,ln utb nlyo ANDM lwlaso C++a ilufxn (and oyln ni a leoavgt peeendtnd mneran aetrf stenffiicu eaptidnozarlio sah eicasldpd teh othbniiri +M+g ion ni eth ean)c.lhn

BAGA dna ylniegc = nbtoiirihy eruneitr.sstramotn 1) GAAB-A dan G-AACB = itncriooop aenclsnh htta aeld ot lexfu fo ,C-l dna tiepesd ihts ugacnis aznieporatdi,ol eht unnero itlsl ssayt owelb rgetnsi atnleio.pt A-GAAB dibnign tsei for trtuabse,abir ,tiseodrs GAAB, nda tiroocnipx = niesdi opre of hnncea.l B-AAGA nigdinb itse of pezseideozabinn = iseudot of rpeo fo nhaecl.n )2 lcGiney cnehanl si a yevr alirsmi -lC elxfu .haecnnl 3 ) ABG-AB is a btaroocpmeti anhencl taht iatsactev iG lngiade to rddacseee cAPM hwhci eivtaatcs fuexfl +K nacehlsn nda sbniitih +Ca+ filunx enhncasl iadlgen ot hriorniotplzae.ayp

oeBcngii aenmis = ctmiaaleesnhoc eanpmdoi oitcodroinna( fo bydo tvo,nmeme earr,wd aviion,tmot )neocrtifren,em rpepnernenhioi ee(lps, nlkfs,sewaue non,tettai fiegend e,rhoiabv rnpeheneipi lewsot( cncraoonittne in CS,)N lusp rsoteinno le,(pse nklfwseause, eoeirdnps,s aeiytn,x a)euasn nda ienahismt a(ru,aols ett,ianton g,llerya tiusse g,mdeaa and aym nnicuefle lobdo riabn )fl.ow ublO,iysov lal of isth si in dodaitin ot gicrdaenre rnnoreassmiositun and ,flihgt ,tgrhif adn ghtif neseorp.s

ATP nda rheot isurenp = ctrytaioxe s,ssominairnt cerol-eaesd thiw hoert easmll-uolceml tse.toeurrsntarimn enndosieA n'tsi lsclicalays dreednosci a erorrtnastnemuti acuesbe it st'in asdd/erstloeree in +C+a denndetep anmn,re tbu evdredi romf APT ofereb ngiahv na ttciyraoex lpn.etatoi

otcehlylnieAc = ojamr timnrrntetaoesru nlodeivv ni isrsntnsmeanoiruo via smcruina dna coitininc rpsoee.rtc

ePipted teatmristnernuors = cmlyoomn eeralesd sa eprpodietp argerl esoruscrpr htta are ceavled by fieispcc yezmens htta were in eht sema snrttnoremreiatu selevci unop sarl.eee iveF ypste = rainbg/ut p,sdtieep doipio pdt,piese rpyiutati t,ipspde cyaahihtpmol lnieserga ,rnomhseo nda osteh not lsca.siiedf elpaExms = ruocerspr atth sevgi isre to stbunasce P oi(ucpaphsp,m ,xoenrocet nda TIG nda deleersa form llmas mirteaed NPS C ifsrbe taht atmistrn pnia nda reeamuteptr innriomato,f leouwpfr hyspoievetn, dnteihibi by podiio sdp)eptie, ineuioknrn A, dpopeitunere ,K dna uepoetpnedri ,gamam nda piodio deseppit igcunnidl pntal sialdokla ei(kl omr,iehnp) sttyinhce ipdooi aie,vdrvesit nad nrnpdsio,he hyspd,irnno and pheasil.nkne nI galnree podiio iesdptpe aer ntssspderea i..(e lasgeaian nmmeaih,sc) vnvileod in loecxmp irbehsoav l(uaexs ta,toatirnc erisvaesibvguis/esmgs )hoaevb,irs nda alempdicti (uhgoht otn neditvfi)ei ni siytrcpahic srdo.ersid

llre,aOv tintssarreeurnmto = ypte sptey: oul-cllmlamees msaerrtttisn dna onuepited,sper erewh caeomlulls-lmes ttmesartsinr era fretsa and etaeimd iadrp taspiycn trinimsonssa ei.(. orndneag SNS /fhitg/lfgihrtgihft icukq rsosep)e,n wheer as eednopreutpsi (gnaol tiwh oglciibo sinmae adn omse amlsl ceolmleu sitant)tsrmre rea erwosl and maedeti laarg,ud ndogpreol ii.rnnsssmunareoto

oemS ut:cpseir rt/trafrwuaopv.trd_nwe_ttohhrsp_/p.totwmnbd/indcsil/:emnmei.esveeukok/aheeuuip, 4u:pif/sp68shee23ede3ah2od7i6aiwnoo9/ptnl-abub-de.bpceeoi10a0c131-4wtrct5-auR4s8rB/BrpAbrefagrPs.tfie6r---a-l6t/eg0mg30srfhwg/iGgs/n2lctT1/a0reArd1, adn i9bda/st/rel/da1#ddt-t-sa&lstl-1-0xe-gf2.U7e3hca8ffubeb3ae-aenwgp-.tb6-fpeign5.g=e16wd=neg1ba2/i0h4wrw/ha/l_:;oirmx5

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sweetmed  ishT is ngzia.am thank oyu +
sweetmed  Tshi si .agazmin haknt oyu +
paulkarr  ..aWh.o +
brotherimodu  trhoS idove esnemoo otepds mofr M2BN1-E :wsenrsa 2wuoczowa/Hsv.?tpt.=:owycDuve/w-4bhhmtwu/Qt +6
dorischang  itdn'D isfnih agnried hi,ts btu it osokl aoemesw +3
kcyanide101  If yuo nawan iwter a txte oobk ujst asy o.l.osl.. ): +

  • effect of glutamate antagonist on pt with acute cerebral infarction = targets NMDA receptor

  • decreases calcium entry into neurons = decreased excitotoxicity = promotes recovery from acute cerebral infarction.


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 +19  upvote downvote
submitted by sympathetikey(1600)
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Tgouh nuieqt.os

aeclRl atth aeMimnent (hzal'msreie )ugdr si a NMAD eceRoptr soingtnAat tath slhep petvrne xxtyoiitcetco yb ikgonclB Ca+2 yetrn. ah'tsT hwo I errembem sih.t

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veryhungrycaterpillar  sne/j/:wro90.n/wsgc.oothoe/u03sth.tnrt91rwpct/i/ater G etillt aed,r dan tish si the aeprp htey tetpyr hcmu asbed shti neiqotus .on +
veryhungrycaterpillar  ndLeik hte rowng re.ppa aetnM to iknl ihst oe:n l8m7nvtwobcc//gtail.0C6s/M.wp5/m/w.nP:pie2r.h/nci6ths +

a picture for better understanding https://2e.mindsmachine.com/asf04.02.html

^ link is dead :( (they published a 3/e) but here is the re-route to the new site if anyone wants to dig in https://learninglink.oup.com/access/watson3e-student-resources

+/- drdoom(1206)

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 +4  upvote downvote
submitted by spow(50)
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  • A) AGAB-A otsrrepec lte C-l in
  • B) cneiGly si dues ni the snlipa odrc sa na oritbyhiin umostrrr;netintea saol etls C-l ni
  • C nda )E ectMoiptbroa mgealtuta prsecrteo rea petonGri- ulcpdeo
  • fehoerT,er the nloy tighn ttah locdu elt aC2+ ni si DAMN tecpsrreo
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thotcandy  dgccaroin to isht, T35H is na ino hanlecn ny(alim aN dan K, tbu meos C)a os atht swa kidna fefy imo +


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 +3  upvote downvote
submitted by lfsuarez(160)
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MDNA rtsrepeco ni sith aecs era bigen dues rfo nglo rtme pineattntooi niitwh het raibn dna uot of all fo reteh ceoshci lnoy ihst rpceerto sseu C+a

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 +1  upvote downvote
submitted by chasingdreams101(4)
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I ekipdc NADM eubscae ’sti ruiya,ltstom tbu si rhete yan depeer asrone orf hst?i

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tea-cats-biscuits  hTe Q si atulyalc gnksai cihhw fo het repcoerst seu a+C oin,s and fo eth hcceosi envig ylon NMAD recortpes od .so +32


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 +1  upvote downvote
submitted by adong(144)
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You can rnwsae by psrosce fo nmoeaiinti.l t"pietmoievC tasinnieo"tcr ekmas uoy ntihk mtryaouitsl .TN ssCro out BAGA and ely.cing nI eth trexoc so at.ategulm poitobatcMre lduwo eamn ese'hrt ocsned seeenrssgm envdivlo adn the protcree owldu tno ttnrimsa muliac.c nceHe ANM.D

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 +1  upvote downvote
submitted by an1(114)
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usde ni ongl ertm tinepttoiona ,ae(gaulng rmoy,)me yaM lsao alpy a oler in egne inprsantocirt in ronuesn

)1 NDMA si a aGulattme roertpce ytsu2b)pe PAAM is a tyusbep fo MDNA that is yalliniti iveattcad by gmtuatlea )3reelaes DAMN rerocetsp are duonf arne AMPA etsrcorpe utb ear ton aaetcitdv by wlo eselvl fo tlaaeugmt eesrael due ot a Mg oin ock’‘iglnb eht )4nn lecah etqneFur tAicon aloptenit g;—&t usimitonlat fo AMAP >— aospzdeielr psot anysictp ueonnr &g;t— eaoltgv eeenntpdd Mg bcklo of NAMD prterceo mdvoere 5) xulinf of aC tghohur DNAM ;—> eucsas even rmoe MAAP peesctror ot be eerditsn into teh rbaememn T(O:EN AMAP is resisneovp to Ca dan am u6g)aett)l aeueBsc eethr are emro etsrrcope to ndseorp to ,ti hte elcl is omer epvsisneor ot eautmtlga

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 +0  upvote downvote
submitted by zpatel(36)
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lla hte hsreot a inpvteoitconem eicns hety ehva citcifecsicipieys(fp adsni,gl) MDAN is eht lyon nonccviheneees(elt mvopetticei r,)ptreceo ash a dlgain tsei dan ca , an dna gc.heemn.. tiepciomvte

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hello  eht neistoqu ayss evitpoiemtc nanoris,citte i nhitk hist si rdneftfei omfr etmocpetvii bgndn.ii +


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