effect of glutamate antagonist on pt with acute cerebral infarction = targets NMDA receptor
decreases calcium entry into neurons = decreased excitotoxicity = promotes recovery from acute cerebral infarction.
Tohug unesqoit.
lelcRa ttah mMtnniaee 'irees(lahmz gud)r is a DMAN Reeportc Agntsnoiat tath hples envprte txceittcxiooy yb Blcogikn Ca2+ tnyre. tTash' ohw I rreembme stih.
a picture for better understanding https://2e.mindsmachine.com/asf04.02.html
^ link is dead :( (they published a 3/e) but here is the re-route to the new site if anyone wants to dig in https://learninglink.oup.com/access/watson3e-student-resources
AMDN ereosptrc in htis saec rea bgeni euds orf ognl mrte tteipiontnao ihitnw the arbin dna tou of lal of eerht cioeshc onyl isth otceerpr sues aC+
I kpcdei ADMN beausce is’t oalyr,utimts btu is erhte yan rpdeee seoarn for ihs?t
Yuo acn wnrase by prsceso of aineiltmi.no mi"petotveiC inotirsacten" mkaes you nhitk ulsmitratoy T.N rsCos uto AABG nad lgney.ic In eth rxotce os emlg.atuta tetopbroaMic dwulo anem 'hrsete nodesc senesesrmg evnidlov dan the tperecro dolwu ont tmnratis alcim.cu ceeHn M.NDA
edus ni long tmer itennpoaiott gl(neu,aag r)m,myeo aMy salo aply a oler in nege cirnsntptoari ni uonersn
)1 DAMN si a ulGaaemtt potceerr )yp utesb2 MPAA is a yestbup fo DMAN htat is tllayiini atviceatd by mtglataue a )3eelres ADMN strerpoce ear udnfo eran APMA esprrecot tbu aer otn tadeivtca yb low lsleve of gltmaaetu elsaree deu to a Mg oni kg’oni‘cbl the nl4) cehan quFteenr onAict etatlponi gt&—; toinauimstl fo APMA g;—&t osrdeplaeiz sopt ciayntsp rnnueo ;&g—t gotalve edtnpnede Mg ckblo of NMAD eecpotrr moeevrd 5) xulifn of Ca oghhrtu ANDM g&t—; easucs nvee remo PMAA oretscrep ot eb eteirdsn tnio hte emmernba :N(TEO APAM is evnresisop to aC dan l)eua6t tg)am acuBese ehtre rea remo pocrestre to pnersdo to ti, eth lcle si eomr enrieospsv ot leagautmt
lla eht hoesrt a epinenvtooitmc insec htey vahe iiyc(icpcpefscifseti d,gins)la DMAN si eth noly hinvtleee(nenscoec eiimtceovpt ,ecp)troer sah a glidan teis and ac , an adn nchm...ege mpoievtitec
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yM mani ekaayautaws :m-ttlGea = amjro yetacrotxi mtron.teairsteunr Tow sepyt of :orcs)e rtpe1 praoie,ttocmb osmt fo wihhc ear anrtyecppsi iG hhwci ealds ot seeradecd DNMA reoretpc aititcyv dna kris of iytoxecixt,itioc or sntoaictppsy Gq epertcors thta elda to niaeecrs a+,N K,+ and deecdasre telaguamt ssucea ooaelpraziitnd nad esaierdnc g+M+ nscmledptaei dna AMDN eerorctp titvciya dan srki fo xtietoi,xticcyo and )2 otciporoni cnhasnel gdiniucln NADM nda aanAePi/MkAt ,nleanshc icwhh lla alwol scinpfeoicn coitna fix,unl but noyl ADMN lwsloa a++C fxuiln dn(a lony in a egvlato eendtdnpe ermnan frtae tfiiucesfn ldoeiztpionaar ash dapledisc hte otribhini Mg++ oin ni eth chl)nane.
AAGB nda iclengy = ihniotrybi .rttnrimtsansereou )1 AABAG- and CAGA-B = iictonoopr cnhensla thta aedl to exlfu fo lC-, adn ptesdei tish ucnigas ardleit,pzoaion eht oneunr lsitl ssaty lbeow tngiers toaipnt.el AA-AGB gidnbin stei fro rriuatb,satbe ,drsoeits AGA,B adn onptiirocx = disein orpe of cnan.lhe A-AABG ginnbid tsei of pinznozeeaedbsi = oiedsut fo oerp of nahle.nc )2 neclyiG laehcnn is a eyrv ilisarm -lC xeufl al.ennch 3) -BABAG is a ptarbotcimoe hcannle taht iatcesvat iG naidegl ot eeaserdcd MPAc hchwi aeasttcvi effuxl K+ alhnncse nda inbiihts +Ca+ nxilfu aslennch ilgdane ot proaipnhtorezlyia.
geicBoin semnia = ieocahlscetnma eaipdomn anocondtiri(o of dboy no,mveemt rraed,w ntoiivma,to rfnrenc,eim)teo hieopnernnepir pl(ees, nssueekwlf,a ttennia,ot feigned hve,raibo phneirpniee l(owste tancieornnotc ni )S,CN ulsp oinotsnre ,elpes( euswa,nlksef opsdrnsee,i tneia,xy anuea)s nad taihmseni (saoalu,r aenintot,t lyg,real stiuse adagem, dan yma inneluecf ldobo nabir o)l.fw uv,loOibsy lla of hist si in dadionit to dcgrieeran risoaotumnnsernsi dan t,fihlg gt,hfir dan tghfi nsseerp.o
PAT dan eohtr piesurn = trayixceot tosnmrassi,ni slocaee-rde hiwt eothr llosmcl-leueam u.rtrmtaensneoitrs enonAidse it'ns lillsaycacs isrdoeecnd a mtresnurenrtotia ceausbe it itns' dlestsd/areeeor in +Ca+ tndeeepdn ,nmnera tbu edvirde orfm PTA reebof aghvni an iyettoxarc .tatploien
oAyclieltenhc = omarj eratunrnmoesttir veolindv in siamronsnounrseit aiv nruciasm dan ciciiotnn repc.ortes
Pedpeit msrtretteiosarnun = myomcnlo seaderle as rodpeeitpp rrlgae reorsrpcsu htta aer laecvde by cfeiipcs eenszym taht rwee ni het aems tneatimentsrrruo csveile pnou eerse.la viFe sypet = /gantbriu pdeitse,p odiipo p,tesepid aytirutpi ,tdseipp ihpclohaamty nlaegiesr ,soohenmr dna ohtse ton scsalf.eiid mxalseEp = cruesorrp ttha svgei srie ot casnetsub P caspp(pim,ouh ntxeoc,ore dan ITG nda ealresde rmof sallm rdiateem SPN C birfse atth mstnitra pnai dna ertumepetar f,intnrmaioo wloruefp vh,seytnpoie inhitideb yb iodiop eepid),spt nriokuinne A, rnepetpuedoi ,K adn operipdeutne agam,m nda ooidip eedpspit diunniglc pltan ksloadali kile( ne),piormh eitcstynh idpooi avsired,teiv dan rensohn,ipd siopd,hnrny adn lipksnnhaee. In eealrgn ipodio dspetpei ear eeanrsdstsp .(e.i naaslaeig ic)msaehnm, ondeivlv ni epmcolx risabhvoe s(uxlae toatntarc,i sveesis/vsegumibagris e,b)roishav adn mclpitidae gutoh(h tno ftiedniiev) in hcsryicapit sdds.rrioe
e,ravlOl rtssranurmoteenti = pety tsype: ull-loemcelsma rtrsaitntesm adn iedupspeontr,e weehr esclloae-llusmm snartrtietms rea terafs nad atimede airpd acpintys nstmnirissao i..e( nregonda NSS flhf/ritgg/htfghiti ikuqc ),nrpessoe wehre as eriuetposepdn ona(gl twih cbioolgi naesmi dan meso mlsal cmueolle s)maittrrtesn ear eslrwo nad itemade lr,udaag edolrnopg usomsr.nnstaiornie
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