oS, ofr emso nroe,sa umratnstterensoir si eomgnshti v'eI YASLAW ugltregsd t.whi.. lyarbbop cbuease I wnsat' uhtgat ti ewll os eenvr lrealy eerlnad it, jstu erldaen enuhog rof evatrhew e.max I jtus uodnf isht obo roghhut NBCI and tis CS!IAATFTN s'tI omfr 0210 os hgimt eb ,old tbu ti saw get.ra ouY anc shreca ouhrthg teh boko nda dinf het c.rhpteas I terpyt mcuh jtsu wten otrguhh lal fo the uneronmtesttrrai h.artcpe n1hil.c/B.pN./s7twg/onwtwm9ob0bnK.vikho9:/s/

My mani lteseaaGtykaw a-u:atm = omarj oiyttecrxa nutsaiot.mrrtenre Two etsyp of :etr e)cpo1sr oraec,ibmttop otsm of hichw era nptycsaprie iG hhcwi elsda to ceedredas NDMA eocerprt ayvtctii dan iskr of t,xxeitooccyitii ro stcpiotnpsya qG ctrspreoe hatt leda ot snireaec aN,+ ,K+ adn ceesaedrd aumegaltt easucs loriapztieaond dna ediacrnes +Mg+ ansltpmceied dan MDNA orretpce vayiittc and iksr of ooxitei,tcixcyt adn )2 roincopoti slaennhc ciunigldn MNAD adn /aPkiAAMtena snehncl,a hhcwi lla lwola ipneosnccif oactin uf,xnli btu yoln NADM laswlo C++a uxlnfi dan( onyl ni a ovagtel neeedpntd eanmnr frate tcuffneiis dlareanpotziio hsa sdcaledip teh itirhnoib M++g oin ni eht cnn.al)eh

GABA and gceinyl = ihointbyri aoim.strenutntrrse ) 1 AABG-A and BCAAG- = corniiotpo esnnlhac atht deal to lfuxe of C,l- nad pesiedt sthi giasncu ploadoaitz,rein eht nenrou itlsl asyts wbole tginsre l.ptianeot AAB-AG ninigbd itse fro s,trraebauitb i,odetssr GAB,A and ooptxrinci = snieid rpoe fo n.nlchea GABA-A ninidgb etsi of oesazzeinpedibn = todueis of erop fo lncane.h 2) celGiyn anhlnec is a veyr alrsmii l-C leuxf ncheanl. 3) G-BAAB si a pectomtiraob nehlnca that teatiacsv Gi enagidl ot adecesred cPMA hhwci itvtcaaes fufxle +K slnacenh adn iiibstnh aC++ luixfn nnlahsce gelidna ot iinpztr.orypaaehol

Bgneciio msiane = nohailceatecsm eindmpoa tonaronoici(d fo obyd et,nevmom adrrw,e io,vmationt t,enerofei)rcmn hrnnieoeepprni l,ee(sp wssnl,euakfe itneotn,ta edngfei haovbire, inpeepnierh oe(swtl nrceittcnnoao in CS,)N plus eirntonso eps(,le fln,seekwsua diss,eeropn yexan,it ae)usna nad nsahimtei ,saualor( at,tetinno lr,eygal eussti eag,mad adn may feeilcnnu odblo iabrn lf)ow. Oouyl,svib lal fo hist si ni itiaodnd ot rrgcnaidee aenoinusrnoristsm dan ithflg, hrt,igf nda thifg rps.snoee

TPA dna oerht esriupn = oxirtyeatc nsosarit,nism cleedsr-eao wiht ohter lmmelcausoell- nreasmtoistrr.tune eseinoAdn 'nsti yailalslscc ersdeindoc a esaurmrtttnonier ecaeusb ti tnsi' edraeredl/etsso in +Ca+ peetnndde nema,rn but veridde rmfo ATP febero nvahig an teitxacory nto.liptae

lheconylitecA = ajrom orstmeetntrinaru dvvnielo ni eaimnisuornorsnst avi arinmsuc nda oiniinctc rs.ertocpe

pteideP eattiursoesnnrmrt = ncomymlo edleaers as ipertpepod raeglr rocseusprr htat are vceeadl by iipcefcs ymsznee htta ewre ni hte same oattensirrnreumt elcivse ponu e.rlseea veiF estpy = nri/bgtua pidtsepe, diooip ,tpsieped iuytpairt e,tspdip tcypoaiahhml laeignesr reshomo,n nad osteh otn eilia.scfds axslEepm = rerrcspou ahtt siegv iser ot sbeucnsta P m(o,cpsppahiu teoc,neoxr adn ITG nda sdreaele rofm malls ireatmed SPN C freisb ttha ntartism pani adn tupemrereta ofaontiir,nm eufwrolp otnpvse,yeih tibdeihni by oipiod tpp)d,iees eiunknrnio A, ueirondetpep K, dna etereponudpi mmga,a nad ioiopd eppedsti nignduicl ltnpa ilkasdola e(ilk ie,rhn)mop tenytshci ooipdi s,dtievvarei nda nrpdiesohn, p,ohysnnrdi and spkneel.nhia nI lgreaen doopii ietpepsd aer dpesntsersa .i.(e aanglseia c,ameh)msin dvlvenoi in mxocepl avsoirbhe l(useax oacit,tatnr vaegmivessgrissiseub/ vrbe,osaih) dna deptmiical ho(tugh ton ievdteni)if ni cirpcyaisht orsrdeds.i

Ov,ealrl aotnnrumestisrert = ypte spyte: esll-lmlaumoce tremnaisrtst dna pperosuti,eend ewrhe meclllussol-ema mteatssrinrt are efastr and emdieta pdari istcapny nositisrsnma ..i(e nrdagone SSN i/tgirh/hfhftlfitgg kuiqc rse,epnso) weerh as seenouedrpipt nga(lo tiwh loiocgbi inemsa nda smoe lmasl lmecoule tmaris)rstent aer worsle dan dtiemea ar,gauld grpoelond osirurmi.anennosts

oeSm et:rspuic :tdmauo.dp_s_mhfin/hicdu_/.opbt/ienmenlrteowt/staerpw/kntke.eourvrawsieeputvhr, p14rr3nasRl6wl-srgae0.hinBdnhcs1s6lrrcpae/otcw/Pap2Ggd10d/airweehiB-f14tab5r3s6oe2sftepiuf-A039103i.7/e/e:48artb-g-e0omr-/pfeTdbg/tatA2-ugiec6b8uo-, dna x&-=ef5gswbegbiamg:na1rt/trlel-b/1a_o0-w.adngapl3d=#-bn.Uwe6i-/522as/8-4fhe0i/edtdtl.g37eu1/1e-wffext-cap;9hr6hasbid

ugohT ne.tousiq

leRlac tath eamMitnen lermazs'i(eh g)rud is a NMDA orcRtpee sgtiaotnAn ttah hepls vnrepte ootcyciitexxt yb cnikgBol aC2+ ernty. t'shaT woh I eebrmrem tish.

• A) -ABGAA repsrocet elt lC- ni
• )B clyineG si eusd in eht planis drco as na ohitrnibyi ntriatm;tsreeruon salo ltse l-C in
• C dan )E ticbtprMoeoa tagelmtau eecrpstro rea nre-iotpG oupclde
• ,ererfoThe teh oyln nhtig tath cdlou tel C2+a ni si AMDN rspteeroc

DAMN tceropers in ihst asce era engib deus fro nglo term ttpenotoniai thniiw teh nbari nda uto fo lal of rthee csohcei lony tish teeprrco uses +aC

Yuo anc aensrw yb pcsores fo .mitiloenain etimp"oetvCi ansncitte"roi msaek you hitnk aotmiltsruy .NT srosC tuo BAGA dan ycig.lne nI het extorc os meuatlt.ga ooptricetMab dlwou mena steh'er cdnose sgsnsreeem lednvivo adn eht rretpcoe wlodu tno mnrttais ucm.acli nHeec MN.AD

esud in onlg ermt otetntpiinoa u(al,ageng ,m)eomyr Mya oasl yalp a rloe in eegn cisointrrpnat ni eurnson

1) ANMD si a uatteaGml percteor )ub2sp tye MAAP si a tpyusbe of DMNA tath si itnililya taedctiva yb mtlaatgeu re leea)s3 MADN croesrpte are onduf nrea AAMP rsoeretcp but are tno ttvdiacea by low lvlese fo auameltgt esraele ude to a Mg oin kgbncloi‘’ eth hencl)n4a Feentqur Atiocn eipatnlto &—g;t aimnittsolu fo MAPA t&—g; zedioaprles tosp ynatscpi nnoreu ;&—tg ovlgaet eendetpdn Mg lbokc of AMDN eectrpor erdmove )5 iflxun of Ca turghoh ADMN ;g—&t esusca evne orme PAMA eocertprs ot eb itredsen iont eth narmbeem (TN:EO APAM si sinovesrep ot Ca adn mat6egtl)u )a aesuBec trhee rae rmoe etprorcse ot edsopnr to ti, eht elcl si erom snropesiev to gaeamlttu

lal eth ortehs a omtoipcnvitnee ecisn yeth hvae sppiteccfifeics(ciiy g,sdln)ia MAND is eth loyn nevlctesoeinec(hen ovtitcepeim etpcero)r, ahs a dgnali tsei nad ca , na nad egh..emnc. veecpoiittm