o,S for emos eo,rsan uretmrornnatetsis si imohntgse 'Ive WALYSA sedrlgutg .hwti.. rbpyloab caesueb I a'sntw ugahtt ti ellw os evren llyera dneaelr t,i tjus edaenrl oguhne fro verehawt .mxae I tjsu fundo htsi boo rgotuhh CINB and its TFCASN!ATI s'It from 1200 so himtg be ,old tbu ti saw gaer.t oYu anc rseahc uohthgr the obok dan ifnd hte hs.ctreap I tterpy hmuc just ntew horhgtu lla of the nerarrsemnoitttu hrta.pce mb.ws.tovwgl///h/konn0ich9KsB/n.b9Np:iw1t7o.

yM naim ma s:auwetaattay-eGlk = rjamo otyaixtrce .sretttrunmireaon Two pesyt fo rt1:esroc)e p cportema,ibto most of hcwih rae cnrptaseypi Gi ihhcw seald to decserade NAMD tecoerpr atviityc nda rsik fo ,cioxixoyctittei or sapsctypinot qG pesrtcreo tath dael ot rneecasi +a,N ,K+ dan dcsdaeere tgtmaleua sceaus zeoadpnitiolar adn scidrenea +gM+ sdaitemlcpen dan NDMA ocerprte aiittyvc and srki fo xiitotycxcte,oi nda ) 2 cnoioorpti cenhlnas nlgcnudii DANM adn netiAaP/AMak nn,hcaesl wihch all alowl eccpfnnsioi aitcno x,nlfiu utb lony ADNM alolws +aC+ ixnlfu dna( olny ni a lvtgoae neenedptd mennar rafte iftcfensui oatdizpnareilo sha sailpcedd teh itiihronb g+M+ oni ni teh en)nc.ahl

GAAB nad lnceiyg = tinrbyhoii rnmrri.tatuontsese 1) BGA-AA dna BG-ACA = npiooocitr annhscel ttha ldae ot fluxe fo -Cl, dna itdsepe stih scnigau drnoa,lziaptoei hte nunoer tilsl ysast lwobe eigrstn eo.pttnail -AAABG gbdinin iset ofr reutb,isaabrt rtidso,se GA,BA and rootnxpici = iendsi reop fo nhn.ealc GABA-A ibnindg esit of bznpenziaidseeo = uioestd of rope of na.elchn ) 2 ynGclei nchnlea is a yver msirlia Cl- exufl .hlecann 3) GA-BBA is a amcptoiteobr hcnneal htat ciatvtsae iG ialngde to eesedcrda PAcM cihhw tcviasate uxflef K+ clsahnen nad bistnhii aC++ nufilx clseanhn lgdanie ot aiotlrepaznprhiyo.

oncBiige seniam = emtsaealhcionc odinaepm roncoin(oidta of bdoy vnmmoeet, d,erwra moiattivn,o ,ce)etreinmonfr niipnnerehpero e,sp(el fulaweesn,sk otneitnta, nidegef veihaor,b npheepiirne wo(lets anncenittcroo in CS),N plsu ersonoitn (,elspe funsseeawlk, psosnidr,ee yneti,ax sua)nae and minteaish (a,arlous ottta,enin rag,leyl etisus gdem,aa adn yma cienflnue bdloo ibran l)fwo. boi,Ousylv lla fo this si ni tnoiaddi ot ecdrriegan oeounriinmntrsssa dan lthi,fg ihrfg,t dan gftih ser.posen

APT and ertho urnspie = xioecyrtta mtrn,oiaisssn e-leracesod hwti eorht mlselamo-llceu osrnnutmeerttaisr. nieoesAnd in'st lyliacsascl edcdoiners a taeumtenrsniotrr ucebesa it t'sin sradeseeeortl/d ni aC++ pdeteednn nmrnea, tbu eerdvid rfmo TPA rbeofe ngahvi an aoexitytcr toati.npel

Acleyiceholtn = amrjo trernanteiruotsm ovnvdeli in osuisminnonartser iav munarcis dna oitiicncn ep.strerco

dPeipet nrtmsoarsnreuetti = onmyomcl esrdleea sa popedtrpie raegrl sreroucsrp htat rea cevlade by iscfpcie yeesnmz atth wree in eht mesa entreirtsruontma eeslciv unpo lesr.eae viFe etyps = rubian/tg psd,iptee odpioi dpeietsp, uryptiait pets,pid ltphcaahyiom igelerans ehnorso,m adn sheot not iafds.escil axsmlepE = ucrrsepor taht egisv iers ot scanbtesu P ahpuci,smop(p oroxne,tec adn GTI dna seaeledr ofmr smlla teamedir PNS C irsebf ttha ittsarmn ianp adn teerrpeuatm ,tamononrifi orpefulw ieytp,evohsn itheibdni yb dopiio ),peeistdp ronneikuin ,A tenieuerpdpo ,K adn eotrpienpued mamg,a nad iidopo pdsteipe idungicnl tapnl dsailaklo l(kie ompn)erhi, nthitsyce iodpoi dtesvirai,ev nad prnd,oeishn ydpnhir,osn and ealhkeins.np nI nlegera odipoi petiesdp aer ptnsseesdra e.i(. gaialeasn inahms,mc)e vlvdeion in xlemcpo shaerivob se(xula ttr,tnaocai se/suabimsievgirgvess )aioh,rbves nda ciiledtpam gh(uoht nto )itieneidfv in yptsirhccai d.srrioesd

all,revO srnruetsnoirttmae = yetp y:tpes easlluleco-mlm tiattnrmrses and eirosnp,peedut werhe scoalemsl-lmuel amtrsisrtetn rea taefsr nad etimaed prdai aitycnsp ritinsamnsos e(i.. readngon SNS gfhgigirhf/lt/ihtft ukicq esosern,)p ewehr sa epuripeesdtno ngo(la thiw biloigoc asemin dan smoe smlla eemolulc rnti)etmrssta rae orslwe dan idmaeet ug,raald gnperdolo o.nnnsesuiiatrrmso

meoS eptc:iurs nminkeup/e./p_tbmeoesthwta_drr_:wr/rnturfnthssaoevpep.e/.tu/kdodwaieviuhmtlcoi, a50rs-02-ba8s-uerPrisi0pug/t/lfftiee/1:aee0.67s21rof/b2/te-seGfehdgb3-oa1pp-Bci9wicaT63cd34ow1RoAnbid3g8g1Are/Bachtper.4gme/uanrdt0prhwl-4nr6s-lt6a, nad ltla-eg-rbid-_xa&g1aeg.litrdade2rww=1fp1i#t8snn-hU-at7bhc26a/p3fewfb69b1edwgxe:=o;i5/5um3helest//-e.g4/0-/asabn.-d0f

ghuTo eosiqtun.

cllRea htta tiMnnmeae sem'lrehiz(a gud)r si a NDMA epeRrcot agtnAoisnt atth phsle etnvepr oytitecxxcito by iokBglcn +aC2 enryt. st'Tha woh I meebmrer .ihts

• )A AAG-AB crreospte tle -lC ni
• B) cleGiyn is eusd ni teh pasnil crdo sa na ioihibtryn raoriurmnentse;tt lsao elts lC- in
• C and )E ctMrpoaobeit lttaemgua eeprorsct are pntirGe-o oupldce
• oeTefe,rrh teh olyn ignht ttah doulc tle 2+aC ni si DNAM ceorsptre

DAMN rsepctoer in sthi ecsa rae genib used fro olng mter aoetinptinot thinwi hte irbna adn tuo fo lal fo terhe icheocs oynl tihs tepcrero usse a+C

You nca snrawe by osscerp of t.naieimlion Cvtopiee"tmi c"triateninos emkas uyo hkitn iltatosurym T.N sosCr otu BAGA nda eig.lync In eth xrocet os ut.taelmga tiortapceboM wdoul name tre'she deonsc merssneseg vondvlei dan hte ptreoerc udlow ton tstarmin clmica.u eHcne DM.AN

sedu in long rtem oointeatpint gage(lua,n )ymrmo,e May salo lypa a leor ni eegn acrnntrostpii ni ernonsu

)1 MNAD is a etamGutal rperetco e2py)b stu AAMP si a suepbyt of DNAM htta si nytlailii atdcvtaei by tlauatgme eeer3)als MADN poecesrtr rae udonf earn PAAM serptrcoe but are not itatvaecd by owl lsevle fo agelttuam serleae eud ot a gM nio bo‘c’gnkli teh haec 4)nln ereuqnFt ictonA itnpaotle —g;&t tiotmilnasu of PMAA &—gt; aseoidrplez opts pyaictns onrune gt—&; vtageol pednenetd Mg blokc fo NMDA creeptro moeevrd 5 ) nlfuxi fo aC hthogru DMNA &—gt; cassue neev mroe PMAA resptcoer to eb sitedrne toin teh armnbmee E:ON(T AMAP is sropnesvei ot aC and m a)tle)ta6gu ucaesBe herte rea emro posercret ot ondpesr to ,it the clle si reom espoensirv to autaetmgl

lla hte thsroe a ienotevncmtoip icens ethy ehav ipcei(eftiicpcsiycsf gisl,)and DNMA si eth ynlo oetinevnslch(eceen eceoipmtvti o,cet)erpr sah a ngilad tesi dan ca , na nda m.ec.hnge. epevcimtoti