o,S rfo esmo eraosn, tsrtosaumeenrtrin is stmgoihen Iev' WAYSAL rgletsgud h..w.ti rpalobby ebucaes I asn'wt atutgh it lwel os rnvee lyaler deleanr ,it utsj elnread hnuego ofr whtareve xam.e I stju uodfn isth obo utrohhg ICNB nad tsi INSAATT!CF tsI' mfro 0120 so mhtig eb d,lo btu it asw are.tg uYo acn echras rhgohut teh koob adn dnfi eht s.aphrect I yepttr mcuh jsut ntwe ohhturg all fo the senrutietmtroarn aerhct.p i9olbNgn/pn/n.7s.c1o:tbh.t9/wowsBm/vhKk.0/wi

yM inma etaGesuykt-awta:la ma = maroj aertxotiyc oumt.rnnrtesitera oTw tpsye fo 1r)tsc:erop e bo,oeimaptctr sotm fo whihc are crpetpisyan iG iwhch asedl to eeddesacr NDMA ctrepeor ytcivait nad iskr fo octo,exyixtiitci ro cnspoapytsti Gq cotrepers thta dlea ot arnicees aN,+ ,K+ nda dereacdse mgttealau sucesa lotoinrdpzaaie and raeenidsc M++g enidclseatpm dan MADN eercotrp vitcayit dan ikrs of xyiitteicto,ocx dna )2 iooopintrc helsnnac cniniguld MNAD adn MPAt/akeAnai ecns,lnha hchwi lal laowl ocnfnpsicie itcnoa fuxni,l utb lnoy MNAD aslolw aC++ xufinl an(d noyl in a evgtloa dendpente neanmr raeft fftsiuniec ntodreoaliazpi ahs lpddsciea teh itniibhro Mg++ ino in the lnench)a.

ABAG nda eclngyi = iihibornyt iamosnrenrtrs.uett ) 1 GABA-A dna A-BCAG = notiporico cashnenl atht aedl to fulex fo C,-l dan tespied tsih aicnugs nodlpiraeaiz,ot teh eunonr tsill atsys woleb rietgsn ai.nplotet G-AABA inignbd seti fro urraatsbebt,i trsie,sod B,AAG dan icxnriopto = nideis oepr of ncen.hal AA-GAB iinndgb stei fo eizpzdnsaioeneb = soitude fo erpo fo .ehnclan )2 lnceiGy elnachn is a yvre lsrimai -lC xleuf enh.clan 3) GABAB- is a tritcbamopoe ehnanlc thta tcivseaat Gi elnagid to sedaeedrc PAMc hchwi vtaasicet xfluef +K naechlns adn ntisbihi +a+C lxuinf nnealshc lgnaied ot hiazlpyotaoprr.ine

cBgniioe meisan = aalosicnhetecm poeidnma oodtroai(nnci of oydb mn,ovetme r,dearw ,tnatmiovoi mnrfe,)nietreoc noeehnpeniprri p,ee(sl kweue,slnsaf ioane,ttnt infedeg eihvorb,a eirnnpepieh owsetl( rooncetnniact ni CN,)S upls otsnniroe ls(e,pe ,fwuneesaslk seso,iedpnr ynx,eiat na)easu dan nsamiithe uola,s(ra n,aittenot lyale,gr steius aeagd,m nda yam elnecnfui doblo riban lwfo). oysluv,Obi lla of hsti si ni tdodiian ot gnideercra iissotosnuaernrnm adn fihg,lt g,hrift dna tfigh rsoesep.n

APT nad trhoe perunsi = otrxeitcya anntmiisr,oss ocseaerd-el tihw roeth mlmllceloua-es saetnr.semnttorrui osnnideAe int's yaacsilllcs rdedecnsio a ettasenrimotnrru eseabuc it snt'i o/eedtslrraedes in Ca++ petnendde mearn,n utb eiddevr rmfo PAT eeorfb vhngia an eyxactirot noitleatp.

eilhotAcenylc = raojm trmernstruotaeni lvdnoevi in onmssnoinristareu via nimaurcs dan nciiotnci .pcotreers

epiedtP nnstarreiosturetm = cmmoloyn rdleease as rdptoipeep grealr reuosrpscr ttah era cevleda yb iseicfpc nyzmese ttha eewr ni teh smea mnonutseettrriar iecvesl noup aer.seel Fvie types = /utbganir set,peidp dopiio eiptdps,e tiiytapur seip,pdt hachtyimloap einsraelg rn,msoeho dan theso otn .desialfcis lEsxpaem = prsrueroc taht gsvie esri to ustcnesba P s,coph(apmiup ,ncoxtoeer adn GTI adn reseelda rfom mlasl aerietmd PSN C ebifsr ttah tsamtirn aipn dan pmrereuttae nmiionat,rof rpwufole sp,oteihnvey htbiiedin yb pdioio eidsp,etp) nrkinineuo A, utepeiedrpno K, dna neidtepruepo am,gam dna odpiio stiedepp dugnlicin tlapn kdilaosla lek(i p,)rhminoe ycsetniht ioiodp dsrvei,teiva and neh,onspidr dnpryi,nhso and h.nleinsepka In laeregn pooidi pseeipdt are rdeeapsnsst .ei(. nsaiagael n,m)isehmca liovedvn ni olepxmc eivsaorbh exsul(a ctornta,tai msebeus/gisegarivssiv bo,si)havre dna emaipldcit uo(hthg otn i)fditieevn ni csicyirthpa orsrsdedi.

velarO,l aorsttrumesnnreit = ptey yeps:t oaleule-mcslml nsritrtstmae and tpeeoidrpsne,u ehwer lussmlecl-aoelm strianrstemt ear ratsef nad meaetid iardp pitycnas nmraitsosnsi .i.(e oerandng NSS hg/thftggiifihtfl/r icqku ns)eer,ops erewh sa sertedponipeu gl(ona twih blcgiooi ieamsn nad osem laslm ulcmolee tsmetnta)rsri are rwloes dna eaemtid a,uldarg ogrnodlpe rstnseanio.snoiumr

mSoe :ustpcrie pnwtnptehwirk_ru.tevee/se/l.setwfadbnut/rce_rdi.ho/tsmapivmudaoki:mop_treo/hnu, re-4/Tlis2Rwtiaaebir9-eA0nro0/BewofPu.gs-r2mefsbgal5/a8h/31ceer/30apBgaiscd6d-1sg2g4thwelpdas-rb/ntf-ineur.731co-ptt6ifperhod6/63rt01cuA0b8p:e1G4a-, dan b:p1-p5awtxtl-;=h7-igx04ldbcggdafstr6.g&det5aw2ef/m2fee6#at1g9as.n-/h8.naoeb_-hirw-aai//r-1i3/3blw/dl-fe1ue=en0dsUeb

Toguh euinq.ost

lcRael ttah ennatiMme (lh'esmeiraz gurd) is a ADNM pocRtere otsngnAita ttah eshlp petrven oxxcetyitoict by iognkBlc Ca+2 nryet. a'tshT hwo I eerbemrm tih.s

• A) GAAA-B ertroecps lte -lC in
• B) nyGeilc si edsu ni eth aplnis cord sa na yhiiortinb nriear;neotrstutm olas tels Cl- ni
• C and )E oabtproceMti tletaumga rretecpso rea potnr-Gie cpeloud
• re,fheTreo teh ylon ntihg tath cdluo elt a+2C ni si MADN cetprosre

AMDN petrecosr ni shit cesa ear bgeni sdeu ofr lngo mtre tniiooapetnt hnwiit eht riabn dan uto fo all of heert siceoch nlyo hsit preteorc suse aC+

ouY acn ewrasn yb orescsp fo mlieitona.ni v"poieemiCtt ntsnr"ioactei skeam yuo ithkn ourlamyitts T.N ssorC tou GBAA nad cgy.niel In the oxretc so ateguml.at beorpoMctati odwul anme tsr'hee noedcs egseressmn novevdli dan eht preortce lowud ton mtratsin mcul.aci ceenH ND.MA

dseu in ngol etmr ointaitnetpo al(aen,ugg mmyo),er ayM aosl lyap a lero ni geen oniantctrrisp ni uresonn

1) MDAN is a lmtatuGea tcepoerr pueysb t2) MPAA si a pebtsuy fo ADNM that si ynaitiill dicvtatea by umatetalg 3elee)ras DMNA resotpcer aer oufdn raen AAMP terprcseo but ear otn adtaivcte yb low veells of tlaemutga leesrae eud ot a gM ion klbo’cngi‘ teh 4 lnachne) Frnetqeu coAitn toptaelin tg;&— silinotuatm of MAAP g&—t; paedrliseoz stpo npyisatc nroeun —t&g; oltaveg dnntepdee Mg kcblo of AMND epoerrct eodrmev 5) fnxuli of Ca hrhougt DMAN >— uscsae veen orem APAM postrreec to eb denestri toni eth nrbemame OT:EN( MAAP is enpvirsseo ot aC dan mt)g6l) uatea cuseaBe hrtee era moer osrcteper to prodesn to ,ti hte lcel is omre ponsrveeis to atgmleaut

all eth rethso a eviepmtonitcon ceins they avhe stpsieicc(icieypffic lnsgida,) MDNA si het ylon nioheeen(ntvcclsee tomeptevcii tc)reoep,r ash a nagldi esti adn ac , an dan .eem.cgh.n etiopcvetmi