,oS fro oesm ranoe,s atieurotnerssmrnt si igsoethnm v'eI LAYWAS gustregdl t..ihw. lryaobpb beusaec I twa'sn htutag ti ellw os rvene alrely rneedal t,i ustj nadlere egnuho rfo teevrhwa a.mxe I jstu unfdo htsi obo rgutohh ICNB dan ist AN!TCISATF st'I mofr 0102 so hgmti be d,ol btu ti wsa tga.er oYu nca ahcesr urhotgh hte ookb adn dfni hte apr.chste I tytpre hmcu ustj nwte ohhugtr lla of eth srnmitteratrnoue tph.earc B/w70bn1tkwi.o/9sNngh/c/ml.bwpK/.so:vin.hot9

My ainm a:atam-y ltuasekatGew = jrmoa taxcyitore etirteoum.tnanrrs Tow seypt fo sco pete:r)r1 btt,moipoarce tmso fo ihwhc ear yptsiaerpcn iG hwhci elsad ot drsaedcee ANDM ceetrorp tvtcyaii nda rski of ixoy,cieioticttx or natscppoiyst qG ercosertp ttah alde ot ecesrani aN,+ ,K+ and reedscead aegmutlta uscsea laairoiopzntde nad ediercnsa g++M telmnaicsepd nda DMNA pocterre tayiivct dna rksi fo ,txiciexcyttoio dan )2 ooprtoicni nhaeclsn idgunincl DAMN nad MianteAaPAk/ nhle,nsac whcih lla llwao pifcoennics itanco x,influ btu olyn NADM sllaow +Ca+ nxfiul and( lyon in a gvtoela dtdenpnee ernmna rtefa cfinftieus inzioadoaltpre has idelacpsd the rinhoibti g++M noi in eth nlnh)c.ae

AGAB and clinegy = boihiirnyt tm.uettsrsirnneaor )1 -GBAAA adn GBCA-A = pnciootiro hclnneas htat ldea ot uxlef fo C-l, adn epdseit hsti iaugcns przeaio,ildnota hte rnueon tlsli sytsa woelb itnesrg olanit.tep A-AABG igdnnbi etsi fro tsbuarrt,ieba ride,sots GABA, dna pxrootciin = nedsii roep fo acnehln. ABA-AG ndnibgi eist fo sanndziepeizobe = osiudet fo pore fo anec.hln )2 Gcnilye hneancl is a yrve lriamis -Cl xfleu cnnal.he ) 3 BBAGA- is a ateotpbcriom nlachen atht aaesctvit Gi ilgaden to erdcaeesd PAMc hhciw aiatctsev felfxu +K nshclnae dna bshintii aC++ xlnifu alcnnesh leaigdn to iealitzpayohnr.por

egniciBo saneim = echesmictaaoln eadnmopi rna(oticdooin of dbyo evnemomt, re,drwa tvto,iomnia nrrenmeoi,f)tce nnreeiproneiph ,ee(spl wsneasul,kef in,teoattn dgifene bo,riehav ieeehrpninp (oelwts nciocttnrnoea in N)CS, plus snorinoet e,es(pl ns,ekfaesuwl osdnsrpeie, ,xaiyent saea)nu dna natshiime su,oaarl( ne,tattino g,aellyr itsues mg,adae adn amy ienfnleuc olbod bnari wolf). vusibyO,ol lal fo ihts is in odiiadtn to nrigrcedae eosomunrntsiasrni dna lhtgf,i hi,ftgr nda hgitf .penersso

APT dan roeth pirsnue = artetcxyio otmaris,nissn calo-esered ihwt oreth lloa-elemmcsul sirrnmsneutteaort. dnisoeeAn t'sni sasllcyacli ercdsdioen a urarietsrtnnetom csueabe ti 'itns et/ereordessdla in +C+a eeptnendd rnemn,a btu eridevd rfom PAT beefor agvhni na rtayectixo atpnole.it

llAioechtncye = mrajo normiarturntstee eindvlvo ni sirnranostenmiosu iav uarcinsm adn nniciicto ecrr.osetp

iePpdet nrmituseotretasnr = cnmmooyl eelsread as edprioptpe rgrlea epurrcossr ttah ear vleadce yb ecfcsipi semznye ttha reew in the mase oarneremuistrntt isvecle nupo reeeas.l Fiev ptsye = trb/ungai dipe,stpe iipodo espdpt,ie utryitpai pptsde,i hctpaihmyola nirseealg noo,hsmre adn eohst otn ficsd.lesia xlameEsp = cuporrers htat gveis rise to sbtasecun P pc,ppiahsou(m xeroten,co nad GIT nda eedearsl orfm lmals reaimedt SPN C riefbs htat srnatmit npia nad tmeeuperart rnmt,fiaonoi oferluwp neoe,yhistpv ehitnibdi yb doopii epdi)s,etp niokrneniu ,A ntpeoipdeure K, nda nieudeepprto mma,ag adn pooidi etpdisep indniuglc atpln iadloslka ke(li ne)ipmh,ro tyeihscnt iodpoi svetd,viraie and oinernhs,pd prnnoyhis,d dan nseaklnehi.p nI aeernlg idpioo ptpsedie are stersdaenps .i.(e sneiaagal nha)ismme,c dlenivvo ni lemocxp orashbive alxeu(s iractatnot, i/svsimesbguisavgesre v,aibsrh)oe adn epmtalcidi g(htouh not iedii)ntvef ni rshacpitiyc s.seoidrrd

rOaell,v nintseatroutmrser = tyep :tpyse olmmllseeualc- rtematrnisst dan pt,sipeneodure reweh l-melaclusoemls eitarmrsnstt rea atesfr dna teamide ipdra pniascty tssinsniarom e(i.. gadnnoer SNS lif/hgrgtf/thtihfgi qukic e)n,sspore wrehe sa reeoipptudsne nogla( iwth olcbgoii inemas and meos lmsla oelcemlu rmtaitssrnet) rae lsrewo nad dmeetai ugr,lada repnoodgl onmitsiennsu.osarr

Semo pcsrutei: atoeteelt_.nein/.s/npwtb/ofiapsnekcr_tuiraodhdktwsrpt/u_.dehievrmmreouvmhuw/p:, i60h1fst3daBaee-rpehe3s8ra1ri02f643pwbeAbcwse6er0.g.udgnra3ntifncbo4/2A7oi-aaahuodrgGg11u8Brrtif-s-eictll/trls/m9-cR2-s61-p/b0Tw-Ppea4/:ote/dg0ep/5, adn gp1b-shab3i-didte3e/x:8lbangl6ew0#wfaau.aeanw/-w/=U.5-rht5at--=gc9-bxr_ft2dg0siddia1psr41etbl;oh2ele7.gf6f/ene/m&/1-

guohT o.uqsient

clelRa atth Mnmetaeni halie('mzser )grud si a NMAD peRroect gAoitanstn htat hpsle peentvr tyxciexotitoc by Bngkiolc a+2C ntrye. Tahst' how I mrermeeb ti.sh

• )A AABAG- eprorctse lte l-C ni
• )B Glincye si udse in het lipsna rdco sa na iyhioibtrn t;mraesttrneoruin osla elts lC- in
• C nad E) aMroottcipeb eaulagtmt rpcsretoe era i-nrGpeto eplodcu
• hoTerr,eef eht oyln ghtin atht uldoc etl 2+Ca ni si ANDM escprreot

DNMA eesrctorp in htsi scea era ginbe edsu ofr nlgo rmet ptneiaotinto nihtwi the nibra adn otu fo all fo hreet choeics only tihs cepeotrr ssue Ca+

ouY anc rwenas by rsepsco of ie.niintamol mvietpCe"toi nircatneio"st skeam you itnkh lyauistmrot .TN Crsos tuo GBAA dan ycgl.nei In eht crxeot os teagaltmu. oipetMrbtcoa wduol naem 'sehtre sndoce nseegmssre idlnvoev adn eth eporcetr duowl otn mnisrtat cimucla. Hncee .ADMN

deus in ognl etmr ntottnoieiap gnae,ga(ul yme),mro yMa aosl ypal a lroe in egen nracinstoprit ni runsoen

1) NDAM si a uaGetamlt oetrcrep suypbt e2) AMPA is a puebyst of MDNA atht is yiinltali vtdcaetia yb muaaettlg 3ersaee)l NAMD soepctrer ear uodnf enar AMAP eprecosrt tub era tno teaadvict yb olw lveles of lgetamatu eealers due to a gM noi c‘gb’koinl eth enah)nc l4 qturenFe ciAotn iapttonel g—;t& iounmtialst of AAMP t—;&g idprlaeozse ospt sipynact noenru t—;&g aogeltv edpntneed gM kbloc of DANM otercrep deomrve 5) ilxunf of aC hgtruho MDNA g;t&— uscesa enev oerm MPAA ceprserot to be eensdrit ntoi eth nbaermme NTEO(: MPAA si isepnvseor to Ca nad )uetalam6t g) eBsceau erhet aer meor tsrrpceoe ot edsrnpo ot ti, eth lecl si ermo isevnsoepr to aetamlugt

lal eht ohtesr a tmionevietponc seicn eyth vhae petfiii(csciycepifcs igal,dn)s AMND is eth oynl evtscnioenlee(ehcn ptviotimeec rrte)c,poe has a alidng ites dna ca , an dan g.enc..ehm ietmetpvcoi