,So ofr osem nras,oe aietrntnrsemorsut si sotmghien Ie'v SLWAYA rltgugsed hw..ti. lpbbyrao uasebce I ta'wns thtagu it lwle so enerv leyarl arednle ,it jstu ealernd eugnoh rof ravhetew .mxea I tsju dnfou isht oob thgrhou NCBI dan its F!NSICATTA ts'I orfm 0102 so gimth eb ,ldo utb ti swa agr.et uYo can raechs hourgth hte boko and dfni hte erths.acp I eypttr much utjs ewtn hrthugo lal of the nuntemtirrartsoe he.crapt wi9/tno:kob/i.1t.hsbBcK97osh.wwgN.0/nv//plmn

yM imna wea-ttGtaaksamayu: le = omrja oxriyetatc rmetut.nnortieras owT syetp fo p 1r:etrseo)c ao,comitertbp most of hchwi era petnraspyic iG hchwi dslae ot aecdresed AMDN ocrertep vytcitai nad riks of ioec,oxittyctxii ro scstiypponta qG tcrsoreep ttha lead to isnecera ,N+a ,+K nda eercseadd tagtemlau suecas diroaneztaoipl and cidrsanee +M+g entcemlspida and MDAN oeeprctr aittvcyi and kris fo c,iyexoottctxii dna 2) oiipoortnc lhcnesna iuingndcl ADNM dna aMPniAAe/tka acsnheln, hhciw lal ollaw icfnpceonsi ncotia ,xnfilu ubt ylno NADM lasolw a+C+ funlix dan( ynlo ni a alegvto nepededtn amnner rfeta fifecuitsn aporiloazeditn hsa piledcsad het bthiironi +gM+ nio ni het )cenln.ah

AABG dan nlgicye = bnhioiityr e.rnttrrsimnseauto 1 ) AG-ABA dan ABAGC- = onpocitoir nlecsahn htat lead to exlfu of ,-lC dan esetpdi tish igaucns izondira,pelaot het oenrnu lsilt stasy bewol igtrnse oentip.lta GA-ABA gdbinni eits ofr sabtitrreau,b soisrdt,e BGAA, nad pxioonctri = sdenii oper fo e.nlcnha A-ABAG dinnbig ties fo opebeinazzdsnie = oeudsti fo erop fo ann.ehcl )2 ylGicen eacnhnl si a evyr ilarism lC- xuefl nlc.hena 3) BAGBA- is a tpetbraooicm nnecalh htta vsecatiat Gi gaindel to reecasdde PMcA ihhwc eatcvstia xueflf K+ cesanlhn nad bhiintsi +aC+ lxniuf nsahclne aedgnli to t.heolnzypaiaoirpr

iginBoec simaen = elsamchoiaetnc dpminaeo ntoon(darocii fo ybod meventm,o rr,awde ita,toonimv crfnnirteo)em,e ennhpeirpioenr (s,eelp l,ausneefwsk ettnntoi,a diengef ieah,rbvo ihpeenepirn etls(ow ontcntcrieano in CSN,) puls ionotnser epsl(e, w,slukenfase nsrspeoe,di ney,atxi euansa) and mheniista aarl(,suo tnea,tinot elyra,lg suteis g,eaadm and aym efncneuli olodb ranib )wlfo. ivsOubyol, lal fo shit si ni oiddatin to iranegercd mruaietsosinnnosr nda fhlti,g fitr,gh nad ghtfi pser.eson

TAP adn throe epnrusi = aioxyetctr niirnat,omsss ecreoslead- ihwt rteoh l-ocsmaemllleu osrtmtrtrnnieaeus. oieesndnA tsn'i caalilcslsy endicredso a tentirnuaseomrtr usebeac it nsit' tdor/redlasesee ni +aC+ dedenpetn ,nemnar tub rdeievd rofm ATP fboere vngaih na txyctaorei paotlenit.

leicAhnctlyoe = rjamo oemerrrtnsnaitut nveiodvl in soinsasrturmeoinn vai scraimnu and icioninct creosptre.

piPtdee rtunesermrasttino = mlcnyomo eedlares as peidptoepr rgarle rrepsuscor ttha are vlcaede by pccsieif ymzense atht weer ni het msea mrenautoietntrsr velesci onup erlaees. Fvie tyeps = iarnugbt/ stee,ipdp diiopo ippdstee, ttiyupria tdpisp,e haalhmyopcti iseanregl eonmsr,ho nda oetsh tno acfesdli.si samxleEp = crpsrueor ahtt vseig rsei ot abusnects P p(sm,ucoihpap eceo,txron dna IGT dna lardeees mfro sllma aiertmed SNP C bsrfei tath ntsiramt pani and umptteaerer ,nimfoaitrno urlowepf topvsnheyie, dineihtib by idpooi d)ep,istep uinonrneik A, deuprtiopeen K, dan udotpneerpei mmg,aa dan oidipo eseidppt ciiudlgnn pntal ksdalaoli (ekli ohn)rimp,e hcsetytin odioip tvdasiire,ev nad dpsnonhri,e nndyhrspoi, and .eapnsihelkn nI ageerln doopii sptdiepe aer sdsersatnpe ..ei( gnasilaea n)shime,mac dinvovel in pcloemx bvserihoa xlaues( icrtat,otan siseamssgresebuivv/ig vsi)r,heabo nda ipeimtdacl hthou(g nto viidetnei)f in pcrcsaythii dossrri.de

l,Olevar rrnestntmeoiruats = epyt tsye:p lmmleloucsle-a tmsntrtiasre and speoedt,piruen rwhee esamslcl-euolml nmsrtretista era staefr adn aeetdim pardi ynacspit tsimsnoaisrn ie(.. agnerndo NSS ihf/thtrftg/iggihlf kqiuc eeno)prs,s hrwee as euspeotpnrdie nogl(a iwth cobigiol mesani and semo amlls oecellmu tet)snritsrma rea rleows dan ietmeda raua,ldg olrepngdo a.isronsteisnumnro

eomS uestcr:ip totpeuvtumorneaiw_ee.vd_eonm/mt/siruuw:roisdscpk.tnpitawb/epetrl.nfkrhd_h//hae, a14rri62/8rnri33ptBr8/bb2ese/.-5ur/o--dde2Asuob0ecowpf61adrr-7a:paptalwbg10gP-43s/a64G0.aple1dow3ftscfh9Tt-tue0lRe6sAhBeeirin/gnhca1-gegtf-se/ii0cm, nda c3t#wm-sueU=n0/1/e/at.hlnr.xoga2t1fe8_l5d/0-2e-ldat-pb;bpn7ieeifbg5bs36ad/daf&ewbe-rgei16agrs9dwha.4ix-/a-wlh1f=gt:-

hougT .intusqeo

lelaRc htta mnitenaeM hlszaemr'e(i gu)dr si a DNMA eerRoptc ngAansoitt ahtt hpesl eprvtne tyictieooxtxc yb lckgionB a2C+ eytnr. Tstha' owh I mrreeemb th.si

• A) -GAAAB sperortec let C-l in
• )B liceGyn si used in hte snapil rcdo as an ortiyibinh mrtieo;rutnnsrate aslo tsel lC- ni
• C dan E) ettipMcboaro altumgeat rtsocpeer era G-inptoer lpcuode
• eroferThe, the ylno hitng ttha locud tle +aC2 in si MNAD rcpeserto

AMND rosercept ni thsi csea era iengb deus for ngol ermt epntntiiotoa whtnii het narbi nad uot fo lla fo erhet isehcco nlyo iths pcretore essu C+a

You anc nwsear yb pesoscr of iile.nanmoti ttmCveiep"io nsicniarett"o semak oyu nhtki atiorutslym TN. ossrC out GABA nda nelygc.i In eht rcteox os lauamgte.t reipbtoMtaco olwdu anem esreh't escodn seemsenrgs inovlevd and hte rteoprec owudl not sttramin .lucimca enceH DN.MA

sude in long rtem tepiitnontoa ge,agua(nl r),ymmoe Mya osal pyal a leor ni ngee ostapitirnncr in eonurns

1) MAND is a utemGtaal rtorpeec )u tysebp2 PMAA is a puetsby fo NDAM hatt is yililnati vedtiacat by gmlutaaet )es a3rlee MAND pcterreso are fuond nera APAM prresceto ubt aer otn aditeacvt by wol eesllv of algamtuet eersael eud to a Mg ino gko‘lcbin’ eth lnchen )a4 Feqnrute iAncto tnpolaeti g—&;t iuoitntmsla of MPAA ;—tg& zrsipeadeol ptso isnapytc uonrne &—tg; gvaltoe deendeptn Mg lockb of DMNA reerctop mverode ) 5 fixlun of Ca hhturgo ANDM t—g;& ceassu eenv eomr PAMA rsrcpoete ot eb sdenrtie into eht embermna :ONTE( MPAA is esnvoepirs to aC dan tga ml)ea)t6u ueBesca rthee are mroe pocrstere ot serpnod to ti, teh cell is oerm vspnersieo to taglmutae

all the reohst a ovtimoietnecnp seinc yhte hvae ifefcpi(siiccisetypc )lis,agdn MNAD is eth lnyo inchnevcensoeetle( cmpoeiitvet teer,roc)p has a alding itse dan ca , na and .n.ghe.cem eecpivitotm