oS, orf eosm resna,o srraetnormsitunte si ogenstihm evI' LAASWY ggdeustlr hw...it oabryblp ubseaec I wst'an attghu ti well so evren allyre erdenal ,it tujs redlnae euognh rof wteaervh mex.a I utsj ufnod htsi oob rothugh NCIB dna tis ATFNSAT!IC 'sIt rfom 0210 so gmiht be ,lod ubt it aws t.gare You anc carehs hhurogt hte kobo dna dfin the raste.chp I tptyer mhcu stuj wnet oturghh lla of teh tinsrernmutaoert rpet.ahc /oK9:bto7wik.//09ohlw1/gp.tNwvhcnm.nbBis./sn

yM nami tasaelaGtkua:ae- mwyt = ojarm txtciyeroa noutrrr.esiaettnm woT tepsy of tcresp):re1o ttp,iraoemcob omst fo which rea scniaprytep iG ihwhc sdlea ot eeaddrsec MADN teroprce tyicvita nad rsik fo xoo,iitiytcexict or cysaopptnits Gq rotsreecp atth dale to ancresei a,+N +K, dna ecedsdrea altgtmuea uacess airionlepotzad dna rdeescian +gM+ edaitscelmpn nad DNAM peotrrce aivictty nad sikr fo cxoi,toiettcxyi dna 2) toiicoonrp cnshnlea ndilucing MDNA nad kAtiPnaAeMa/ slche,nna iwhhc lal owlla cpoesniifcn atcoin xulifn, tbu lnoy MNAD wlsoal +C+a inulfx na(d noly in a volaetg edtnepned anenmr eartf ueiticnsff ioodlanarpiezt ash sleiacpdd the bhntroiii ++Mg oni in eht la)nne.ch

AABG nad lginyec = oiyrinbiht tnettmseoarnru.sir )1 BAAG-A dan G-BCAA = oopctnrioi lschanen atht lade to lexfu fo Cl-, and sepdeti tsih icunsga izptldnarei,ooa eht neornu lsitl atyss lebwo itrseng tlaepntoi. AAABG- dbnniig seti fro ,atibuabretrs setdisr,o ABA,G adn ointxoipcr = desiin epor fo cenanl.h ABAA-G idinnbg ties of eizennzsebdioap = tiseduo of rpeo fo lhaenn.c )2 ciynGel lhannce si a vyer isamlir C-l ulfex nlahne.c 3) A-BGBA is a biomatecrotp nnaehcl atth tsaateivc Gi gndeial ot rdeeasedc PMAc chiwh aietcvtsa xffuel K+ asenlnch nda nbithisi C++a fnxliu hasnlnce ndlegai to .aenrzhoalryoitipp

ecBgioni smaine = hoccimasnletae inapemdo oritnac(oodni fo bydo tmeno,emv we,rrad n,moavotiti enren)ieftr,moc eopperhrinenin p,e(sel s,fkwnlauees etaontt,in nefeigd r,veaobih irnhnipepee (teolws cenatorcionnt in ),NCS spul sontoeirn s(,lpee kaenuslfew,s iopesesd,nr anxy,tei eaan)us nad aehimstin la(s,oura at,ntineto lar,elyg sseitu daa,gem nad yma uefnnielc dlobo banri lf.ow) yO,bslviou lla of isht is in diitando ot gircnaeder nrourmsinenitsaos and thlgfi, ihgtr,f dan ifgth rpsee.sno

ATP nad trhoe iupnesr = iaettcxoyr insaoss,rimtn asocre-edel thwi terho emsel-lcalmoul raoeteumstrsnr.nti sAndioene ni'ts alilslccysa ddscioneer a srtienaerorntumt eeabcus ti t'nsi tlaeds/edreeosr ni a++C ddeennetp ne,namr btu deirdve ormf APT erefbo nvahgi na ictotyaerx eo.atpltin

nyocAclihetle = jmoar notmtsiernareurt vndlvioe in issunrnntmeoariso aiv sncuaimr dan icconniit rtpseorec.

tePedip tansrrureisonemtt = ylocnmom eareedls sa edoetprppi rlrgea escrrospur hatt rae aleedcv yb fsecpiic ysneezm ttah erwe ni eth easm umtrionaetntresr ecesilv opun slae.ere eFiv spyet = tuibgr/an ,tpepseid opodii ,sepdiept iatryptui psdeitp, clhtyahmopia rnligaese onrmo,hse dna soeth otn fed.saiicsl Eaxlmpse = ueorrcspr thta segvi rise to utasnebsc P opcm,ppsa(uih ,cnxrotoee nad IGT dna rleeseda mfor llsma meedrita SNP C fsiebr tath ainsmtrt pian dan aptmruteree ,rimnnooaitf flerpwuo ,pnsthevyeoi btniheiid by oipodi d,ts)eepip ionknueinr ,A pernteupeodi ,K dan erppdoeineut ,agmam and ipoido tpieepds gcnlunidi tpnla llsoidaka il(ek ioe,mnrph) snectiyth podioi daivristve,e nda enopsnirh,d ,sydpoihrnn nad heplkasne.ni nI aegnerl odoipi ieespdpt era spnatrsseed .(ie. asniaegal ihnmcms),ea dvneviol ni lmoxcpe osrieabhv uea(xls t,ocattrani ssviiaev/egmsirusbseg )shoabvire, dna cmlateidpi u(hghot not neiiedfiv)t in scrtichayip doseir.sdr

elO,lrva rnisruentsrtotame = tpey :petsy sl-meeacmuolll isentrtmrtas nad pi,tsounrpeede eehwr mmleecuolasll-s ittstmaerrsn rea atsfer dna itedaem apdri scanpity sminsnrsatio (.e.i doneagnr SNS tfhif/lgigghrttifh/ kicqu oe)snre,ps ewreh sa oepupdisnerte o(angl hwit gcblioio aisemn nda eosm mllas ecelloum tsttmrras)ien ear wrelso nad atmdiee gd,alura ooegrdlnp nrn.ssoarotimneius

omSe st:uicper ee/rtnimtu_.opekhb_h/rwwan.vdetmp/_./rterthpkpclutddtrfaoisoenvsnw/siue:miuaeo, h/lean293odu0Aptrb0.6fBdRcie13/Gr6ptagel/peten-1mh/bgeoiico4uPcg0wtb:dw00ti4-see-a6fw8siri.ru-as5e7gg--1p4lrepr/sAT-ca8-f6afB3r/2ehrotsd112na/brs3a, and /s0g2b6&cdta92b/_p5ag-e.=hgmedib/leaaan.Uaphr/-su-owe45fel1wfrb8-a3t;-ft=d03d-lergs1#ba:/iw7e.ixnd-hngxet6ef1wtl1-/i

ouhTg onu.qesit

cRalel htta menitMena shmrzele'(ia g)udr si a NMDA tpceoRre gonanitAts ttha lepsh rvntepe xyciicttteoxo yb Bkgcloin 2C+a ytrne. hstaT' ohw I rremmbee iths.

• )A GAABA- eptrorces let Cl- in
• B) nceyilG si uesd ni eth nalpis ocdr as an itybinoirh aittmteneu;nsorrr loas tsel -lC ni
• C nad E) ooaitrpteMcb agmtlaute srtcrepeo aer G-tpireon pecould
• Tfereh,oer the lnyo ghnit atht olucd tle Ca2+ in is ANDM etcseorpr

MADN tecsrpero ni ihst case ear ebign ueds for ngol trme itponitoanet ihtniw hte ianrb dan otu fo lal fo heter scehoic noyl tihs perretoc ssue +Ca

You anc nwsare by crpseos fo onaimtii.nel Cptmeoti"vei "onnstricaiet maeks yuo tkinh atotlmiyurs .TN sCors out GBAA nad .eglynci nI het cxroet os glt.mteuaa etpcrtobMoia ouwdl nmae 'tseerh senocd rgmesnsese olvneidv dna teh eoeprtrc odlwu not iarnsttm cmi.caul ceenH DN.MA

euds in nogl remt otnttipieona lnaeug(,ag m,oeym)r yaM lsao lypa a orel in eeng toiartincpnsr ni ronunes

1) NMDA si a tumaGtlae errcpeot uyetbs 2p) PAMA si a pbuyste fo MDNA ttha si anliitily dciatteav by tatmauleg r)le ea3es DMNA scoerpetr ear ufodn rnae MAAP tpsrcreoe tbu ear otn adaecttvi by wlo lseelv of eaumattgl earslee ude ot a gM noi kcg’ibonl‘ the 4anlec )hn nuFeetrq niotcA lneaiptto &g;t— miottuasinl of AAPM &tg;— dsprzlaeoei spot natcypis oeunnr ;g—t& algotev dpdeenent gM olbck of NMAD trprceeo edveorm ) 5 lnfxiu fo Ca ghortuh ADNM —tg&; sacuse neev mroe AAPM esercotrp to be seirnted nito the mnrmbaee :TENO( PAMA si eosspinvre ot aC and e)al)6m agutt eauBces etehr rea moer oresptcre ot rodpens to ti, teh llec si omer seiornevsp to ltagametu

lal hte ortshe a neivotitpeomcn censi teyh aehv ecfiscic(pftpseyciii ),gdnlias NADM si eht lyon eenlei(ocvecenhnts voettmcepii retco)ep,r ash a ingdal tsie nad ac , na nad g..hc.eenm pitecoivetm