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Retired NBME 20 Answers

nbme20/Block 1/Question#11 (reveal difficulty score)
The sequence surrounding the first two exons ...
Disruption of normal splicing by creation of a new 3′ splice site 🔍 / 📺 / 🌳 / 📖
tags: biochem dna repeat

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 +20  upvote downvote
submitted by drdoom(1206)
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sA sdbecdire in het isqoetnu sem,t tish toamuitn cosucr wintih na rotinn a( enge snegmet wihhc si dbsrcantire RA[DN-]>NA; tbu ont stdtn.rl)eaa NRA glinipsc n)(ezmeys rgab RNA and oop“l ;”it na trinno si ctu tuo nad eht oxesn no riehet sdie fo het nnroit ear do,jndeia like isht:

rtox2oxe1nn—n—eino =;gt& nex—on2ox1e

a,iclTpyly tshi ngciplsi sccour ta eth ryve egsde fo hte iortnn (hwat I deotdne hiwt eth “—” hcrce)atr.a Btu in our ae,sc a moutnita iwithn eth rinont is cuagisn RAN lipcsngi eemzyn to eriogcnze a nwe ei:ts het ricpsel usct iwnhit hte roitnn dae(tisn of ta het ervy e,egd as ti losd).uh S,o ew teg hgtoneism that kosol kile :hist

xnrtnxe—2—ei1oon

tash’T a oltalyt einfterdf mRAN ,omleuelc nda ts'i ggnio ot akem ruo nbilβo-g teponri lkoo nd(a habee)v aufllyw e.rgants

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drdanielr  I mebemrer htta in het Np,AemR-r eht incilpsg tisse fo eth irotnn ewher the ooecmsislep atesctha ear odrduuensr by ""-GG--AU klei "acu"g, os heer hte mooshuoglo ADN to tihs rsntda dluow be bsirtdrecan toin a."......g.....g..u..".. adn shti owlud aetecr a '3 ecisl tsei oot nsoo +7
vivarin  fi siht si odpsepus to eb Re-mNA,rp hyw aer htere T's ni teh ?eeqenscu m'I os fnsdeuoc by hsit rfo eosm nasero +8
sars  isTh si eht eneg ,AN(D) tno etenghsuroeo mRN.A +
athenathefirst  eTh iggbest ecul yeth asdi isth is B ha,imatlessa wihch veen fi ouy dd'tin wokn yhgntina uobat noesx and nsriotn oyu shdulo vaeh konwn ttha b lmaaihsaets nelvoisv a itntaumo ni lncpigsi or prroteom etis oah(tapm epag .)44 I tog shti qseutino gwron oto :( +1

Translocation may result in failure to transcribe RNA because of disruption of a regulatory element (eg, promoter) within a gene.

The affected gene will not be expressed or will be expressed in a dysregulated manner compared to the normal phenotype


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 +5  upvote downvote
submitted by monoloco(155)
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shTi ash to od whit rnoint s.pnliicg Rmmereeb TGG.A ihTs ioumtatn dneiduc an GA esorcl hrewe it wsa popudess ot b,e os smeo fo htta rntoni ustj ecbeam na ox.ne

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 +4  upvote downvote
submitted by waterloo(126)
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I denerptirte scqnuee"e rodunnrisug iftrs two ensxo of gnee" - to naem they mtsu be iltknga about sinn.tor eTreh of eth aewrsn scchoie 'tdno veha chum ot do with .ntoinrs

  • sesnsiem tinouatm uolwd ehva to eb in eth xone to ucesa cnhage in manoi cdia.
  • llenpyoanitdoay si ta the end fo eht NmRA
  • ihioibnnit of aciepnliort si AND

ahtt mya ton be ira gtth,i btu eslph ronraw dwn.o solA nwonikg eosm eshaalBsitm-a si eud to rainsvat ni noaabmlr pgnilcis l.pehs A(F 9012 gp )34

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 +1  upvote downvote
submitted by s1khwitit(1)
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losa eemrrbme htta s-Beaahialstm is eud ot opitn mtntoaius in clieps etiss nda petoorrm sseqenecu A(F91 10p4)g. fI you rteeac a mitnouat ni a icsple stie yuo lliw yrlues ssem pu the tccrero RANm deedne to meka a iconlntafu lonbigB- proitn.e aTht si ohw I esrnwade hte suino.tqe

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