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Retired NBME 20 Answers

nbme20/Block 1/Question#11 (reveal difficulty score)
The sequence surrounding the first two exons ...
Disruption of normal splicing by creation of a new 3′ splice site 🔍 / 📺 / 🌳 / 📖
tags: biochem dna repeat

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 +20  upvote downvote
submitted by ∗drdoom(1206)
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As dcrsbiede ni hte uqniteso etsm, hist noumttia rsoucc nhwiit an rninto a( gene mgtenes cihwh is bstircnader N;t[]R&gDAAN- tub ont .aet)adlsrnt NRA pinilcgs s)(meynze rbga NRA and plo“o ”i;t na inotrn is cut tuo nad eth soenx no eiehtr esid fo teh ritnon aer aoddjei,n leki htis:

eo1oxon—nine2n—xrt &;=tg xe2en1o—oxn

lyycT,pali iths slniigpc ocsurc at het yerv geeds fo teh itnnro ahw(t I tdnodee whit teh “—” .ccrtaerah) tuB in our scae, a ouitmtna within hte nortni is snicuga ANR lipicsng enzmey to ezogicner a wen si:te eth isrlecp usct iiwnht eht ortnin satie(nd fo at the rvey ede,g sa ti duhs)lo. So, ew get gnteomish htat lkoos kiel h:sti

nteo2eioxnr—x—1n

shTat’ a lltyaot idenrtfef ARNm lemucol,e and ts'i nigog to kmae oru -oβbling oeptnir ookl ad(n hbeav)e flwayul s.getarn

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drdanielr  I mreebmre that ni teh AemN-,rpR het liispcgn essit of eth itnonr wheer teh oesslcmpoie ctahtsea are rdnrusduoe yb G-GA-U""- elik a,ucg"" so heer eht hoolmogous DNA to siht srdant wodul be nritadrebcs onit g"..."......u.....a....g adn isth uldow aercte a '3 iescl etsi oot soon +7
vivarin  if shit is dpeuspso ot be rp,mNeRA- ywh are rhtee 'Ts ni eht q?ceseenu Im' os dseuofnc yb sith orf smeo neasor +8
sars  sThi si eth egen ,D(A)N tno uheneoetgsro .AmRN +
athenathefirst  Teh ibggest eclu tyeh aids thsi si B l,taaesiashm hhwic enve if ouy nddt'i nkwo nagtyhin uoatb sxone dan nitsorn you uholsd aehv nnkwo thta b tsalamesiah oilvvsne a aitnoutm ni csgipnil or oomtprre esit paha(mto gape 44.) I tgo hits oqeitusn wnorg too (: +1

Translocation may result in failure to transcribe RNA because of disruption of a regulatory element (eg, promoter) within a gene.

The affected gene will not be expressed or will be expressed in a dysregulated manner compared to the normal phenotype

+/- namesthegame22(14)

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 +5  upvote downvote
submitted by ∗monoloco(155)
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This ahs to od with inntro igsl.npic Rbmemeer .TGGA iTsh niutmato iucdden an AG oeclsr rhewe ti swa seopdpus ot ,eb so omes fo tath otninr tujs beaecm an .onex

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 +4  upvote downvote
submitted by ∗waterloo(126)
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I prnetteired eue"qecns urrdsoginun irstf owt oxens of n"eeg - ot nmae htye tsmu eb kigalnt baotu t.nsrnio eTreh of het ewansr cciehso tn'od aevh chmu ot od itwh ni.ostnr

  • senismes iunamtot dwulo veha ot be ni hte noex ot ceuas ncehag ni namoi caid.
  • lloeyanptondyia is at eth nde of eth NRmA
  • iinbhotiin of iritaopnlce is ADN

atth aym not eb ari ,gihtt but selhp awrnor d.nwo sAol nnikowg emso -maesitsalhaB is ude to atanirsv in anomalrb iplcisng .spehl F(A 1029 gp 4)3

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 +1  upvote downvote
submitted by ∗s1khwitit(1)
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olsa emmberer taht maieahBlas-st si ude to iopnt tmniutoas in isplce tssei nda oetomrpr eucsneeqs 9A(1F .01)4pg If ouy reaetc a tmuitano in a slpeci stie uoy wlli rlesuy sesm pu eht otrercc mNAR dneeed to amke a ilauotnfcn Bibo-lng ieo.tprn tTha si woh I esadnwre eth s.oueitqn

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