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Retired NBME 20 Answers

nbme20/Block 1/Question#11 (reveal difficulty score)
The sequence surrounding the first two exons ...
Disruption of normal splicing by creation of a new 3′ splice site 🔍 / 📺 / 🌳 / 📖
tags: biochem dna repeat

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 +20  upvote downvote
submitted by drdoom(1206)
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As dersdiebc in eht untoqesi em,st thsi mnoaiutt sccrou ihntiw na oinrtn a( neeg ngteesm ciwhh is screbrtnadi RN[N-&gA;AtD] utb otn sat.nrt)dale NAR nicsigpl )smy(eenz bgar NRA nad opo“l ;”ti an ntrino si tuc tou adn teh sxneo no iheert sdie of eht nitnor era dnjoiad,e kiel sh:ti

no2o——onrexien1xnt ;&g=t x—oxnneeo12

alylTy,pci siht gnpilcis rusocc at eth eyvr sgeed fo eht noitnr (hwat I dodtnee hiwt teh ”—“ t.earrc)ahc uBt ni rou e,sac a notiutam nwiith het inrtno si uacgins RAN gcnpiils enezmy to oczengeir a ewn e:its teh clpisre ctsu twihni hte rtnnio t(saeidn of ta teh veyr e,deg sa it ulh)o.sd ,So ew egt sgmtnieho atht osolk keli ts:hi

nxt1o——rxee2nino

’shtTa a ytltalo ridfneeft RANm uc,lemoel and s'ti ggoni to meak rou ogβb-lin otrnepi kolo and( v)ebhea afulwyl a.egnrst

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drdanielr  I ermember that ni het r-,AmeRNp eth picsgnli essti fo teh itnrno eehwr teh cseloepmsio asatcteh era uresodunrd by G""-GAU-- keil "ucg"a, so rehe eht somogloohu DAN to tsih sdratn would be cirtnadbrse toni .""..g....a...g........u nad hits lduwo rtaeec a 3' ilesc iste oto noso +7
vivarin  if htsi is opdssupe ot eb rRN,p-Aem yhw aer trehe T's in eht qe?ucense 'Im os nesocfud yb isth for moes asneor +8
sars  shTi is het enge (,)AND ton uetgosoneher NA.Rm +
athenathefirst  hTe tggbsie ecul yeth isda isht is B stsaahm,iael hhiwc even fi uyo tn'ddi oknw yhntangi atobu oexsn adn onnisrt uoy dlsuho ahve nknwo htat b stlaiaseahm slieovvn a itmouant ni glncpisi ro rormoetp iest aompt(ha geap 4).4 I otg hits tunesoqi gownr oot (: +1

Translocation may result in failure to transcribe RNA because of disruption of a regulatory element (eg, promoter) within a gene.

The affected gene will not be expressed or will be expressed in a dysregulated manner compared to the normal phenotype


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 +5  upvote downvote
submitted by monoloco(155)
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hsTi ash to do wthi toninr sniplcg.i reRbeemm TG.GA ihsT utaomtin ecindud na AG csoler ehrwe it saw pdoseusp to ,be so some of tath trinno jsut ebacme an eox.n

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 +4  upvote downvote
submitted by waterloo(126)
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I peeidtetrrn "euseqenc ngidrusroun itsfr two onxes fo eeng" - ot amne ethy tusm eb atginlk btauo noisnrt. Teehr of teh renwsa cceohsi ndo't ehva hucm to od tihw .nrnsoti

  • snseiesm tniuomat odwul hvae to eb ni hte oxen ot easuc aghcen ni imnao ciad.
  • aponnliyydtaeol si at teh edn fo het RmAN
  • nibtinoiih of citlieporna si DNA

ttah may otn eb ria gih,tt btu plseh rorwna odnw. oAsl knniowg esom aB-ssahetmail si due ot arniavst ni rmnlaoba nigcilsp hpe.sl AF( 0129 pg )43

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 +1  upvote downvote
submitted by s1khwitit(1)
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olsa beemremr taht laBaa-itmshse is eud to otinp anmiotsut ni ceplis estis nad tomrerop eqnusesec F(91A )4.p10g If oyu eacrte a ittmuona in a cplise esti you iwll ylseur emss up eht terocrc NmAR deedne to kaem a fiolucnnat on-bBgil troe.pin thaT is how I aewsednr eth tu.ieosqn

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