sA bsrcddeie in eht istqeuno emt,s shit nuottmia uorscc inwiht na onirnt a( gnee tnemgse whcih si isnecbrdatr DNNg]tAR[A-&; tbu tno erd)taantsl. RAN snigilpc ()yznmsee bgra RNA nad op“lo ”i;t na toinnr si utc uto nda eht soexn on trihee ides fo hte itnnro ear d,aineodj klei t:his

nx2e—1—rnnnoxeoiot => —1xoonen2xe

caylpy,liT htsi lngipsic scoucr at eht evry deegs fo het nnitor aht(w I eendotd tihw eth “—” e).rhtcarca utB ni uor eac,s a atuotnmi nwthii teh rotinn is agcnuis NRA ginlscpi eynzem ot ezneircog a wen ise:t het rpicels utsc nhiitw teh trionn aeint(ds of ta hte yevr g,eed as it uso.)hdl o,S ew egt nmgstoehi that ooskl ekil th:is

e12tnrxxoonie——n

ast’Th a tlyolta tffrendei ARmN mlco,leue adn 'its gniog to make rou βb-igoln eirptno olko dan( hea)ebv wfulayl t.rngesa

sThi sah ot do ihwt irnton pin.ilgsc meeembrR TGA.G hTsi omantitu eincdud na AG leosrc heewr it wsa udopseps ot be, os esom fo that nrntoi sujt aecbem an onx.e

I eerteirdntp e"enqsuec srrgniuundo tfsri owt oxesn of "geen - to eamn htey must eb igtlakn utboa n.snirto eehTr fo eth asrwen cihcoes dt'no aehv uchm to od whti riotsnn.

• inssmese oaumntti dwulo have to be in hte enxo ot usaec aegchn in mnoai ica.d
• otnpylaiendlaoy si ta teh ned fo het mNRA
• ioiihbntin of inoceatrlip si ADN

thta amy tno be air ith,gt ubt lspeh wrrnoa w.dno slAo ngwniok emos ma-Blesiasath si ude to tvraisan ni ornambal ilsgncpi phse.l F(A 2190 pg )43

olas rebrmeme taht ea-tmsaBihsal si edu ot piont smtnioaut in sclpei tseis dna rpemroto seqencsue 9A(1F 14pg.)0 If yuo recate a tmointua ni a lipsec stie ouy liwl uylser ssem pu het recoctr ARmN eendde ot eamk a tucionanfl Bnligbo- ripetn.o tTha is owh I sednrawe teh oseqtin.u