Translocation may result in failure to transcribe RNA because of disruption of a regulatory element (eg, promoter) within a gene.
The affected gene will not be expressed or will be expressed in a dysregulated manner compared to the normal phenotype
hsiT sah ot od thiw ntniro pclsing.i erbmmRee GGAT. ihTs attnuoim eddincu na GA slecro ehwer it wsa psdoueps to eb, os smoe fo ahtt tinnor sutj mcbaee na ox.en
I eptirrednte ncqs"eeue urdsgnoruin sfitr tow oenxs fo "geen - ot mnea eyht tmus eb ilkagnt utoab irn.onst Three fo hte sanrwe ehicsoc o'tnd aevh hcmu ot od tihw ori.snnt
atht yma ont eb ira t,hitg ubt lehps owrnar own.d soAl kogwinn eoms tisah-aeaBmls si ued ot arnvaits in mnabarol giisplcn slph.e (FA 2019 pg )43
aols mreberem that aBamshel-siat si ued ot intpo utsmtoian in elpisc tesis nad mtrropeo euqecssen 9AF(1 p04.)g1 If yuo etrcea a tontauim in a clipse tsie ouy illw sreylu smes pu eht tcrcero RAmN denede ot ekam a cntiulnofa -giolnbB nr.petio Ttha si woh I ernawesd hte iosu.qent
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$279$49sA ediedrscb in eth uietosqn mts,e tihs oittamnu srcuoc ithniw an nnitor (a neeg steengm ihcwh is rredinatsbc ;[t&DRAAg-N]N tub otn tat)edrla.ns RNA pgilsnic ey(mzen)s gabr ARN and oolp“ ;”ti an ntniro si tuc tou and het eoxns on ereith ides fo teh orinnt are de,ajdoni ilek stih:
—1ote—nrio2xonxnen &;=gt e1nne2oxxo—
aly,Tciply hits gsiicnpl ruscco ta hte ervy deesg of teh iotnrn wt(ah I eotednd thwi eht ”—“ ha).arccert But in uro a,esc a auntmito tiihnw het nnorti is asucing NRA isignlcp emnzey ot cgzeinero a wne s:eti the sceirlp ucst itnwhi teh ronitn tsdei(an fo ta eht yerv ,edeg sa it ).ludohs S,o we get sgieomhtn atht osokl ekli ti:sh
n1—tonxrx2iee—no
thasT’ a otllyta renitdeff RNAm ,oulecmle dan t'si noggi ot meka rou lniβ-gbo inoptre kool a(nd )vbeaeh lyfualw ag.rnste
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