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Retired NBME 20 Answers

nbme20/Block 1/Question#11 (reveal difficulty score)
The sequence surrounding the first two exons ...
Disruption of normal splicing by creation of a new 3′ splice site 🔍 / 📺 / 🌳 / 📖
tags: biochem dna repeat

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submitted by drdoom(1206)
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sA bsrediced in het usieqton ,smet isht uniattmo rcuocs ithnwi na ontrni (a ngee enmstge whhci is rscntredaib RD&;AAgtN[-]N tub nto .neatr)dstla ARN cgipsnil )esz(ynem gbra NRA adn pl“oo it”; an nnitor si tuc tuo nda eth onxse no rheite sedi of teh inrtno are aoied,djn ielk :htsi

e—rt—2eonoo1xixnnn t=g&; oex—nx1neo2

llap,iTcyy hsti lpncsiig osrucc at teh evry gdees of hte niornt hta(w I eetddon hiwt het —”“ a.ctrch)ear uBt ni our a,ces a tinmoatu wtinih hte nrotin si sgnaiuc NRA sliipgnc zeynem to iregenzco a enw se:ti hte clirpse cuts hinwit eth inrotn ienadst( of ta teh ervy eg,de sa ti hu.dlos) oS, we teg enogtismh ttha loosk ielk :isht

1xtxnone—o2e—rin

hatsT’ a aotlylt feentidfr NARm ulelmceo, and t'si inggo to kema our onli-βbg itproen oolk na(d ehveba) yullfwa ta.rnges

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drdanielr  I ebemmerr hatt ni het RNe,-mArp het clipsgni itsse of the irnont erweh eth poslsicmeoe thteaasc aer rdroeusndu by --U"-AG"G ekli a"ug,c" os heer the soholomugo ADN to isht atnrds ludwo be srtearcdnib tino u...a..."g...g."........ and isth duwol ceetar a '3 ieslc etis oot onos +7
vivarin  fi siht is puspdeos to be ,Ap-rmeNR wyh aer htere s'T in teh e?qnsueec mI' os edosucfn by htsi orf smeo renosa +8
sars  sTih is the eeng DN,)A( nto tuensherooge Nm.RA +
athenathefirst  hTe ggtesib uecl yteh dais hits si B emilahstsa,a iwhch eenv fi uyo ntdd'i kwon ngnhtyai tauob esnxo and ntsorni uoy uoldsh ehav owknn atth b eslaimtahsa niovevls a atmtouin in ilpnsicg ro erpmtoro site matp(aho agpe ).44 I ogt stih tqusioen nogrw oto (: +1

Translocation may result in failure to transcribe RNA because of disruption of a regulatory element (eg, promoter) within a gene.

The affected gene will not be expressed or will be expressed in a dysregulated manner compared to the normal phenotype


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 +5  upvote downvote
submitted by monoloco(155)
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isTh has ot do tihw ornitn cinpis.lg Rbememer TGAG. Tshi iaunotmt dunedci na GA clsreo erweh it saw pesosupd to be, so smeo fo atth nirotn jsut mbceea na e.onx

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 +4  upvote downvote
submitted by waterloo(126)
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I rpntieeetdr esu"eqnce nuiorrdsugn itrsf tow oenxs fo e"gne - to amne eyth msut eb likgant tbaou rnitnos. Teerh of het rwsaen hcsecoi dnt'o aveh chmu to od ihtw on.tsnri

  • nesmseis imtonaut udwol eahv ot eb ni hte xeno ot uacse gaehnc ni maion .icda
  • yntleopayaoidln si at teh den of teh RmNA
  • hntnibioii fo ropitcialen si AND

htta aym tno eb iar tght,i but phsel anorrw d.wno losA kningow eoms -lhteBamssiaa is ude to isranvta ni nombaarl nsiicglp sl.hpe (AF 1209 pg )43

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 +1  upvote downvote
submitted by s1khwitit(1)
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olas meebrrem taht shmsB-aealita is ude ot ption tmusitona ni ipcsel tssei nda reptoomr esnueqcse (19AF p1)40g. fI yuo aeterc a uotnimat ni a pcleis tsei ouy ilwl sylure smes up hte eocrtrc AmRN deened ot akme a ouclanifnt ni-olbBg iornp.te htTa is owh I rnesadwe hte nqoeisu.t

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