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Retired NBME 20 Answers

nbme20/Block 1/Question#11 (reveal difficulty score)
The sequence surrounding the first two exons ...
Disruption of normal splicing by creation of a new 3′ splice site 🔍 / 📺 / 🌳 / 📖
tags: biochem dna repeat

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 +20  upvote downvote
submitted by drdoom(1206)
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sA ediedrscb in eth uietosqn mts,e tihs oittamnu srcuoc ithniw an nnitor (a neeg steengm ihcwh is rredinatsbc ;[t&DRAAg-N]N tub otn tat)edrla.ns RNA pgilsnic ey(mzen)s gabr ARN and oolp“ ;”ti an ntniro si tuc tou and het eoxns on ereith ides fo teh orinnt are de,ajdoni ilek stih:

—1ote—nrio2xonxnen &;=gt e1nne2oxxo—

aly,Tciply hits gsiicnpl ruscco ta hte ervy deesg of teh iotnrn wt(ah I eotednd thwi eht ”—“ ha).arccert But in uro a,esc a auntmito tiihnw het nnorti is asucing NRA isignlcp emnzey ot cgzeinero a wne s:eti the sceirlp ucst itnwhi teh ronitn tsdei(an fo ta eht yerv ,edeg sa it ).ludohs S,o we get sgieomhtn atht osokl ekli ti:sh

n1—tonxrx2iee—no

thasT’ a otllyta renitdeff RNAm ,oulecmle dan t'si noggi ot meka rou lniβ-gbo inoptre kool a(nd )vbeaeh lyfualw ag.rnste

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drdanielr  I ebmremre htat in eth e-pRANm,r the ipgsincl itses of eth tninor eerhw the eeoisplmsco csaahtet aer usdrrouedn yb -G"-U-"AG ekil ",agc"u so reeh the osomguhool AND ot shti sdtarn wodul eb ierbnstcrad inot ....g.....g."..a...."..u dna iths dlouw eeatrc a '3 icsle iets oot noso +7
vivarin  fi thsi si psodesup to eb eRNAr,m-p ywh are three s'T ni the q?eueescn mI' so ounsdcfe by hsti ofr soem eorans +8
sars  iTsh si het geen ,(AND) nto hngtsoeoeeur Am.NR +
athenathefirst  Teh gsitbeg eluc yteh iads thsi si B alahseaism,t cihwh eevn if yuo ddint' okwn ngiyhnat abtuo nsxoe adn irnntso oyu lhdsou heav kwnon tath b easmatalhsi sevvoiln a maouintt in giisclpn or mretoopr stie o(phatma page 4.4) I got hist utnqeosi wgnor oot (: +1

Translocation may result in failure to transcribe RNA because of disruption of a regulatory element (eg, promoter) within a gene.

The affected gene will not be expressed or will be expressed in a dysregulated manner compared to the normal phenotype


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 +5  upvote downvote
submitted by monoloco(155)
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hsiT sah ot od thiw ntniro pclsing.i erbmmRee GGAT. ihTs attnuoim eddincu na GA slecro ehwer it wsa psdoueps to eb, os smoe fo ahtt tinnor sutj mcbaee na ox.en

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 +4  upvote downvote
submitted by waterloo(126)
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I eptirrednte ncqs"eeue urdsgnoruin sfitr tow oenxs fo "geen - ot mnea eyht tmus eb ilkagnt utoab irn.onst Three fo hte sanrwe ehicsoc o'tnd aevh hcmu ot od tihw ori.snnt

  • msesisne ouitanmt dwolu ahve ot eb ni eth xeno ot esuac canheg ni minao .cdai
  • nolyynoateplida is ta teh den of eth RNmA
  • tiibhoinni fo ipaociternl is DNA

atht yma ont eb ira t,hitg ubt lehps owrnar own.d soAl kogwinn eoms tisah-aeaBmls si ued ot arnvaits in mnabarol giisplcn slph.e (FA 2019 pg )43

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 +1  upvote downvote
submitted by s1khwitit(1)
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aols mreberem that aBamshel-siat si ued ot intpo utsmtoian in elpisc tesis nad mtrropeo euqecssen 9AF(1 p04.)g1 If yuo etrcea a tontauim in a clipse tsie ouy illw sreylu smes pu eht tcrcero RAmN denede ot ekam a cntiulnofa -giolnbB nr.petio Ttha si woh I ernawesd hte iosu.qent

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