Translocation may result in failure to transcribe RNA because of disruption of a regulatory element (eg, promoter) within a gene.
The affected gene will not be expressed or will be expressed in a dysregulated manner compared to the normal phenotype
isTh has ot do tihw ornitn cinpis.lg Rbememer TGAG. Tshi iaunotmt dunedci na GA clsreo erweh it saw pesosupd to be, so smeo fo atth nirotn jsut mbceea na e.onx
I rpntieeetdr esu"eqnce nuiorrdsugn itrsf tow oenxs fo e"gne - to amne eyth msut eb likgant tbaou rnitnos. Teerh of het rwsaen hcsecoi dnt'o aveh chmu to od ihtw on.tsnri
htta aym tno eb iar tght,i but phsel anorrw d.wno losA kningow eoms -lhteBamssiaa is ude to isranvta ni nombaarl nsiicglp sl.hpe (AF 1209 pg )43
olas meebrrem taht shmsB-aealita is ude ot ption tmusitona ni ipcsel tssei nda reptoomr esnueqcse (19AF p1)40g. fI yuo aeterc a uotnimat ni a pcleis tsei ouy ilwl sylure smes up hte eocrtrc AmRN deened ot akme a ouclanifnt ni-olbBg iornp.te htTa is owh I rnesadwe hte nqoeisu.t
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$279$49sA bsrediced in het usieqton ,smet isht uniattmo rcuocs ithnwi na ontrni (a ngee enmstge whhci is rscntredaib RD&;AAgtN[-]N tub nto .neatr)dstla ARN cgipsnil )esz(ynem gbra NRA adn pl“oo it”; an nnitor si tuc tuo nda eth onxse no rheite sedi of teh inrtno are aoied,djn ielk :htsi
e—rt—2eonoo1xixnnn t=g&; oex—nx1neo2
llap,iTcyy hsti lpncsiig osrucc at teh evry gdees of hte niornt hta(w I eetddon hiwt het —”“ a.ctrch)ear uBt ni our a,ces a tinmoatu wtinih hte nrotin si sgnaiuc NRA sliipgnc zeynem to iregenzco a enw se:ti hte clirpse cuts hinwit eth inrotn ienadst( of ta teh ervy eg,de sa ti hu.dlos) oS, we teg enogtismh ttha loosk ielk :isht
1xtxnone—o2e—rin
hatsT’ a aotlylt feentidfr NARm ulelmceo, and t'si inggo to kema our onli-βbg itproen oolk na(d ehveba) yullfwa ta.rnges
$279$49