,So rof osem asreno, teaonimrsturretsn is onhtsmgie e'Iv WSAYAL rdutsggel h..tiw. ybproalb asceebu I nsat'w gtathu it well os reven ellayr deearln ,it ustj aeneldr ougenh for veterahw e.max I jstu odfnu thsi oob hruhgto IBNC nda sti !CASTATFIN 'tsI fmro 1200 so mtigh be do,l but ti aws t.raeg uYo nac acresh grthohu het obok adn dfin eth ehp.csart I trtpey cumh tujs wtne uhhgort all fo eht mrennreasourttti .trhpcea /lwib.wpo7nh./cB9Nh.mtnbk9/s:o/Ktwvgi/no.01s

yM aimn tka-:aal Gmtayswaeetu = amorj ioyxeatrtc tinsarrotmre.tenu Two eypts fo er s1e)tr:cop ioocaebtrp,mt tsmo of cihwh ear cesaiyprtpn Gi icwhh easdl ot deesedrac NMDA ceeorptr avitytci and srki fo ctxi,iixootcitye ro satpcypntois qG reoptrecs htat eadl ot aenrcies ,a+N K,+ and rdedeasec auattmgel cseasu noepzolairadit nad endrseiac +g+M sdiemepcltan nda NMAD oeprterc yvicitta dna iksr fo txto,cictioyiex dan 2) irncotpoio seclnanh lgincdinu MDNA dna tiaMa/AnAPke nn,scaehl hchiw lla awlol onsineccpif tionca ,unlfxi utb nlyo MDAN wsalol +Ca+ flnixu a(dn lyno in a gteloav npetdeend anermn taefr icuteiffsn zdptoaionrlaei ash apcedslid eth niitbohri +g+M ino in eth l.c)nehna

GBAA and gileycn = hrbyiiniot me.orteisnrntsurta )1 BGAA-A nda C-ABGA = rnotioipco canhlsen tath dlea to exluf of Cl-, and pdseiet hist incsgau nrodai,ltezpiao the runeon tlsil stsya ewolb trnsige latoe.nitp BA-AGA ibgnnid etsi ofr sbrareut,bati ois,restd GAA,B and tpxoirnoci = iineds orep of nac.hnle AGAA-B niibdgn seti fo eieioanzebpsdnz = tisdoue of orep fo helnnca. ) 2 elGnicy nelncah si a yver lrimsia -Cl uxfel .enlahnc )3 -BBAAG si a ttopbaecromi annhcle htat tviaeatsc iG agndile to eacrdedse MAPc cwihh scattveia fulfex +K caeshnnl nda bishiint C++a ifunlx selnnhac dlenagi ot ptrrayznapoo.iheli

Beioincg amsnei = oseaahcilcment iemdpona oooidcn(antri of yodb enemvt,mo rdra,we amot,vtniio entne,rcfmre)oi rpnnpeneoehiri ep,(esl ulsekswean,f taon,tneit nedigef b,raeiovh irepnehpine lto(ews etotcnacnionr in N)C,S pusl trsinenoo ee(psl, le,wfukseasn eiepd,nsros yenax,ti eaan)us and siinhmate aa(,ruosl ,tenaitnot ayg,ller estsui ,emgaad nad amy lenfceiun olbod rniba l).owf Oulviysob, lal of stih is ni dnatodii to redgneriac osnausinrseoitnrm adn hfgl,it ,igrthf nad ghtfi nprsees.o

APT nda trohe spirune = coayxtrite sntmnssoi,air elasderce-o htiw rohte e-slllumceamlo umenrr.taoinrsestt soeiAnedn snti' aalclcisyls nesdoedcri a rtitenrrtesnuaom easecub it ins't eoseedls/ardert in a++C depdnenet amn,ner but reidvde ofmr APT eeorbf gvnahi an xreoyttica enito.lpat

ieocAtnlecylh = ormaj ruoittenrnsmerat ndevoilv in rosanrsestiounmni iav mainrcus dan nctiioicn rct.erespo

ditPpee sruomaeentnrittsr = cmolnymo erelaesd as petpidpero rragel orcurpessr htat rea delecva yb csefpiic snmyeez that eewr ni hte smae uresetmnritartno vcielse pnou lraeese. Fiev tespy = grnubait/ itdes,epp iidoop i,desppet ytpaiitur tdsipe,p aaytmlchhiop ngilseera msronh,oe dna stoeh otn sisid.lceaf smEplaex = orerpucsr atht esigv ries to stscbuaen P pmi(cu,aposph rxcn,teooe nad GTI nda asdereel rmfo lmsal aeitdmre SNP C isfreb ttha rnaimtst apin dan tmeaerutper itramifonno, fplorewu ns,yepivetoh neidbiith by oiopid it)de,epsp okennniiru ,A ereutepnidpo K, nad uieprepondet am,mga and odoiip dtieepps cdnnliigu ptnal aidllsako e(kil noh)eimpr, hsnciytte ooiidp eaviitvdesr, and hinse,onprd rhyndnispo, dan eesknnlpiah. In rlgenea dpiooi ipesdetp rea aentsderssp ..(ei eangaisal nehia,cm)sm ledivnvo ni oelmpcx hvsrbieoa xlaeu(s otir,attnac uaie/eivbssrmvessggis sie,ob)vahr dna cdeitaipml (huohgt nto vfidiint)ee ni trasciyihcp odss.iedrr

ale,vlrO snrietretnusatorm = ptey :speyt l-lomclsmuelea rrtitamsetns dna ppteuneid,sreo eewrh caslmollslm-uee istrntamstre rea frtesa dan iaetemd diapr ntiypsca sisnatosirmn .(ei. nnreaodg SNS gfhfgtfihhti//gltri uikqc npe,seo)rs herew as pioenetursepd ola(gn tihw igoobcil sainem and smoe lmsal lulmeeco )mtansritters are sorlew nad edtmiea ar,algdu doplonrge nsrasmnetunsio.ori

oemS ire:tuspc ttrv/wiihwt.eemsualf./phs_w.cpsubitrutpv_kuddeaee/_rnoo/ikmetot/preeod:ramnnhn, tnGh10f.aadpudfgti/1p6gr2rR2-3-ac6neh3awstlwosfeer-e5feler3eaPthar1ueseioub7.-p-ti/c2iaeAb1dpbggi/Tr0nAr/c-0B-s0p84m-/0/4bssw98oe36gco14radBr:li6/t, nda i.slhsgruxe=/&fg7/6niali--th1e0b/_fr2ewaeda5d-dln=#1e0-fx;a/3aeb1bht8s.a1g-5b.p:rm-f9/-t3aen6lU4wodpdaigb/twe2t-gwec

hgoTu .osnutiqe

ellcaR htat enatMemin 'zeameshr(il d)gru is a DNAM oeRrctep gatAnniots ttah ehpls nveretp eoctxiitxyoct yb klgociBn aC+2 nrety. 'Thsat owh I mbrereem hsit.

• )A B-AAAG rocsteper tel C-l ni
• B) lGnyice is eusd in het inaslp odrc as na tyiibnhroi mntnetrurao;irets laos selt -Cl ni
• C nad )E aoecbirpoMtt matleguat crrostepe rea teroi-pGn lpcduoe
• ehfr,eeoTr the lony igthn tath duocl tle a2+C in si DMNA esctorrep

MDNA epetrcors in tihs saec rae beign esdu fro lngo retm itnntaeopoit ihwint the ainbr nad tuo of lla fo rheet esoihcc lyno stih perotrec sesu C+a

uoY acn sanwer by essrpoc fo otiinmlaie.n ottiCvieme"p ceinnit"ostar easkm ouy hknti trilsumtoay NT. osCsr tuo BAGA dna egily.nc In hte oectrx os lmtgaeut.a epiMortotbca dowul eamn re'tesh encdso snsegrmees onveivld and eht rpetcero wudlo ton mnsttira cu.claim ecHne N.DAM

esdu in glon mert epntniiatoto agangeul,( )mmryeo, aMy sola aypl a olre ni gene nrtisoiractpn in rensoun

)1 NAMD is a tmGuatela erorpcet 2esbp )tuy PAAM si a esptuby of NDAM htat si aliliytni ditcetvaa yb almtgutea eae)r3sel MAND reeocrstp rae ofund anre MPAA tsoerercp but rea tno actedavit by owl elvles fo ttuleaamg lereeas eud to a Mg oni oci‘blgkn’ teh nenal4)ch ueqnFrte ontiAc tainpteol &;—gt uamtiltnosi fo APMA —t&;g ezodeprasil spot pyitnacs onuren &tg;— lvgeato edptnnede gM lcobk fo MNDA pteceror vdmreoe 5) nifulx fo Ca hghotru NDAM gt—&; sscaue nvee erom AMPA eosprrect ot be rentsedi iton eth nbeemmra NTEO:( PAMA si iesevsnorp ot Ca dan )am6et)agl tu aeesucB erhte rea moer rtpeecosr to peorsnd ot ti, eht clel si rome sivnseeorp to alautmteg

lal het ertsoh a tecoiinnvmopte eincs htye aevh isefctpipisceiicy(cf nsa,g)idl MNAD is teh onyl evneconnieesth(cle ettoecivipm eocp,ert)r sha a glidan ites nda ca , na nda ecnm..e.hg cvieopetitm