effect of glutamate antagonist on pt with acute cerebral infarction = targets NMDA receptor
decreases calcium entry into neurons = decreased excitotoxicity = promotes recovery from acute cerebral infarction.
oguhT nq.iuseot
alRecl atht emanMniet lieshze(r'ma rdgu) is a MAND crepeRto aAtngtsino ttha phesl erpevnt xiticxttocoye yb ckgnliBo +Ca2 etrny. s'atTh how I meremebr i.sht
a picture for better understanding https://2e.mindsmachine.com/asf04.02.html
^ link is dead :( (they published a 3/e) but here is the re-route to the new site if anyone wants to dig in https://learninglink.oup.com/access/watson3e-student-resources
MDNA srrotpece in isth ecsa are nbgei used for olgn etrm otnittpeiano wihnit the aribn dna uto fo lal of eterh cesohci only ihts trecreop suse aC+
I idpcek NMAD buescea ’sit ils,tamyotur tbu si rhtee yna eepdre seorna rfo st?ih
Yuo nac ersawn yb porsecs fo neoli.mtiain optti"veCmie crositt"iaenn akems yuo thikn rialuostmty .NT rCsos uto BAGA and eygcl.ni In teh xertoc so autme.altg riteoctapoMb owlud mnea eset'hr codnse esmgnrssee ldnovvei nad teh creoetrp wldou otn snamittr mc.ucila ceHen .DANM
dues in ognl trme itittoapoenn ,ggalu(ena ,ery)mmo May sloa alyp a erlo ni eeng pciirttoranns ni esnronu
)1 AMND is a ataGlmteu tprreoce )pt2yesb u AMAP is a psbtyue of ANDM htta is ylniitali daeatctiv by tegmaatlu eer3e sa)l MDNA pscrretoe aer ufond aern MAAP etesocrrp but rea ont cidettvaa yb wol slevle fo aglettaum ereaesl eud ot a gM oin boil‘’ckgn hte 4ea)h nncl ruqtFeen cnAoti tpalntieo >—; totilsanium of AAPM t&;—g eareisodzlp ptos syainctp eunorn gt&;— gaelovt epdntndee gM klcob fo MADN pertcero orvdeem 5) lxfnui fo aC uhtgohr MDAN ;g&—t uecass eenv omre MAAP pcrtsoree ot eb sedtenri tnoi eht emreamnb :OTEN( APAM is vsoeriepns to aC adn 6meu)lttaga) ceeBsua terhe ear orme presrecto ot dpoerns to it, the lecl si omer eronsvpies ot uetagmalt
all eht throes a ovimntpteconei nesci hyte eavh pieiss(cftyiicceficp si)andl,g DANM si eth lyon sevoenenlche(tcnie tcoetmipevi or)pc,tree sah a gidlna tise dna ac , an adn ch.e.n.gme mepvtioceit
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$279$49,So orf meso aoe,rsn meruttrtsesonnria si gistmonhe I've YSLAAW sdlgtruge .whit.. yorlabbp eaubcse I swtan' gatthu it well os vrnee elrlya nraedle it, tusj lrdeane uhneog orf vateewrh xmea. I jstu ndufo sith boo urthogh ICNB nda tis AIS!NATCTF I'st rmfo 0012 so gitmh eb ld,o but it aws g.rate Yuo nac eharsc oghhurt eht okob dna indf eht s.tcraphe I reptty umch ujst enwt gthourh lal fo het ronemitasurtertn ace.trph /tkb9omh1nwbw0iNnglcB/7.Kh./o//9ni:wv..tspos
yM amni wsaaet G:amulakyat-te = moraj rotyxtcaei .senoianttrumtrer woT sepyt of )te1ps croer: tbooaiemptr,c somt of chwhi rae iastneprcpy iG chhiw aesld ot drseeaced NMAD rcerteop civitayt adn ksir of eitixcyiototixc, or spaponyticst qG eepstcror that adle ot rnseacei +Na, ,K+ dna cdrdaesee mtgaeltau scueas iadznolroiteap nad dsaicerne +Mg+ ladicemtnpes adn AMDN errpcteo itvatyic nda srki fo ieytooxic,xttic nad ) 2 cotripioon chnanles uindnclig ADMN dan aMtAAaki/enP lcehnas,n ichhw lal loalw iicnesnocfp iconta ux,infl but nyol NAMD wlsaol a+C+ ifulnx an(d olny in a evlgoat pneendted rnmnae teraf ftesicunfi zndetapolaioir hsa sacpdiedl hte inrbihtio M+g+ nio ni hte e.nnlcah)
BAAG and nygielc = iybnhoriit rmrst.ratitesneuon ) 1 AG-BAA dna GAC-AB = inprotioco nlasenhc atth leda to feuxl fo Cl,- dna esdtepi ihst aniscgu drtaailion,poez teh orunen ltsil stays loebw ngteris .neapoltit B-AAAG gnbiidn esti fro btestrrauab,i id,srsote AB,AG nda nxorptcioi = isdnie oepr fo nea.lcnh AAAGB- bnniigd seit fo aonzebdseeziipn = tiseodu of eopr of lncah.ne )2 Gyclein hcnanle is a yerv rlisaim Cl- fuelx chlnena. ) 3 AG-BAB is a metobcioarpt cnnlahe tath tvtcaisae Gi aiedlng ot eedacdsre McAP ciwhh atestvcai ffluxe K+ sheanlcn nad sbitnihi a++C nifxul hanlcnse dnagiel to lhppzeoant.ryraoii
gnioeciB siamen = tmciaenslaoech apoinedm ocin(otoiadnr fo oydb te,mvnoem rr,dewa t,ovotimnia nrc)ie,oefnmetr rreoinhneppnei pee,s(l nsfklsuweae, ,eottanint nedigfe via,bhroe nepeeihrnip t(oelsw nnirccootnate ni CSN,) uslp ooerinstn e,(elps euwnsleas,fk neide,osprs ,yineaxt eanasu) and eatmhsnii ,aorsua(l nn,ioettat ,ygellra esstui agmead, adn mya ncleinuef lbdoo irban of).wl b,lsyviOou all fo tish si ni iadntdio ot rndrecaeig srnesooruiatmnnsi and lft,gih hgit,rf adn tfgih rse.pnsoe
TAP nad eroht uinpesr = rxoieyctat oisnmis,ranst ecreosael-d ithw ethro ecles-lmmlloau tnsiestrrneaoum.tr Aonesdnei 'sitn ilclsasycla erdonseidc a mtrnetsarnrtouei buseeac ti 'nits oseltree/edrdas ni aC++ nedetdpen nemran, utb evridde mrfo TAP eofreb nghiva na otteyricax t.neapiotl
Altconcyleeih = mjoar esrnraoutirtmten idonlevv in seanorsmonnuirtsi iva acmsiurn dan onciticin crep.orste
tdpPeie eiuornartnetsrsmt = nolomcmy ldeseaer as ppreptdieo agelrr rpocseusrr hatt rae lecdeav yb cfeiipcs eezmsny ttah reew ni teh amse iometantrtrsreun lesciev oupn slee.rea iFve tpyse = unai/brgt ,ipdestpe opiiod idse,ppet ittuyipar ,tieppds imltopayhhca siaelregn sr,nheomo and stohe ont asidsce.ilf aElempxs = erpsrrcou atht gvsie eirs to steubacns P pis,aupo(hpmc toeoer,xcn nda TIG dan reaseled romf mlals edireamt PSN C firseb hatt mairstnt niap dna eurteareptm niimtnofaro, ofwulepr htienpv,yseo eihiibndt by ooiipd te,idepp)s uniknoiner A, unoidperptee K, adn ordeetiepnpu aa,mmg dna oopdii sdepietp incudlngi nalpt klialados (lkei ehro)n,mpi ncttheiys iooidp adistvi,erve nda dihersonn,p ,dhnoipsnry nda i.lnhaneskep nI rageenl ipidoo pesedipt ear dastseprnse (..ei nagliaeas )aenmicshm, vedlvion ni oxmepcl ierhsboav (xelasu attitanc,ro sirueasesbegv/vsgismi rbo,asie)vh and imdcpailet h(hgtuo not nt)eieviifd in hpiyaiscrtc siode.rsdr
av,ellrO arnetsrsnuimterto = etyp ype:ts lscome-mlleual ttsrantmrise dan pnouder,eeitsp heewr ucl-amoeellsmsl nerrmtisatts aer rasfet nda timeead apird cstapyni moitssiansrn (ie.. oeadnngr NSS igttr/fhlfihighfgt/ ikcuq )speo,senr whree as peeitnrdepuso anglo( hwit lociboig nsimea and seom mllsa leluemoc steanrrm)itst are sorelw dan mdteaie rau,ldag glprdoone nonoseu.sinasrmitr
Semo :cstpueri edestipahnrmhudsh.ouowsrtu/nild:ia.rwompweoke/tt/.nf//ebaekpei_rtuttv_ecvnmrp_, 7enw0aetglc-pf.-l23/s1r.rrAt0ep9ab38f3piuh/wg-tit/o5/:u1s-gsa0nsT1/ie/Bhcdre4rbh1arGc-a6f48-eb6Aor2ibrdtsw4rid/0epgce-3lepm1sf2o-oRienatd60geuPaaB6, and sde1/ime4flra--g_iabseU=n/fg/t03w0aelb1.-ae2.bpr/w.wgetol-g;2i8fete6d/xfxl3b&5=ap1t:ru#-ia6a1ed/-btdhhgd9swa7n5h-cn-
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