Answer = C. (Decreased hepatic VLDL synthesis)
Nicotinic acid = Niacin. Niacin works by:
Inhibiting lipolysis (hormone sensitive lipase) in adipose tissue)
Reducing hepatic VLDL synthesis
The only place where FA2019 talks about - pg. 67, on Hartnup dz: pellagra-like symptoms. Treat with high- protein diet and nicotinic acid.
well, great
A: cholestryramine and other bile acid resins prevent the reuptake of bile acids from the gut. B: Statins inhibit HMG-CoA reductase, preventing the liver from making mevalonic acid, a precursor to cholesterol. C: Niacin (nicotinic acid) reduces hepatic VLDL synthesis and also inhibits lipolysis in adipose tissue by inhibiting hormone sensitive lipase. D&E: Fibrates upregulate lipoprotein lipase (LPL), increasing triglyceride clearance (VLDL and chylomicrons are full of triglycerides) and also activate peroxisome proliferator-activated receptor- alpha (PPAR-alpha) to induce HDL synthesis.
Could someone please explain which drugs (if any) are at D and E?
1) label D (VLDL -->ILD --> LDL) = anything that increased LPL = Fibrates which use PPAR-alpha (Rx) are good at reducing [VLDL]; therefore, less VLDL means more ILD.
2) VLDL --> fatty acid oxidation = using fats (TAGs) for energy production Here PPAR-gamma plays a role= which are Thiazolidinediones (also called glitazones) are a class of medicines that may be used for the treatment of type 2 diabetes. They are also good at reducing serum TAGs
Note VLDL are very rich in TAGs
I miss so many questions on NBME exams not knowing the common names for things lol fuck me
submitted by โbtl_nyc(72)
A: cholestryramine and other bile acid resins prevent the reuptake of bile acids from the gut.
B: Statins inhibit HMG-CoA reductase, preventing the liver from making mevalonic acid, a precursor to cholesterol.
C: Niacin (nicotinic acid) reduces hepatic VLDL synthesis and also inhibits lipolysis in adipose tissue by inhibiting hormone sensitive lipase.
D&E: Fibrates upregulate lipoprotein lipase (LPL), increasing triglyceride clearance (VLDL and chylomicrons are full of triglycerides) and also activate peroxisome proliferator-activated receptor- alpha (PPAR-alpha) to induce HDL synthesis.