NBME 22 Answers : Block 4 : #20 = During a study of symptomatic proximal deep ...

NBME 22 Answers ↦

nbme22/Block 4/Question#20 (34.2 difficulty score)
During a study of symptomatic proximal deep ...
Open-label clinical trial🔍
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submitted by aesalmon(78),

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nalclCii tlrai - mocerasp etathrcipue fesnteib of +2 tnesttemra arrf(inwa .vs ndeeeplaOrbtn-l)l paia - boht the hhteal oivsrerdp dan het tp aer aaewr fo het udgr inebg nigev

jackie_chan How are we supposed to know in the question the patients and providers are aware that they know what they are being given? +

haydenelise I went back and forth about it, but in the end figured that they were aware since one regimen involved subQ injection + oral med and the other was subQ injection alone with no oral placebo. +2

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submitted by asharm10(15),

When you are comparing the therapeutic effects of two drugs it's a clinical trial and when both the patients and providers know which drug it's open label. Clinical trial could be done between tx/control or tx/tx. It can't be crossover as there is no wash out phase

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submitted by hello(246),

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hWy tsi'n hsti a hrtcoo tud?ys

drdoom This is a cohort study! (Since it involves splitting people into "groups"; group = cohort.) But the stem asks what "best describes" the design. So, yes, it's a cohort study but a more precise ("more specific") description is Open-label. In other words, "Open-label clinical trial" is a type of cohort study, and, in this case, "Open-label" is a more precise description of what is described in the stem. +6

drdoom For a more technical explanation of "Cohort studies", see the definition from the National Library of Medicine: https://meshb.nlm.nih.gov/record/ui?ui=D015331 +1

angelaq11 It is a cohort, just as @drdoom said, but it isn't an "Observational" one. +1

pg32 It's actually not a cohort study, imo. In a cohort you find people with an exposure and see if they develop some outcome. In this experiment, people were RANDOMLY ASSIGNED to the different exposures. That doesn't happen in cohorts. +5

pg32 It may be a cohort in that these people are in groups, but for the purposes of Step 1, I don't think we will deal with typical "Cohort" studies in which participants are randomly assigned. +2

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submitted by niboonsh(280),

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I ma cuofsonin. yhw oudtwnl sith eb a rscso oerv ?tsdyu

shokay there is no washout period and the order of drugs given isn't switched +6

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submitted by ahmedfuc(0),

cohort is observational study so you just see what is result of exposure in clinical trial we do intervention like giving medicine and comparing its eficacy to control therapy

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submitted by ahmedfuc(0),

cohort is observational study so you just see what is result of exposure in clinical trial we do intervention like giving medicine and comparing its eficacy to control therapy