This Question its about respiratory burst
Patients with NADPH deficiency=chronic granulomatous disease (CGD)
Even though patients with CGD can't make Superoxide, they can use it from the bacterias and convert it to bleach HCLO and kill the bacterias.
BUT bacterias with catalase enzymes neutralize their own superoxide and thats why the CGD patient can't kill them.
Catalase positive: S. aureus - Aspergillus
please help -- If catalase-positive bacteria neutralize their own superoxide, why isn't it the case for catalase-positive bacteria to infections in everyone?
I'm not understanding the connection to NADPH oxidase deficiency.
Question is asking about encapsulated organisms infecting CGD patients. E.coli is also encapsulated. Can anyone expand on this?
Note: the questions stated "respiratory burst" suggesting an URT infection.
1) this rules out anything but respiratory infection (non rep infection: E. coli, E. faceium)
2) G6PD deficiency more susceptible to catalase positive organisms -- this rules out (all strep organisms)
3) Left with H. influenzae & Straph. aureus (BOTH are catalase positive)
4) Encapsulated organism are most concerning when there is asplenia.
submitted by rogeliogs(1), 2019-07-26T23:33:07Z
This Question its about respiratory burst
Patients with NADPH deficiency=chronic granulomatous disease (CGD)
Even though patients with CGD can't make Superoxide, they can use it from the bacterias and convert it to bleach HCLO and kill the bacterias.
BUT bacterias with catalase enzymes neutralize their own superoxide and thats why the CGD patient can't kill them.
Catalase positive bacterias: S. aureus - Aspergillus