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Retired NBME 22 Answers

 +13  upvote downvote
submitted by โˆ—upstairs_bumblebee(31)
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The question asks about parenteral administration of the vaccine (meaning, not using the oral route). Non-oral vaccines will not strongly elicit IgA response. Non-oral vaccines not super helpful in combating a gut mucosal infection such as V. cholera, where IgA is more salient. Not sure if this is the actual correct reasoning, but it led to the right answer.

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aesalmon  I totally skipped over the word "parentally" when taking this - ugh! +22
imgdoc  Wow, I feel like such an idiot for getting such an easy question wrong...I skipped over parenteral and starting thinking about Cholera toxin MoA. ffs... +



 +3  upvote downvote
submitted by โˆ—happysingh(57)
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Injection = ONLY IgG
Vs Oral = IgG & IgA

Cholera is transmitted via GI (oral) route , so you'd need the IgA protection, since it's mostly IgA that protects from GIT pathogens

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