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NBME 20 Answers
The frequency of an autosomal recessive disease in ...
Nice! ...and we are supposed to read the stem and do all this in a minute or so? :-/
Allele frequency 1/40. so carrier freq 1/20. 80% of 1/20 is 1/25 (80/100 x 1/20)
So apparently I don't know how to format very well. Sorry!
So because i couldnt spend more than a minute on this question and honestly didnt recall the Hardy-Weinberg equation this is how i solved it under a minute:
so you know in a given population half of them will be carriers since its an autosomal recessive disease Aa Aa= AA aa Aa Aa
so of that half 80% are due to deletion mutations and 20% are due point mutations
by that logic 80% of half into 20% of half will give you 1/25