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Retired NBME 20 Answers

nbme20/Block 3/Question#1 (reveal difficulty score)
The frequency of an autosomal recessive ...
1/25 ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
tags: biostats

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 +16  upvote downvote
submitted by jotajota94(14)
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sUe hte ynriabdHeWgr-e uetnaiqo

  1. aTke eht aqrues root fo 0,/6011 nad that lliw gvei uoy eht eyufqcnre of teh crvsesiee eellla = 0./14
  2. taecualCl eth yeeqnrcfu of hte tdmnoani allele tihw q+1=,p ihchw si p= .0.795
  3. yhTe era leintlg oyu to utlaaccle teh neqercufy of eth saidsee ,rcaierrs chwih si tihw eht noeuaqit 2.pq
  4. eThy twna noly eht aiedess reraircs ni ihwhc itndeloe is .sernpte To elalacuct htsi, seu eht q eavlu 14()/0 and lmypitlu by 08% ni hsti lohusd veig oyu .02.0
  5. n,Fliayl ltaulacec rfo 22Pq .5.20)90(7)0(= 40.0 = 25/.1
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yex  !ceiN dn.a.. ew are posuedps to raed het tsem dna od all siht in a inetum or os? :/- +28
charcot_bouchard  llAeel nyfcqreue 4.0/1 so rarreic freq /02.1 %80 of 102/ is /125 00(108/ x 01)2/ +15
dickass  hA fekc, 2qp got em +1
hello_planet  A hdayn stcuhrot rof nargreie-ydWHb si hatt you enreallyg nac museas p =~ 1 fi q if lrifya .wol It olas ntsed ot be ieaers to rokw in itansorfc fi het srnaew socheci rae ni fcrioastn so you 'ntod veha ot ceubon bkca and rthfo eebntew ntrsciafo adn ldesic.am So itwh ha,tt yuo dsen up ihtw p2q = 2 * 1 * 0/51 = /520 = 512/. +9
topgunber  htae siht ehlwo braelsmc tn:ihg I n eon nli:e 2 * q * ih8T0%.s is fro siseedda svailinddui tw(o q sl)e.aIlel = 101/06 = 2hTe^q fecunyqer fo q = N/410o w rearicsr si 2 p q. P is oslec ot one ngumassi HW mqe (p)q+=.1 eTh'ser na danotidial tesp in hsit utiqneso due ot het owt enfdteirf mons.u soitat (2q) = 120./ 08% fo sthee rrserica are esotdeinl os uplyitlm 21/0 * 80. = 125/ +

@usmlecrasher

1/40 = .025 = q P + q = 1 -> P + .025 = 1 -> P= 0.975

+3/- alexp1101(11)


 +2  upvote downvote
submitted by โˆ—topgunber(68)
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heta tihs whoel eclramsb hitng: In neo e:lni 2 * q * 80%.

hTsi si rfo asseiedd dunlidsiiav ow(t q aeIlsle)l. = 61100/ = 2hqT ^e eneuqcryf of q = /401

oNw eriacrrs si 2 p .q P is cselo to one gsnumisa WH mqe )+(1q=p. seheT'r na ddoaitianl teps ni isht etisuoqn eud ot teh owt ndefiftre uta.mtsino

os )2q( = .102/ %08 of ethse rrcrisae rea etdoeslni os lmtpluiy /210 * 0.8 = 1/52

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 +0  upvote downvote
submitted by thechillhill(1)
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p + q = 1 p^ 2 + 2qp + ^2q = 1 i f q^2 = /01610 = .000603 hte n q = s(2tq)r^q = 5002. esolv for p ot teg p = 1 - r = 1 - 00.52 = .5097 het gthyeurzooes ircraser = q2p = 1 - 2^p = 1 - 50.9 = 5.0 ^q2 acn eb dorppde /cb t'si mhuc rmalels athn .p^2 e hT netlodei si posnslribee for 80% of eht isout.tanm .08 x .50 = .040 = 001/4 = 52/1

Teehr thgim eb an irease way ot od sht,i but it rdowke for m.e

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thechillhill  oS ypnerlapta I to'dn wkno who ot fmotar very .wlle rrySo! +1
pakimd  oS cbeesua i ctluodn sdnep oemr atnh a meintu no ihst otinsequ and lsyentoh itdnd raclel het Wger-irayedbnH iuqoetan this si owh i elosvd it dnrue a uo s:nmeti you kwon ni a nievg laoppntiou flah of hetm iwll eb rreasrci nceis tsi an autsoomal ervcissee esiedsa Aa Aa= AA aa aA Ao sa of ttha hlaf %80 rea deu ot ilenoedt tmniuatso nad %20 aer edu inpto numttbaiyos ttah ogilc 80% of alfh otin 20% of alhf wlil ievg yuo /152 +1
draykid  0.8 x 5.0 is 0.4 +
topgunber  taeh shit oewlh embasrcl ngt:hi In one :niel 2 * q * s %08.hTi is for ediadses insuiadidlv (otw q lIae.)lesl = 0611/0 = e^2 Thq eefunyqcr of q = 0/wo4N 1 riearscr si 2 p .q P is selco to one siugnsam HW qem pq1.=(+) Te'sher an nltiaiddoa epst in shti einotusq deu ot eht two ifendtfer iust to.snoam )2q( = ./201 %08 fo etehs erarcirs are doleseitn so tplyiulm 02/1 * .80 = 215/ +



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